longitudinal studies of gene environment interaction in common diseases—good value for money
Báo cáo y học: "Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking" potx
Ngày tải lên :
09/08/2014, 10:23
... models Gene- environment and gene- gene interactions We conducted assessments for gene- environment interactions by testing for both additive and multiplicative interactions For additive interactions, ... the P value for attributable proportion (AP), one of the indices of additive interactions between binary smoking variable and binary PTPN22 genotype fPmulti is the P value for multiplicative interaction ... presence of the PTPN22 polymorphism and smoking in determining RA risk Their gene- smoking interaction analyses used data from the Swedish Environmental Investigations in RA incident RA cohort, in which...
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studies of pathogenesis-related proteins in the strawberry plant partial purification of a chitinase-containing protein complex and analysis of an osmotin-like protein gene
Ngày tải lên :
13/11/2014, 09:25
... during the cycles of freezing and thawing, which leads to the exposure of new Ca++-binding sites Binding of Ca++ to these sites caused inhibition of the antifreeze and chitinase activities of ... extracellular chitinases are involved in generation of signal and transfer of information about infection, whereas vacuolar chitinases take part in repressing pathogen growth (Collinge et al., 1993) ... plant program for nodule formation The involvement of chitinase in nodulation has been reported in a number of studies In the alfalfa–Rhizobium meliloti interaction, several chitinases were activated...
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Association studies of genetic polymorphisms found in interleukins 12, 13 and CD14 gene with asthma and allergic diseases
Ngày tải lên :
30/09/2015, 14:23
... disease in children There is increasing evidence suggesting the pivotal role of interactions between the environment and genes in the pathogenesis of these multi-factorial diseases Prior linkage studies ... background staining, the agarose gel is de-stained by soaking in de-ionized water for 10 minutes 3.7 Sequencing for polymorphisms Chain termination sequencing was employed This method involves the ... swelling and redness of the site of prick Results are obtained within 20 minutes of initial prick (Fig 3.1-3.2) 23 Figure 3.1: Lancet used for skin prick test 3.3 Figure 3.2: Results of skin prick...
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A meta analysis and risk assessment of heavy metal uptake in common garden vegestable
Ngày tải lên :
15/03/2014, 23:10
... electroplating, smelting, and ore processing (ATSDR 1994) Mine tailings and drainage from mines can contain high concentrations of zinc (Cobb et al 2000) The fate and transport of zinc (Zn+2) in the environment ... conducted field studies using plants growing in field-contaminated soil) Sources of contamination for soils used in these studies included mine tailings (20%), sludge amendments (20%), industrial ... of paint chips or the inhalation of aerosolized lead from decaying paint In 1991, the amount of Pb was greatly reduced in gasoline (Anonymous2001a) Most of the environmental lead contamination...
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Báo cáo khoa học: Nature, nurture and neurology: gene–environment interactions in neurodegenerative disease docx
Ngày tải lên :
16/03/2014, 19:20
... be responsible for the variability in brain ageing and associated cognitive 2355 Gene environment interactions in neurodegenerative disease decline in all human populations, forming a template ... age of onset [8] – evidence for familial modifiers independent of CAG repeat length Several genes in uencing age of onset have been identified, including a polymorphism in an allele for a noncoding ... other things, the exploration of the interactions of the environment with neurodegenerative pathology Environmental factors appear to play a role in the risk of developing AD and interact with genetic...
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zen ritual studies of zen buddhist theory in practice nov 2007
Ngày tải lên :
11/06/2014, 10:47
... Describing the ritual as it is performed today in Japan, the essay shows how continuity of ritual tradition is maintained in Zen even into the postwar era in which the Emperor’s role in maintaining ... (shusan), or sutra reading (kankin) Just sit in meditation (taza) and attain the dropping off of mind and body (shinjin datsuraku).20 ¯ ¯ In the generations following Keizan Jokin (1268–1325), however, ... Rekindling of a Tradition: Menzan Zuiho and the Reform of Japanese Soto Zen in the Tokugawa Era.’’ ALBERT WELTER is professor of religious studies at the University of Winnipeg, specializing in...
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Báo cáo hóa học: " Research Article Combining Evidence, Specificity, and Proximity towards the Normalization of Gene Ontology Terms in Text" potx
Ngày tải lên :
21/06/2014, 22:20
... of the number of words per term in the individual branches of Gene Ontology might play a role in the performance of the systems Indeed, Figure shows the distributions of the number of words in ... recall of 0.6 Such performance provides satisfying results for assisting biologists in the task of curating manuscripts when the localization of Gene Ontology terms in text is needed The remaining ... types of corpus will be presented in Section The formula illustrates that a frequent word carries a low amount of information whereas a rare word is rich in information Considering the amount of information...
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Báo cáo y học: "Perspectives and limitations of gene expression profiling in rheumatology: new molecular strategies" doc
Ngày tải lên :
09/08/2014, 01:23
... collating of information and development of molecular network models will be essential and will provide the basis for functional interpretation Current status of gene expression profiling in rheumatic ... misinterpretation In the face of our limited knowledge of the role and function of most of the genes that we discover in our experiments, strategies for systematic investigation are essential Gene ... not yet been investigated in RA, was identified in both synovial tissue and synovial fluid Besides the application in human studies, gene expression profiling was also performed in arthritis...
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Comparative genomics of gene-family size in closely related bacteria pdf
Ngày tải lên :
09/08/2014, 20:20
... might insert preferentially in gene family members Something similar is found in the case of M leprae (Figure 3), although in this case the main mechanism for gene inactivation is the generation of ... ATP-binding component of spermidine/putrescine transport and for some reason its amplification has been selected in this species Proteins involved in the transport of spermidine and putrescine ... smaller gene families However, part of the variability is also due to intrinsic differences between the species For example, P syringae contains some large gene families involved in invasion of the...
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báo cáo khoa học: " Simulating gene-environment interactions in complex human diseases" pdf
Ngày tải lên :
11/08/2014, 12:20
... Ritchie MD: A comparison of analytical methods for genetic association studies Genet Epidemiol 2008, 32:767-778 Li D, Conti DV: Detecting gene- environment interactions using a combined case-only and ... simulated, the individuals generated may not have enough genetic variations to allow adequate modeling with a GxE model because of insufficient combinations of genetic and environmental factors For example, ... al [6], who used a genetic algorithm to discover, among a large number of plausible theoretical models, a special set of high-order gene- gene interaction models in which genes influence disease...
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Báo cáo y học: " 3′-coterminal subgenomic RNAs and putative cis-acting elements of Grapevine leafroll-associated virus 3 reveals ‘unique’ features of gene expression strategy in the genus Ampelovirus" potx
Ngày tải lên :
12/08/2014, 04:20
... 18,498 nt warranted generating full genome sequence of the Washington isolate In addition, having genome sequence information for the parental isolate of GLRaV3 would enable mapping the 5′-transcription ... isolates containing 158 nt, and South Africa and Washington isolates having 737 nt In general, the genome of Washington isolate of GLRaV-3, downstream of 5′NTR sequence, showed higher level of nucleotide ... sequence obtained This strategy, instead of cloning and sequencing by random oligonucleotide primers, decreased the number of steps required for determining the complete genome sequence of the virus...
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Báo cáo y học: "Influence of enrollment sequence effect on observed outcomes in the ADDRESS and PROWESS studies of drotrecogin alfa (activated) in patients with severe sepsis" pptx
Ngày tải lên :
13/08/2014, 11:22
... terminated at the recommendation of the safety monitoring board because of a low likelihood of meeting the prospectively defined objective of demonstrating a significant reduction in the risk of ... applicability of the study results to a more general severe sepsis population The use of severity scoring systems in clinical trials may require training and validation of the training to ensure ... determined but certainly cannot be excluded Determining the influence of sequential changes in patient characteristics on the outcome of ADDRESS is difficult Previ- Page of 13 (page number not for...
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Báo cáo y học: "The determinants of gene order conservation in yeasts" pdf
Ngày tải lên :
14/08/2014, 08:20
... proportion of gene pairs retained as neighbors and the number of inversions between two taxa Figure Differences in intergene distance Differences in intergene distance Intergene distances of gene pairs ... comparing the nominal values of the determinants of those genes remaining nonadjacent in the least distant species to S cerevisiae, C glabrata, with those of the genes retained as adjacent in the ... the protein-protein interaction network [11,12] Figure in distance3 of gene pairs Proportion S cerevisiae conserved in a comparator versus intergene Proportion of gene pairs conserved in a comparator...
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A simplified method for conducting ecological studies of land snail communities in urban landscapes
Ngày tải lên :
14/09/2014, 20:14
... size for each method, i.e the minimum size providing more than 80–85% of the species, obtained by adding samples The shape of the curve allows this minimum sample to be determined (Fig 1) For ... fauna of the sampled urban sites is representative of the common species found in semi-natural environments in this area and accounts for approximately one-third of the global fauna of the area In ... index), respectively, for JE and BN The difference between the number of individuals (for all species) found by all of the methods tested in a park, and the number of individuals identified using...
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GENOME WIDE ASSOCIATION STUDIES OF CORONARY ARTERY DISEASE IN SINGAPOREAN CHINESE POPULATIONS
Ngày tải lên :
09/09/2015, 08:17
... significant gene- gene interactions influencing HDL-C iii) Validate the interactions in additional cohorts We believe investigations of CAD in Asians would provide insights into Asian genetics, ... significant gene- gene interaction, identified for the first time, provides new insight into the potentially new mechanisms influencing circulating HDL-C x LIST OF TABLES Table Genes associated with increased ... posits common interacting variants and their interactions with environmental factors underline most of common diseases In other words, CAD candidate genes could be numerous; the effects of common...
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Single DNA studies of architectural proteins involved in bacterial pathogenesis and meiosis in saccharomyces cerevisiae
Ngày tải lên :
09/09/2015, 11:25
... protein molecules and their interactions with DNA in real-time reactions and the dynamics of their DNA-binding Therefore, my objective of finding the characteristics of protein binding to single ... cell resulting in the formation of a copy of the information encoded in a gene in the form of messenger RNA (mRNA) with the help of RNA polymerase The mRNA subsequently travels out of the nucleus, ... virulence genes The Nterminus of SsrB contains the site of phosphorylation and the C-terminus consists of a DNA-binding domain Dimerization occurs upon DNA binding and is required for subsequent...
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Numerical simulation studies of ihe geothermal resource in singapore 1
Ngày tải lên :
10/09/2015, 09:28
... SIMULATION STUDIES OF THE GEOTHERMAL RESOURCE IN SINGAPORE HENDRIK TJIAWI B.Eng.(Hons.), NUS A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF CIVIL AND ENVIRONMENTAL ENGINEERING ... 91 4.19 Temperature profiles for simulations with varying k of ‘sedim’ 95 4.20 Salinity profile for model with ‘sedim’ λ: 2.1 W/mK 96 4.21 Salinity profile for model with ‘sedim’ ... Modeling of Singapore Geothermal Reservoir 190 B.3 Engineered Geothermal Power Systems for Singapore 197 B.4 Geothermal Power for Singapore 206 vii Abstract Singapore...
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Numerical simulation studies of ihe geothermal resource in singapore 2
Ngày tải lên :
10/09/2015, 09:29
... known hot springs in Singapore, i.e one at Sembawang and two at Pulau Tekong Those hot springs are part of the series of hot springs in the granite terrain of Malaysian Peninsula [57] Out of the three ... coated cutter, with dry cutting The refining cut (smoothing and polishing of flat 28 surfaces) cannot be performed in the lab due to tool limitation in handling the thin sample (12 mm thick), and ... banks of Waikato River in New Zealand), space conditioning of residential and commercial buildings by installing heat pump systems, cooking, industrial heating, and so on Electricity can also be generated...
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Numerical simulation studies of ihe geothermal resource in singapore 3
Ngày tải lên :
10/09/2015, 09:29
... A.1 Core Logging of BH9 166 167 168 169 170 171 172 A.2 Core Logging of BH16 173 174 175 176 177 178 179 ...
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Numerical simulation studies of ihe geothermal resource in singapore 4
Ngày tải lên :
10/09/2015, 09:30
... B.1 Geothermal Desalination in Singapore 181 182 183 184 185 186 187 188 189 B.2 Natural State Modeling of Singapore Geothermal Reservoir 190 191 192 193 194 195...
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