lessons from animal models and clinical trials
Báo cáo y học: "Cartilage-specific autoimmunity in animal models and clinical aspects in patients – focus on relapsing polychondritis" ppsx
Ngày tải lên :
09/08/2014, 06:22
... in RA Animal models for RP have been described as those immunized with either collagen type II (CII) or matrilin-1 and as models that appear spontaneously [1–3] These models differ in clinical ... as well as antibodies to COMP were detected in sera from RP patients [13,28] Additional arthritis models and spontaneous models Several other models for arthritis have been reported but these will ... induction of RA, play a role in RP pathogenesis Animal models provide good tools in the search for potential autoantigens and candidate genes in RP, RA and related autoimmune diseases Further knowledge...
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Báo cáo y học: "The role of T cell interleukin-17 in conducting destructive arthritis: lessons from animal models" pps
Ngày tải lên :
09/08/2014, 06:22
... ligand (RANKL), IL-1, tumor necrosis factor (TNF) and the modulatory role of IL-4 and osteoprotegerin (OPG) is presented OC, osteoclast positive and negative regulators of osteoclastogenesis and ... cells [19] IL-17 stimulates transcriptional NF-κB activity and IL-6 and IL-8 secretion in fibroblastic, endothelial, and epithelial cells, and induces T cell proliferation [1,5] Furthermore, it triggers ... IL1 and TNF It can activate NF-κB and all three classes of mitogen-activated protein (MAP) kinases including extracellular signal-related kinase (ERK)1 and ERK2, c-Jun N-terminal kinase (JNK), and...
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Báo cáo y học: "Lessons from animal models of arthritis over the past decade" pot
Ngày tải lên :
09/08/2014, 14:22
... classic arthritis models and this holds as well for the more novel models such as KRN and SKG arthritis and passive GPI/KRN arthritis In fact, both T cell- and IC-driven murine models appear IL-1 ... targets and, as such, clinical data will help shape and define the models TNF and IL-6 are good examples of molecules with general pro-inflammatory roles that were identified in various models and ... References Conclusion Models are tools that mimic aspects of human disease It is clear that animal models have contributed considerably to further our understanding of arthritic processes and concomitant...
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5 twitter lessons from the obama and romney campaigns
Ngày tải lên :
07/01/2014, 15:28
... high on the list when people clicked on "Big Bird." Build and engage your communit y Find out what people expect and want from your brand As an example, Steele said the Romney campaign posts behind-the-scenes ... statements in real time." Also, Steele pointed out, after Romney announced he would cut PBS's funding and mentioned "Big Bird" during the first debate, "Big Bird" began trending on Twitter Early on, ... Convention, the Obama digital media team tweeted a photo captioned: "This seat's taken." Witty and amusing tweets can show that you don't take yourself or your company too seriously Connect t...
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Báo cáo khoa học: Protein tyrosine phosphatases: functional inferences from mouse models and human diseases pot
Ngày tải lên :
30/03/2014, 04:20
... ligands and substrates and the experimental drawbacks of overexpression in cell models, insight into the physiological role of individual phosphatases has come mostly from loss-of-function animal ... principles and structure–function relationships displayed by classical and dual-specificity tyrosine phosphatases PTP function: animal models lead the way Because of their high enzymatic activity and ... subsequently moves into the nucleus and enhances secretory granule gene expression by binding and protecting STAT5 phosphotyrosines For the R4 (RPTPa and RPTPe) and R5 (RPTPc and RPTPf) receptor-type PTPs...
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lessons from deregulation telecommunications and airlines after the crunch
Ngày tải lên :
03/06/2014, 01:55
... Lessons from Deregulation This page intentionally left blank Lessons from Deregulation Telecommunications and Airlines after the Crunch Alfred E Kahn ... requirement or be to or from small hub and non-hub airports The condition limited the total number of code-sharing flights between Delta and Continental and between Delta and Northwest to 2,600 ... re-regulation67—as distinguished from safeguards against outright fraud and doubledealing by corporate executives and dishonest accounting, auditing, and appraisals by investment analysts and advisers.68 On...
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Báo cáo y học: "Stress and Childhood Asthma Risk: Overlapping Evidence from Animal Studies and Epidemiologic Research" potx
Ngày tải lên :
08/08/2014, 21:20
... nonhuman primate and rodent models of prenatal stress and early adverse caregiving13,14,16 have helped us understand the consequences of similar experiences in humans.17,18 Maternal and fetal stress ... 1.48–3.88; p 0009) Summary Evidence from both animal and human studies supports the notion that HPA functioning and other stress pathways may be altered by in utero stress and early caregiving experiences ... primate and rodent models of early adverse caregiving13,14,16 have helped us understand the consequences of similar experiences in humans.17,18 Disturbed regulation of stress systems (eg, HPA axis and...
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Báo cáo y học: "Lessons from dynamic cadaver and invasive bone pin studies: do we know how the foot really moves during gait" potx
Ngày tải lên :
10/08/2014, 21:23
... accessing and measuring the biomechanics of individual anatomical structures in the foot have been taken, (i) static and dynamic cadaver models, and (ii) invasive in-vivo research Cadaver models ... absent from most if not all clinical models of the foot For the forefoot, data have confirmed the greater stability of the first, second and third metatarsals compared to metatarsals four and five ... surgical practice is based, and the development of clinical and experimental hypotheses as to how pathology occurs This links directly to how foot orthoses, footwear and surgery might be best used...
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Báo cáo sinh học: " Equivalence of multibreed animal models and hierarchical Bayes analysis for maternally influenced traits" potx
Ngày tải lên :
14/08/2014, 13:21
... 1973 and 1990 on both purebred and crossbred individuals, including progeny from inter-se matings, backcrosses, and rotational crosses (Table 2) A detailed description of the mating design and ... inspired on the class notes from Misztal [28] The code is based on programs from the BLUPF90 package [29] and specific F77 routines from our research group [R.J C Cantet and A.N Birchmeier, personal ... retrieved the null-row and null-column patterns from the incidence matrices of breeding values and from the partial numerator relationship matrices Finally, on using these matrices and by means of appropriate...
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moloney - how to protect investors; lessons from the ec and the uk (2010)
Ngày tải lên :
01/11/2014, 21:27
... intractable, the retail constituency quiescent and unhelpful to the beleaguered regulator, and the empirical and analytical pyrotechnics of law and finance and of law and economics, typically applied to ... Central Bank Working Group on Clearing and Settlement, and part-time Professor of Commercial Law, University of Ghent HOW TO PROTECT INVESTORS Lessons from the EC and the UK NIAMH MOLONEY CAMBRIDGE ... products and which provide diversification (pp 15 and 17) E.g C Borio, Change and Constancy in the Financial System: Implications for Financial Distress and Policy (2007), ssrn abstractid=1022874 and...
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4 project management lessons from building marshmallow and spaghetti towers
Ngày tải lên :
27/11/2015, 12:21
... marshmallows & tape Tell them to build the tallest structure You’ll discover valuable lessons in team behavior and project management Photo by kjarrett - Creative Commons Attribution License https://www.flickr.com/photos/29304822@N00 ... roles before a project starts! b Iterate to innovate faster c Mix skills and personalities on your team d Incentives and experience combined boost performance For more strategies on building ... perfect plan, the kindergarteners built successive prototypes, always keeping the marshmallow on top and refining their design along the way An iterative process allows the team to innovate at a faster...
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Báo cáo y học: "Tolerability and adverse events in clinical trials of celecoxib in osteoarthritis and rheumatoid arthritis: systematic review and meta-analysis of information from company clinical trial report" potx
Ngày tải lên :
09/08/2014, 06:22
... conducted using information from company clinical trial reports, supplied by Pfizer Ltd, of completed randomised, double-blind trials from the celecoxib clinical trials programme The objectives ... Clinical ulcers and bleeds Clinical ulcers and bleeds in the company clinical trial reports were as reported by investigators, and were not subjected to independent, blinded adjudication in trials ... analyses, and protocol amendments Full clinical trial reports were not available for eight trials, but extensive clinical trial summaries were provided Information was extracted directly from the clinical...
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wehn et al (eds.) - rethinking valuation and pricing models; lessons learned from the crisis and future challenges (2013)
Ngày tải lên :
01/11/2014, 16:43
... parametric and non-parametric models With regard to parametric models, the research has mainly focused on three models: The stochastic volatility (SV), stochastic volatility random jump (SVJ) and stochastic ... (1994), Garcia and Gencay (2000), Gencay and Altay-Salih (2003), Gencay and Gibson (2009), and Gradojevic et al (2009) Non-parametric models, which lack the theoretical appeal of parametric models, ... market crash of 1987 and the credit crisis of 2008) This conclusion may result from the estimation and the pricing ability of non-parametric models being impeded by a regime switch from stable economic...
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Global perspectives on governance: lessons from east and west
Ngày tải lên :
19/01/2014, 21:30
... customers and community alike Many western standards and laws have been set in place specifically to break these opaque networks Global perspectives on governance: lessons from east and west | ... tighten checks and balances A new emphasis on the behavioural aspects of governance is overdue Both models have their strengths and it is important to understand the benefits and drawbacks of ... transparency and appropriate disclosure, and to define the roles and responsibilities of stakeholders in running a company These principles are necessary to establish a stable and competitive business and, ...
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Tài liệu Women’s Health and Postsocialist Healthcare Reforms: Lessons from Poland and Eastern Europe ppt
Ngày tải lên :
13/02/2014, 06:20
... depleted Poland’s health system, leaving only 203 doctors per 100,000 population—a dismal ratio ranking Poland near the bottom in Europe, and only surpassed by Romania, Bosnia and Herzegovina, and Albania, ... Brazil, Britain, France, the Netherlands, Mexico, Thailand, and Sri Lanka—these states are succeeding in improving their public healthcare, including reproductive and sexual health services (Berer ... access to comprehensive, available and affordable healthcare, including services essential to reproductive and sexual health, and stable coverage for low income and medically underserved communities...
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Tài liệu FIRMS AND THEIR DISTRESSED BANKS: LESSONS FROM THE NORWEGIAN BANKING CRISIS (1988-1991) docx
Ngày tải lên :
16/02/2014, 10:20
... Ødegaard and Øyvind Norli for supplying Norwegian data, and Andy Naranjo for providing us with data from Datastream Ongena thanks the Center for Financial Studies in Frankfurt for their hospitality and ... initial and seasoned public, rights, and private equity and all convertible bond issues (both and foreign) made by non-financial firms listed on Japanese stock exchanges The numbers come from the ... equity and rights category includes initial public offerings, taken from Helland and Samuelson (1999) To calculate the Norwegian ratio of total equity raised to market capitalization, we use data from...
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Social Marketing and Public Health Lessons from the Field pptx
Ngày tải lên :
07/03/2014, 00:20
... chitlins) Each November and December after that, Women, Infants, and Children (WIC) clinics offered flyers and short lectures emphasizing handwashing and protecting children from exposure to chitterlings ... line) and applications for employment • Improved retention and reduced turnover of current LTC workers • Increased positive recognition and rewards for LTC workers, from the general public and from ... rates, and drug and juvenile justice data Target Audience(s) The target audience was sexually active youths aged 14-18 who had tried condoms and used them inconsistently and who were from 15...
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Connecting gender and economic competitiveness: lessons from Cambridge''''s high-tech regional economy potx
Ngày tải lên :
08/03/2014, 06:20
... balance the demands of work with child-care and other home and family commitments, and so increase the ability of female employees to further their own careers and economic well-being, and to contribute ... interactions, daily and weekly work patterns, informal socialising, intrafirm and interfirm peer relationships, and the nature of dependants and homelife We taperecorded the interviews and later employed ... (Henry and Pinch, 2000; Lundvall and Johnson, 1994; Storper, 1996) Those firms, sectors, and regions that can learn and innovate faster become more competitive because their knowledge is scarce and...
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LESSONS FROM SCOTCH: SUSTAINABILITY, COMPETITVENESS AND TECHNICAL CHANGE potx
Ngày tải lên :
09/03/2014, 00:20
... away from clear-cutting and towards selective felling and the use of cuttings; and the emergence in the mid-1990s of demands for forest certification (Forest Stewardship Council (FSC) and ISO standards) ... manufacturing, running between and 14 per cent in the US, and exceeds other commodity sectors like chemical and allied products and plastics (Butner and Stapley, 1997, p.155-6) In Finland, the capital investment ... amongst pulp and paper firms, and any consequent differential impacts on their competitiveness Competitiveness issues in the EU pulp and paper industry The EU pulp and paper industry from a global...
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