Ngày tải lên: 05/09/2013, 16:10
... these three arginines in TClpB. By combining an arginine mutation with the WalkerA mutation in the other AAA+ module, we tested the roles of the arginines in ATP binding and hydrolysis in each module. ... of the hexameric form, but not for the ATP-induced motion of the middle domain. Results The conserved arginines are not involved in nucleotide binding To examine the roles of conserved arginines, ... the roles of the arginines in individual AAA+ modules were not elucidated. The role of the other conserved arginine (P2) in AAA-1 was also unclear. Here, we investigated in detail the roles of...
Ngày tải lên: 06/03/2014, 00:20
Báo cáo khoa học: Flexible nets The roles of intrinsic disorder in protein interaction networks potx
... contained regions of intrinsic disorder. One example of an ordered hub, calmodulin, makes use of a flexible hinge to facilitate binding diversity. Each of these classes and their roles in protein–protein ... in interaction with Cdk2 and cyclin A: 1, domain 1 interacting with cyclin A; 2, a linker helix involved in binding both cyclin A and Cdk2; 3, domain 2 inter- acting with Cdk2 [122]. Blue and dark ... determine what fraction of protein– protein interaction in regulatory networks relies on intrinsic disorder. Abbreviations CaM, calmodulin; Cdk, cyclin-dependent protein kinase; CKI, Cdk inhibitor...
Ngày tải lên: 07/03/2014, 21:20
Báo cáo khoa học: Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting pdf
... their main roles focus on ectodomain shedding and nonpro- teolytic functions, such as binding to adhesion mole- cules, integrins and interacting with phosphorylation sites for serine ⁄ threonine ... through integrins because the shedding of E-cadherin results in b-catenin translocation to the nucleus, leading to cell proliferation [23]. It is worth noting that the inactive proform of TGF-b, ... tetracyclines, lacking antibiotic activities, may inhibit MMPs by binding to metal ions such as zinc and calcium. This family of inhibitors, including metastat (COL-3), minocycline and doxycycline, cause...
Ngày tải lên: 15/03/2014, 00:20
Báo cáo khoa học: Different roles of functional residues in the hydrophobic binding site of two sweet orange tau glutathione S-transferases pdf
... of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72, 248–254. 40 Laemmli UK (1970) Cleavage of structural proteins during the assembly of head of ... were observed in the case of the superimposed PKV–RKV models, whose major nonoverlapping regions are, instead, localized in the H-site of the enzymes (Fig. 2B). These findings are in agreement ... the maintenance of a high-affinity CDNB-binding site. However, the substitu- tion E117K gives rise to mutants showing increased k cat values for CDNB, suggesting that Lys117 might positively in uence...
Ngày tải lên: 15/03/2014, 09:20
Báo cáo khoa học: Essential roles of lipoyl domains in the activated function and control of pyruvate dehydrogenase kinases and phosphatase isoform 1 pot
... higher rates of phosphorylation of the E2-bound E1. Binding of a kinase dimer to a lipoyl domain containing a reduced lipoyl group fosters a further increase in kinase activity (PDK* state). Binding of ... portion of the 13-fold activation of PDK3 by L2 [18] is, in fact, due to preventing or reversing a decrease in activity of PDK3 undergoing self association in the absence of L2. Binding of two ... domain, mutation of glutamates 162, 179 and 182, and glutamine 181 greatly reduces binding. Indeed, substitution of alanine or glutamine for Glu182 blocks binding of PDP1 and PDP1c to the L2 domain. As...
Ngày tải lên: 17/03/2014, 09:20
The Roles of the Aesthetic in Mathematical Inquiry doc
... pattern emerging in a sequence of numbers; a point of coincidence found in a group of lines; a large change resulting from a small variation; a finite real thing proved by an infinite, possibly ... role in motivating and sustaining inquiry. AESTHETIC IN MATHEMATICAL INQUIRY 281 nomenon, some experience which either disappoints an expectation, or breaks in upon some habit of expectation of ... by influencing the discernment of features in a situation, and thereby directing the thought patterns of the inquirer. According to Dewey’s theory of inquiry (1938), the heuristic function of...
Ngày tải lên: 30/03/2014, 16:20
Summary phd thesis in philosophy roles of the government in the integration of economic growth with ecological environment protection in vietnam nowadays
... team of professional staff by planning, training and developing skilled staff and Government officials. Then, there will be a team of skilled staff, ensuring the continuing hierarchy in terms of ... organizing, building the team of professional staff that is in charge of performing the management of resources and environment. Strengthening the government’s roles in the management of resources ... strengthening the roles of the government in the incorporation of the economic growth with ecological environment protection. 2.2.3. Roles of the government in performing the inspection, checking and supervision...
Ngày tải lên: 14/07/2014, 13:34
Different roles of functional residues in the hydrophobic binding site of two sweet orange tau pps
... of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72, 248–254. 40 Laemmli UK (1970) Cleavage of structural proteins during the assembly of head of ... were observed in the case of the superimposed PKV–RKV models, whose major nonoverlapping regions are, instead, localized in the H-site of the enzymes (Fig. 2B). These findings are in agreement ... rate-limiting step of the CDNB– GSH catalytic reaction is the physical event of product release, probably involving structural motions or con- formational changes of the ternary complex. In this context,...
Ngày tải lên: 07/08/2014, 01:20
Báo cáo y học: "Elucidation of the potential roles of matrix metalloproteinases in skeletal biology" pps
Ngày tải lên: 09/08/2014, 01:21
báo cáo khoa học: " Beneficial effects of physical activity in an HIVinfected woman with lipodystrophy: a case report" ppsx
Ngày tải lên: 10/08/2014, 23:20
Báo cáo y học: " Echoviruses are a major cause of aseptic meningitis in infants and young children in Kuwait" ppsx
Ngày tải lên: 12/08/2014, 01:21
How group work is used in speaking lesson of the first year major students of english at viet nam university of commerce
... researcher wants to investigate the use of group work in teaching speaking of English major students with a focus on the process of group work organization in hope of finding information which ... toward individualizing instruction 10 Brainstorming is often put to excellent use in preparing students to discuss a complex issue. It is a technique whose purpose is to initiate some sort of thinking ... ten interviews were conducted in Vietnamese. At the beginning of each interview, the students were explained clearly, explicitly and unambiguously about the nature of the study. During the interview,...
Ngày tải lên: 07/11/2012, 14:50