... illustrate the inverse (3BrP and IA) and direct (5-FU) correlation that exists between the bioenergetic signature of the cells and the death-response to the chemotherapeutic agents Sánchez-Aragó and ... activation of caspase (an apoptotic indicator) was observed following any of these above treatments in any of the cell lines tested (data not shown) Therefore, inhibition of the activity of glycolytic ... between the bioenergetic signature of a cell and the extent of cell death following 3BrP (R = -0.633; n = 36, P < 0.01) and IA (R = -0.616; n = 36, P < 0.01) treatment, supporting the relevance of these...
Ngày tải lên: 18/06/2014, 19:20
... illustrate the inverse (3BrP and IA) and direct (5-FU) correlation that exists between the bioenergetic signature of the cells and the death-response to the chemotherapeutic agents Sánchez-Aragó and ... activation of caspase (an apoptotic indicator) was observed following any of these above treatments in any of the cell lines tested (data not shown) Therefore, inhibition of the activity of glycolytic ... between the bioenergetic signature of a cell and the extent of cell death following 3BrP (R = -0.633; n = 36, P < 0.01) and IA (R = -0.616; n = 36, P < 0.01) treatment, supporting the relevance of these...
Ngày tải lên: 20/06/2014, 03:20
Báo cáo y học: "Five-year follow-up of Japanese patients with Paget''''s disease of the bone after treatment with low-dose oral alendronate: a case series/" ppt
... suitable for the treatment of Japanese patients since the dose of alendronate used for the treatment of osteoporosis in Japanese patients (5 mg per day) was half of that used for the treatment of osteoporosis ... arrow) and sclerotic (white arrowhead) changes in the left acetabulum, half of the ilium, and the pubic bone dosage of alendronate for one year after the cessation of treatment [9] Furthermore, ... cancer, and other sclerosing bone dysplasia [2,3] To monitor disease activity and the effects of treatment, we measured T-ALP and uNTX levels of our patients every three to six months and assessed their...
Ngày tải lên: 11/08/2014, 12:20
Báo cáo y học: "Cost estimates of HIV care and treatment with and without anti-retroviral therapy at Arba Minch Hospital in southern Ethiopia" docx
... more of a chronic problem [3] Ethiopia may therefore have to assume the major share of the cost of care and treatment in the future This may involve policies and strategies that ensure the cost-effectiveness ... costs of each of the services by dividing the cost of inputs incurred along each of the serv- http://www.resource-allocation.com/content/7/1/6 ices during the base year by the total number of output ... the limited duration of follow-up may not capture the pattern of service use and the corresponding cost over several years This might affect the precision of the estimates and the result may need...
Ngày tải lên: 13/08/2014, 11:22
Báo cáo y học: "Insect sting allergy. A study from 1980 to 2003 of patients who started treatment with venom immunotherapy between 1980 and 1998" pps
... care of the questionnaires from 1989 and 1993, compiled the data, drafted the tables and is the main author LKD participated in the consultations and the follow up from 2001–2003, designed and ... angioedema of the head and neck or symptoms from two organ systems, to a sting from bee and/ or wasp and who were willing to comply with a minimum of five years of treatment were offered IT The SPT ... to offer continued IT to some patients and still keep the total number treated low The rest of the patients will have to rely on epinephrine Epinephrine offered as the only treatment instead of...
Ngày tải lên: 13/08/2014, 13:22
TARGETING ACUTE PHOSPHATASE PTEN INHIBITION AND INVESTIGATION OF A NOVEL COMBINATION TREATMENT WITH SCHWANN CELL TRANSPLANTATION TO PROMOTE SPINAL CORD INJURY REPAIR IN RATS
... disruption and degradation to glial growth, proliferation, and migration As the interaction between the various cells and structures within the CNS is essential to the health and function of each and the ... CHARACTERIZATION OF PTEN/PI3K EXPRESSION AND SIGNALING, AND ASSESSMENT OF THE EFFECTS OF PTEN INHIBITOR BISPEROXOVANADIUM ON NEUROPROTECTION AND RECOVERY OF THE INJURED RAT FORELIMB FOLLOWING SCI Hypotheses: ... pharmacological therapeutics Table highlights some of the most commonly used chemical inhibitors, their targets, and functions for assessing the roles of particular steps of these pathways and for experimental...
Ngày tải lên: 24/08/2014, 09:14
Tài liệu Báo cáo Y học: Proteolysis of bovine b-lactoglobulin during thermal treatment in subdenaturing conditions highlights some structural features of the temperature-modified protein and yields fragments with low immunoreactivity pptx
... portion of the b-barrel structure (strands B, C and part of strand D), along with part of the distant I strand in the C-terminus region that includes Cys160 and connects to the leftovers of strand ... during the thermal treatment, hydrolysis of BLG was extensive, in spite of significant inactivation of the enzymes This indicates that the transient conformers originating in the course of thermal treatment ... amount of time At the end of the heat treatment the mixtures were placed in an ice/water bath, and the enzymatic activity was stopped by lowering the pH of the reaction mixture to by addition of...
Ngày tải lên: 21/02/2014, 15:20
báo cáo hóa học: " Comparison of the discriminative ability of a generic and a condition-specific OHRQoL measure in adolescents with and without normative need for orthodontic treatment" potx
... analysis and drafted the first version of the manuscript CMdO organized and conducted the study, and has critically revised the manuscript AS supervised the entire study and critically revised the ... ethnicity and orthodontic treatment status), the prevalence of oral impacts was also compared between adolescents with and without normative need for orthodontic treatment For that, the prevalence of ... 44 Jenny J, Cons NC: Comparing and contrasting two orthodontic indices, the Index of Orthodontic Treatment need and the Dental Aesthetic Index Am J Orthod Dentofacial Orthop 1996, 110(4):410-416...
Ngày tải lên: 18/06/2014, 19:20
báo cáo hóa học:" Health-related quality of life in relapsing remitting multiple sclerosis patients during treatment with glatiramer acetate: a prospective, observational, international, multi-centre study" pdf
... initiated the study, contributed to conception and design of the study, acquisition of data, analysis of data and interpretation of data, drafted the manuscript, and has given final approval of the ... hospitals and MS centers in the Netherlands, Sweden and Belgium The protocol was submitted to the Independent Review Board (IRB), an approved ethical committee residing in Amsterdam, the Netherlands The ... conception and design of the study, acquisition of data, interpretation of data, revised the manuscript critically for important intellectual content, and has given final approval of the version...
Ngày tải lên: 20/06/2014, 15:20
Báo cáo y học: "Residual sleep disturbance and risk of relapse during the continuation/maintenance phase treatment of major depressive disorder with the selective serotonin reuptake inhibitor fluoxetine" docx
... literature search and in the preparation of the manuscript SJY contributed in the review of the manuscript YC was the statistician for the original study, and helped interpret the data for the current ... conceptualized the study, participated in the preparation of the manuscript and provided critical review of the manuscript LSY participated in the editing of the manuscript SC contributed in the literature ... reason, there is the need for more studies specifically examining the role of residual sleep disturbance as a predictor of relapse in MDD Therefore, the purpose of the present study was to explore the...
Ngày tải lên: 08/08/2014, 23:21
Báo cáo y học: " Predictors of infusion reactions during infliximab treatment in patients with arthritis" docx
... monotherapy The aim of the present study was to evaluate the predictive value of ANA status, methotrexate and other concomitant immunomodulating agents before the initiation of infliximab treatment ... analysis and interpretation, and wrote the manuscript LL contributed to the collection of data, its interpretation and preparation of the manuscript GS contributed to the idea and to the critical ... revision of the article LT was responsible for laboratory analysis TS contributed to critical revision of the manuscript and supervised the study PG was responsible for the planning of the study and...
Ngày tải lên: 09/08/2014, 08:22
Báo cáo y học: " The potential role of appetite in predicting weight changes during treatment with olanzapine" ppt
... olanzapine treatment should receive regular monitoring of weight and lifestyle educational programs early in the course of illness and of treatment Acknowledgements The authors thank Dr Alexandra ... Canada and Memorial University of Newfoundland, St John’s, Newfoundland and Labrador, Canada Authors’ contributions MC was involved in the design of the study, performed the statistical analyses, and ... of treatment, and by weeks weight changes were as informative as appetite changes Additionally, the use of different appetite assessment scales limits comparisons across studies and most of the...
Ngày tải lên: 11/08/2014, 16:22
Báo cáo y học: " Impact of race on efficacy and safety during treatment with olanzapine in schizophrenia, schizophreniform or schizoaffective disorde" pdf
... subsequent drafts of the manuscript SKW coordinated the development of the initial and final drafts All authors participated in the analysis and interpretation of the data, and revising the manuscript ... tailored therapeutics and identifying patients who will have the optimal response with minimal adverse events either before the treatment initiation or early in the course of therapy The field of genomics, ... subsidiary of Eli Lilly and Company Authors’ contributions VLS conceived the study and contributed to the design and coordination JLS and JG performed the statistical analysis KWP wrote the initial and...
Ngày tải lên: 11/08/2014, 16:22
Báo cáo y học: " Dynamic analysis of CD127 expression on memory CD8 T cells from patients with chronic hepatitis B during telbivudine treatment" ppt
... with the downregulation of CD38 and PD-1 and the upregulation of CCR7 expression [9,11,12] All occurred in concert with resolution of disease and containment of viral antigen, supporting the theory ... (Hangzhou, Zhejiang, China) The diagnosis of CHB was made according to the diagnostic standards from the National Program for Prevention and Treatment of Viral Hepatitis A total of 20 HLA-A2 + patients ... from the Department of Science and Technology of Zhejiang Province, China to Y D Yang, grant no 2009C33009 from the Department of Science and Technology of Zhejiang Province, China to L Zheng and...
Ngày tải lên: 12/08/2014, 01:21
Báo cáo y học: "Regulation of IFN response gene activity during infliximab treatment in rheumatoid arthritis is associated with clinical response to treatment" potx
... between the studies in SS [11] and SoJIA [9], on the one hand, and our studies in RA and spondyloarthritis (SpA) [31], on the other, could have their origin in differences in design between the studies, ... at baseline and weeks and and subsequently every weeks) After 4, 8, 12, and 16 weeks of treatment, another PAXgene tube was obtained All patients gave written informed consent, and the study protocol ... between the individual RA patients and unrelated to medication and disease activity In the present study, we studied the effect of TNF blockade on the transcription of type I IFN response genes Therefore,...
Ngày tải lên: 12/08/2014, 11:22
Báo cáo y học: "Endovascular Treatment of Bilateral Carotid Artery Occlusion with Concurrent Basilar"
... Occlusion Begnning of the CCA Begnning of the CCA Begnning of the ICA Left cavernous sinus part of the ICA, right beginning of the ICA Begnning of the ICA Symptom Other aeurysms SAH PCA SAH No SAH ... the formation of anastomosis between the middle meningeal and intracranial arteries, the submandibular artery from the external carotid artery and the artery underlying the cavernous sinus, and ... apex aneurysm with clipping of the others, and one case used the balloon assisted technique for embolization of the basilar apex and other aneurysms Taken together, the data show that http://www.medsci.org...
Ngày tải lên: 25/10/2012, 11:04
Tài liệu Báo cáo khoa học: Analysis of oxidative events induced by expanded polyglutamine huntingtin exon 1 that are differentially restored by expression of heat shock proteins or treatment with an antioxidant ppt
... distribution of the size of the inclusions was noticed Moreover, the percentage of cells presenting inclusions as well as the distribution of the size of the inclusions were dependent on when the analysis ... downstream of the initiator ATG in exon (Ex1) of the 67 exon-containing htt gene [5] Pathogenesis in HD correlates with the cleavage of mutated htt and the release of an N-terminal fragment bearing the ... Note the presence of the granules in the cytoplasm of the cells Bar, 20 lm (D) The percentage of EGFP-containing cells displaying granules is shown The average percentages, including standard...
Ngày tải lên: 19/02/2014, 06:20
On public health use of influenza antivirals during influenza pandemics (with particular reference to the pandemic (H1N1) 2009) docx
... development of new therapies Considerations should also be given to the public health implications of ensuring appropriate prescribing practices in order to limit the risk of the emergence and spread of ... account: • • • • the total volume and availability of antivirals; the underlying epidemiology (projected attack rates, etc.); anticipated size and duration of transmission; and the size of population ... use? There are a range of different strategies regarding the use of antivirals that depend on the overall public health goals authorities wish to attain, the availability of antivirals, and other...
Ngày tải lên: 05/03/2014, 22:21