khái quát về du lịch sinh thái

... and COX-2 [10], are believed to contribute to the robust production of VEGF-C, the molecular regulatory mechanisms involved in tumor-induced lymphangiogenesis of ESCC have remained unclear One ... and NF-B signaling and tumor-induced lymphangiogenesis Taken together, our findings imply that Notch1 and NF-B signaling have counter-acting roles in tumor-induced lymphangiogenesis in ESCC, ... cervical cancer and neuroblastoma, consistent with the presumed oncogenic role of Notch signaling during tumorigenesis, the finding that Notch signaling is diminished in epithelial squamous cell...

Ngày tải lên: 10/08/2014, 10:21

... manipulation of stomatal activity is emerging as a promising approach to reduce the water requirement of crops, and to enhance productivity under stress conditions [2] Proper engineering of stomatal ... regulatory units [10] Modular organization of the AtMYB60 promoter In this study we also investigated the regulation of the AtMYB60 promoter activity in response to ABA ABA treatments induce global changes ... data suggests a modular organization for the AtMYB60 promoter as summarised in Figure Through a serial deletion analysis, we defined the AtMYB60 minimal promoter, sufficient to induce 14 guard cell-specific...

Ngày tải lên: 11/08/2014, 11:21

... expected were it due to a viral infection The discovery of MCPyV raises several interesting questions It will be important to determine the prevalence of MCPyV in healthy individuals as well as ... before the helicase domain required for viral replication Such truncations were probably selected during tumor development to render the large T antigen protein inactive for viral DNA replication ... cell-cycle progression functions (pRb binding) are preserved [18,19] Thus, the predicted protein products of the two truncated MCPyV large T antigens are likely to maintain pro-carcinogenic effects...

Ngày tải lên: 14/08/2014, 08:21

... conducted The University of Wisconsin-Madison researchers have no competing interests to declare http://www.ovarianresearch.com/content/2/1/8 10 11 12 13 14 Authors' contributions CARG conducted ... were analyzed by Western blotting Results Expression of Muc16 mRNA in MOVCAR cells We first conducted RT-PCR experiments to determine expression of Muc16 by the MOVCAR cells Specific primers ... in each of the four MOVCAR cell lines tested by RT-PCR (Fig 1) After DNA sequencing, the PCR product from the MOVCAR-2 cell line was found to have 99% identity with the projected sequence of Muc16...

Ngày tải lên: 20/06/2014, 07:20

... medium due to the high ionic strength To evaluate whether nanocomplexes, or their components, caused non-specific cytotoxicity, cultured Karpas 299 cells were treated for 48 hours with the individual ... concentration (μg/ml) Figure Cytotoxicity assays of individual nanocomplex components A, Cultured Karpas 299 cells were treated for 48 hours with the individual components of the nanocomplex at their maximal ... shown in Figure 6A, a 71% reduction in eGFP expression was detected in Karpas 299 cells treated with nanocomplexes containing eGFP-targeted siRNA, but there was no reduction in cells treated with...

Ngày tải lên: 11/08/2014, 00:22

... inflammation-induced carcinogenesis via stimulation of PPR or pro-inflammatory cytokine production, there is now evidence linking T cell-mediated immune responses in infection-induced carcinogenesis The production ... colibactin-producing bacteria can promote the induction of genomic instability by direct secretion of bacterial genotoxins and activation of a chronic inflammation, which is associated with the production ... psk genomic island (A) Schematic representation of the CDT genes from H ducreyi and S enterica, serovar Typhi In all CDT-producing bacteria identified to date, excluding S enterica, the three cdt...

Ngày tải lên: 14/03/2014, 22:20

... experiments were conducted in accordance with institutional and national guidelines Collagen-induced arthritis and collagen antibody induced arthritis Collagen-induced arthritis was induced as described ... diseases, TNBS-induced colitis and collagen antibody-induced arthritis, were exacerbated in BMhIL-32 mice Furthermore, hIL-32β-transduced CD4+ T cells showed marked exacerbation of collagen-induced arthritis, ... on the induction of TNFα production, especially in the macrophages Our results also suggested that in vivo expressed IL-32β collaborated with TLR4 signaling to induce IL-1β and IL-6 production...

Ngày tải lên: 09/08/2014, 08:23

... paddling and transplanting were conducted on June and June 8, and the inundation began on June in 2007 A weir was at the outlet point, the height of which was fixed during the observation period The ... shown in Fig 1b Three experiments using each three charcoal were conducted at a time, and a total of twelve experiments were conducted in this research Charcoal chips were collected from the experimental ... were made from thinned Japanese cedar (Sugi in Japanese), and carbonized at 1,050°C in order to produce charcoal that is good at removing recalcitrant dissolved organic matter from water (Miura et...

Ngày tải lên: 05/09/2013, 10:15

... signal transducers then bind to these adaptors to initiate multiple signalling pathways, including mitogen-activated protein kinase, phosphatidylinositol 3-kinase ⁄ AKT and the signal transducer and ... cleft formed between these two lobes The C-terminal regulatory domain has several tyrosine residues that are phosphorylated specifically upon ligand binding, as described below (Fig 1A) Eleven ... that specifically bind to EGFR (including EGF, transforming growth factor-a, amphi- A B Signal transduction by ERBB proteins Binding of a family of specific ligands to the extracellular domain of ERBB...

Ngày tải lên: 16/02/2014, 09:20

... mutant receptors preferentially induce ligand-independent dimerization and activate downstream signaling pathways EGFR mutations result in repositioning of critical residues surrounding the ATP-binding ... Japanese people than in individuals from Europe or the USA, in patients with adenocarcinoma than in those with other histological subtypes of cancer, and in individuals who have never smoked than ... analyzed updated individual patient data from seven Japanese prospective phase II trials of gefitinib monotherapy, including a total of 148 EGFR mutation–positive individuals [22] The Iressa Combined...

Ngày tải lên: 16/02/2014, 09:20

... that Bim is essential for gefitinib-induced apoptosis of NSCLC cells The induction of Bim after treatment with gefitinib is a consequence of both transcriptional induction and dephosphorylation Thus, ... Yanase N, Yoshimoto T, Moriyama M, Sudo T & Mizuguchi J (2003) Calpain-induced Bax-cleavage product is a more potent inducer of Molecular mechanisms of sensitivity to EGFR-TKIs 52 53 54 55 56 ... mediator of apoptosis induced by the tumor suppressor p53 [29,30] and it can be directly activated by p53 through p53responsive elements in its promoter region PUMA can also induce p53-independent...

Ngày tải lên: 16/02/2014, 09:20

Ngày tải lên: 18/02/2014, 11:20

... amino-acid residues (i.e K, E, and R) in hyperthermophilic proteins As S and T can catalyze the deamination and backbone cleavage of Q and N residues [48,50], a reduction in all four of these residues ... of the plasmid pBL1 insert with that of plasmid pWH1450 [37] indicated Heat-induced enzyme precipitation Heat-induced enzyme precipitation was monitored from 25 8C to 90 8C by light scattering ... mg·mL21) in 10 mM Mops (pH 7.0) Absorbance measurements were conducted in 0.3-mL quartz cuvettes (pathlength cm) using a Beckman DU- 650 spectrophotometer equipped with a Peltier cuvette-heating...

Ngày tải lên: 22/02/2014, 07:20

... focus on Hormones that control asthma, such as ‘prednisone’ (right column) Each drill down/up induces a subset of the documents that correspond to the aforementioned selections The retrieved document ... text exploration can profit greatly from representing information not only at the level of individual concepts, but also at the propositional level, where the relations that link concepts to one ... Propositions A set of propositions, extracted from the corpus document The propositions are usually produced by an extraction method, such as TextRunner (Banko et al., 2007) or ReVerb (Fader et al.,...

Ngày tải lên: 07/03/2014, 18:20

... below Residues identical in all sequences are indicated by asterisks Highly conserved motifs in the X domain of group II IEPs RGWXNYY (RmInt1 residues 349–355) and R(K ⁄ R)XK (RmInt1 residues 380–383) ... region contains a conserved lysine residue in domain X (K483 in LtrA) [13], whose mutation reduces maturase activity [12] Interestingly, the amino acid residue in the equivalent position of ORF ... residue (L396 in RmInt1) located at the C-terminus of a-helix a4 Upstream of this conserved leucine residue at the N-terminus of a-helix a4, the domain X contains the conserved amino acid residues...

Ngày tải lên: 15/03/2014, 09:20

... of these repeats may reduce the effect to a minimum Overall, Q-FISHFCM is by far the most suitable method for telomere length measurements due to its sensitivity, reproducibility and speed (within ... high base-pairing specificity and the products are resolved on a denaturing polyacrylamide gel However, the T-OLA assay can be a time-consuming procedure due to the gel-based length detection Also, ... acridinium ester (AE) In the HPA procedure, DNA from cells or tissue lysates is treated with a telomerespecific AE probe and unbound probe is washed off The entire procedure can be performed in a reaction...

Ngày tải lên: 17/03/2014, 09:20

... estimated that the average number of such CH2 groups per fatty acid residue was 9.1 This was used for calculation of the fatty acid residue concentrations based on the NMR integrals For most fractions, ... The evolution time (t1) was incremented to obtain 200 free induction decays, each with 32 scans for cells, and for the rafts 160 free induction decays, each with 256 scans The total relaxation delay ... choline-containing residues (3.2 p.p.m) [4] The CH2/CH3 ratio increased from 1.44 to 3.02 after stimulation, with a concomitant increase in the CH2/choline peak height ratio from 0.44 to 2.82, due to a decrease...

Ngày tải lên: 23/03/2014, 17:21

... region, we detected a segment of 11 residues strikingly similar to the N-terminal fusion peptide As shown in Fig 1A, the segment ranging from residue to residue 17 is similar to the segment 21–31 ... N-terminal fusion domain is composed of two repeats Panel A, the segment ranging from residue to residue 17 is homologous to the segment 21–31 The mutations G7A and G12A, known to increase cell-cell ... 11 residues strikingly similar to the N-terminal fusion peptide (Fig 1) We found that, when anchored to the membrane by palmitoylation of its N-terminus, this segment (WT-palm-19–33) induces membrane...

Ngày tải lên: 23/03/2014, 21:21

... Summary Chapter 1: Introduction Chapter 2: Background on U.S Dairy and Beef Production A Primer on Dairy Production A Primer on Beef Production 10 A Primer on Corn Production 11 Chapter 3: Fats ... of milk production, which lasts from 20 to about 100 (Blayney 2002), and the 12 to 14 months Cows are inseminated on a schedule amount of milk that each cow produces has that will produce a calf ... Pasture-based Production Systems The nutrition advantage that pasture-raised meat and milk may have over conventional products is only one reason to support this emerging industry Our review...

Ngày tải lên: 24/03/2014, 04:20