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... showed the presence of the 1100delC variant Discussion None of the investigated 91 patients with SCCHN carried the CHK2 1100delC variant The incidence of 1100delC in the population of the state ... patients, they did not detect any truncating mutation Therefore, we were able to confirm these results Nevertheless, they found the missense I157T mutation in 4.1% of the cases In this study, the incidence ... (less than once a week) The remaining patients were mostly heavy smokers and drinkers Sequence analysis of exon 10 of the CHK2 gene was performed for all patients However, none of the patients...

Ngày tải lên: 11/08/2014, 07:21

... independence, which refers to the become failed states Permanence of such an entity may effective independence of the putative state the real be a relevant piece of evidence supporting the case for ... principle intended to last forever, they can be terminated Servitudes may be terminated by the merger of the servient and the dominant state, by agreement between the states concerned, by express ... vested in the separate authorities of the territory.272 The second is actual independence, which refers to the effective independence of the putative state the real governmental power at the disposal...

Ngày tải lên: 16/02/2014, 11:20

... proteins Gradients above the dashed line indicate exposed NHs, whereas those below indicate sequestered NHs As can be seen in Fig 2, all the backbone NH, with the exception of the Arg2, are above ... provides a better correlation with partial structuring of a flexible linear peptide The dashed line (Dd/DT ¼ )7.8 (CSD) )4.4) represents the cut off of Dd/DT between exposed and sequestered NHs of ... (Table 1) The most well-defined fragment of the peptide hormone contains the amino-acid residues 3–7 Figure 5A (a,b) provides a superposition of backbone and heavy atom of the entire ensemble of the...

Ngày tải lên: 20/02/2014, 23:20

... revealed that although the OPS of the LPS was partially cleaved, the mAb 2625 epitope in the remaining LPS species was not affected After de-O-acetylation of the LPS, the HF treatment completely ... 15±20 residues of legionaminic acid was the smallest one that displayed these signals and, moreover, the relative intensity of these signals was the highest compared to other pools from the same strain ... FEBS 2002 However, interference of the mAb 2625 epitope with binding of the core-speci®c mAb LPS-1 in Western blot suggested that the N-methylated legionaminic acid residue is located in the...

Ngày tải lên: 08/03/2014, 10:20

... markers when measured in the serum of patients with prostate cancer and benign prostate hyperplasia [34] In line with these observations, we detected up-regulated expression of S100A9 proteins ... role in the development and progression of CRC Further functional and clinical analysis of the proteins is necessary to elucidate their precise role in the process of CRC and the formation of metastases ... triplicate, and the paired Student’s t test was used to evaluate the mean change in protein abundance corresponding to each target spot across the gels The protein spots of interest were cut from the...

Ngày tải lên: 23/03/2014, 03:20

... interacting with the protein, because the resonance signals of the glucose residue overlapping with those of the galactose residue within the lactose affected the subtraction of the free induction FEBS ... in the previous study [26], disappeared in the completely sugar-free state (Fig S1) The resonance signals of EW29Ch in the completely sugar-free state were therefore reassigned using multidimensional ... sugar-binding site because of the number of intermolecular hydrogen bonds and of residues interacting with lactose Our results agreed well with those from the crystal structure of the complex between EW29Ch...

Ngày tải lên: 23/03/2014, 04:21

... lines are so invisible that the person isn’t even aware of their existence If they keep overstepping the mark, though, they leave us silently smouldering 11 Behind with the Laundry:Behind with the ... spirit, they get excited and they even start to look different When people have a passion, they start planning They make phone calls, they gather information, they leave the excuses behind and they ... purpose, knowing they will steal the limelight People who are vain the same So preoccupied are they about how they look, they forget that other people have feelings and often fail to notice when...

Ngày tải lên: 28/03/2014, 19:20

... with the procurement office The assigned contracting officer, in consultation with the small business representative and the project officer, will then make several key decisions One of these ... also selected at this time Doing Business with the Department of Education Page of 21 Once these decisions have been made and funds are committed for the requirement, the contracting officer begins ... set-aside criteria in the federal procurement regulations The SBA Office of Technology strengthens and expands the competitiveness of U S small high technology research and development businesses...

Ngày tải lên: 29/03/2014, 18:20

... analysis of the stratified data using survey-weighted generalized linear models We wanted to know whether there was any association of the health-related quality of life with the seasonal changes in ... which the GSS is comprised were computed in order to elucidate which of the seasonal changes explained the association best Results To see whether mental health contributes to the HRQoL in the current ... northern latitudes may have adapted better than others [25] Milder forms of seasonal affective disorder are more prevalent in more northern latitudes, whereas the prevalence of affective disorder...

Ngày tải lên: 18/06/2014, 19:20

... overwhelm the genetic effect on the IL-6 levels There is substantial evidence that the increase in IL-6 serum levels with age results in part from the loss of sex steroids such as estrogen, testosterone ... traditionally regarded as evidence for linkage r2 is a correlation coefficient between pairs of loci they were pooled and the results presented here apply to the whole series, except that the statistical ... respectively (P = 0.007) There were no differences between the groups in allele frequencies or carriage rates at the promoter location -572 At G-174C the combined GG and GC genotypes increased...

Ngày tải lên: 09/08/2014, 10:23

... cross-sectionally compare the presence and extent of CAC between RA patients and a subset of the MESA cohort from the same geographic area utilizing the same equipment, laboratories and core reading ... these associations We also explored whether differences in CAC between RA and control groups varied by gender, age, and level of RA severity equipment limitations); and CT scan of the chest within ... collected by questionnaire Resting blood pressure was measured three times in the seated position, and the average of the last two measurements was used in the analysis Hypertension was defined by systolic...

Ngày tải lên: 09/08/2014, 13:22

... character of development The rate of development of the offspring of the measured during the same experiment (table 2C), but no significant difference was detected between the means Nevertheless, offspring ... of bristles n A higher percentage of this category is obtained rence The effects of egg sterilization on the duration of development were estimated using data from the same experiments The results ... SimES strain, and secondly, the results of the measures of some fitness parameters of the SimES strain free of these pathogenic microorganisms Finally, these « curedSimES strain properties were...

Ngày tải lên: 09/08/2014, 22:22

... of selected regions was performed using the Pfu proofreading DNA polymerase (Stratagene) and the purified products were sequenced using the Thermosequenase radiolabeled terminator cycle sequencing ... samples respectively HeLa cells were co-transfected with each pSGTax2531 construct together with the pLTRLuc reporter plasmid containing the firefly luciferase gene under the control of the BLV ... most rodent leukemia models in which a short mean latency precedes the aggressive acute phase, the ovine BLV-associated leukemia effectively recreates the temporal events that occur during the initiation...

Ngày tải lên: 13/08/2014, 05:22

... boundary between science and politics? Are there any base line differences between “doing science”, that is, being actively involved in research where the results are expected to be of relevance for ... contribute to the development of a reality producing eGovernment; is it the system developers, employees, authorities, management, business or the citizens themselves or all of these? The advisory meetings, ... […] every reference to the ”real world”, even where the reference is to physical or biological events, is a reference to the organized activities of everyday life […] Ethnomethodological studies...

Ngày tải lên: 04/11/2013, 20:15

... e The RNA pol II–Pol e interaction does not depend on DNA replication Pol e is one of the three major replicases in the eukaryotic cell [22] Therefore, we tested the effect of the replicative ... complexed with Pol e, we examined the effect of phosphatase on the precipitated RNA pol II Immunoprecipitates were incubated at +37 °C, in the presence or absence of calf intestinal phosphatase, ... remove bulk DNA Protein–nucleic acid complexes were extracted with phenol, precipitated with acetone, collected at °C and washed three times The dried protein–nucleic acid pellet was resuspended...

Ngày tải lên: 07/03/2014, 11:20

... easier for people to see the relevance of Cancer Research UK to their lives and those affected by cancer, thereby hopefully engendering greater support for us to invest in research 18 Cancer Research ... increase the risk of breast, bowel, prostate and lung cancer These genome-wide studies identify people who are at increased inherited risk of developing the disease through combined effects of ... make the fastest progress in cancer research Providing the right people for research To achieve our goals, we need the best biomedical scientists, the best clinical researchers and the best research...

Ngày tải lên: 22/03/2014, 16:21

... acid) The sufficient removal of non-bounded dye was verified by FCS-measurements of the wash steps prior to the elution of the labelled peptide The fluorescent-labelled peptide was subsequently eluted ... the increment of the size of the particles because of the interaction of E4 1–60 with H1–47 according to the Stoker–Einstein relation The calculations were performed using confocor software version ... calculation of the relative amounts of free labelled peptide E4 1– 60 with the short diffusion time, in comparison with an increase of the diffusion time The increase of the diffusion time is caused by the...

Ngày tải lên: 30/03/2014, 04:20

... leads on a limited budget that helps fuel the sales team Unfortunately, this hard work and diligence often goes underappreciated Seventy-three percent of chief executive of cers (CEOs) believe ... refers to the website and landing pages What percentage of them are from search? Social media? Other websites? E- mail marketing? Review the breakdown of website traffic Then, dig a layer deeper What ... conversion rate and overall volume of leads Step 1: Get the Basics Right Generating leads using social media starts with three core elements that are the linchpin for the entire online lead generation...

Ngày tải lên: 29/05/2014, 21:25

... located relative to the zones Case : The rows of L are selected from the same zone, say the j-th zone Referring to the proof of Theorem we see that the leading columns of Ci ’s form a rearrangement ... prime power congruent to (mod 4), then the Paley graph of order q, written Pq , is the graph with vertices the elements of GF (q), the field of order q, and distinct vertices are joined iff their ... grateful to the referee for pointing out a few minor errors and the following There are some strongly regular 3 -e. c graphs that are not Paley graphs Some of them, however, have the same parameters...

Ngày tải lên: 07/08/2014, 06:22

... most of the graphs generated have the n -e. c property in Section 4, thereby completing the proof of Theorem 1.1 The proof of the n -e. c property uses bounds on the expected number of pairs of subsets ... (mod 4) Let q denote the finite field containing q elements, where q is a power of a prime The vertices of the Paley graph Pq are the elements of q and there is an edge between two vertices x and ... that q ≡ (mod 4) Let q be → the finite field on q elements The vertices of the Paley tournament P q are the elements of q and there is a directed edge from a vertex x to another vertex y if and only...

Ngày tải lên: 07/08/2014, 06:23