leukemia small lymphocytic lymphoma b cll sll

báo cáo hóa học:" Intrinsic and extrinsic factors influencing the clinical course of B-cell chronic lymphocytic leukemia: prognostic markers with pathogenetic relevance" docx

Ngày tải lên : 18/06/2014, 15:20

... lymphocytic leukemia Blood 1999, 94:1840-1847 Dohner H, Stilgenbauer S, Benner A, Leupolt E, Krober A, Bullinger L, Dohner K, Bentz M, Lichter P: Genomic aberrations and survival in chronic lymphocytic ... Papp J, Kearsey G, Aebi S, Graber H, Jaggi R, Luthi JM, Meyer-Monard S, Lathrop M, Tobler A, Fey MF: A highresolution allelotype of B- cell chronic lymphocytic leukemia (B- CLL) Blood 2002, 100:1787-1794 ... replicative features of the B- CLL subgroups defined by immunoglobulin V gene mutations Blood 2004, 103:375-382 Grabowski P, Hultdin M, Karlsson K, Tobin G, Aleskog A, Thunberg U, Laurell A, Sundstrom...

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Báo cáo hóa học: " Prognostic impact of ZAP-70 expression in chronic lymphocytic leukemia: mean fluorescence intensity T/B ratio versus percentage of positive cells" pot

Ngày tải lên : 18/06/2014, 16:20

... chronic lymphocytic leukemia Blood 1999, 94:1848-1854 Krober A, Bloehdorn J, Hafner S, Buhler A, Seiler T, Kienle D, Winkler D, Bangerter M, Schlenk RF, Benner A, Lichter P, Dohner H, Stilgenbauer ... with B- chronic lymphocytic leukemia Blood 2006, 108:2950-2956 Tinhofer I, Weiss L, Gassner F, Rubenzer G, Holler C, Greil R: Difference in the relative distribution of CD4+ T-cell subsets in B- CLL ... determination by flow cytometry: the French experience Cytometry B Clin Cytom 2007, 72:103-108 Letestu R, Rawstron A, Ghia P, Villamor N, Boeckx N, Boettcher S, Buhl AM, Duerig J, Ibbotson R, Kroeber A,...

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Báo cáo hóa học: "Quantification of newly produced B and T lymphocytes in untreated chronic lymphocytic leukemia patients" ppt

Ngày tải lên : 18/06/2014, 16:20

... copies/106 PBMC or copies/mL obtained respectively by multiplying the above calculated value by 106, or, as done by Chen et al [15], by the number of lymphocytes plus monocytes (which are the cells obtained ... PBMC preparation) Finally, the average number of B- cell divisions was evaluated, as reported by van Zelm et al [5], by calculating the difference between the cycle threshold number obtained by ... newly produced B cells and measure of the average number of B- cell divisions in CLL patients While the decreased Ig synthesis in CLL has been previously ascribed to the release of inhibitory cytokines...

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Báo cáo y học: " Successful long-term monotherapy with rituximab in a patient with chronic lymphocytic leukemia of the B-cell-lineage: a case report" pdf

Ngày tải lên : 11/08/2014, 21:22

... with small lymphocytic lymphoma (SLL) and CLL who had shown an initial response or stable disease after rituximab induction therapy could be successfully retreated at 6-month intervals [4], but ... with alemtuzumab was considered, but preference was given to rituximab because of the less severe compromise of the cellular immune system by rituximab, and because of the possibility that autoimmune ... http://www.jmedicalcasereports.com/content/2/1/275 man Chronic Lymphocytic Leukemia Study Group: Rituximab therapy of patients with B- cell chronic lymphocytic leukemia Blood 2001, 98(5):1326-1331 Srock S, Schriever F, Neubauer A, Herold M,...

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Báo cáo khoa học: Control of transforming growth factor b signal transduction by small GTPases pot

Ngày tải lên : 07/03/2014, 01:20

... fibroblasts such as H-ras transformed NIH3T3 fibroblasts, mouse embryo fibroblasts and Swiss3T3 fibroblasts [145–148] In fibroblasts transformed by inducible expression of the H-Ras oncogene, TGFb ... Swiss3T3 fibroblasts, TGFb induced rapid activation of both RhoA and RhoB small GTPases as early as post TGFb1 addition which remained high for h before decreasing [147] Activation of RhoA and RhoB was ... TGFb induced fibroblast to myofibroblast differentiation, which was evidenced by enhanced expression of a-SMA and the subsequent incorporation of a-SMA into microfilamentous structures [148] Fibroblast...

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Báo cáo khoa học: Structural and functional roles for b-strand 7 in the a-crystallin domain of p26, a polydisperse small heat shock protein from Artemia franciscana pdf

Ngày tải lên : 07/03/2014, 12:20

... domain is preceded by a poorly conserved N-terminal region proposed to function in oligomer assembly, subunit exchange and substrate binding [17– 22], and is followed by a ﬂexible, polar, C-terminal ... incubated with antibody to p26 followed by ﬂuorescein isothiocyanate-conjugated goat anti-rabbit IgG (green) Nuclei were stained with propidium iodide (red) The scale bar represents 100 lm and both ... and B in dimer and C and D in dimer (Fig 8) The a-crystallin domain of each monomer is composed of nine b- strands (labeled b2 b1 0), with the b6 strand situated in a large loop, L5 ⁄ 7, located between...

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Báo cáo Y học: GPI-microdomains (membrane rafts) and signaling of the multi-chain interleukin-2 receptor in human lymphoma/leukemia T cell lines doc

Ngày tải lên : 17/03/2014, 23:20

... cellsÆmL)1) and labeled by incubation with approximately 10 lg of SFX-, RhRX- or Cy3-conjugated Fabs (or mAbs) for 45 on ice The excess of mAbs was at least 30-fold above the Kd during the incubation To ... subjected to fixation and permeabilization (Fix&PermKit,CaltagLaboratories,Burlingame,CA,USA) and incubated (20 min) with specific rabbit anti-(STAT3/ STAT5) Ig or rabbit polyclonal anti-(phospho-STAT3/ ... promoted by their Ó FEBS 2002 Fig FRET between IL-2R subunits and HLA glycoproteins in T leukemia and lymphoma cell lines (A) Representative FRET efficiency (E, %) histograms measured on T lymphoma/ leukemia...

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Báo cáo khoa học: Small exterior hydrophobic cluster contributes to conformational stability and steroid binding in ketosteroid isomerase from Pseudomonas putida biotype B pot

Ngày tải lên : 23/03/2014, 13:20

... Val127 was found to be located on the center of three b- strands (B4 , B5 and B7 ) that occupy the entry site of the steroid-binding pocket (Fig 1B) A Mutational effect on catalysis B Val127 Val127 ... solvent-exposed b- sheet Contribution of the SEHC to conformational stability The hydrophobic interaction in the SEHC of KSI-PI was perturbed by replacing the hydrophobic residues with amino acids having smaller ... of Bacillus stearothermophilus was found to be stabilized by utilizing a hydrophobic residue at the solventexposed site [3], and a hydrophobic pocket on the surface of neutral protease of B subtilis...

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small gtpases and their regulators, part b

Ngày tải lên : 11/04/2014, 10:32

... diluted fivefold with buffer B and applied to a CM-Sepharose column (1.5 x 20 cm) equilibrated with buffer B Elution is performed with 50 ml of buffer B followed by buffer B containing 300 mM NaCI ... the solubilized membrane components including membrane-associated cytochrome b - 5 24 Preparation of Solubilized Membrane Components The solubilized membrane components including membrane-associated ... DISSOCIATIONINHIBITOR 45 Affinity Purification of GST-Rho-GDI Glutathione-Sepharose 4B beads are packed onto 10-ml disposable syringe (bed volume, ml) The beads are washed with 30 ml of buffer B and equilibrated...

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CHRONIC LYMPHOCYTIC LEUKEMIA ppt

Ngày tải lên : 27/06/2014, 13:20

... receptor B2 9 (CD7 9b) gene in chronic lymphocytic leukemia Blood 90, 1387–1394 [62] Payelle-Brogard B. , et al (1999) Analysis of the B- cell receptor B2 9 (CD7 9b) gene in familial chronic lymphocytic leukemia ... CD38 engagement in CD38pos/CD49dpos CLL B- cells and also CCL3 was found to be expressed by CLL B- cells from bone marrow biopsies (BMB) of CD38pos/CD49dpos but not CD38neg/CD49dneg cases High ... chronic lymphocytic leukemia (B- CLL) Blood 107, 3584–3592 [94] Crespo M., et al (2006) ZAP-70 expression in normal pro/pre B cells, mature B cells, and in B cell acute lymphoblastic leukemia...

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báo cáo khoa học: "An operative case of hepatic pseudolymphoma difficult to differentiate from primary hepatic marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue" ppt

Ngày tải lên : 09/08/2014, 01:24

... hepatitis B virus surface antigen (HBsAg), hepatitis B virus core antibody (HBcAb) and hepatitis C virus (HCV) antibody Also, tumor markers including carcinoembryonic antigen and carbohydrate ... negative for CD5, which rules out other small B- cell non Hodgkin lymphomas, including lymphocytic lymphoma and mantle cell lymphoma (original magnification ×4) (E) Bcl-2 expression in the mantle zones ... Cancer 1983, 51:476-486 Kulow BF, Cualing H, Steele P, VanHorn J, Breneman JC, Mutasim DF, Breneman DL: Progression of cutaneous B- cell pseudolymphoma to cutaneous B- cell lymphoma J Cutan Med Surg...

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Báo cáo khoa học: "Non-polypoidal, synchronous mantle- cell lymphoma of small intestine: a rare case" potx

Ngày tải lên : 09/08/2014, 03:22

... [12] Conclusions Non-polypoid lymphomas of the small bowel can be a rare place of occurrence for mantle cell lymphomas In such cases of lymphomas presenting as small bowel individual tumors, with ... Nagahara A, Sakamoto N, Shibuya T, Kawabe M, Terai T, Ohkusa T, Ogihara T, Sato N, Kamano T, Hayashida Y, Watanabe S: Malignant lymphoma in the ileum diagnosed by double-balloon enteroscopy World ... Immediate publication on acceptance • Inclusion in PubMed, CAS, Scopus and Google Scholar • Research which is freely available for redistribution Submit your manuscript at www.biomedcentral.com/submit...

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Báo cáo y học: "Effect of a small molecule inhibitor of nuclear factor-κB nuclear translocation in a murine model of arthritis and cultured human synovial cells" pps

Ngày tải lên : 09/08/2014, 07:20

... (CIA) [17], but it appeared to be less efficient, possibly because it selectively affects T cells and not fibroblasts or endothelial cells Recently, a peptide inhibitor of NF- B that blocks association ... factor nuclear factor- B (NF- B) forms a heterodimer or a homodimer of the subunit members, and in the cytoplasm of unstimulated cells it binds to natural inhibitors of NF- B (I B) , which prevent ... IgG (Southern Biotechnology Associates, Birmingham, Available online http://arthritis-research.com/content/7/6/R1348 Figure Inhibition by DHMEQ of NF- B in rheumatoid arthritis fibroblast-like synoviocytes...

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Báo cáo khoa học: "High grade B-cell gastric lymphoma with complete pathologic remission after eradication of helicobacter pylori infection: Report of a case and review of the literature" pdf

Ngày tải lên : 09/08/2014, 07:21

... large B- cell lymphoma that responded to antibiotic therapy had been described and, more recently, Chen et al [7] reported in a prospective study the disappearance of primary gastric large B- cell lymphoma ... and p53; in the patient with Burkitt-like lymphoma, malignant cells expressed bcl-6 and p53; in the with Burkitt-like lymphoma, malignant cells expressed bcl-6 and not bcl-2; in two patients there ... genetic aberrations, arises de novo [32] Not all DLBCLs without areas of MALT lymphoma arise de novo The absence of the low grade component could be due to sampling bias or to overgrowth by large...

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Báo cáo y học: "Frequency of intravascular large B-cell lymphoma in Japan: Study of the Osaka Lymphoma Study Group" doc

Ngày tải lên : 10/08/2014, 21:23

... intravascular lymphomatosis: an updated review of malignant histiocytosis-like B- cell lymphoma Leuk Lymphoma 1999, 33(5-6):459-73, Review Erratum in: Leuk Lymphoma 1999 Jun;34(1-2):following 206 Table Brief ... R-CHOP: rituximab-cyclophosphamide, doxorubicin, vincristine, and prednisone R-THP-COP: rituximab-pirarubicin, cyclophosphamide, vincristine and prednisolone PBSC: peripheral blood stem cell ... summary of intravscular large B- cell lymphoma Number of cases Source Publication Country B- IVL/ total (%) Age (y) Sex Symptoms range (M/ neurological cuteneous Blymphadenopathy hepatomegaly splenomegaly...

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Báo cáo y học: "High nuclear expression of STAT3 is associated with unfavorable prognosis in diffuse large B-cell lymphoma" doc

Ngày tải lên : 10/08/2014, 21:23

... polyclonal antibody, Santa Cruz Biotechnology) for STAT3, anti-P-STAT3 antibody (9145, rabbit monoclonal antibody, Cell Signaling Technology) for P-STAT3Tyr705, and antibodies for BCL6, CD10, MUM1 ... STAT3 expression in ABC-DLBCL patients correlated with inferior overall survival, but not with GCB-DLBCL patients However, STAT3-high and STAT3-low subsets within ABC-DLBCL did not differ in ... improved outcome of diffuse large B- cell lymphoma in British Columbia J Clin Oncol 2005, 23(22):5027-33 Calo’ V, Migliavacca M, Bazan V, Macaluso M, Buscemi M, Gebbia N, Russo A: STAT proteins:...

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báo cáo khoa học: "Persistence of TEL-AML1 fusion gene as minimal residual disease has no additive prognostic value in CD 10 positive B-acute lymphoblastic leukemia: a FISH study" doc

Ngày tải lên : 10/08/2014, 22:20

... terms of predicting the probability of OS The relationship between the TEL-AML1 fusion and a favorable prognosis represented by survival has already been described [2,9] Rubnitz et al [9] reported ... French American British (FAB) classification of lymphoblastic leukemia and determination of immunophenotypic markers They were B precursor ALL patients diagnosed as common and preB-ALL by flowcytomety ... that reported by others [26,29,30] that several patients were found to be positive for TEL-AML1 fusion, but the persistence of detectable MRD was not associated with a better probability of OS...

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báo cáo khoa học: "ALK-positive diffuse large B-cell lymphoma: report of four cases and review of the literature" pptx

Ngày tải lên : 10/08/2014, 22:20

... diagnosis of ALK-DLBCL should include lymphoblastic lymphoma, anaplastic variants of DLBCL, plasmablastic lymphoma (PBL), primary effusion lymphoma (PEL), solid variants of PEL and plasmablastic myeloma ... rearrangement observed in ALCL could not be shown [1], modern techniques have been able to prove recurrent chromosomal abnormalities in ALKDLBCL The most commonly observed cytogenetic abnormality ... neck region ALK-DLBCL differs somewhat from other subtypes of DLBCL with plasmacytic differentiation Plasmablastic lymphoma (PBL), a CD20-negative DLBCL associated to HIV and EBV coinfection, tends...

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báo cáo khoa học: "An unusual presentation of precursor T cell lymphoblastic leukemia/lymphoma with cholestatic jaundice: case report" pot

Ngày tải lên : 10/08/2014, 22:20

... 2:12 Background Precursor T-lymphoblastic leukemia (T-ALL) /lymphoma (T-LBL) is a neoplasm of lymphoblasts committed to the T-cell lineage Clinically, if there are >25 percent bone marrow blasts ... in PubMed and archived on PubMed Central yours — you keep the copyright BioMedcentral Submit your manuscript here: http://www.biomedcentral.com/info/publishing_adv.asp Page of (page number not ... muscle antibodies, HIV, along with EBV and CMV antibodies were all negative CT guided biopsy of the mediastinal mass (Figure 2A) showed features of malignant lymphoma characterized by a diffuse...

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báo cáo khoa học: "Adult B lymphoblastic leukaemia/lymphoma with hypodiploidy (-9) and a novel chromosomal translocation t(7;12)(q22;p13) presenting with severe eosinophilia – case report and review of literature" pdf

Ngày tải lên : 10/08/2014, 22:20

... lymphoblastic leukemia, as a result of different cytogenetic abnormalities In majority of the cases there is absence of blasts in the peripheral blood film Adult B lymphoblastic leukemia/ lymphoma ... absence of blasts in the peripheral blood film The bone marrow biopsy of this patient showed presence of 40% blasts, which stained negative with Sudan Black B, and were of common precursor B- cell ... 2:26 sis (FC500 Beckman Coulter) was done after incubation of bone marrow mononuclear cells with a panel of fluorescence labeled antibodies (obtained from Becton Dickinson, USA) The blast cell population...

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