localization expression levels in the retina and substrate specificity
báo cáo khoa học: " Selection of reference genes for quantitative real-time PCR expression studies in the apomictic and sexual grass Brachiaria brizantha" ppt
... and sexual reproduction within Brachiaria makes it an interesting system for understanding the molecular pathways involved in both modes of reproduction The identification of genes involved in ... genes [26] The median Ct data in the 22 samples are shown in Figure 1, and the Ct variations among the samples for the different primers are shown in Figure The range and distribution of the Ct values ... on the geometric mean of the expression values of the set of the control genes tested The lower the M value, the more stably expressed the gene is Also, the program enables the exclusion of the...
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Báo cáo y học: "MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system" docx
... miRNAs1expressed in proliferating and/ or differentiating cells in the developing and adult zebrafish brain miRNAs expressed in proliferating and/ or differentiating cells in the developing and adult ... expressionininthezebrafish brain about miR-135cexpressionthespecificity brainbrain and miR-128 expression2 thezebrafish of zebrafish brain expression miR-124expressiontestmiRNAs the miR-153abrainused ... out the in situ hybridization and sectioning experiments and participated in the design of the study and drafting of the manuscript EB participated in the in situ hybridization and sectioning experiments...
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CHOLESTEROL INDUCED GENE EXPRESSION CHANGES IN THE BRAIN AND CEREBRAL VESSELS
... Abbreviations ICLAD Intracranial Large Artery Disease IDE Insulin-degrading enzyme IgG Immunoglobulin G IL12 Interleukin 12 IL-1β Interleukin-1β IL23 Interleukin 23 INSIG Insulin-induce gene IPA Ingenuity ... SREBP inhibitors were studied in vitro Increased expression of APP/Aβ and SERPINB2 induced by SREBP inhibition were observed in the human endothelial and neuroblastoma cell lines, thus, implying ... Dietschy and Turley, 2004; Vaya and Schipper, 2007) In the brain, cholesterol is divided into two pools: major pool with 70% of the brain cholesterol residing in myelin sheaths, and minor pool with the...
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Gene expression changes in the brainstem and prefrontal cortex in a mouse model of orofacial pain
... inflammatory pain Inflammatory pain is due mainly to the action of prostaglandins and bradykinin, and substances released during the inflammatory process (Okeson and Bell, 2005) Together, they act to increase ... different region of the brain i.e brainstem and PFC could play different roles in pain and contribute to different part of the pain system The use of KF38789 in inhibiting P-selectin and the use of mS100A9p ... produce and release neurotransmitters, influencing the neural activity in the area – either enhancing or inhibiting the ascending input (Okeson and Bell, 2005) Several nuclei are located in the reticular...
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Tài liệu Báo cáo khoa học: Treatment of neutral glycosphingolipid lysosomal storage diseases via inhibition of the ABC drug transporter, MDR1 Cyclosporin A can lower serum and liver globotriaosyl ceramide levels in the Fabry mouse model doc
... pathology is in the kidney [1], the major site of Gb3 synthesis in man [11], and in the heart, possibly due to the association of Gb3 synthesis with the microvasculature GSL synthesis in man and mouse ... staining is brown The section is counter stained with hematoxylin (B) In situ staining of renal VT1 bound in vivo VT1 (50 lg per mouse) injected i.p and bound within the kidney was immunostained ... background in the wildtype mouse liver (Fig 6A), but within the Fabry liver VT1 binding detected Gb3 in the stellate Kupffer cells, distributed throughout the section, and in cells lining the portal...
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Báo cáo khoa học: Lysosomal localization of GLUT8 in the testis – the EXXXLL motif of GLUT8 is sufficient for its intracellular sorting via AP1- and AP2-mediated interaction docx
... However, the findings have been contradictory with regard to localization of the endogenous GLUT8 in testis, the nature of its sorting, and the interaction of its Nterminal dileucine motif with the ... APs in GLUT8 sorting, and (c) understand the role of the EXXXLL motif in GLUT8 sorting The data provide evidence that endogenous GLUT8 co-localizes with the lysosomal proteins LAMP1 and LAMP2 in ... cells The N-terminal domain of GLUT8 contains a transplantable internalization signal To determine the significance of the N-terminal dileucine signal in GLUT8 for its intracellular sorting, we...
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Báo cáo khoa học: H2O2, but not menadione, provokes a decrease in the ATP and an increase in the inosine levels in Saccharomyces cerevisiae An experimental and theoretical approach pot
... of inosine is the intracellular pool of adenine nucleotides, (b) the decrease in ATP and the increase in inosine, promoted by H2O2, cannot be explained solely by a change in the level of the ... ATP and inosine were determined as described in Materials and methods H2O2 evokes a decrease and an increase in the intracellular concentration of ATP and inosine, respectively Searching for the ... described in the text and in [3] Simulation was made considering the kinetic values for the enzymes E1E7 determined in the cytosol of control cells, grown in glucose In the case of enzyme E2, the Km...
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Báo cáo khoa học: Identification and localization of glycine in the inner core lipopolysaccharide of Neisseria meningitidis ppt
... indicated in the inset figures also performed on two other meningococcal strains of clinical origin and the compositions of the glycoforms observed are listed in Table In each case where glycine ... illustrating the -CH2- group of the glycine residue and the -CH2-CO2- connectivity within the glycine residue, respectively with relay between the carbonyl carbon and the CH2 protons of the glycine ... corresponding to glycine containing glycoforms (Table 1), thus confirming that the glycine residue is attached to the core oligosaccharide via an ester linkage In order to confirm and further characterize...
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Báo cáo khoa học: The heterogeneity of mast cell tryptase from human lung and skin Differences in size, charge and substrate affinity ppt
... conceivably bind by either the P1 or the P3 argininyl residue to the S1 binding pocket Although binding via ể FEBS 2003 282 Q Peng et al (Eur J Biochem 270) the P3 Arg could result in cleavage of the substrate ... heparin-binding site, a region of positive surface charge extending along the left- and righthand sides of the ring in Fig 10A [23] This region is comprised of ve histidines, nine lysines, and ... blots washed and incubated with diaminobenzidine and hydrogen peroxide A combination of the biotinylated lectins Sambucus nigra agglutinin (SNA; 10 lgặmL)1) and Maackia amurensis agglutinin (MAA;...
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báo cáo hóa học:" MicroRNA and gene expression patterns in the differentiation of human embryonic stem cells" doc
... contained the genes that were upregulated in both hES cells and EB, node B contained the genes upregulated in hES cells only, node C contained the genes upregulated in EB only, and node D contained ... miR-130a and miR-190, the difference in their expression between EB and hES cells and between EB and adult cells were significant (P < 0.05) The difference in expression of miR-17-5p between EB and ... The differences in expression of these miRNA expression between adult cells and hES cells and between adult cells and EB were significant (P < 0.05) Of note, the expression levels of let-7b and...
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báo cáo hóa học:" Expression of Bone Morphogenetic Protein-2 in the Chondrogenic and Ossifying Sites of Calcific Tendinopathy and Traumatic Tendon Injury Rat Models" doc
... by BMP-binding proteins such as Noggin and Chordin as well as intracellularly by Smad6, tob and Smurf1 [2] Information on the expression of these osteogenic factors and BMP antagonists, in addition ... dilute the expression at week 12 Care therefore should be taken when interpreting the mRNA data and studying the expression also at the protein level by immunohistochemistry is suggested in tissue ... interpret the results and draft the manuscript LSC, YCC, YWL carried out the animal operation, immunohistochemical staining and RT-PCR and analyzed the data KMC designed the study and draft the...
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Báo cáo y học: "Early and stable upregulation of collagen type II, collagen type I and YKL40 expression levels in cartilage during early experimental osteoarthritis occurs independent of joint location and histological grading" ppt
... Knee instability is very likely to increase inappropriate mechanical loading in many parts of the joint and, in keeping with this, col II and YKL40 expression rose in all locations after ACLT in ... from the GAPDH standard curve A GAPDH standard was included in every LightCycler run, and the expression of each gene was normalized to the mRNA level of the housekeeping gene GAPDH in the corresponding ... sensitive and quantitative molecular analysis of the response of articular cartilage to increased joint instability and altered mechanical loading, and thus to gain more insight into the very...
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Báo cáo y học: "Identification of intra-group, inter-individual, and gene-specific variances in mRNA expression profiles in the rheumatoid arthritis synovial membrane" pot
... IL13 and CXCL13 (cytokine–cytokine receptor interactions) The mean gene expression (blue line) and the intra-group inter-individual variances in RA and NC synovial membrane (red bar) are indicated, ... contributed to the design and coordination of the study and participated in the writing of the manuscript All authors read and approved the final version of the manuscript The following Additional ... example, 2.6% in the human retina [20]) To analyze inter-individual mRNA expression variances in RA, the occurrence of gene-specific expression differences in the SM was analyzed using the Bonferroni/Holm...
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Báo cáo y học: "Expression and regulation of neurotrophins in the nondegenerate and degenerate human intervertebral disc" pdf
... Trk-A and Trk-B protein expression in the nondegenerate and degenerate human IVD Immunopositive staining for Trk-A and Trk-B was largely cellular in the chondrocyte-like cells of the NP and IAF, and ... neurotrophins Cellular staining for NGF and BDNF was identified in the native chondrocyte-like cells of the NP and IAF tissue and in the fibroblast-like cells of the OAF (Figures 1a to 1f and 2a ... innervation and the pathogenesis of low back pain, however, remains to be determined The neurotrophins NGF and BDNF function principally through their high-affinity receptors Trk-A and Trk-B Indeed,...
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Báo cáo y học: "Cigarette Smoke Exposure Alters mSin3a and Mi-2α/β Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function" ppt
... known about either the composition or the stepwise construction and targeting of the mSin3a and Mi-2 co-repressor complexes or their role in disease The reduction in mSin3a expression in the lungs ... understanding of the roles of these co-repressor complexes and thereafter their roles in disease In summary cigarette smoke exposure reduced HDAC2 activity and the expression of mSin3a and Mi-2α in ... alteration of both the formation and targeting of these complexes Consequently, an oxidant-mediated reduction in the protein expression of Mi-2α and mSin3a and increased protein expression of Mi2β...
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Báo cáo y học: "Cigarette Smoke Exposure Alters mSin3a and Mi-2α/β Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function" pdf
... known about either the composition or the stepwise construction and targeting of the mSin3a and Mi-2 co-repressor complexes or their role in disease The reduction in mSin3a expression in the lungs ... understanding of the roles of these co-repressor complexes and thereafter their roles in disease In summary cigarette smoke exposure reduced HDAC2 activity and the expression of mSin3a and Mi-2α in ... alteration of both the formation and targeting of these complexes Consequently, an oxidant-mediated reduction in the protein expression of Mi-2α and mSin3a and increased protein expression of Mi2β...
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báo cáo khoa học: " HC-Pro silencing suppressor significantly alters the gene expression profile in tobacco leaves and flowers" docx
... genes encoding proteases and protease inhibitors (cysteine proteinase, serine carboxypeptidase and trypsin inhibitor), structural proteins (proline rich proteins), and other proteins acting on carbohydrates ... cycle and pathogenicity Potyviral HCPro protein has domains of a cysteine endopeptidase and thioredoxin that may function in degradation of proteins containing cysteine residues, and changing the ... Acknowledgements and Funding The Finnish Microarray and Sequencing Centre (FMSC) at Turku Centre for Biotecnology is acknowledged for labeling the cDNAs, hybridizations, scanning the chips and producing the...
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Báo cáo y học: "Effects of typical and atypical antipsychotic drugs on gene expression profiles in the liver of schizophrenia subjects" docx
... of the gene expression findings [26,28] Therefore, appropriate statistical adjustment using available information is critical in order to improve inferences in determining candidate genes and the ... chlorpromazine has been shown to increase insulin sensitivity in the liver by attenuating insulin and leptin signaling pathways [55] It is interesting that one of the main side effects of atypical Page ... of the typical AP chlorpromazine decreases SOD enzyme activity in the brain and in erythrocytes [61], the effects in the liver are not known The interleukin receptor antagonist (IL1RN) gene inhibits...
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Báo cáo y học: " 3′-coterminal subgenomic RNAs and putative cis-acting elements of Grapevine leafroll-associated virus 3 reveals ‘unique’ features of gene expression strategy in the genus Ampelovirus" potx
... in comparison to the other members of the Closteroviridae Four of the eleven putative 3′-coterminal sgRNAs accumulated at high levels, two at intermediate levels, and the rest at low levels in ... predict the possible involvement of RNA secondary structures in the sgRNA synthesis analogous to TMV, CTLV and CTV, the 50 nt sequence corresponding to the minus strand sequence around the TSS of the ... sgRNAs in GLRaV-3-infected tissue are variable during the growing season and remains to be elucidated to determine whether their profile changes in relation to the developmental stage or expression...
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báo cáo khoa học: " Gene expression analyses in maize inbreds and hybrids with varying levels of heterosis" ppt
... can include expression levels between the mid-parent and parental values, expression levels equivalent to one of the parents or expression levels outside the parental range The identity and frequency ... topics regarding gene expression and heterosis, such as the relative frequencies of additive and non-additive expression levels in the hybrid Additive expression occurs when the hybrid expression ... B73 [17] were included in downstream analyses for comparative purposes A comparison of the expression profile of the inbred lines, B73 and Mo17, indicated that the profiles obtained in both experiments...
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