management of metastatic breast cancer

... unexpected areas of breast metastases that occurred following the IC infusion of the brain seeking 231BR breast cancer cell line [11] Methods Tumor cell line The 231BR breast cancer cell line ... development of metastatic breast cancer was organ dependant Figure contains representative BLI and MRI of the distribution of metastases in the spinal cord and bones Prussian blue Page of 10 (page ... 231BR breast cancer cell line resulted in the development of metastases in the skeleton Follow-up high-resolution MRI studies of these areas confirmed the presence of metastatic breast cancer By...

Ngày tải lên: 18/06/2014, 15:20

... review of 31 reported cases of paraneoplastic neurological syndromes due to breast cancer reported only 29% of patients responded to chemotherapy with an improvement in neurological deficits [3] Often ... the nervous system and the underlying cancer Each of these antibodies is associated with a narrow spectrum of clinical syndromes and a restricted subgroup of cancers [2] Paraneoplastic syndromes ... visceral disease Biopsy of the axillary lymph node confirmed the diagnosis of an oestrogen receptor (ER) positive invasive carcinoma of mammary type Mammography and ultrasound of the breasts were unremarkable...

Ngày tải lên: 09/08/2014, 07:22

... therapy in human breast cancer Nat Clin Pract Oncol 2006, 3:269-280 Bernard-Marty C, Cardoso F, Piccart MJ: Facts and controversies in systemic treatment of metastatic breast cancer Oncologist ... al: Safety of treatment of metastatic breast cancer with trastuzumab beyond disease progression J Clin Oncol 2004, 22:1063-1070 Fountzilas G, Razis E, Tsavdaridis D, et al: Continuation of trastuzumab ... is feasible and safe in patients with metastatic breast cancer: a retrospective analysis of 80 cases by the Hellenic Cooperative Oncology Group Clin Breast Cancer 2003, 4:120-125 von Minckwitz...

Ngày tải lên: 11/08/2014, 02:22

... classification of breast cancer by the WHO (1968) and its prognostic value] Arkh Patol 1980;42(4): 13–19 Singletary SE, Greene FL: Revision of breast cancer staging: the 6th edition of the TNM Classification ... in patients with pT1–2 breast cancer Anticancer Res 2004; 24(5): 3221–3224 Stein RC, Zvelebil MJ: The application of 2D gel-based proteomics methods to the study of breast cancer J Mammary Gland ... since none of them alone is useful for the majority of the BC and none of them is specific for cancer or breast tissues No biomarker has been suggested to date for the early diagnosis of BC (24)...

Ngày tải lên: 25/10/2012, 11:15

... Trust Professor Philip Home Professor of Diabetes Medicine, University of Newcastle upon Tyne Dr Peter Jackson Clinical Pharmacologist, University of Sheffield Professor Peter Jones Professor of Statistics ... This represents 12% of all new cancer cases in women and 14% of all new cancer cases in men The incidence of colorectal cancer increases with age In people between the ages of 45 and 49 years ... years of initial diagnosis) The 5-year survival rate for metastatic colorectal disease is 12% 2.4 The management of metastatic colorectal cancer is mainly palliative and involves a combination of...

Ngày tải lên: 14/02/2014, 22:20

... care of women who are at a raised or high risk of developing hereditary breast cancer Breast cancer is the most common cancer in women Most women with breast cancer not have a family history of ... dominant inheritance of early onset breast cancer Cancer 73: 643–51 Collaborative Group of Hormonal Factors in Breast Cancer (2001) Familial breast cancer: collaborative reanalysis of individual data ... breast cancer 12 1.2 Breast awareness and examination 1.2.1 Women at increased risk of breast cancer should be breast aware’ in line with Department of Health advice for all women (see www.cancerscreening.nhs.uk/breastscreen/breastaware.pdf)...

Ngày tải lên: 15/03/2014, 00:20

... disease free interval (DFI) between the date of diagnosis of breast cancer and the date of first diagnosis of metastatic disease (under or above two years); metastatic site (bone and/or node and/or ... survival in metastatic breast cancer during first-line paclitaxel chemotherapy Anticancer Res 2003; 23(2C): 1939-42 Nomura Y Different survival determinants of metastatic breast cancer patients ... chemotherapy: results of a randomized trial Essen Breast Cancer Study Group Breast Cancer Res Treat 1999; 55 (1): 51-59 Berruti A, Zola P, Buniva T et al Prognostic factors in metastatic breast cancer patients...

Ngày tải lên: 08/08/2014, 17:20

... the standard of care in a large population of breast cancer patients A strength is that our study found that African Americans were younger at time of diagnosis of their breast cancer and were ... Frequencies and percentages of women who received standard of care and addition to standard of care are presented in Table Only two-thirds of all breast cancer cases received standard of care No differences ... two-thirds of women in the overall study population received standard of care for their breast cancer While no racial differences were found, many breast cancer cases are not receiving standard of care...

Ngày tải lên: 08/08/2014, 17:20

... breast cancer [21] The risk of subsequent contralateral breast cancer was highest for men aged less than 50 years at the time of the first cancer diagnosis, which is consistent with studies of ... M, Lopez Gomez M, Casado E: Male breast cancer Cancer Treat Rev 2010 Auvinen A, Curtis RE, Ron E: Risk of subsequent cancer following breast cancer in men J Natl Cancer Inst 2002, 94:1330-1332 ... with breast cancer [22,23] Estrogen receptors and progesterone receptors have been suggested to play a role in breast cancers in men, and they are present in about 90% and 81% of breast cancers...

Ngày tải lên: 09/08/2014, 01:24

... management of advanced oral cancer in a Jehovah’s Witness using the Ultracision Harmonic Scalpel Peter J Kullar1*, Kristian Sorenson2, Ruwan Weerakkody1 and James Adams1 Department of Maxillofacial ... head and neck cancer surgeon due to their refusal to accept transfusion of any blood products However, our experience reinforces the view that surgical management of head and neck cancer is possible ... refusal, since 1945, to accept blood transfusions even in cases of medical emergency[1] This has been the centre of a number of high profile medical ethics cases[2] The Harmonic Scalpel (HS), an...

Ngày tải lên: 09/08/2014, 02:21

... 2011, 6:52 http://www.ro-journal.com/content/6/1/52 of colorectal cancer often present with pelvic pain, one of the common manifestations of local recurrence involving nerves in the presacrum ... (50%) had single organ metastasis regardless of the Page of number of metastatic nodules, and 40 patients (50%) had two or more organ metastases The common metastatic sites were liver (33 patients, ... symptom of pain; 54 cases (79%) achieved palliation of pain and 35 cases (51%) experienced reappearance of pain Eighteen cases had the symptom of bleeding; 15 cases (83%) achieved palliation of bleeding...

Ngày tải lên: 09/08/2014, 09:20

... Reirradiation of recurrent breast carcinoma of the recurrence and a subgroup of patients (n = 13) are shown Figure Reirradiation of recurrent breast carcinoma Survival proportions of a subgroup of patients ... progression-free start of retreatment; n = 29) cancer Local progression-free survival of reirradiated breast cancer patients (months after start of retreatment; n = 29) A heterogeneous group of patients ... recurrences Methods Since 2003 we offer patients reirradiation of recurrent breast tumours based on recommendations of an interdisciplinary tumour board panel of gynaecology, medical oncology,...

Ngày tải lên: 09/08/2014, 09:22

... toxicity Biological tools: To determine breast cancer patients at high risk of local relapse The current locoregional management of early breast cancer consists of breast conserving surgery (i.e., lumpectomy ... MF: The prognostic role of a gene signature from tumorigenic breast- cancer cells N Engl J Med 2007, 356:217-26 van Beers EH, Nederlof PM: Array-CGH and breast cancer Breast Cancer Res 2006, 8:210 ... Fourquet A: Risk of breast cancer recurrence and contralateral breast cancer in relation to BRCA1 and BRCA2 mutation status following breast- conserving surgery and radiotherapy Eur J Cancer 2005,...

Ngày tải lên: 09/08/2014, 10:20

... therapeutic potential of candidate biomarkers, such as IGF-1 for the early detection of breast cancer These studies are important since the breast cancers from populations of women at high risk ... BRCA1-associated breast cancer, increased expression of several components of the IGF axis is seen in liver, normal mammary tissue and mammary tumors of these mice along with increased levels of IGF-1 ... and breast cancer in young women: a pooled re-analysis of three prospective studies Eur J Cancer Prev 2005, 14:493-6 Renehan AG, Frystyk J, Flyvbjerg A: Obesity and cancer risk: the role of the...

Ngày tải lên: 11/08/2014, 00:23

... analysis of miRNA expression, mRNA expression and genomic changes in human breast cancer and may serve as a basis for functional studies of the role of miRNAs in the etiology of breast cancer Furthermore, ... normal human breast and primary human breast cancer To generate a comprehensive set of miRNA expression profiles for primary human breast cancer we selected 99 primary human tumors, normal breast samples ... classification of human tumors using mRNA microarray profiling is an area of intense research A number of classifiers have been developed for human breast tumors, including the use of expression...

Ngày tải lên: 14/08/2014, 08:20

... medicine in the treatment of disease states like breast cancer 1.4 Rationale and purpose of this study Breast carcinoma is a common cancer in women and is a leading cause of cancerrelated deaths in ... of these medical interventions and the stress of living with breast cancer can negatively affect the patients’ quality of life QOL research has become an important part of the assessment of cancer ... 63 Figure BR-23 scores of breast cancer patients at baseline and after 11-13 weeks of TCM treatment……………………………………………… 65 Figure Single item score distribution of breast cancer patients at baseline...

Ngày tải lên: 15/09/2015, 17:10

... TREATMENT OF CANCER 1.2.1 THE MECHANISM OF CANCER CELL PROLIFERATION 1.2.2 THE REDUCTION OF CANCER CELL PROLIFERATION WITH DOCETAXEL AND TAMOXIFEN 1.2.3 THE COMPLEXITY OF TUMOUR ... protection of anti -cancer drugs with nanoparticle, which suggested its great potential in anti -cancer applications [4] 1.2 RATIONALE FOR THE MULTIMODAL TREATMENT OF CANCER 1.2.1 THE MECHANISM OF CANCER ... cell signalling TAM had been used in the treatment of ER positive breast cancer and in the reduction of breast cancer risk [42–44] Side effects of DCL included acute toxicities such as hypersensitivity,...

Ngày tải lên: 01/10/2015, 17:28

... TREATMENT OF CANCER 1.2.1 THE MECHANISM OF CANCER CELL PROLIFERATION 1.2.2 THE REDUCTION OF CANCER CELL PROLIFERATION WITH DOCETAXEL AND TAMOXIFEN 1.2.3 THE COMPLEXITY OF TUMOUR ... protection of anti -cancer drugs with nanoparticle, which suggested its great potential in anti -cancer applications [4] 1.2 RATIONALE FOR THE MULTIMODAL TREATMENT OF CANCER 1.2.1 THE MECHANISM OF CANCER ... cell signalling TAM had been used in the treatment of ER positive breast cancer and in the reduction of breast cancer risk [42–44] Side effects of DCL included acute toxicities such as hypersensitivity,...

Ngày tải lên: 03/10/2015, 20:58

...  MANAGEMENT OF BREAST CANCER IN WOMEN 2.3.2 staging of breast cancer In early operable breast cancer (T1-2, N0-1; see annex 2), there is no current evidence to support routine screening for metastatic ... treatment of breast cancer Clinical practice guidelines for the care and treatment of breast cancer: 14 The role of hormone replacement therapy in women with a previous diagnosis of breast cancer ... Email: sco@breastcancercare.org.uk • www.breastcancercare.org.uk Breast Cancer Care provides information, practical assistance and emotional support for anyone affected by breast cancer CancerBACUP...

Ngày tải lên: 08/03/2014, 14:20

... breast: diagnosis 37 38 Guidelines for management of breast cancer Figure 15 Cancer of the male breast: management Management of special problems in breast cancer Figure 16 Unknown primary presenting ... in breast cancer This chapter gives guidelines on management of special problems in breast cancer (Figures 11–16) Figure 11 Phyllodes tumour of the breast 36 Guidelines for management of breast ... of breast cancer Figure 12 Bilateral breast cancer Management of special problems in breast cancer Figure 13 Paget’s disease of the nipple-areola complex Figure 14 Cancer of the male breast: diagnosis...

Ngày tải lên: 28/03/2014, 23:20