macrophage monocyte inhibitory factor mif

... interface [21,22] Macrophage migration inhibitory factor (MIF) was originally identified as a protein derived from T lymphocytes [23,24] MIF is a proinflammatory cytokine produced by macrophages in ... c-Jun Figure (MIF) Signaling cascade activated by macrophage migration inhibitory factor (MIF) Rheumatoid arthritis (RA) synovial fibroblasts were pretreated hour before stimulating with MIF (25 nM) ... by macrophage migration inhibitory factor Arthritis Rheum 2001, 44:1273-1280 Chesney J, Metz C, Bacher M, Peng T, Meinhardt A, Bucala R: An essential role for macrophage migration inhibitory factor...

Ngày tải lên: 09/08/2014, 08:22

... al.: Mutation screening of the macrophage migration inhibitory factor gene: positive association of a functional polymorphism of macrophage migration inhibitory factor with juvenile idiopathic ... Recombinant human migration inhibitory factor has adjuvant activity Proc Natl Acad Sci USA 1992, 89:8049-8052 Larson DF, Horak K: Macrophage migration inhibitory factor: controller of systemic ... FQ, Liew FY, Weiser WY: IL-10 inhibits the synthesis of migration inhibitory factor and migration inhibitory factor- mediated macrophage activation J Immunol 1993, 151:4325-4332 29 Cvetkovic I,...

Ngày tải lên: 09/08/2014, 10:20

... mitogen-activated protein kinase; M-CSF: monocyte- colony stimulating factor; MEM: minimal essential medium; MEK1: MAP kinase kinase-1; MIF: macrophage migration inhibitory factor; MMP: Kim et al Arthritis ... effect of macrophage- colony stimulating factor and other humoral factors (interleukin-1, -3, -6, and -11, tumor necrosis factor- alpha, and granulocyte macrophage- colony stimulating factor) on ... by macrophage migration inhibitory factor J Rheumatol 2004, 31:1038-1043 Onodera S, Nishihira J, Koyama Y, Majima T, Aoki Y, Ichiyama H, Ishibashi T, Minami A: Macrophage migration inhibitory factor...

Ngày tải lên: 12/08/2014, 15:22

... release of sCD40 is therefore a marker of immune activation Conclusion Scheme of macrophage migration inhibitory factor (MIF) induction of systemic inflammatory response syndrome (SIRS) and multiple ... pituitary secretion of MIF and ACTH ACTHstimulated glucocorticoids and/or immunologic mediators may induce release of MIF by Th2 cells [5] Most importantly, MIF counter-regulates the inhibitory effects ... and macrophage functions The Th2 cytokines generally support the humoral mediated responses related to B-lymphocyte function and immunoglobulin isotype Integration of macrophage migration inhibitory...

Ngày tải lên: 12/08/2014, 23:23

... tuberculosis, malaria and pneumococcal bacteraemia [14,15] Finally, the cytokine macrophage migration inhibitory factor (MIF) has been found to be a valuable marker of microbiologically documented ... 0.25 μg/l and 7.5 × 109 cells/l, respectively Sensitivity and specificity of macrophage migration inhibitory factor (MIF) , soluble triggering receptor expressed on myeloid cells (sTREM)-1, soluble ... (e) soluble triggering receptor expressed on myeloid cells (sTREM)-1 and (f) macrophage migration inhibitory factor (MIF) in patients with no infection (circle), bacterial (triangle, apex up),...

Ngày tải lên: 13/08/2014, 03:20

... mice due to deletion of macrophage migration inhibitory factor (MIF) Cytokine 2004, 26:187-194 26 Mikulowska A, Metz CN, Bucala R, Holmdahl R: Macrophage migration inhibitory factor is involved in ... neutralization of macrophage migration inhibitory factor Nat Med 2000, 6:164-170 Bozza FA, Gomes RN, Japiassu AM, Soares M, Castro-Faria-Neto HC, Bozza PT, Bozza MT: Macrophage migration inhibitory factor ... in inflammatory disease: macrophage migration inhibitory factor Intern Med J 2005, 35:419-426 18 19 20 21 Renner P, Roger T, Calandra T: Macrophage migration inhibitory factor: gene polymorphisms...

Ngày tải lên: 13/08/2014, 16:21

... R: The macrophage migration inhibitory factor- glucocorticoid dyad: regulation of inflammation and immunity Mol Endocrinol 2007, 21:12671280 Calandra T: Macrophage migration inhibitory factor ... P, Hermans PW, Hazelzet JA, Calandra T: Association between high levels of blood macrophage migration inhibitory factor, inappropriate adrenal response, and early death in patients with severe ... whether MIF is a potential target for adjunctive therapy in the future Competing interests The authors declare that they have no competing interests References Ostergaard C, Benfield T: Macrophage...

Ngày tải lên: 13/08/2014, 18:22

Ngày tải lên: 16/02/2014, 15:20

... loss of inhibitory factors for survival and neurite formation of cerebral cortical neurons Brain Res 481, 190–193 Uchida Y & Ihara Y (1995) The N-terminal portion of growth inhibitory factor is ... neuronal growth inhibitory factor FEBS J 276, 3547– 3558 2920 17 Hasler DW, Jensen LT, Zerbe O, Winge DR & Vasak M (2000) Effect of the two conserved prolines of human growth inhibitory factor (metallothionein-3) ... multiple factors The TCPCP motif is an important factor, which induces the characteristic conformation in the N-terminus of GIF Such a conformation is indispensible for the neuronal growth-inhibitory...

Ngày tải lên: 16/02/2014, 15:20

... relationship of human neuronal growth inhibitory factor (hGIF) J Inorg Biochem 102, 1965–1972 10 Howells C, West AK & Chung RS (2010) Neuronal growth inhibitory factor (metallothionein-3): evaluation ... neuronal growth inhibitory factor Biochemistry 36, 13341–13348 22 Hasler DW, Faller P & Vasak M (1998) Metal-thiolate clusters in the C-terminal domain of human neuronal growth inhibitory factor (GIF) ... metallothionein-3 neuroinhibitory activity into the inactive isoform metallothionein-1 J Biol Chem 277, 37023–37028 Ding ZC, Ni FY & Huang ZX (2010) Neuronal growth inhibitory factor (metallothionein-3):...

Ngày tải lên: 16/02/2014, 15:20

... revealed that it correlated with the loss of a specific neuroinhibitory factor, rather than the presence of a neurotrophic factor This factor was later isolated and identified as GIF, its name derived ... of inhibitory factors for survival and neurite formation of cerebral cortical neurons Brain Res 481, 190–193 Uchida Y, Takio K, Titani K, Ihara Y & Tomonaga M (1991) The growth inhibitory factor ... growth inhibitory factor after stab wounds in rat brain Brain Res 688, 143–148 20 Hozumi I, Inuzuka T, Ishiguro H, Hiraiwa M, Uchida Y & Tsuji S (1996) Immunoreactivity of growth inhibitory factor...

Ngày tải lên: 16/02/2014, 15:20

... Heath, J.K (1997) An antagonist for the leukemia inhibitory factor receptor inhibits leukemia inhibitory factor, cardiotrophin-1, ciliary neurotrophic factor, and oncostatin M J Biol Chem 272, 26947–26952 ... by nerve growth factor J Biol Chem 270, 13585–13588 Hudson, K.R., Vernallis, A.B & Heath, J.K (1996) Characterization of the receptor binding sites of human leukemia inhibitory factor and creation ... Shiojima, T & Kinoshita, M (1995) Neuroprotective effect of cholinergic differentiation factor/ leukemia inhibitory factor on wobbler murine motor neuron disease Muscle Nerve 18, 1344–1347 Aebischer,...

Ngày tải lên: 22/02/2014, 07:20

... Metcalf, D., Roberts, B & Nicola, N.A (1997) The unusual species cross-reactivity of the leukemia inhibitory factor receptor alpha-chain is determined primarily by the immunoglobulin-like domain J Biol ... immunoglobulin-like module of gp130 is required for signaling by interleukin-6 but not by leukemia inhibitory factor J Biol Chem 273, 22701–22707 Timmermann, A., Pflanz, S., Grotzinger, J., Kuster, A., ... Different ¨ epitopes are required for gp130 activation by interleukin-6, oncostatin M and leukemia inhibitory factor FEBS Lett 468, 120–124 Mosley, B., De Imus, C., Friend, D., Boiani, N., Thoma, B.,...

Ngày tải lên: 18/03/2014, 01:20

... 3741 identification as leukemia inhibitory factor Proc Natl Acad Sci USA 89, 698–702 Pepper, M.S., Ferrara, N., Orci, L & Montesano, R (1995) Leukemia inhibitory factor (LIF) inhibits angiogenesis ... of BBCE cells (data not shown and Fig 5) The inhibitory effect of LIF on endothelial cell proliferation did not, however, exclude a direct autocrine inhibitory effect of LIF on neuroblastoma cell ... C.M., Jenatschke, S.S & Schulte, H.M (1997) Transcriptional regulation of the human Ôleukemia inhibitory factor gene: modulation by glucocorticoids and estradiol Mol Cell Endocrinol 127, 71–79 Kunisada,...

Ngày tải lên: 31/03/2014, 23:20

... treatment of granulocyte -macrophage colony-stimulating factor (GM-CSF) Peptide peak intensities increased or decreased by the treatment of granulocyte -macrophage colony-stimulating factor (GM-CSF) m/z ... colonystimulating factor (G-CSF) maintains neutrophil production at steady state and increases production of neutrophils in emergency situations [7,8] By contrast, granulocyte -macrophage colony-stimulating factor ... Granulocytemacrophage colony-stimulating factor in rheumatoid synovial effusions J Clin Invest 1989, 83:876-882 Bell AL, Magill MK, McKane WR, Kirk F, Irvine AE: Measurement of colony-stimulating factors...

Ngày tải lên: 09/08/2014, 01:22

... granulocyte -macrophage colony-stimulating factor (GM-CSF) Stem Cells 1994, 12(Suppl 1):229-239 discussion 239240 13 Rapoport AP, Abboud CN, DiPersio JF: Granulocyte -macrophage colonystimulating factor ... Scopelitou AS, Malamou-Mitsis VD, Kappas AM: Influence of growth factors erythropoietin and granulocyte macrophage colony stimulating factor on mechanical strength and healing of colonic anastomoses ... effect on liver regeneration after ischemia and reperfusion injury [9-11] Granulocyte -Macrophage Colony Stimulating Factor (GM-CSF) is a cytokine that, besides the proliferation and differentiation...

Ngày tải lên: 09/08/2014, 03:21

... and macrophage colony-stimulating factor receptor (MExpressionmonocytes of patientstumour necrosis factor receptor (TNFR1/2) and macrophage colony-stimulating factor receptor (MCSFR) on monocytes ... type of macrophages characteristic of RA It has been shown that IL-10 augments the macrophage colony-stimulating factor (M-CSF)-induced growth and differentiation of human monocytes, and macrophages ... induction on monocytes stimulated with interleukin-10 (IL-10) and macrophage colony-stimulating factor (M-CSF) (a) Induction of on monocytes stimulated with interleukin-10 (IL-10) and macrophage...

Ngày tải lên: 09/08/2014, 08:22

... demonstrated that expression of NFATc1, a key transcriptional factor of osteoclastogenesis induced by macrophage colony-stimulating factor (M-CSF) and receptor activator of NF-κB ligand (RANKL) ... metalloprotease-9 by human osteoclasts (a) osteoclasts Peripheral blood monocytes were incubated in 96-well plates with macrophage colony-stimulating factor (M-CSF), receptor activator of NF-κB ligand (RANKL), ... collected by Ficoll-Conray gradient centrifugation, and monocytes were positively selected using MACS microbeads (Miltenyi Biotec, Auburn, CA, USA) The monocytes (5 × 104/ Estimation of RANKL and M-CSF...

Ngày tải lên: 09/08/2014, 10:21

... factors detected in FCM from RASFIL-17/TNF – such as granulocyte colony-stimulating factor, CCL2 and CXCL8 – failed to inhibit neutrophil survival any further Soluble, temperature-sensitive factors ... ***** ****** IL-10 IL-15 Granulocyte macrophage colony-stimulating factor * ** Granulocyte colony-stimulating factor * ** * ***** CCL2 ***** CCL3 * *** * * CCL5 ... TNF alone (Table 1) Since GM-CSF is a well-characterised neutrophil survival factor, we tested whether this was the factor responsible for neutrophil survival by specific immunodepletion from...

Ngày tải lên: 09/08/2014, 10:23