... Analysis structures and equipment associated with the resources In , the value of the stock of subsoil assets was to times as large as the value of the associated stock of invested structures ... capital cost of additions to the stock of proved reserves The use of these variables as described in the following paragraphs represents s assessment of the best estimates given existing source ... Because of the simplifying assumptions used in the calculation of stocks for this method, closing stocks are not necessarily equal to opening stocks plus additions less depletion For most years,...
Ngày tải lên: 17/02/2014, 09:20
... Board seeks comment on all aspects of the proposed amendments and is particularly interested in responses to the specific questions in the following sections A Disclosure When Assuming Responsibility ... Accountants ("AICPA") or standards of the International Auditing and Assurance Standards Board In some countries outside the United States, there are statutory requirements regarding disclosing the ... investors Some suggested that engagement partners already feel accountable for the statements in the audit report due to existing factors such as the partners’ sense of professionalism and strong...
Ngày tải lên: 23/03/2014, 04:20
A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 1 ppsx
... effects of the intervention on different subgroups (women as well as men, smokers as well as nonsmokers, diabetics and nondiabetics) and to assess the effects of concurrent medications and various ... agents in the same class of drug/device In some instances, for example, when you want to demonstrate that your treatment is as efficacious as the standard but has fewer, less severe side effects, ... carve out each letter by hand and cost their companies millions in unnecessary added costs and millions more in lost profits because of the delays And why the delays? So our manager won’t rock the...
Ngày tải lên: 14/08/2014, 07:20
A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 2 pps
... be stated as precisely as possible Consider the following: “The purpose of this trial is to demonstrate that X763 is as effective as aspirin in treating stress-induced headaches and has fewer side ... tasks, and make, not defer, decisions He or she is responsible for establishing milestones, making personnel asignments, and tracking progress Procrastinators need not apply A Manager s Guide ... discrepancies and missing values immediately See Chapter 14 Call meetings of the safety committee if necessitated by adverse event reports Pay physicians and testing laboratories as completed reports are...
Ngày tải lên: 14/08/2014, 07:20
A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 3 pps
... sensitive and less sensitive—whose distribution resembles that of Figure 6.2 Too often, a normal distribution is used to estimate the necessary sample size, regardless of whether or not it is ... discussion, it is easy to see that baseline measurements offer two opportunities for reducing person-to-person variation First, some components of the baseline measurements such as demographics ... determine your sample size Software We’ve listed some of the computer software that can be used for sample size calculations such as nQuery, Pass 2000, Power and Precision, S- PLUS, and StatXact in...
Ngày tải lên: 14/08/2014, 07:20
A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 4 potx
... sclerosis using MRI: sample size calculations for relapsing-remitting and secondary progressive subgroups using placebo controlled parallel groups J Neurol Neurosurg Psychiatry Vickers A; Cassileth ... Overview should present the strengths and limitations of the development program and study results, analyse the benefits and risks of the medicinal product in its intended use, and describe how the study ... (as is the entire submission), and you as the manager are responsible for seeing that its pledges are honored Study Committees Possible study committees include an executive board (consisting...
Ngày tải lên: 14/08/2014, 07:20
A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 5 potx
... trials the center has assisted in, the number of resident physicians, their backgrounds and clinical trials experience, and their medical specialties One center in these listings advertises a single ... etiologies in addition to those of primary interest The second is that academic physicians, professors, and fellows at medical schools and research institutions, while understanding your need for a ... newsletter should be distributed on at least a quarterly basis (and more often if there is actual news) The contents of such a newsletter might include current statistics on the study s progress,...
Ngày tải lên: 14/08/2014, 07:20
A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 6 pdf
... electronic trials run at sites increases and the sites develop or outsource a local support infrastructure EDC vendors and sponsors must carefully survey the technical support abilities of sites and, if ... it is ready to loop through the test again and again, a thousand times or more if necessary Stress Testing Automated testing suffers from the same weakness as the original programming process: ... automated test—the third stage—is as easy as pressing a button and requires an equal level of skill A log of the test results is produced automatically and provides a permanent record of success or...
Ngày tải lên: 14/08/2014, 07:20
A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 7 pot
... these responsibilities, remind investigators of their responsibilities as necessary, and with the assistance of the CRMs reward investigators for successful execution of their responsibilities ... access to the data they need A single individual, normally the database manager, is entrusted with issuing passwords and security levels to all those seeking access to the database.36 Full access ... misspellings such as “asperin”), domain tables provide faster queries, faster sorting, lower storage, and ease in updating They’re a standard part of most relational systems, present in both the least and...
Ngày tải lên: 14/08/2014, 07:20
A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 8 pot
... Thus the first steps in our analysis must be to address these issues Consider the results summarized in Table 15.1 obtained by the Sandoz drug company and reproduced with permission from the StatXact ... tests based on the original observations These tests always provide exact significance levels if the two basic assumptions of independence and equal variances are satisfied Permutation tests based ... the results for site 15 be combined with the results for the other sites? As it turns out, an analysis of this data shows that there are statistically significant differences The analysis of a...
Ngày tải lên: 14/08/2014, 07:20
A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 9 doc
... as seminars at Are the assumptions for the test local universities and think tanks are satisfied? musts If the only texts your statisti• Samples randomly selected cian has at her desk are those ... disclosing the results of the trials you follow this sequence: investigators, participants and their physicians, the scientific press, marketing materials All publications should adhere to CONSORT ... lines and work assignments A summary table listing all programs should be maintained as in Table 15.8 FOR FURTHER INFORMATION Abramson NS; Kelsey SF; Dafra P; Sutton-Tyrell KS (1992) Simpson’s...
Ngày tải lên: 14/08/2014, 07:20
A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 10 potx
... SAS Campus Drive, Cary, NC 27513 (Windows, MVS, CMS, VMS, Unix) www.sas.com SPSS The poor man s SAS, offers ease of use along with a large number of statistics A bootstrap subcommand provides ... validated and has been used in APPENDIX SOFTWARE 243 dozens of submissions Versions for Windows or Unix Also available as an add-on module for both SAS and SPSS Cytel Software Corporation, 675 Massachusetts ... analysis Windows and Macintosh versions info@datadesk.com http://www.datadesk.com/DataDesk/system.shtml StatXact While not a comprehensive statistics package, it is a must for the exact analysis...
Ngày tải lên: 14/08/2014, 07:20
frantz - 1999 - auditor's skill, auditing standards, litigation, and audit quality
... Proposition is straightforward and is thus omitted The intuition is as follows Consider a setting in which audits are mandatory and investors’ loss XL XF strictly exceeds trial awards A An increase ... analyses an auditor s litigation and audit quality choices as a function of his level of skill, trial awards, litigation costs, and auditing standards The basic model Demand for audit services is ... higher levels of skill to raise the quality of their audits to implement the new standards As qBest n is strictly increasing in n, the auditors endowed with AUDITOR S SKILL, AUDITING STANDARDS, LITIGATION...
Ngày tải lên: 06/01/2015, 19:42
C# Coding Standards and Best Programming Practices
... code Use session variables only within the classes and expose methods to access the value stored in the session variables A class can access the session using System.Web.HttpCOntext.Current.Session ... supervisor to inform that the address is updated SendEmail ( address, email ); void SaveAddress ( string address ) { // Save the address // } void SendEmail ( string address, string email ) { // Send ... the supervisor that the address is changed // } Not Good: // Save address and send an email to the supervisor to inform that // the address is updated SaveAddress ( address, email ); void SaveAddress...
Ngày tải lên: 18/08/2012, 08:47
Lecture 6 WLAN Standards and Organizations.ppt
... IEEE and oversees the standards process Many IEEE standards become ANSI standards q The Computer Society is responsible for the IEEE 802 series of standards through its LAN/MAN Standards Committee ... members 10 regions 36 technical Societies q The IEEE Standards Association administers the standards process within the IEEE The American National Standards Institute (ANSI) accredits the IEEE and ... provides a clearinghouse of information about wireless local area applications issues and trends It serves as a resource to customers and prospects of wireless local area products and wireless personal...
Ngày tải lên: 13/09/2012, 11:16
Jane Austen’s Romaticism in Pride and Prejudice
... completed six novels: Northanger Abbey, Persuasion, Sense and Sensibility, Pride and Prejudice, Mansfield Park and Emma and left behind three fragments By May 1817,she was so ill that she and Cassandra, ... there is love and same tastes, which is a kind of representation of romanticism So she still rejects Darcy at the first time because his proposal seems to be a sacrifice to her by saying that she ... restraining her own passion She pursues happiness under the condition that she must obey the moral standards So, the author still arranges a happy marriage for her After all, it is Austen s view...
Ngày tải lên: 10/04/2013, 21:34
A teacher's guide to interference and other problems
... Speakers of Spanish and Catalan 90 Portuguese speakers 113 Greek speakers 129 Russian speakers 145 Polish speakers 162 Farsi speakers 179 Arabic speakers 195 Turkish speakers 214 Speakers of South ... half, sword, psychiatrist, etc Stress Dutch and English stress patterns in words and sentences are quite similar There are some problems, though Dutch compounds regularly have stress on the ®rst ... me a scissor? *The police is looking for him Possessive `s German has an equivalent of the English possessive 's structure, but it is mostly used with names In other cases von ( = of ) is generally...
Ngày tải lên: 17/08/2013, 08:35
Ghana's biofuels policy: challenges and the way forward
... ethanol is about 97 per cent.) Based on these assumptions the demand for cassava for producing ethanol in 2015 and 2020 assuming further that only cassava will be used to meet this demand was estimated ... is important that it is pointed out that it is dangerous to adopt foreign standards without any modifications especially for biodiesel The main reason is that standards are developed for a specific ... other hand encouraged the production and usage of biofuels by allowing individual member countries to institute measures such as tax exemptions, financial assistance to companies, and establishing...
Ngày tải lên: 05/09/2013, 16:10
Let''''s go 1b _adjectives and cross
... 11 What is ? It 's a ball A this B they C your name D Scott 12 Is it a yo-yo ? A It is a yo-yo C Yes, I am B It 's an eraser D No, it isn't 13 Is it ? Yes, it is A square B an square ... is this ? B Are you 10 years old ? D What is your name ? 17 ? She is 10 years old A How old are you ? C How old is he ? B How old is she ? 18 John ? is nine years old A I B He 19 Is ... square C a box square D box 14 it ? It 's a kite A Is B What C What 's D What color 15 What is it ? A They are dolls C It 's a doll B Yes, it is D No, it isn't 16 ? Yes, I am A How...
Ngày tải lên: 27/09/2013, 17:10