... regardless of treatment or subject grouping either by gender or caffeine usage. Subjects in the present study ingested 39 mg of p-synephrine and 528 mg of caffeine the day before testing followed ... p-synephrine, 239 mg caffeine, 5.7 mg octopamine and undisclosed amounts of other ingredients including catechin polyphenols. The hemodynamic effects of a single dose of a C. aurantium extract ... occurred in all three treatment groups. The increase in heart rate does not coincide with the pharmacokinetics including blood levels and half–life of p-synephrine [11, 13], but does coincide...
... nitrite” is a mixture of pentyl nitrite isomers containing isoamyl nitrite as a main component.b) In the commercial products of an alkyl nitrite, small amounts of corresponding alkyl alco-hol, ... lowered in some analytical cases; however, the contamination of the injection port due to low temperature is concerned. e author tested the possibility of decomposition of the compounds in the injection ... and kept airtightly in a refrigerator. A 5-µL volume of the above solution is placed using a microsyringe in a glass vial containing 1 mL of dimethyl sulfoxide (DMSO), capped airtightly and mixed...
... the use of t-BDMS derivatization of EMPA, the nal solution containing a large amount of the derivatization reagent has to be injected into GC/MS, resulting in the marked contamination of the ... AT (1999) Principle of Toxicology – Science of Poisons. Jiho Inc., Tokyo, pp 131–173 (in Japanese) 16) Tu AT, Inoue N (2001) Overall View of Chemical and Biological Weapons. Jiho Inc., Tokyo, ... et al. (1981) Trace Analysis of Chemical Warfare Agents. An Approach to the Environmental Monitoring of Nerve Agents. Ministry of Foreign Affairs of Finland, Helsinki, pp 27, 28, 37–39, 59–64,...
... 60 °C for 20 min. A er cooling, a 1-µL aliquot of it is injected into GC/MS.iv. Derivatization-2One of the above dry residues is dissolved in 2 mL of solution of diazomethane in ethyl ether ... delta-9-tetrahydrocannabinol in men and women. Clin Pharmacol Ther 34:352–363 2) Agurell S, Halldin M, Lindgren J-E et al. (1986) Pharmacokinetics and metabolism of ∆1-tetrahydrocannabinol and other cannabinoids ... is mainly used for the resin of the cannabis plant. Since the main component of cannabis, ∆9-tetrahydrocannabi-nol ( ∆9-THC), has various psychopharmacological e ects including hallucination,...
... detection of low levels of morphine starting from a large amount of a specimen cannot be a proof of the intake of the drug. e level of morphine in urine of healthy subjects determined by GC/MS ... or dihydrocodeine is commonly included in over-the-counter drugs of antitussives.> Figure 3.1 shows metabolic pathways of morphine, heroin and codeine. Since morphine and codeine are nally ... containing poppy seeds [9]. It should be noted that an amount of codeine comparable to that of morphine are also included in the poppy seed- containing foods [10]. e half-life of heroin disappearance...
... requiring NADH as a cofactor) pres-ent in mammalian red cells. e concentration of methemoglobin in blood of normal subjects is not higher than 1–2 % [1]; in case of higher concentrations of ... of unknown origin but presumably due to ingestion of nitrate. Int J Legal Med 113:164–167 5) Ellis M, Hiss Y, Shenkman L (1992) Fatal methemoglobinemia caused by inadvertent contamination of ... Cyanosis in infants caused by nitrates in well water. JAMA 257:2788–2792 12) Fan AM, Steinberg VE (1996) Health implications of nitrate and nitrite in drinking water: an update on methe-moglobinemia...
... determination of methemoglobin in blood. Clin Chim Acta 30:679–682 5) Katsumata Y, Aoki M, Oya M et al. (1980) Simultaneous determination of carboxyhemoglobin and methemoglo-bin in victims of ... blood samples at the ratio of 1:1.References 1) Evelyn KA, Malloy HAT (1938) Microdetermination of oxyhemoglobin, methemoglobin and sulfhemoglobin in a single sample of blood. J Biol Chem 126:655–662 ... carboxyhemoglobin. Forensic Sci Int 17:177–184 7) Sato K (1983) A method for determination of methemoglobin in blood containing carboxyhemoglobin. Jpn J Legal Med 37:133–144 (in Japanese with an English...
... 285 plus 217 (pentazocine) were used at the retention times of 3–7 min and 7–8 min, respectively. The amount of pentazocineand IS spiked into 1 mL of blank whole blood or urine was equally 50 ng.⊡ ... quantitation of both therapeutic and toxic levels of pen-tazocine in blood. e recovery of pentazocine using the Sep-Pak C18 cartridge was close to 100 % for both whole blood and urine [8]. In this ... Figure 5.2223 In two autopsy cases of pentazocine poisoning, its concentrations were 9.2 and 3.3 µg/mL in blood, 43 and 34 µg/g in the liver, and not detectable and 4.5 µg/mL in urine, respectively...
... powerful hallucinogenic drugs of abuse. LSD was explosively abused in U.S.A. in the latter half of the 1960s. In Japan, the amount of seizure of LSD is much smaller than that of methamphetamine. However, ... ab-sorption of LSD from the digestive tract is rapid and distinct visual hallucination takes place 45 min–1 h a er oral intake of about 20 µg of LSD [1]. e hallucination becomes most marked ... methamphetamine. However, in recent years, it has been increasing markedly; 3,500 tablets of LSD were seized in 1996, while 53,043 tablets in 2000 (about 15-fold increase), arousing a serious concern...
... are shown in > Fig. 7.5.For the proof of the use of MDMA, detection of MDA along with MDMA itself is being usually performed [12–14]. However, the main metabolic pathway of MDMA inhumans ... Services Administration (SAMHSA) is 250 ng/mL.Symptoms, and toxic and fatal concentrationsMDMA causes increased catecholamine (including serotonin) release and blockade of reuptake resulting in cardiac ... analyses of MDAs in the forms of tablets and those for GC/MS analysis of MDAs and their main metabolites 4-hydroxy-3-me-thoxymethamphetamine ( HMMA) and 4-hydroxy-3-methoxyamphetamine ( HMA) in urine...