mammalian models of iron homeostasis

... GSEA of transcriptome data using an individually designed metal homeostasis category Surprisingly, GSEA of MapMan categories did not reveal hits of the transport metal category in each of the ... significant alterations of gene expression patterns of an entire category of genes representing the components for metal homeostasis Over Representation Analysis (ORA) of 258 differentially expressed ... S3: Annotated gene list of the self-defined category “metal homeostasis Additional file 6: Table S4: Gene list of the self-defined category metal homeostasis. txt Page 10 of 10 10 Additional file...

Ngày tải lên: 11/08/2014, 11:20

... Molecular control of iron homeostasis 2.3.1 Regulation of cellular iron homeostasis The expression of some iron homeostasis- related genes has been shown to be involved in the modulation of transcription, ... Regulation of systemic iron homeostasis, 33 2.3.2.1 Systemic iron regulators, 33 2.3.2.2 Hepcidin is an iron regulatory effector, 34 2.4 Diseases related to impairment of iron homeostasis, 35 2.4.1 Iron ... Biological importance of iron, 23 2.1.2 Iron and free radical production, 23 2.2 Iron homeostasis, 24 2.2.1 Systemic iron homeostasis, 24 2.2.1.1 Iron absorption, 24 2.2.1.2 Iron excretion, 26 2.2.2...

Ngày tải lên: 16/09/2015, 15:55

... method, a majority of the people in the lower part of the river is dissatisfied with the quality of tap water Moreover, in case of accidental spill of pollutant, the distribution of water should ... Sampling point of this study Fig Development areas of bankfiltrate - 134 - Journal of Water and Environment Technology, Vol.1, No.2, 2003 Nanofiltration to hardness removal Nanofiltration experiment ... reaction - 139 - Journal of Water and Environment Technology, Vol.1, No.2, 2003 References Baveye, P and Valocchi, A., An evaluation of mathematical models of the transport of biologically reacting...

Ngày tải lên: 05/09/2013, 08:40

... women in the form of the right to an abortion as an instrument of care-giving not to the fetus, of course, but to others We can see a good example of the use of a traditional model of motherhood ... model of motherhood and abortion rights Underlying the problem deWnition of abortion rights is a traditional view of motherhood – one that rests upon a relational view of women, deWned in terms of ... Clause of the Fourteenth Amendment of the Constitution prohibits the state from depriving ‘any person of life, liberty, or property without due process of law’ This Due Process right of privacy...

Ngày tải lên: 01/11/2013, 08:20

... Animal models of Alzheimer’s disease O Philipson et al Transgenic animal models Models devoid of any disease-causing APP mutations Animal models expressing wild-type (wt) human APP are of interest ... disease pathogenesis Familial forms of AD, with an autosomal dominant mode of inheritance, account for < 2% of all AD cases Onset is most often before 65 years of age, and the penetrance is nearly ... [54] A substantial amount of CAA is often found in transgenic mice with the Swedish mutation, which is likely to be because of the high rate of synthesis and accumulation of Ab1-40 In Tg2576, more...

Ngày tải lên: 16/02/2014, 09:20

... applications of the Rudebusch-Wu model illustrate the range of issues that such a macrofinance model can address The first of these is an exploration of the source of the Great Moderation—the period of reduced ... yield curve Many of these models are arbitrage-free latent factor models Unfortunately, there are many technical difficulties involved with the estimation of AF latent factor models, which tend ... of accuracy, Figure also plots survey-based measures of expectations of CPI inflation, which are obtained from the Blue Chip Consensus survey at the five-year horizon and from the Survey of Professional...

Ngày tải lên: 17/02/2014, 03:20

... bands, TLC plates were dipped into a charring solution consisting of 0.63 g of MnCl2Æ4H2O, 60 mL of water, 60 mL of methanol and mL of concentrated sulfuric acid, briefly dried and heated at 100 °C ... hydrolysis of lipid extracts [68] The protein concentration of 10 mL of culture with an attenuance at 600 nm of was determined and cells were incubated for h at 90 °C together with 0.6 mL of methanol, ... 30 °C and terminated by the addition of 300 lL of chloroform ⁄ methanol (2 : 1, v ⁄ v) Lipids were extracted twice for 10 with shaking using 300 lL of chloroform ⁄ methanol (2 : 1; v ⁄ v), each...

Ngày tải lên: 18/02/2014, 13:20

... surfaces of natural killer (NK) cells, as well as on CD4+ and CD8+ T cells It promotes apoptosis, which may aid in the resolution of infection and the attenuation of the development of streptoxotocin-induced ... a wide range of responses, depending on cell type and levels of ROS within the cell [23,24] The aims of this study were to investigate the major signalling pathways and effects of hypoxic conditions ... Evaluation of articular cartilage after experimentally induced osteoarthritis (A) Photomicrographs of articular cartilage (B) The evaluation of osteoarthritis in the right and left joints of dogs...

Ngày tải lên: 18/02/2014, 14:20

... if they delay the evaluation of the probabilities of the same words and if they have the same number of lexical heads, and if the first two elements of their lists of lexical heads are identical ... impact of capturing different kinds of long-range dependencies, four different models were investigated: The baseline model is like the LexCat model of (2002b), since the structural probabilities of ... Table gives the performance of all four models on section 23 in terms of the accuracy of lexical categories, Parseval scores, and in terms of the recovery of word-word dependencies in the predicateargument...

Ngày tải lên: 20/02/2014, 16:20

... is often associated with enhanced blood vessel supply An important application of this technology includes breast cancer visualization The proof of principle of PA imaging in the detection of ... approaches are often applied to evaluate the cost-effectiveness of healthcare technologies at different phases of their product lifecycle This can be used to inform the reimbursement of funding of healthcare ... examining MR-images of breasts) were asked to estimate the importance of different tumor characteristics in the examination of images of breasts Following this, the performance of visualizing these...

Ngày tải lên: 20/02/2014, 16:20

... binding of ligands on the iron of Fe(porphyrin))13G10 complexes: (A) binding of H2O2 on the iron of 13G10-(Fe(ToCPP), (B) binding of two CN± ligands on the iron of 13G10-(Fe(ToCPP), (C) binding of ... Binding of cyanide to the iron( III) of Fe(ToCPP) and Fe(ToCPP))13G10 First of all, the aforementioned results show that the iron( III) of the Fe(ToCPP))13G10 complex is able to bind, like that of free ... imidazole on the iron of 13G10±Fe(ToCPP) is even more dif®cult than the binding of two 1-substituted imidazoles on the iron of free Fe(ToCPP) In addition, the in¯uence of the nature of the substituent...

Ngày tải lên: 21/02/2014, 03:20

... consequence of the presence of the same kind of spectrum for 4N complexes of GGH, where the a carbon of the His residue is the sole source of chirality [10] However, while positions of the component ... studies of the Ni(II) complex of HSA [6] Due to different protonation patterns, the stability constants of particular complexes of model peptides cannot be compared directly There are two ways of ... in the middle of the range of values for both Cu(II) and Ni(II) Note that the variation of side chain substituents can result in changes of complex stabilities by up to six orders of magnitude,...

Ngày tải lên: 22/02/2014, 04:20

... reason is the existence of the Mozart Programming System Panorama of computation models This book presents a broad overview of many of the most useful computation models The models are designed not ... (including improved versions of Java) The kernel language approach Practical programming languages scale up to programs of millions of lines of code They provide a rich set of abstractions and syntax ... consisting of hardware, operating system, middleware, and application layers, each of which is based on the work of thousands of people over several decades They contain an enormous number of abstractions,...

Ngày tải lên: 22/02/2014, 06:20

Ngày tải lên: 23/02/2014, 04:20

... involved identification of interaction-deficient mutants as determined by loss of the His3+ phenotype and loss of activation of the lacZ reporter gene Subsequently, clones showing loss of interaction were ... Therefore, characterization of TOR signaling pathway regulator-like (TIPRL; TIP41), the mammalian ortholog of Tip41, may provide clues to better understand the regulation of type 2A phosphatases ... subunits of the type 2A phosphatases PP2Aca (one cDNA), PP2Acb (three cDNAs), the C-terminal region of PP2Aca ⁄ b (one cDNA), PP4c (three cDNAs) and PP6c (two cDNAs) Initial mapping of the region of...

Ngày tải lên: 07/03/2014, 05:20

... internals of generative syntax models such as the “infinite tree” (Finkel et al., 2007) In some ways, our models are less ambitious than comparable syntactic models as they focus on specific fragments of ... 0.1 0.1 50 100 150 No of classes (a) Verb-object 200 0.1 50 100 150 200 No of classes 50 100 150 200 No of classes (b) Noun-noun (c) Adjective-noun Figure 1: Effect of number of argument classes ... the topical structure of documents can be adapted to learn probabilistic models of selectional preference These models are especially effective for estimating plausibility of low-frequency items,...

Ngày tải lên: 07/03/2014, 22:20

... a vector v of numerical values; one might, e.g., think of the level of excitation of neurons Then, an external stimulus or signal, such as a perceived word, will result in a change of the mental ... underlying word space models; e.g., the models of Widdows (2008) and Giesbrecht (2009) feature dimensionality reduction while that of Mitchell and Lapata (2008) does not In the light of these findings, ... combine a variety of distributional and symbolic aspects of natural language This nourishes the hope that matrix models can serve as a kind of lingua franca for compositional models This having...

Ngày tải lên: 07/03/2014, 22:20

... efficiency of parameter-setting acquisition models We have recently run experiments of seven parameter-setting (P&P) models of acquisition on the domain What follows is a brief discussion of the ... a comprehensive study of parameter-setting algorithms or acquisition algorithms in general There is a large number of models that are omitted; some of which are targets of current investigation ... several types of non-generative acquisition models, a generative (or hybrid) learner is faced with the task of selecting the rules or parameter values that generate the linguistic environment being...

Ngày tải lên: 08/03/2014, 04:22

... terms of a tree structured representation, the set of nonterminal nodes is fully specified, while some of the terminal nodes may be omitted One central characteristic of hidden understanding models ... Markov models, we refer to the combination of these two models as a hidden understanding model The word "hidden" refers to the fact that only words can be observed The internal states of each of ... with hidden understanding models SHOW: FLIGHTS: TIME: PART -OF- DAY: morning ORIGIN: CITY: Boston DEST: CITY: San Francisco DATE: DAY -OF- WEEK: Tuesday Expressing Meanings One of the key requirements...

Ngày tải lên: 08/03/2014, 07:20

... features of credit risk models; from a practical point of view a link between the different types of models enables us to apply numerical and statistical techniques for solving and calibrating the models, ... maximum likelihood fitting of Bernoulli mixture models is a feasible method of obtaining estimates of model parameters and the precise choice of the mixing distribution is of lesser importance Moreover, ... credit risk models leading to the same multivariate distribution of S or Y Since this distribution is the main object of interest in the analysis of portfolio credit risk, we call two models with...

Ngày tải lên: 15/03/2014, 04:20