key lipid mediators in the regulation of pulmonary hypertension
PULMONARY HYPERTENSION – FROM BENCH RESEARCH TO CLINICAL CHALLENGES pot
... being one of the best studied the integrins (Jean et al., 2011; Schwartz, 2010) It is known that binding of integrins to their ligands is dependent on the presence of divalent cations including ... underscore the importance of EC including endothelial caveolin-1 in maintaining vascular health 3.3 Inflammation It is well established that inflammation plays a significant role in the pathogenesis of ... NO induces the expression of αvβ3 integrin, and the synthesis and release of collagen IV (a major component of endothelial basement membrane) from EC Binding of these two molecules leads to the...
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Báo cáo y học: " Involvement of mast cells in monocrotalineinduced pulmonary hypertension in rats" pot
... development of pulmonary vascular remodeling in chronic hypoxic rats and in the regression of the remodeling upon bringing them back to normoxia [22,23] Activated MCs produce several mediators including ... and inflammatory mediators that have been incriminated in the pathogenesis of PH [1,3,21,45] In line with our findings, Banasova et al demonstrate that MCs play a role in the development of PH in ... activation of MCs in the lungs contribute to the development of PH in MCT-rats This study offers important pathophysiological insights into the role of MCs in the pathogenesis of PH in MCT- rats...
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Báo cáo y học: "Inhaled nitric oxide in persistent pulmonary hypertension of the newborn refractory to high-frequency ventilatio" ppsx
... none of the infants with CDH responded to INO therapy Inhalation of NO significantly decreased OI (P < 0.0001) and improved the a/A ratio (P < 0.0001) within the first h of INO therapy in 61.1% of ... whether INO would reduce the incidence of death or the need for ECMO in infants with hypoxic respiratory failure [9] HFOV was used in 55% of the infants The authors found that treatment with INO ... INO therapy and 62.5% survived to discharge Recently, the NINOS Study Group In this study, we found that 61.1% of the responders responded within the first h after the initiation of INO and their...
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Báo cáo y học: "Prophylactic antibiotic treatment is superior to therapy on-demand in experimental necrotising pancreatitis" pptx
... (Figure 2) These findings support the hypothesis that translocation of enteric bacteria occurs during the early stage of acute necrotising pancreatitis This is in accordance with the results of rat ... patients survive the first phase of severe acute pancreatitis and therefore the prophylaxis and treatment of infected necrosis is of increasing clinical importance [30] In many cases infected pancreatic ... investigator who was unaware of the experimental design using a scoring system previously described in detail [26] In brief, the head of the pancreas was removed, fixed in 4% buffered formalin...
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Báo cáo y học: " Effects of inhaled iloprost on right ventricular contractility, right ventriculo-vascular coupling and ventricular interdependence: a randomized placebo-controlled trial in an experimental model of acute pulmonary hypertension" ppt
... maintained during the entire procedure using an infrared heating lamp A 7.5-Fr central venous catheter was inserted into the femoral vein A 16-G arterial catheter was advanced into the descending ... whereas the other group (n = 8) underwent inhalation of placebo (5 ml isotonic saline solution) In a subsequent study, including 10 pigs, the effects of inhaled iloprost (Ilomedin®; Schering Deutschland ... obtained by fitting a regression line (solid line) through the points of maximal (end-systolic) elastance, delineated for each cardiac cycle with grey circles The induction of pulmonary hypertension...
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báo cáo hóa học: " Development and validation of a preference based measure derived from the Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) for use in cost utility analyses" doc
... invited to participate in the study Consenting adults were visited in their home for the TTO interview A small pilot study (n = 15) was undertaken in advance of the main study to check that interviewees ... was the aim to include a reasonable spread of items in terms of the degree of severity they represented The logit severity of the selected items ranged from -1.25 to 2.09 • Regression: Ordinal ... sample of six items These six items were combined into four domains such that two domains had three levels and the other two domains had two levels The items were selected by re-analysis of the...
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Báo cáo y học: "Cold hands — strained heart? Advances in the management of Raynaud’s phenomenon and pulmonary hypertension" ppt
... Since there are commonalities in the pathophysiology of PAH and RP, particularly in the context of connective tissue disease, inhibition of the renin–angiotensin system may prove effective in ... than nifedipine in reducing both the frequency and the severity of attacks [14] PDE type V inhibitors such as sildenafil inhibit the degradation of cGMP, which mediates the signalling of several ... combine vasodilator and antiproliferative activity include angiotensin-converting enzyme inhibitors, angiotensin receptor blockers and PDE type V inhibitors [5] The use of angiotensin-converting...
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Báo cáo y học: "Role of chymase in cigarette smoke-induced pulmonary artery remodeling and pulmonary hypertension in hamsters" doc
... 30 min, and then the right lung was removed and submersed in the same fixative overnight at room temperature for paraffin embedding, sectioning and histological staining The remainder of the ... To determine whether chymase is involved in cigarette smoking-induced pulmonary artery remodeling and PAH, chymase protein and mRNA levels in the lungs of the smoke-exposed hamsters and the control ... defined as the amount of enzyme producing ng Ang I decrease per The activity not inhibited in the presence of lisinopril, aprotinin and EDTA was considered to be chymase-like activity and the...
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Báo cáo y học: " Beta-estradiol attenuates hypoxic pulmonary hypertension by stabilizing the expression of p27kip1 in rats" ppsx
... cyclin-dependent kinases (CDKs) and their specific regulatory cyclins The cyclin-dependent kinases inhibitors include INK4 family and cip family which can inhibit the activity of the CDK-cyclin complexes The ... an index of RV hypertrophy The lungs were dissected into 3-mm-thick slices at the same point (the lower lobe of the right lung) and placed in neutral buffer (pH 7.4) containing 10% formalin The ... decreasing induction of erythropoietin [20], inhibiting endothelin-1 expression [21], initiating nitride oxide synthesis [22], activating prostacyclin synthesis [23], and downregulating various adhension...
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Báo cáo y học: " Effect of chemokine receptor CXCR4 on hypoxia-induced pulmonary hypertension and vascular remodeling in rats" pps
... We thereafter investigated the effect of the CXCR4 inhibitor on hypoxia-induced pulmonary hypertension in rats in this study As shown in the results, two weeks of treatment with the CXCR4 inhibitor ... is involved in regulation of bone marrow cell migration during development of pulmonary hypertension and vascular remodeling induced by hypoxia This finding also demonstrated the involvement of ... cell migration in hypoxia-induced pulmonary hypertension We hypothesized that inhibition of systemic CXCR4 through administration of AMD3100 will inhibit hypoxia-induced pulmonary hypertension...
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Báo cáo y học: " Protective effects of hydrogen-rich saline on monocrotaline-induced pulmonary hypertension in a rat model" potx
... study, in order to avoid having the antioxidant activity of hydrogen-rich saline interfere with the transformation of MCT in the liver Based on the results, we can presume that hydrogen-rich saline ... light microscopy Determination of TNF-a and IL-6 levels in the serum Levels of TNF-a and IL-6 in serum were measured with commercial ELISA kits following the instructions of the manufacturer Absorbance ... Therefore, we hypothesized that the antioxidant and anti-inflammatory effects of hydrogen-rich saline might prevent the progression of PH To test this hypothesis, we investigated the efficacy of hydrogen-rich...
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Báo cáo y học: " Adrenomedullin in inflammatory process associated with experimental pulmonary fibrosis" pot
... remodelling Thus, we studied total TGF-b in lung sections by immunohistochemistry Bleomycin induced a remarkable increase of TGF-b staining in the alveolar epithelium and in the inflammatory infiltrate ... reduced this staining in the tissues We propose that AM, acting on cytokines, inhibits the iNOS expression, and the subsequent formation of nitric oxide, resulting in the reduction of nitrosative ... the model of lung injury used leads to a substantial increase in the levels of TNF-a and IL-1 in the lung after BLM administration and we report by first time that the production of the pro-inflammatory...
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Báo cáo y học: " Therapeutic efficacy of TBC3711 in monocrotaline-induced pulmonary hypertension" pot
... the index of proliferation (IOP) of perivascular cells in monocrotaline (MCT) model of pulmonary hypertension In situ proliferation of perivascular cells in rat lungs was investigating by using ... PH in the newborn piglet, suggesting the effectiveness of the compound in pulmonary hypertension caused by different stimulus, like hypoxia [27] Taken together, the findings from our study indicate ... calculated as the product of the velocity time integral of the pulsed-Doppler tracing in the left ventricle (LV) outflow tract, the cross-sectional area of the LV outflow tract and the HR [33]...
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Báo cáo y học: " Endothelial-like cells in chronic thromboembolic pulmonary hypertension: crosstalk with myofibroblast-like cells" pptx
... staining of endarterectomized tissue The neointimal layer of distal vascular wall tissues was assessed by immunohistochemical staining G), Hematoxylin and Eosin (HE) staining; H), Single staining ... endothelial (CD31) and SM (a-SMA) markers in the PEA tissues of patients with CTEPH, a double immunostaining method for CD31/a-SMA was performed The HE staining of the neointimal layers of both the ... thromboemboli in CTEPH mainly consist of fibrotic tissue representing the end-stage of a thrombus organization process Therefore, it remains uncertain whether any of the cellular or molecular findings...
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Báo cáo y học: "Impact of interleukin-6 on hypoxia-induced pulmonary hypertension and lung inflammation in mice" ppt
... using image-analysis software Percent wall thickness was then calculated as the diameter of the external elastic lamina minus the diameter of the internal lamina divided by the diameter of the ... for inflammatory cytokines in the pathogenesis of PH, the involvement of each specific cytokine in pulmonary vascular remodeling remains unclear Neither we know how the multifunctional effects of ... increased in many types of human and experimental PH, including monocrotaline-induced PH in rats, suggesting that IL-6 may modulate the extent of PH despite the absence of a hypoxic pulmonary...
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Báo cáo y học: " Nitric oxide synthases in infants and children with pulmonary hypertension and congenital heart disease" ppsx
... stage of pulmonary hypertension in infants with congenital heart disease Additionally there is co-expression of these two enzymes in pulmonary endothelial cells of these infants These findings support ... patients of similar (A) Intensity 2of staining forage eNOS, (B) iNOS and (C) nNOS in lungs from infants with pulmonary hypertension and from conIntensity of staining for (A) eNOS, (B) iNOS and ... when endothelium dysfunction becomes severe The aims of the present study were therefore to immunohistochemically determine the expression of the three isoforms of NOS in the lungs of infants...
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Báo cáo y học: "Collagen V-induced nasal tolerance downregulates pulmonary collagen mRNA gene and TGF-beta expression in experimental systemic sclerosis" doc
... Figure 4A shows the slight expression of TGF-beta in the endothelium and epithelium of control lungs contrasting with the significant cytokine labeling in the endothelium and epithelium in immunized ... characteristic of the expression of this type of collagen in the bronchi and vessels of these animals (Figure 3F) The expression of mRNA in lung tissue is significantly decreased in the group of animals ... was used to intensify the normal birefringence of collagenous fibers and to determine the location of collagen-containing fibers The number of collagen fibers in lungs was determined by an image...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ