... significantly decreased in the exposure period in patients with sitagliptin, vildagliptin, teneligliptin, and linagliptin, and significantly decreased during months in patients with alogliptin Serum HDL ... 0.4 in sitagliptin users, 64.2 ± 0.8 in vildagliptin, 66.0 ± 0.8 in teneligliptin, 63.5 ± 0.8 in alogliptin, and 67.2 ± 0.9 in linagliptin The percentage of females was 317 (36.1%) in sitagliptin ... in the exposure period in patients with sitagliptin and vildagliptin Serum TC concentration was significantly decreased during months in patients with sitagliptin, vildagliptin, and alogliptin
Ngày tải lên: 30/05/2020, 21:23
... glycation end products (RAGE) is increased in patients with diabetes mellitus, and its activation through interaction with its ligands (AGEs) is the primary concern in the development and progression ... this study, we investigated the role of NF-κ B signaling in osteogenesis of PDLSCs from periodontitis patients with diabetes (D-PDLSCs) We found that inhibition of NF-κ B signaling in diabetic microenvironments ... loss in diabetic mice, but also decreased generation of the proinflammatory cytokines in gingival tissue9 Enhanced RAGE expression in an environment, such as the periodontium of an individual with
Ngày tải lên: 24/11/2022, 17:43
screening for coeliac disease in adult patients with type 1 diabetes mellitus myths facts and controversy
... studies with at least 100 patients with T1DM [9] N indicates the number of screening studies performed on each continent Table 2 Differential diagnosis of gastrointestinal complaints in? ?T1DM patients ... patients resembles that in non-T1DM patients and consists of gastrointestinal complaints (diarrhoea, constipation, vomiting, abdominal distension, anorexia) or extra-intestinal complaints such as growth ... America, in South America, in Australia, in the Middle East and in India (Fig. 1) [9] A remarkable high prevalence of CD in T1DM patients is seen in studies performed in Algeria (16.4 %), India
Ngày tải lên: 04/12/2022, 16:17
Cognitive behavioral therapy and mindfulness-based cognitive therapy for depressive symptoms in patients with diabetes: Design of a randomized controlled trial
... symptoms in patients with diabetes are scarce The Mood Enhancement Therapy Intervention Study (METIS) tests the effectiveness of two treatment protocols in patients with diabetes Individually administered ... controlled trial in patients with diabetes Both interventions are expected to improve depressive symptoms in patients diagnosed with diabetes and suffering from comorbid symptoms of depression, in comparison ... namely Mindfulness-Based Cognitive Therapy (MBCT) has become increasingly popular, both in clinical practice and research MBCT integrates CBT with mindfulness The concept mindfulness has been defined
Ngày tải lên: 10/01/2020, 12:44
Emergency tracheal intubation during offhours is not associated with increased mortality in hospitalized patients: A retrospective cohort study
... Access Emergency tracheal intubation during offhours is not associated with increased mortality in hospitalized patients: a retrospective cohort study Jun-Le Liu1, Jian-Wen Jin2, Zhong-Meng Lai1, ... Furthermore, the causes of worse outcomes during off-hours in real-world settings remain uncertain Presumably, a difference in human and technical resources during different times is possible, and the ... clarify the association between inpatients undergoing ETI during off-hours and mortality The primary goal of this study was the 30 days mortality of inpatients after ETI during the daytime or offhours;
Ngày tải lên: 13/01/2022, 01:05
Effectiveness of sulphonylureas in the therapy of diabetes mellitus type 2 patients: an observational cohort study
... treatment with metformin (MET) is insufficient, treatment guidelines recommend second-line treatment with agents including sulphonylureas (SU), thiazolidinediones, alpha-glucosidase inhibitors, ... (MACE) and diabetes- related hospitalizations in T2DM-incident patients newly treated with metformin (MET) versus sulphonylureas (SU) monotherapy and in T2DM-prevalent patients newly treated with MET+SU ... (MACE) and diabetes- related hospitalizations in T2DM-incident patients newly treated with MET versus SU monotherapy and in T2DMprevalent patients newly treated with MET+DPP4 versus MET+SU combination
Ngày tải lên: 24/11/2022, 17:44
Systematic review and meta analysis of optimal p2y12blockade in dual antiplatelet therapy for patients with diabetes with acute coronary syndrome
... with clinical outcomes for P2Y12 inhibitors in adult patients with diabetes with ACS were scrutinised independently by authors with applicable data was extracted for primary composite end point ... disease The remaining studies were analysed to confirm there was clinical outcome data of P2Y12 receptor inhibition in patient with diabetes presenting with ACS Any discrepancies in results were ... shows the addition of a P2Y12 inhibitor is superior to placebo, with a trend favouring the use of prasugrel in patients with diabetes with ACS, particularly those undergoing PCI KEY QUESTIONS What
Ngày tải lên: 19/03/2023, 15:20
Báo cáo y học: "Heterogeneity of autoantibodies in 100 patients with autoimmune myositis: insights into clinical features and outcomes" ppt
... to patients with DM rashes (two patients with DM, and one patients with CAM associated with a DM rash), whereas anti-Mi-2-LIA (three patients) were associated with OM. None of the patients with ... definite myositis. Definitions for overlap CTD features, target organ involvement, and clinical characteristics are described in detail elsewhere [14] and are summarized in Table 1. All living patients ... observed in patients with SLE (n = 30; except for anti-PL-7 in none patient) or SSc (n = 20) or in healthy blood donors (n = 50; data available online [33]). In addition, anti-Mi-2 was not detected in
Ngày tải lên: 09/08/2014, 10:20
Báo cáo y học: "Ex vivo effects of flavonoids extracted from Artemisia herba alba on cytokines and nitric oxide production in Algerian patients with Adamantiades-Behcet''''s disease" pptx
... However, other investigators have reported increased sera levels of Th2-type cytokines, including IL-4, IL-10, and IL-13 in ABD patients [8], suggesting disturbed cytokines production in ABD Such ... types The involvement of cytokines and chemokines in ABD pathogenesis is reflected by the increase of their concentrations in sera of patients with ABD and some of these mediators correlate with the ... ABD was diagnosed according to the criteria defined by the international study group for ABD set up in 1990 [35] All ABD patients were showing the major symptoms including uveitis, aphtosis, articular
Ngày tải lên: 11/08/2014, 03:20
Báo cáo y học: "Effectiveness of adalimumab in treating patients with ankylosing spondylitis associated with enthesitis and peripheral arthriti" doc
... assessed by mea- suringthechangefrombaselinetoweek12inthe MASES (for patients with MASES of at least 1 at baseline) and the change from baseline to week 12 in the percentage of patients with enthesitis ... costochondral joint R 1st costochondral joint L 1st costochondral joint R % of Patients Week 12Baseline Site of Inflamed Entheses Figure 2 Percentages of patients with inflamed entheses at baseline and ... M, Listing J, Sieper J: Comparison of the Bath Ankylosing Spondylitis Disease Activity Index and the modified version of the index in assessing disease activity in patients with ankylosing spondylitis
Ngày tải lên: 12/08/2014, 12:20
Báo cáo y học: "Validating English- and Spanish-language patient-reported outcome measures in underserved patients with rheumatic disease" doc
... and mood in patients with rheumatic disease have previously been tested in other Hispanic communities, they were included in this cognitive interviewing process to validate their use in respondents ... age (±SD) of 51.3 ± 13.2 Instruments During the preliminary phase of designing an outcomes evaluation for patients with rheumatic disease attending the CHC, an interdisciplinary group of physicians, ... duration from 46 minutes to hours, 10 minutes Conventional interviews using the same instrument were from 30 to 60 minutes in duration Updating the questionnaire was undertaken using an iterative
Ngày tải lên: 12/08/2014, 15:22
Báo cáo y học: "Canakinumab (ACZ885, a fully human IgG1 anti-IL-1b mAb) induces sustained remission in pediatric patients with cryopyrin-associated periodic syndrome (CAPS)" ppsx
... http://arthritis-research.com/content/13/1/R34 Page 3 of 10 remaining three patients. Improvements in symptoms were evident in all patients within 24 hours of admin- istration of canakinumab; at baseline all patients had moderate disease ... was severe in two patients, moderate in three patients and mild in one patient. One day post-dose “fatigue” was absent in five patients and minimal in two patients and this was maintained until ... canakinumab were rapid with improvements in symptoms being observed within 24 hours of administration of the first dose in most patients. In addition, most patients achieved a complete response within
Ngày tải lên: 12/08/2014, 15:22
Báo cáo y học: "Promoter polymorphisms in the chitinase 3-like 1 gene influence the serum concentration of YKL40 in Danish patients with rheumatoid arthritis and in healthy subjects" ppsx
... encoding the YKL-40 protein [6]. YKL- 40 is a 40 kDa heparin- and chitin-binding glycoprotein, and a member of chitinase like proteins. YKL-40 is expressed by a variety of cells, including macrophage ... YKL-40 with the remaining SNPs could be explained by LD. Our findings indicate that serum concentrations of YKL-40 are under the influence of genetic variability in the CHI3L1 gene in both patients ... moderate LD with g 329C/T (R 2 0.78) indicating that the effect on serum concentra - tions of YKL-40 with g 329C/T is caused by LD. These findings are in line with CEU HapMap data (Figure 5). To investigate
Ngày tải lên: 12/08/2014, 17:22
Báo cáo y học: " Absence of xenotropic murine leukaemia virusrelated virus in UK patients with chronic fatigue syndrome" docx
... samples indicates that XMRV infection may occur in the general population, although with currently uncertain outcomes. Background In 2006 , pursuing a link between prostate cancer and an inherited ... Moloney MLV (Table 2) by assaying for a reduction in virus infectivity following incubation of virus-containing supernatant Figure 1 Sensitivity of PCR screening for XMRV in PBMC DNA. VP62 plasmid ... detected in the control groups in multiple investi- gations [5,6,8], with the incidence varying between 1 and 6%. In our serological studies we have also identi- fied neutralising activity against
Ngày tải lên: 12/08/2014, 23:23
Báo cáo y học: " Pharmacokinetics of recombinant activated factor VII in trauma patients with severe bleeding" pdf
... managed with a sin- gle dose of 90 µg.kg -1 . Discussion In this large prospective study evaluating the pharmacokinetic properties of rFVIIa in trauma patients with severe bleeding, we mainly observed ... However, the variability inherent in this clinical setting probably still adds to the intra- and inter-patient variabilities [28]. Conclusion In trauma patients with severe bleeding, the mean clearance ... on in vitro studies and clinical studies conducted in hemophilic patients. Trial product was adminis- tered in addition to standard treatment for injuries and bleed- ing at the participating
Ngày tải lên: 13/08/2014, 01:20
Báo cáo y học: " Serum levels of soluble Fas, soluble tumor necrosis factor-receptor II, interleukin-2 receptor and interleukin-8 as early predictors of hepatocellular carcinoma in Egyptian patients with hepatitis C virus genotype-4." pps
... HCV infection, 30 with HCC, 32 with chronic liver disease associated with elevated liver enzyme levels (with or without cirrhosis) in addition to 17 with chronic HCV with persistent normal alanine ... II, interleukin-2 receptor and interleukin-8 as early predictors of hepatocellular carcinoma in Egyptian patients with hepatitis C virus genotype-4 Abdel-Rahman N Zekri1*, Hanaa M Alam El-Din1, ... cytokines are involved in the process of HCC invasion and metastasis, including soluble Fas (sFas), soluble tumor necrosis factor receptor-II (sTNFR-II), interleukin-2 receptor (IL-2R) and interleukin-8
Ngày tải lên: 13/08/2014, 13:20
Báo cáo y học: " Endothelial Computed tomographic assessment of lung weights in trauma patients with early posttraumatic lung dysfunction" potx
... 36. Clinical and Laboratory Standards Institute: Defining, establishing, and verifying reference intervals in the clinical laboratory: approved guideline. 3 edition. Wayne, PA: Clinical and Laboratory ... assessment of M lung in patients with normal lungs [55]. Patients with atelectasis should also remain unaf- fected by a possible contrast material-associated increase in M lung . In contrast, the ... medians with interquartil e ranges. Atelectasis, patients with lung weights (M lung ) within the reference interval (that is, 584 to 1,164 g) for normal M lung ; above reference, patients with M
Ngày tải lên: 14/08/2014, 07:21
Bishop lecture Advanced laboratory testing in research and practice
... study, covering a wider range of gradings with seven silica sands and silts (including NE 34 and TVS) in ring-shear tests involving interfaces positioned both 46 Fig 34 Friction angles from ring shear ... within a very limited kinematic true (Y1) yield surface that is dragged with the current effective stress point, growing and shrinking with the mean effective stress p΄ and changing in shape with ... demonstrating features of kinematic yielding and interface shear failure that can be tracked in triaxial, HCA and ring shear laboratory experiments Advanced laboratory testing is critical to advancing
Ngày tải lên: 13/08/2015, 10:32
Helicobacter pylori infection in paediatric patients with dyspeptic symptoms
... Summary xviii INTRODUCTION 1.1 H pylori infection begins within families 1.2 H pylori infection in paediatrics 1.2.1 Prevalence during childhood 1.2.2 Association with recurrent abdominal pain (RAP) ... HELICOBACTER PYLORI INFECTION IN PAEDIATRIC PATIENTS WITH DYSPEPTIC SYMPTOMS NG BEE LING NATIONAL UNIVERSITY OF SINGAPORE 2004 HELICOBACTER PYLORI INFECTION IN PAEDIATRIC PATIENTS WITH DYSPEPTIC SYMPTOMS ... pylori infections in Singaporean Children with Dyspepsia and Characterization of the Clinical Isolates Planetary presentation at the International Symposium on Helicobacter and Viral Hepatitis, Singapore,
Ngày tải lên: 16/09/2015, 17:12
A PILOT STUDY OF THE PREVALENCE OF COELIAC DISEASE IN VIETNAMESE PATIENTS WITH GRAVES’ DISEASE
... high in Caucasian with Graves’ disease However, there are no data assessing the prevalence of coeliac disease in Vietnamese with Graves’ disease; nor data regarding micronutrient deficiency in ... micronutrient deficiency was determined in Vietnamese patients with Graves’ disease and in control participants The population of participants included 60 Vietnamese Graves’ disease patients and 120 Vietnamese ... Vitamin D deficiency in the project To Dr Leo Rando, thank you for your referrals of patients from Endocrinology clinic To Sandy Dupuis, thank you for building and managing the database of participants
Ngày tải lên: 04/06/2018, 07:11