kinases fos jun family members and activator protein 1

... AhR, inducing CYP1A1 expression and activity (Meek 19 98; Bonvallot et al 20 01; Baulig et al 2003a) As shown in Figure 11 .1a, DEP and their organic extract induce a transient CYP1A1 mRNA expression ... FIGURE 11 .1 Induction of cytochrome P-450 1A1 (CYP1A1) and NADPH: quinone oxidoreductase (NQO1) gene expression in HBE cells (a and b respectively) Cells were treated or not with DEP (10 mg/cm2), ... 214 CYP1A1 18 S BaP CB OE-DEP DEP DPL DMSO BaP 48 h CB DEP OE-DEP DMSO DPL BaP 24 h CB DEP DMSO DPL BaP 6h CB OE-DEP DEP DMSO DPL 2h OE-DEP (a) 2.7 NQO1 1. 7 18 S 18 S (b) 2h 6h 24 h 48 h FIGURE 11 .1...

Ngày tải lên: 11/08/2014, 21:21

... receptor-tyrosine kinase and G -protein- receptor agonists and vitamin D3 [16 ] As shown in Fig 1, exposure of cultured SMCs to S1P stimulates the expression of the Cyr 61/ CCN1 at both the mRNA and protein levels ... 14 41 14 50 12 Latinkic, B.V., O’Brien, T.P & Lau, L.F (19 91) Promoter function and structure of the growth factor-inducible immediate early gene cyr 61 Nucl Acids Res 19 , 32 61 3267 Ó FEBS 2003 13 ... mechanisms of the Cyr 61/ CCN1 gene (Eur J Biochem 270) 3 413 Fig Induction of the Cyr 61/ CCN1 promoter upon stimulation by S1P and mapping of the responsive elements in the Cyr 61/ CCN1 promoter sequence...

Ngày tải lên: 08/03/2014, 08:20

... 11 7 11 7 11 7 11 7 11 8 11 8 11 8 11 9 11 9 11 9 Contents ix A Return to Violence by the Sons of Iraq 12 0 Iraqi Security Forces ... timelines for the April 30, 2 010 , August 31, 2 010 , and December 31, 2 011 , drawdown dates There are logistical risks associated with the April 30, 2 010 , and August 31, 2 010 , deadlines that can be ... Pittsburgh, PA 15 213 -2665 RAND URL: http://www.rand.org To order RAND documents or to obtain additional information, contact Distribution Services: Telephone: ( 310 ) 4 51- 7002; Fax: ( 310 ) 4 51- 6 915 ; Email:...

Ngày tải lên: 23/03/2014, 02:20

... LRH -1 LRH -1 subnuclear localization in granulosa cells LRH -1 SUMO -1 A SUMO -1 A Vehicle GFP-LRH1 B B GFP-LRH1K173/289R Forskolin C C GFP-LRH1K289/389R CTX D D GFP-LRH1K173/ 213 /289R E GFP-LRH1K289/329/389R ... 429 LRH -1 subnuclear localization in granulosa cells LRH -1 SUMO -1 F.-M Yang et al Merged LRH -1 SUMO-1AA Merged G A GFP-LRH1 H B GFP-LRH1K173R C I GFP-LRH1K 213 R J D GFP-LRH1K289R E K GFP-LRH1K329R ... of Cpy11a1 were 14 -, 50- and 263-fold higher after 3, 12 and 24 h, respectively To determine the effect of cAMP on sumoylation pathway, the expression of the genes for SUMO E1 subunit SAE1 and...

Ngày tải lên: 23/03/2014, 06:20

... vasculogenic erectile dysfunction J Urol 19 98 ;15 9: 2229-36 [11 ] Yiee JH, Baskin LS Penile embryology and anatomy ScientificWorldJournal 2 010 ;10 : 11 74-9 [12 ] Manabe K, Heaton JP, Morales A, Kumon ... 19 97;50: 10 16-26 [12 1] Chen D, Shan YX, Dai YT [Advanced glycation end products and their receptors elevate the activity of endothelin -1 in rat cavernosum] Zhonghua Nan Ke Xue 2008 ;14 : 11 0-5 [12 2] ... ER.(2 010 ) Cardiovascular and metabolic syndrome risk among men with and without erectile dysfunction: case-control study Sao Paulo Med J Vol 12 8, No (2 010 ),pp .13 7-40, ISSN 15 16- 318 0 Zippe, C.; Nandipati,...

Ngày tải lên: 23/03/2014, 17:20

... 1. 7 0.4 2.0 0.6 0.5 2.4 4.7 89.9 39 .1 76.6 33.6 93.3 96.2 15 .4 63.3 Blood population PE1 (%) Siglec-FITC1 (%) FITC1 and PE1 (%) PBMC CD2 01 CD1 41 CD4lo CD4hi CD 31 CD2 81 Granulocytes 8.3 12 .1 11. 7 ... staining(%) Blood population PE1 (%) ALCAM–hIg CD5 –hIg Siglec -10 –hIg PBMC CD2 01 CD1 41 CD4lo1 CD4hi1 CD 31 Granulocytes 11 12 63 65 0 0 0 0 11 0 Expression of siglec -10 Northern blot Northern blot ... chromosome 19 gives the most likely order of D19S 418 /siglec -10 /D19S425 with a cytogenetic location of 19 q13 The marker D19S 418 is positive with YAC 790A05 of the Whitehead genetic map of chromosome 19 ...

Ngày tải lên: 24/03/2014, 04:21

... 1. 0 1. 0 1. 0 1. 0 1. 0 1. 0 1. 0 1. 0 1. 0 1. 0 1. 0 1. 0 1. 0 1. 0 1. 0 1. 0 1. 0 1. 0 1. 0 53.55 13 .04 12 .40 12 .28 11 .17 7.47 7. 21 7 .18 6.22 6.06 6.05 4 .12 3.73 3 .11 2.55 2.30 1. 00 0.98 0.92 5. 61 11. 03 12 .15 ... 6.04 2.35 4.90 4.37 13 .38 2.70 1. 65 11 .23 2.23 0.64 2. 51 0.50 2 .12 2.36 1. 35 0.82 1. 93 1. 14 0.88 0.99 0.86 1. 20 0.62 5.39 0.83 1. 10 4.38 0. 81 0.70 1. 35 0.49 2.05 1. 83 CXCL10 TNFAIP3 CXCL2 NFKBIA ... CXCL 11 CCL2 IL18R1 IL1B IL1B Chemokine (C-X-C motif) ligand 10 TNF-α-induced protein Chemokine (C-X-C motif) ligand NK-κB inhibitor, alpha TNF-α-induced protein Immediate early response G protein- coupled...

Ngày tải lên: 18/06/2014, 15:20

... control 12 94 ± 11 3 12 95 ± 81 1276 ± 77 12 97 ± 69 12 29 ± 50 sham 12 95 ± 11 1 12 73 ± 14 5 12 84 ± 96 12 90 ± 13 5 12 92 ± 68 burn+placebo 11 36 ± 52 407 ± 57* 484 ± 11 7* 559 ± 10 6* 529 ± 16 9* burn+Gsn-L 12 16 ... 77 :14 1 -15 0 62 Smith DBJP, Herbert TJ, Lind SE: Quantitative measurement of plasma gelsolin and its incorporation into fibrin clots J Lab Clin Med 19 87, 11 0 :18 9 -19 5 doi :10 .11 86 /17 42-2094-8 -11 8 ... declare that they have no competing interests Received: 13 May 2 011 Accepted: 21 September 2 011 Published: 21 September 2 011 References Zhou H, Andonegui G, Wong CH, Kubes P: Role of endothelial TLR4...

Ngày tải lên: 19/06/2014, 22:20

... 95.0 ± 14 .4 10 7.3 ± 16 .6 p-ERK/ERK 10 0 ± 6.50 11 7.2 ± 5. 91 126.4 ± 3.32 * p-eIF4E/eIF4E 10 0 ± 13 .0 10 5.9 ± 17 .1 102.0 ± 17 .0 p-AKT/AKT 10 0 ± 11 .8 10 5.8 ± 5.0 10 7.2 ± 7.5 p-mTOR/mTOR 10 0 ± 8.8 10 3.8 ... 10 3.8 ± 17 .0 12 5.7 ± 18 .5 p-TSC2/TSC2 10 0 ± 3.3 97.8 ± 6.8 11 5 .1 ± 5.2 p-4EBP/4EBP 10 0 ± 8.3 12 6.2 ± 11 .1 122.9 ± 8.5 p-eIF4G/eIF4G 10 0 ± 14 .1 76.2 ± 13 .8 10 9.0 ± 16 .7 p-rS6p/rS6p 10 0 ± 12 .5 12 0.3 ... Vehicle nicotinamide 10 mM resveratrol 10 0 µM + resveratrol 10 0 µM p-AMPK/AMPK 10 0 ± 7.3 19 9.8 ± 28 .1 222.4 ± 40.0 p-ERK/ERK 10 0 ± 11 .8 41. 8 ± 8.5 ** 47.2 ± 8.8 ** p-eIF4E/eIF4E 10 0 ± 5.4 27.6 ±...

Ngày tải lên: 21/06/2014, 19:20

... 0 .19 0 .12 5 Z c: 0.38 Z 0.35 Z 0.33 Z 0.30 Z 0.27 Z 0. 21 Z 0.20 Z 0 .14  Z 0 .14  Z [Source: Isakov – Kennametal Inc./pub in American Machinist, 19 96] inserts around the cutter’s periphery (Z) and ... clamping, dictating: how, where and what will be the optimum method of ‘location and restraint 17 of the workpiece, but on exit from cut, the sudden disengagement and release of cutting forces ... favourable/unfavourable cutter and workpiece placement – together with other important factors [Courtesy of Sandvik Coromant] Milling Cutters and Associated Technologies 16 3 Table 7:  The ratio of...

Ngày tải lên: 21/06/2014, 21:20

... 18 0 Chapter Modern Metal Cutting – A Practical Handbook AB Sandvik Coromant Pub., 19 94 Oxley, P.L.B Mechanics of Machining Ellis Horwood Pub., 19 89 Shaw, M.C Metal Cutting ... Press, 19 89 Society of Manufacturing Eng’rs., Tool and Manufacturing Engineers Handbook – Vol – Machining 4th Ed., SME Pub., Dearborn, Mich., 19 83 Smith, G.T Advanced Machining – The Handbook ... Handbook of Cutting Technology, IFS/Springer Verlag, 19 89 Smith, G.T CNC Machining Technology Springer Verlag, 19 93 Tlusty, G Manufacturing Processes and Equipment Prentice Hall, 2000 Usui, E Modern...

Ngày tải lên: 21/06/2014, 21:20

... Structure and Domain Organization of Bacterial Receptors 7.8 Bacterial Receptors Form Signaling Clusters 11 1 11 2 11 3 11 5 11 6 11 7 11 8 11 9 12 1 12 2 12 3 12 3 12 4 12 5 12 5 12 8 ... APC and Naïve T Cell Signals Guide Differentiation into Helper T Cells xv 16 1 16 2 16 3 16 5 16 5 16 7 16 8 16 9 17 0 17 1 17 2 17 3 17 4 17 6 17 7 17 8 17 9 18 0 18 2 18 7 18 8 ... 515 518 520 5 21 523 524 525 526 528 529 529 5 31 532 533 Glossary 539 Index 553 21. 4 21. 5 21. 6 21. 7 21. 8 21. 9 21. 10 21. 11 21. 12 21. 13 21. 14 21. 15...

Ngày tải lên: 27/06/2014, 10:20

... vasculogenic erectile dysfunction J Urol 19 98 ;15 9: 2229-36 [11 ] Yiee JH, Baskin LS Penile embryology and anatomy ScientificWorldJournal 2 010 ;10 : 11 74-9 [12 ] Manabe K, Heaton JP, Morales A, Kumon ... 19 97;50: 10 16-26 [12 1] Chen D, Shan YX, Dai YT [Advanced glycation end products and their receptors elevate the activity of endothelin -1 in rat cavernosum] Zhonghua Nan Ke Xue 2008 ;14 : 11 0-5 [12 2] ... ER.(2 010 ) Cardiovascular and metabolic syndrome risk among men with and without erectile dysfunction: case-control study Sao Paulo Med J Vol 12 8, No (2 010 ),pp .13 7-40, ISSN 15 16- 318 0 Zippe, C.; Nandipati,...

Ngày tải lên: 27/06/2014, 11:20

... hFOXO1 hFOXO3a hFOXO4 DAF -16 T44 S190 S259 Glutamine-rich DBD jumu CG16899 CHES1-like CG12632 CG 117 99 CG 111 52 mmHNF-3γ fkh fd96Ca fd96Cb fd59a croc fd64A slp1 slp2 CG95 71 PEST NLS NES (c) S1 Helix ... 900 800 700 600 500 400 300 200 10 0 (j) 2.0 1. 8 1. 6 1. 4 1. 2 1. 0 0.8 0.6 0.4 0.2 0.0 Jünger et al 20.9 (e) Ommatidial size (arbitrary units) 1, 800 1, 600 1, 400 1, 200 1, 000 800 600 400 200 Ommatidia ... dPKB3/dPKB1, y w; Thor1/+; dPKB3/dPKB1, y w; Thor1/Thor1; dPKB3/dPKB1 regulated by insulin through LY294002- and rapamycin-sensitive phosphorylation [57], suggesting involvement of the Dp 110 and dTOR...

Ngày tải lên: 06/08/2014, 18:20

... 2003, 17 :295-309 16 Boutros M, Paricio N, Strutt DI, Mlodzik M: Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling Cell 19 98, 94 :10 9 -11 8 17 ... kinase ROCK, and mediates cytoskeletal re-organization [8 ,13 ,14 ] Rac activation is independent of Daam1, requires the DEP domain of Dsh, and stimulates Jun kinase (JNK) activity [8 ,15 ,16 ] Other ... receptor-related ␤ proteins and in Wnt/␤-catenin signaling: arrows point the way Development 2004, 13 1 :16 63 -16 77 Wharton KA Jr: Runnin’ with the Dvl: proteins that associate with Dsh/Dvl and their significance...

Ngày tải lên: 06/08/2014, 18:21

... receptors and ephrin ligands in bone homeostasis 11 12 13 14 15 16 17 18 19 Hirai H, Maru Y, Hagiwara K, et al A novel putative tyrosine kinase receptor encoded by the eph gene Science 19 87; 238: 17 17 -17 20 ... signalling Cell Sci J 2002; 11 5: 10 59 -10 72 Irie F and Yamaguchi Y Ephb receptors regulate dendritic spine development via intersectin, cdc42 and n-wasp Nat Neurosci 2002; 5: 11 17 -11 18 Penzes P, Beeser ... Development 2002; 12 9: 36 21- 3632 29 Ethell IM, Irie F, Kalo MS, et al Ephb/syndecan-2 signaling in dendritic spine morphogenesis Neuron 20 01; 31: 10 01- 1 013 30 Dalva MB, McClelland AC and Kayser MS...

Ngày tải lên: 08/08/2014, 17:20

... WNT ligands (WNT -1, WNT5a, WNT-5b, WNT-9a /14 , and WNT16), receptors (FRZD -1 and FRZD-7), intracellular mediators such as β-catenin, and downstream transcription factors such as TCF and LEF -1 (data ... tissues, including bone marrow [54], synovial membrane [16 ], periosteum [13 ], and articular cartilage [12 ,14 ,15 ,18 ], opens the possibility to recruit and guide these cells locally using appropriate molecular ... 54 :12 09 -12 21 14 Alsalameh S, Amin R, Gemba T, Lotz M: Identification of mesenchymal progenitor cells in normal and osteoarthritic human articular cartilage Arthritis Rheum 2004, 50 :15 22 -15 32 15 ...

Ngày tải lên: 09/08/2014, 08:22

... in TTBS 1 only The membranes were then washed once with TTBS 1 for 10 minutes and incubated in SuperBlock Blocking Buffer-Blotting and TTBS 1 (SuperBlock 1: 10 with TTBS 1 ) or in TTBS 1 (for ... PAR-2 (1: 1,000; Invitrogen Corporation) and with mouse anti-human antibodies against the phosphorylated forms of p38 (1: 1,000), Erk1/2 (1: 5,000), c -jun N-terminal kinase (JNK) (1: 5,000), and NF-κB ... Rheumatol 19 91, 18 :18 63 -18 71 Pap G, Eberhardt R, Rocken C, Nebelung W, Neumann HW, Roessner A: Expression of stromelysin and urokinase type plasminogen activator protein in resection specimens and...

Ngày tải lên: 09/08/2014, 10:22

... http://arthritis-research.com/content /11 /5/R136 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 Fuchs S, Skwara A, Bloch M, Dankbar B: Differential induction and regulation of matrix metalloproteinases in osteoarthritic tissue and ... http://arthritis-research.com/content /11 /5/R136 Figure 11 Stimulation of TNF-α and Il-6 by AGE-BSA (a) Transcripts for TNF-α were significantly increased after one and two days (*P < 0. 01, n = 15 ) (b) ILAGE-BSA ... in DMEM (with 10 % FCS and 10 0 μg/ml gentamicin) and cultured at 37°C in 5% CO2 and 95% air Outgrowing cells were isolated by trypsination two weeks later and expanded in DMEM with 10 % FCS Preparation...

Ngày tải lên: 09/08/2014, 14:22

... 19 21 With Without 23 29 0.0 01 23 19 12 0.0 01 High 19 12 0.038 10 21 0. 010 Low 10 19 19 10 High 20 10 Low 21 High 18 11 Low 11 20 High 21 Low 10 21 TNM stages 0.3 61 0.855 Lymphatic metastasis ... P-value Low 14 Gender Male 21 25 Female ≤ 60 17 23 > 60 12 0.4 51 0.887 Age (years) 0.2 01 0.058 Differentiation Well 12 Moderate 16 11 0.2 31 10 17 0.0 01 Poor 12 16 I + II 12 10 10 III 21 19 19 21 With ... NF-B 1. 5 51 4. 716 (1. 037- 21. 454) 0.045 Notch1 -0.273 0.7 61 (0.459 -1. 263) 0.2 91 0.008 VEGF-C 0.866 2.377 (1. 257-4.494) T stage 0 .11 7 1. 125 (0.627-2. 016 ) 0.694 Sex Age -0 .15 7 0.030 0.855 (0 .16 0-4.566)...

Ngày tải lên: 10/08/2014, 10:21