liver resection of colorectal liver metastases

... marked with arrows Picture of liver metastasis of mock treated (PBS) animal (A) day before treatment and (B) on day 35 after treatment (C) Picture of liver metastasis of WT-RGD treated animal one ... established colorectal cancer cell lines The E1-deleted Ad5 control virus did not cause oncolytic cell death in any of the cell lines Antitumor efficacy of RGD modified viruses in the spleento -liver colorectal ... ratio of transgene expression (C) Liver tumor to normal liver ratio of transgene expression *, p < 0.05; **, p < 0.01 tumors were allowed to grow for 23 days Two intravenous injections of viruses...

Ngày tải lên: 18/06/2014, 16:20

... liver resection for colorectal liver metastases was indicated only if three prerequisites were satisfied: no more than three liver metastases, clear resection margin of ≥ 10 mm, and absence of ... after hepatic resection for colorectal metastases Ann Surg 246:295-300 Konopke R, Kersting S, Makowiec F et al (2008) Resection of colorectal liver metastases: is a resection margin of mm enough? ... to resection Instead, colorectal liver metastases should be treated by resection whenever liver resection is technically feasible, with curative intent 3.1 Introduction The value of hepatic resection...

Ngày tải lên: 12/02/2014, 16:20

... liver resection for colorectal liver metastases was indicated only if three prerequisites were satisfied: no more than three liver metastases, clear resection margin of ≥ 10 mm, and absence of ... after hepatic resection for colorectal metastases Ann Surg 246:295-300 Konopke R, Kersting S, Makowiec F et al (2008) Resection of colorectal liver metastases: is a resection margin of mm enough? ... to resection Instead, colorectal liver metastases should be treated by resection whenever liver resection is technically feasible, with curative intent 3.1 Introduction The value of hepatic resection...

Ngày tải lên: 14/03/2014, 22:20

... effects of LA treatment on livers from animals with no tumors LA treatment resulted in the accumulation of Page of 10 Figure Immune responses following LA treatment of liver tissue Groups of mice ... distribution of Kupffer cells in tumor and liver tissues following laser ablation of tumors Figure Temporal changes in CD3+ T cells following LA treatment of selected liver metastases Groups of mice ... thermal ablation of liver and colorectal liver metastases Int J Hyperthermia 2005, 21(4):319-332 Page of 10 20 Muralidharan V, Nikfarjam M, Malcontenti-Wilson C, Christophi C: Effect of interstitial...

Ngày tải lên: 20/06/2014, 03:20

... after resection of colorectal liver metastases defines cure J Clin Oncol 2007, 25:4575-4580 Scheele J, Stangl R, Altendorf-Hofmann A: Hepatic metastases from colorectal carcinoma: impact of surgical ... Unfortunately, only 1020% of patients with colorectal liver metastases are actually resection candidates However, of those patients amenable to resection, five-year survivals of over 50% are possible, ... al.: Resection of the liver for colorectal carcinoma metastases A multi-institutional study of long-term survivors Dis Colon Rectum 1988, 31:1-4 Scheele J, Stang R, Altendorf-Hofmann A, Paul M: Resection...

Ngày tải lên: 09/08/2014, 04:21

... implementation of the gained data regarding the threshold dose of micrometastases in treatment planning of CT guided brachytherapy of colorectal liver metastases seems feasible whereas in external beam liver ... volume) including a safety margin of mm in the 3D CT data Threshold doses for local control of colorectal liver Standard of reference and definitions Colorectal liver metastases were confirmed by ... investigated the significance of margin status for resection of colorectal liver metastases [1,8-12] Although the existence of positive margins is shown to account for a high rate of local recurrences,...

Ngày tải lên: 09/08/2014, 08:23

... M A Morse, P C Kuo and B M Clary, Resection of Non Colorectal Nonneuroendorine Liver Metastases: A Comparative Analysis,” Journal of the American College of Surgeons, Vol 204, No 3, 2007, pp ... with resection of extrahepatic disease in other sites The size is varied, measuring to 18 cm The margin of liver resection was R0 in 50% to 100% Morbidity ranges from 0% to 21% with a mortality of ... 11,14,21] Most of the authors suggest that liver resection, when extrahepatic disease is present, should be able to acquire a complete resection or at least optimal (

Ngày tải lên: 05/03/2014, 15:20

... effects of LA treatment on livers from animals with no tumors LA treatment resulted in the accumulation of Page of 10 Figure Immune responses following LA treatment of liver tissue Groups of mice ... distribution of Kupffer cells in tumor and liver tissues following laser ablation of tumors Figure Temporal changes in CD3+ T cells following LA treatment of selected liver metastases Groups of mice ... thermal ablation of liver and colorectal liver metastases Int J Hyperthermia 2005, 21(4):319-332 Page of 10 20 Muralidharan V, Nikfarjam M, Malcontenti-Wilson C, Christophi C: Effect of interstitial...

Ngày tải lên: 18/06/2014, 19:20

... changes of mean ADC of nontreated and treated tumors at early and follow-up MRI compared to baseline MRI Boxplot illustrates changes of mean ADC of non-treated and treated colorectal liver metastases ... significantly between treated and non-treated colorectal liver metastases at follow-up MRI At follow-up MRI mean TV of non-treated colorectal liver metastases increased significantly by 50.8% to ... Dupuy DE: Radiofrequency ablation of colorectal hepatic metastases J Surg Oncol 2010, 102:978-987 Welsh JS, Kennedy AS, Thomadsen B: Selective Internal Radiation Therapy (SIRT) for liver metastases...

Ngày tải lên: 09/08/2014, 09:20

... Miwa S, Miyagawa S: Detection of hepatic metastases from colorectal carcinoma: comparison of histopathologic features of anatomically resected liver with results of preoperative imaging J Clin ... a relatively high ratio of distant metastases Patients with distant metastases have been shown to have a three-year survival rate of 41% to 46% [6,7] Surgical resection of the primary tumor and ... evidence that resection of the metastases prolongs survival However, the biologic behavior of the tumor of this particular patient, bearing in mind the rapid increase in the size of the lesions,...

Ngày tải lên: 10/08/2014, 23:20

... based on a first pass of signal-noise ratio of and a minimum peak threshold of 20% of all spectra This process was completed with a second pass of peak selection at 0.2% of the mass window, and ... biomarkers in colorectal cancer patients by MALDI-TOF MS We used WCX magnetic beads to screen potential serum biomarkers for colorectal cancer detection A total of 264 serum samples from colorectal ... due to its metastasis to the liver, accounting for over 70% of death cases [6] Surgical resection currently provides the best way of cure However, only 20% to 25% of CRC patients are eligible...

Ngày tải lên: 25/10/2012, 11:18

... higher rates of loss of heterozygosity than the MSS group.69 Two mechanisms for MSI-L status have been advanced: (i) increased generation of methylG:T mismatches due to loss of expression of 0-6-Methylguanine ... loss of expression of the DNA mismatch repair gene MLH1.82,83 These mechanisms might also synergise and account for the high end of the range of MSI-L or ‘super-low’ status.73 Involvement of MLH1 ... single copy of the altered gene may develop small numbers of serrated polyps and be at increased risk of developing CIMP CRC The early evolution of CIMP CRC may be the same regardless of MSI status...

Ngày tải lên: 22/03/2014, 17:20

... described previously [45] Cut-off values were chosen on the basis of a measure of heterogeneity An optimal cut-off value was identified An intensity score of ‡ with at least 50% of malignant cells showing ... development and progression of CRC Further functional and clinical analysis of the proteins is necessary to elucidate their precise role in the process of CRC and the formation of metastases Experimental ... LASP-1, respectively (B) Enlarged images of RhoGDI, S100A9 and LASP-1 in two-dimensional gels of normal colorectal mucosa, nmCRC and mCRC (C) Protein expression of RhoGDI, S100A9 and LASP-1 in normal...

Ngày tải lên: 23/03/2014, 03:20

... quantify the number, average diameter, and position coordinates of metastases Percentage of liver volume occupied by metastases and metastases density (foci number/100 mm3) were also determined ... 18th hour of incubation of monolayer- and 3D-spheroid-cultured CT26 cells For both culture conditions, the concentration of VEGF was expressed as a function of the total number Page of 12 (page ... atmosphere development Proliferation of cancer cells and recruitment of angiogenic endothelial cells and myofibroblasts were studied in subcutaneous tumors and hepatic metastases generated by subcutane-...

Ngày tải lên: 18/06/2014, 15:20

... multitude of SDj of this fam- comparing repertoire restriction of tissue with blood ily CDk of a sample was defined as sum of the moduli of Per-family normalized relative concentration P'jk of a fam- ... sequence homology of at least 50% [18] For analysis of the TCR repertoire, the β-chain is often preferred because of the lower number of families even if a higher overall variability of sequence compared ... subgroups each) Slope of each family specific reaction was estimated analyzing a dilution series spanning three orders of magnitude of a cDNA mixture of diagnostic samples Calculation of the relative...

Ngày tải lên: 18/06/2014, 16:20

... model of CRC In this mouse model of colonic carcinigenesis, the lack of constraints to NF-B driven inflammation, mediated via interleukin-1 inhibition, allows investigation of the effects of enhanced ... of tumor cells [48] We observed a strong correlation between the increased expression of these inflammation markers and increasing tissue dysplasia up to malignancy Page of 16 of the length of ... al Journal of Translational Medicine 2010, 8:112 http://www.translational-medicine.com/content/8/1/112 Page 10 of 16 Figure Staining in murine models of colorectal cancer Comparison of H&E, TLR-4...

Ngày tải lên: 18/06/2014, 16:20

... angiogenesis of CRC [20] Despite increasing knowledge about the expression of CXCL12/CXCR4 in CRC and its involvement of CXCR4 in the invasion and dissemination of CRC the precise mechanisms of CXCL12/CXCR4 ... metachronous colorectal liver metastases expressed CXCR4 in their primary tumor with no significant difference with respect to CRC patients who did not develop metastases Organ-specific expression of CXCL12 ... influence their migration potential Page of 14 Table Clinical characteristics of patients with colorectal carcinomas Factor CRC2 n = 50 Localization of primary tumor Colon Rectum Gender Male...

Ngày tải lên: 20/06/2014, 03:20

... suppression of inhibitory mechanisms and overexpression of BMP-4 [24] Recurrence of HO after surgical resection is one of the most common complications affecting the final outcome The role of prostaglandine ... the benefit of surgical excision of HO lesions of the knee in overall functional status of the patients [6,9,10] Traditionally, the optimal time for resection of heterotopic ossification was considered ... of posterior knee HO in the literature In a study by Garland et al [11] three cases of HO of the knee were reported In only one of them the lesion was located in the posterior knee and none of...

Ngày tải lên: 20/06/2014, 04:20

... after an analysis of peripheral blood of 48 patients [7], and 3) T-129C was associated with lower levels of MDR1 mRNA both in colorectal adenocarcinomas and in adjacent noncancerous colorectal tissues ... mixture of µl of OligofectamineTM Reagent (Invitrogen Corp.) and 22 µl of Opti-MEMR I Reduced-Serum Medium (Invitrogen Corp.) was incubated at room temperature for 10 After that, 360 µL of Opti-MEMR ... its down-regulation as a consequence of the malignant transformation of colorectal tissues, possibly with the suppression of differentiation [6] Lower levels of MDR1 in cancerous tissues than the...

Ngày tải lên: 08/08/2014, 17:20

... Illustration of the operative technique of levator anguli oris muscle based flaps: 2a: design and planning 2b: surgical elevation of the flap 2c: closure of defects Denewer et al World Journal of Surgical ... Page of Figure Operative illustration of the LAOMC flap 3a: design and planning 3b: closure of defects Routine immediate and late follow up was undertaken for evaluation of the viability of the ... 3/0 and then subcuticular closure of the skin, but when a part of the mucus membrane of the oral cavity mucosa is also being transferred, it is closed first Types of nasal reconstruction were as...

Ngày tải lên: 09/08/2014, 01:24