long term implications for the baby of the hyperglycemic mother
Long-Term Care for the Elderly with Disabilities: Current Policy, Emerging Trends, and Implications for the Twenty-First Century docx
Ngày tải lên :
28/03/2014, 17:20
... nature of the demand for long- term care: changing demographics and the health and functional status of the population; the availability of family members and other unpaid, “informal” caregivers; the ... market for long- term care is the extent to which future generations of elderly people will be able to afford these services The economic status of the elderly, and their potential use of formal ... design of long- term care in the United States, including the amount of formal services that may be needed to replace a diminishing pool of caregivers in certain states The future costs of long- term...
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Tài liệu Long-Term Care for the Elderly: Challenges and Policy Options pptx
Ngày tải lên :
13/02/2014, 18:20
... pay most of the costs the elderly incur for prescription drugs, for long- term care (LTC) the picture is mixed Some provinces pay most of the costs of a wide range of LTC services, but others make ... Future Costs of Long- Term Care To encourage voluntary pooling of the risk of high costs of long- term care – and to reduce the tendency for individuals to overlook such risk – one of the Obama administration’s ... even if they return to good health Because most long- term care recipients are elderly, the public funding of long- term care is also relevant in terms of the extent to which the net benefit of taxation...
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Báo cáo y học: "Closure of the NCBI SRA and implications for the long-term future of genomics data storage" doc
Ngày tải lên :
09/08/2014, 22:23
... being deleted RK: If there is a good chance that the data are going to be used by others, then yes, there is a good case for storing them Just storing the raw data for the sake of it, however, is ... where the US is paying to generate all these data - probably the majority of genomics data is coming from the US at Page of present - but where it’s not prepared to meet the cost of archiving the ... archiving project, one needs to con sider the cost of storage relative to the potential future reuse In the course of the 1000 Genomes project, for example, the raw sequencing reads have been realigned...
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Unfolding the Future of the Long War - Motivations, Prospects, and Implications for the U.S. Army docx
Ngày tải lên :
06/03/2014, 20:20
... our understanding of the components of the long war, provided the basis for a set of seven strategy options for the United States in the long war xvi Unfolding the Future of the Long War Divide ... uses of the term long war” and describe our synthesis definition of the long war to aid in further analysis In Chapter Three, we describe the participants in the long war to date and examine the ... about the theory of victory The QDR provides little to go on in terms of “winning” in the long war, or “defeating decisively” the threat that the United States faces The description of the long war...
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báo cáo khoa học: " The role of business in addressing the long-term implications of the current food crisis" docx
Ngày tải lên :
11/08/2014, 14:21
... value all of your insights! There is broad consensus about the need for nutrition interventions to give priority to young women and children under or years of age if the long- term effects of stunting ... a wider range of ready-to-eat therapeutic foods The June 2008 High-Level Task Force of the United Nations on the Global Food Crisis that met in Rome included these elements in their Comprehensive ... talking to each other, are slowly giving way to the development of creative ways of interacting The emergence of new business models that tackle social problems while remaining profitable offers promise...
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Tài liệu Faultlines of Conflict in Central Asia and the South Caucasus - Implications for the U.S. Army docx
Ngày tải lên :
17/02/2014, 11:20
... understand the “rules of the game” the way the United States does That is one interpretation of both the crude Chinese nuclear threats over the Taiwan crisis and Chinese views of the U.S bombing of the ... Russia and the United States and the rest of NATO suggest the danger of further friction in the future 26 Future Roles of U.S Nuclear Forces: Implications for U.S Strategy So far, there has been ... if the need is overwhelming and other options are inadequate may offer a balance of benefits and risks for as long as the United States chooses to retain nuclear forces Both the forces and the...
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Tài liệu China’s Holdings of U.S. Securities: Implications for the U.S. Economy pptx
Ngày tải lên :
20/02/2014, 20:20
... about the “safety” of China’s holdings of U.S debt The sharp debate in Congress over raising the public debt ceiling in the summer of 2011 and the subsequent downgrade of the U.S long- term sovereign ... (4.9%) 19 The report is prepared jointly by the Department of the Treasury, the Federal Reserve Bank of New York, and the Board of Governors of the Federal Reserve System 20 Department of the Treasury, ... depreciate If the value of the dollar depreciated, the trade deficit would decline, as the price of U.S exports fell abroad and the price of imports rose in the United States.52 The magnitude of these...
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Báo cáo khoa học: Enzymatic investigation of the Staphylococcus aureus type I signal peptidase SpsB – implications for the search for novel antibiotics ppt
Ngày tải lên :
07/03/2014, 01:20
... LepB, the SPase of Escherichia coli, is the most extensively studied SPase The crystal structure of the soluble form of this enzyme has been determined [1315] and NMR data are also available for the ... preliminary analysis of secreted proteins indicated in the genomic sequence data of S aureus The criteria for selection of the substrate were a good prediction of the presence and location of the signal ... in the Fig SPase recognition sequence and cleavage sites of the SpsB substrates used in the present study: Showing part of the sequence of the IsaA precursor (upper row) and the sequence of the...
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Báo cáo khoa học: NMR and molecular dynamics studies of an autoimmune myelin basic protein peptide and its antagonist Structural implications for the MHC II (I-Au)–peptide complex from docking calculations ppt
Ngày tải lên :
07/03/2014, 16:20
... characteristic of the structure of the native epitope in Me2SO is the presence of a large number of electrostatic interactions, especially in the central region of the peptide The side chain of Arg78 ... studies of the epitope of MBP therefore we may conclude that the conformation of epitopes of the integral protein must be affected by posttranslational modifications Docking calculations of the MBP(74–85) ... between the side chains of Arg78 and Glu82/Asp81 independently of the nature of the solvent (protic or nonprotic) This might come from the peptide conformation, which drives the orientation of these...
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Báo cáo khoa học: Discovery and characterization of a Coenzyme A disulfide reductase from Pyrococcus horikoshii Implications for the disulfide metabolism of anaerobic hyperthermophiles doc
Ngày tải lên :
07/03/2014, 17:20
... order to determine the extinction coefficient of the enzyme-bound FAD, the FAD was released from the holoenzyme by trichloroacetic acid (TCA) precipitation of the protein The e460 of the enzyme-bound ... results in reduction of the enzyme-bound FAD, forming the EH4 or EH4ÆNAD(P)+ species In the case of a true oxidase, it makes sense for the enzyme to stabilize the EH4 form, since the reduced flavin ... during the addition of the second and subsequent equivalents of NADPH With the exception of the expected increase at 340 nm from the addition of free NADPH, little additional change is seen in the...
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Báo cáo khoa học: Multidrug efflux pumps: The structures of prokaryotic ATP-binding cassette transporter efflux pumps and implications for our understanding of eukaryotic P-glycoproteins and homologues ppt
Ngày tải lên :
22/03/2014, 21:20
... namely the presence of a linker domain between the two halves of the transporter The mouse ABCB1a structure is missing the 56 amino acids between the end of the first NBD and the start of the second ... number of concerns arise from close inspection of the structure Of most relevance to the current discussion are the resolution, the completeness of the structure, the spatial separation of the NBDs ... in the transition from the nucleotide-free to the ADP ⁄ Vi-trapped states of MsbA With all five pairs of residues (located along the axis of the protein perpendicular to the membrane) the sign of...
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Báo cáo khoa học: Structure of a trypanosomatid mitochondrial cytochrome c with heme attached via only one thioether bond and implications for the substrate recognition requirements of heme lyase potx
Ngày tải lên :
23/03/2014, 04:21
... vinyl), as is observed for the C-terminal cysteine of the typical CXXCH c-type cytochrome heme-binding motif [1,13] The heme iron is coordinated by the Ne of the histidine of the ‘AXXCH’ (actually ... blue) Also shown are the heme ligands (histidine and methionine in each case), the cysteines that form thioether bonds to the heme, and the methyl group of the alanine of the C fasciculata AXXCH ... phases from the final model of the halfreduced form, is contoured at the 1.5r level, where r represents the ˚ rms electron density for the unit cell Contours more than 1.5 A from any of the displayed...
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Báo cáo khoa học: The crystal structure of pyruvate decarboxylase from Kluyveromyces lactis Implications for the substrate activation mechanism of this enzyme ppt
Ngày tải lên :
30/03/2014, 10:20
... The cofactors are depicted in space-filling mode The positions of the N-terminal and C-terminal amino acid residues of the model, the position of the flexible loop region, which is omitted in the ... relative to the other For comparison, the corresponding angle found for (nonactivated) KlPDC is 36° The main difference between KlPDC and the activated form of ScPDC is the flexibility of the loop ... of the two dimers within the tetramer: the D2 symmetry of the nonactivated ScPDC is broken, and an open and a closed side of the tetrameric molecule is formed Two different binding sites of the...
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Báo cáo hóa học: " ICP0 antagonizes Stat 1-dependent repression of herpes simplex virus: implications for the regulation of viral latency" potx
Ngày tải lên :
20/06/2014, 01:20
... 105 pfu per eye of HSV-1 strain KOS-GFP or GFP relationship of the genotype and phenotype of these mice is defined in Table c The mean ± standard error of the mean of the logarithm of infectious ... compromised the integrity of the tissue Thus, consistent with other results, the Stat signaling pathway was essential to restrict the spread of wild-type HSV-1 from the site of inoculation to the TG ... [41-43] Given the dearth of evidence that the LAT or L/ST genes actually antagonize the synthesis of ICP0 and ICP34.5, further work will be required to address these hypotheses Clinical implications...
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báo cáo hóa học:" Association of measured physical performance and demographic and health characteristics with self-reported physical function: implications for the interpretation of self-reported limitations" pdf
Ngày tải lên :
20/06/2014, 16:20
... physical performance test batteries, which averaged measures of performance over several domains of functioning [14,15,18-20] One explanation for the weak correlations in these studies may be the problem ... physical functioning, before they had the physical examination and performance testing Analytic framework To maximize the specificity of the association between physical performance tests and self-reported ... meters and then dividing by the time in seconds needed to complete the test We categorized performance on both tests into quartiles, with the bestperforming quartile as the reference group The lock...
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Báo cáo khoa học: "Variation in the phenology of shoot elongation between geographic provenances of maritime pine (Pinus pinaster) - implications for the synchrony with the phenology of the twisting rust fungus" potx
Ngày tải lên :
08/08/2014, 19:21
... for the different tested variables in each of the [site x year] combinations of the study, for each stage and each provenance The coefficients of variation (CV), ie the ratio of the mean to the ... standard deviation of these values, were then calculated The approach using the standard error of prediction is based on the comparison between observed and predicted dates of the onset of phenological ... using the sine curve reconstitution of daily temperatures were slightly higher than those obtained with the simpler formula Tm (Tmin + Tmax)/2 The latter formula was therefore used for the threshold...
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Báo cáo y học: "Duration of bed occupancy as calculated at a random chosen day in an acute care ward. Implications for the use of scarce resources in psychiatric care" pps
Ngày tải lên :
08/08/2014, 21:20
... illness, whereas of 12 not waiting had a psychotic illness Duration of stay was composed of the days preceding the chosen day and the number of days of further treatment in the acute ward Twenty-three ... difference between cost of residency in the acute ward and the chosen secondary facility This cost was withdrawn from the cost of the acute ward stay for each patient The costs used in the calculations ... in training at the time of the study, was aware of the registration of time from the senior psychiatrists decision to the actual day of referral to the next step in the treatment chain, called...
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Báo cáo y học: "Most nuclear systemic autoantigens are extremely disordered proteins: implications for the etiology of systemic autoimmunity" pps
Ngày tải lên :
09/08/2014, 07:20
... spreading to other epitopes in the Sm particle This view of the battle between the virus and the immune system is further amplified by the results of the analysis of MHC II T cell epitopes using the ProPred ... sequences in the B/B' polypeptide followed by spreading to the rest of the Sm particle To further explore the relevance of disorder to the idea of spreading we carried out a PONDR® analysis of the EBNA1 ... predicting order For the 19 LDRs presented in the figures, we have also determined the degree of disorder using the two DISEMBL™ and the DISOPRED disorder predictors For all the predictors, on...
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Báo cáo y học: "Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration" ppt
Ngày tải lên :
09/08/2014, 14:20
... studied These studies investigated the protein expression of these receptors rather than gene expression and separated the groups according to age rather than Page of 10 (page number not for citation ... that the lack of TNF-R1 does not affect the incidence or severity of collagen-induced arthritis in the joints [27] Repeated injections of TNF-α into the joints of TNF-R1 knockout mice enhanced the ... the changes identified in the degeneration of the IVD, which include an upregulation in type I collagen protein in the NP region [20] The results of this study show that TNF-α downregulates the...
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Báo cáo y học: "A quantitative evaluation of gross versus histologic neuroma formation in a rabbit forelimb amputation model: potential implications for the operative treatment and study of neuromas" ppt
Ngày tải lên :
10/08/2014, 10:20
... increase the number of neuromas created per animal (and thereby decrease the total number of animals sacrificed), and the amputation was performed in the proximal forelimb in order to mimic the clinical ... University for their assistance with animal care from the inception of the amputation model and throughout the course of this study The authors would also like to thank Linda Juarez at the University of ... Waller A: Experiments on the sections of glossopharyngeal and hypoglossal nerves of the frog and observations of the alterations produced thereby in the structure of their primitive fibers Phil...
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