kras mutations and efficacy of anti egfr therapy
Báo cáo sinh học: " Attenuation and efficacy of human parainfluenza virus type 1 (HPIV1) vaccine candidates containing stabilized mutations in the P/C and L genes" potx
... vaccine candidates The level of temperature sensitivity of replication of the four viruses with single att mutations was first studied (Table 2, groups 3, 4, 5, and 7) and compared to that of rHPIV1 ... transfected with μg of the FLC, 0.8 μg each of the N and P, and 0.1 μg of the L support plasmids in a volume of 100 μl of Opti-MEM per well Transfection was carried out with Lipofectamine 2000 (Invitrogen, ... phenotype and for replication, efficacy and immunogenicity in AGMs Results Construction and recovery of mutant rHPIV1 viruses Point and deletion mutations in the P/C, HN and L genes that attenuate...
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Báo cáo hóa học: " Attenuation and efficacy of human parainfluenza virus type 1 (HPIV1) vaccine candidates containing stabilized mutations in the P/C and L genes" docx
... vaccine candidates The level of temperature sensitivity of replication of the four viruses with single att mutations was first studied (Table 2, groups 3, 4, 5, and 7) and compared to that of rHPIV1 ... transfected with μg of the FLC, 0.8 μg each of the N and P, and 0.1 μg of the L support plasmids in a volume of 100 μl of Opti-MEM per well Transfection was carried out with Lipofectamine 2000 (Invitrogen, ... phenotype and for replication, efficacy and immunogenicity in AGMs Results Construction and recovery of mutant rHPIV1 viruses Point and deletion mutations in the P/C, HN and L genes that attenuate...
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Báo cáo hóa học: " A predominance of R5-like HIV genotypes in vaginal secretions is associated with elevated plasma HIV-1 RNA levels and the absence of anti-retroviral therapy" docx
... collection of clinical samples NL processed clinical samples and conducted PCR and viral load analyses AA participated in the coordination of the study, directed sample and data analysis, and assisted ... data analysis, and drafted the manuscript PK participated in the study design and conducted the statistical analyses RC participated in the design and coordination of the study and facilitated ... [9,13], the low levels of HIV detected in many of the samples only allowed the analysis of the predominant genotypes in genital secretions Despite this, and the inherent limitations of PCR amplification...
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Báo cáo y học: "Differential clinical efficacy of anti-CD4 monoclonal antibodies in rat adjuvant arthritis is paralleled by differential influence on κ α NF-κB binding activity and TNF-α secretion of T cell" pot
... control antibodies The anti- TCR/ mAb R73 was a kind gift of T Hỹnig (Institute of Virology, University of Wỹrzburg) For sandwich ELISA analysis of cytokine concentrations, the following antibodies ... three anti- CD4 mAbs (all the data not shown) The present study shows differential clinical efficacy of three anti- CD4 mAbs in the preventive treatment of AA The lack of differential clinical efficacy ... (upper panels) Quantification of the bands of all three experiments is shown below (means SEM) All three anti- CD4 mAbs slightly decreased the AP-1 activity, and RIB5/2 induced a profound, significant...
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Báo cáo y học: "Differential responsiveness to immunoablative therapy in refractory rheumatoid arthritis is associated with level and avidity of anti-cyclic citrullinated protein autoantibodies: a case study" pps
... eradication of autoantibodies, we analyzed the influence of immunoablative therapy on the levels of ACPA-IgG and RF-IgM in comparison with antibody levels against control antigens, respectively RL-IgG and ... recall antigens (rubella and TT) remained unaffected by immunoablative therapy Previous studies have reported that avidity of autoantibodies, namely RF, anti- cardiolipin and anti- double stranded ... acquisition of data, analysis and interpretation of data, and preparation of the manuscript RJV contributed to the design of the study and acquisition of the data KNV contributed to the acquisition of...
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Báo cáo y học: "Molecular discrimination of responders and nonresponders to anti-TNFalpha therapy in rheumatoid arthritis by etanercept" docx
... cutoff point to define genes as differentially regulated Second, an algorithm for learning of classifiers used for prediction of the therapy outcome on evaluation of the fold change of pairs and ... 13, and 15 to 19) were characterized by a good therapy response, as indicated by a significant reduction of the DAS28 >1.2 without progression of bone erosions as shown by X-ray scans of hands and ... expression profiles of these selected genes, particularly of pairs or triplets of genes detected days after the start of treatment, were identified as being closely associated with the outcome of therapy...
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Báo cáo y học: " Safety and efficacy of a generic fixed-dose combination of stavudine, lamivudine and nevirapine antiretroviral therapy between HIV-infected patients with baseline CD4 " pot
... weeks of ART (P > 0.05) Group A patients had a median CD4 cell count of 85, 125, 158 and 198 cells/mm3 and group B patients had a median CD4 of 240, 280, 305 and 331 cells/mm3 at 12, 24, 36 and ... initiation of a FDC of d4T/3TC/NVP in HIV-infected patients with baseline CD4 cell count of
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báo cáo khoa học: " Pyrosequencing, a method approved to detect the two major EGFR mutations for anti EGFR therapy in NSCLC" ppt
... (i) EGFR and KRAS mutations are mutually exclusive in NSCLC and (ii) emerging data suggest that KRAS mutations are negative predictors of benefit from both adjuvant chemotherapy and anti- EGFR- directed ... clinical samples Table Prospective evaluation of the EGFR status of exons 19 and 21 % of tumoral cells tumoral samples (n = 206) number % Page of EGFR mutations (n = 18) exon 19 exon 21 %
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Báo cáo y học: " Multiple myeloma presenting with high-output heart failure and improving with anti-angiogenesis therapy: two case reports and a review of the literature" pdf
... for a hemoglobin of 9.1 g/dl, a platelet count of 10,000 per microliter, a blood urea nitrogen of 55 mg/dl, a creatinine of 1.0 mg/ dl, an albumin of 3.6 g/dl, and a calcium of 13 mg/dl The ECG ... for a hemoglobin of 9.1 g/dl, a platelet count of 105,00 per microliter, a blood urea nitrogen of 13 mg/dl, a creatinine of 1.0 mg/dl, an albumin of 3.9 g/dl, and a calcium of 9.2 mg/dl His ECG ... calcium, quantification of the monoclonal protein, stage of disease and degree of bony involvement When separating the cohort into those with an elevated cardiac index (>4 liters/minute/m2) and a...
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Báo cáo y học: "Effectiveness and safety of adalimumab in patients with ankylosing spondylitis or psoriatic arthritis and history of anti-tumor necrosis factor therapy" pdf
... because of an unsatisfactory response Six percent of patients (24 of 376) without prior anti- TNF therapy and 3% of patients (two of 66) with prior antiTNF therapy withdrew from the study because of ... the complete study, 1% of patients with AS (10 of 924) without prior anti- TNF therapy and 3% of patients with AS (11 of 326) with prior anti- TNF therapy withdrew because of an unsatisfactory response ... history of anti- TNF therapy BASDAI 50 responses were achieved by 63.0% of patients with AS without prior anti- TNF therapy and by 40.8% of patients with AS who had received prior anti- TNF therapy...
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Báo cáo y học: " Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial"
... ingredients Use of concomitant prohibited medication (narcotics, oral NSAIDs, topical NSAIDs) within four weeks of randomization Use of acetaminophen or ibuprofen within days of randomization Subject ... compliance Compliance was assessed by capsule count at visits 3, 4, and and review of subject diary Efficacy and Safety Variables Efficacy and safety measurements assessed Adverse events During the study, ... Canada) Appropriateness of Measurements The efficacy and safety assessments used in this study were standard for OA and are widely used and recognized as reliable, accurate, and relevant WOMAC scores...
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Báo cáo khoa học: "The Safety and efficacy of a new self-expandable intratracheal nitinol stent for the tracheal collapse in dogs" ppt
... contrast to self-expanding stainless steel biliary wall stents and other nitinol stents [4,9-11], none of the nitinol expandable stents were broken, shortened or migrated The flared ends of the stent ... likely prevented stent migration and increased stent stability Dorsoventral radiographs comparing the length and location of each stent with the number of cervical and thoracic vertebrae showed ... implantation of only one stent for treatment of tracheal collapse, whereas dogs required multiple implantations of other nitinol stents [4,9,11] In conclusion, we found that implantation of self- expandable...
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Báo cáo khoa học: "The safety and efficacy of gamma knife surgery in management of glomus jugulare tumor" pptx
... of radiotherapy for chemodectomas Mayo Clin Proc 1992, 67:537-540 doi:10.1186/1477-7819-8-76 Cite this article as: Hafez et al.: The safety and efficacy of gamma knife surgery in management of ... external beam radiotherapy was used to treat residual tumors with varying degrees of success ranging from a maximum of 61-71% to an average of 23% Side-effects include osteoradionecrosis of the temporal ... dysphagia The presence of jugular foramen syndrome (paresis of cranial nerves IX-XI) is pathognomonic of this tumor, but it usually follows the initial symptoms of hearing loss and pulsatile tinnitus...
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Báo cáo y học: "Clinical response to discontinuation of anti-TNF therapy in patients with ankylosing spondylitis after 3 years of continuous treatment with infliximab" ppsx
... discontinuation There was no loss of efficacy and no need for an increased dose after the new start of infliximab therapy Thus, if for any reason discontinuation of anti- TNF therapy is considered necessary, ... regarding efficacy and safety This may have definite implications for daily practice, since discontinuation of therapy at certain intervals, such as after or years of therapy, may become a standard ... standard approach Payers and patients may want to make sure that further anti- TNF therapy is needed An intermittent cessation of anti- TNF therapy may be considered in the case of patients who respond...
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Báo cáo y học: " Chylothorax after surgery on congenital heart disease in newborns and infants – risk factors and efficacy of MCT-diet" pot
... assessed the duration of drainage, the day of maximum loss of chylous and the type and duration of treatment (fatty acidfree MCT-enriched diet, TPN, octreotide, recanalisation of thrombosed veins ... in newborns and infants – risk factors and efficacy of MCT-diet Journal of Cardiothoracic Surgery 2010 5:127 Submit your next manuscript to BioMed Central and take full advantage of: • Convenient ... could not methodically analyze the impact of the loss of pro- and anti- coagulation factors, total protein and immunoglobulins on infections, thromboses and on the outcome (Table 2) In our study,...
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Báo cáo khoa học: " Safety and efficacy of analgesia-based sedation with remifentanil versus standard hypnotic-based regimens in intensive care unit patients with brain injuries: a randomised, controlled trial [ISRCTN50308308]" pps
... maximum rate of 60 µg kg-1 h-1 and/ or additional boluses and/ or increases in the infusion rate of propofol up to a maximum dose of mg kg-1 h-1 to attain and then maintain optimum analgesia and sedation ... effects of remifentanil compared with those of alfentanil [8] and fentanyl [9] are similar; remifentanil also has a safety profile similar to that of other opioids [8-10] The predictable offset of ... and sedation beyond day 3, propofol was discontinued and replaced with midazolam in accordance with local transitioning protocols The infusion rates of fentanyl and morphine and bolus doses and...
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Báo cáo y học: "Effect of anti-IgE therapy on food allergen specific T cell responses in eosinophil associated gastrointestinal disorders" pot
... augmentation of allergic responses and conversely downregulation of virally induced innate immune responses Omalizumab is a humanized anti- IgE monoclonal antibody indicated for use in allergic asthma Anti- IgE ... to B cells [11] Because of these multifunctional activities of FcεRI and CD23 beyond immediate hypersensitivity and the ability of omalizumab to block IgE binding to both of these receptors, it ... CFSE proliferation index Six of the subjects were studied with peanut and shrimp, one with peanut and dust mite, and one with egg yolk and egg white extracts Food antigens were saline extracts...
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Báo cáo y học: "The short-term safety and efficacy of fluoxetine in depressed adolescents with alcohol and cannabis use disorders: a pilot randomized placebo-controlled trial" potx
... dose of 20 mg during the course of the study All 14 subjects who were randomized to placebo and completed weeks of treatment had their "dose" of blinded medication "increased" to 20 mg The rate of ... by a clinical evaluation by a child and adolescent psychiatrist Specification of abuse disorder (abuse vs dependence), age of onset of symptoms, and length of illness were based on data obtained ... psychotherapy, pre-randomization positive drug toxicology, and dose increases http://www.capmh.com/content/3/1/11 Efficacy and other psychometric measure analyses As in many recent studies of juvenile...
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Báo cáo y học: "Risk factors for multidrug resistant bacteria and optimization of empirical antibiotic therapy in postoperative peritonitis" pdf
... subjective assessment of appropriateness of care Optimization of empirical antibiotic therapy Analysis of antibiotic regimens classified as monotherapy or combination therapy (two-, three- and four-drug ... Page of Optimization of empirical antibiotic therapy Evaluation of the adequacy rates of 17 theoretical regimens in the 100 episodes of PP according to the presence or absence of MDR bacteria, and ... peritonitis and/ or previous antimicrobial therapy The use of amikacin for spectrum broadening and synergistic combination is optional The adjunction of vancomycin is considered in Page of cases of prolonged...
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