key genes of the lysine and threonine pathways

... 0.0064 a Of the genes analyzed, the GO biological process is known for 739 up-regulated genes and 215 down-regulated genes Others are unknown b Of the genes in the mother population, the GO biological ... for 12 441 Others are unknown c The significance of the appearance of the GO term (biological process) in the up-regulated and down-regulated genes was calculated as a P value by the software GO ... by the dendrogram above to show the similarity of their gene expression patterns The expression profile of each gene is represented in the respective rows Genes are linked by the dendrogram on the...

Ngày tải lên: 30/03/2014, 04:20

... found in the father or the mother of 30 of these 125 HCM-patients, that could thus be regarded as familial cases In 45 patients, none of the parents were available for study A total of 40 of the 245 ... with LVH and healthy controls for DNA polymorphisms at these genes We also determined the effect of these gene polymorphisms on onset age and the extent of the hypertrophy Methods Patients and controls ... of 150 of these controls were examined through electrocardiography to exclude the existence of cardiac diseases All the patients and controls were Caucasians from the Northern Spain regions of...

Ngày tải lên: 18/06/2014, 16:20

... situation and therefore provides a realistic, detailed description of the branch-point between the methionine and threonine biosynthesis pathways In the following the model is used to investigate the ... convergence of two uxes (uxes of Phser and cysteine) Interestingly, the properties of CGS are such that the ux of cystathionine and, as a consequence the ux of threonine, present a low sensitivity to the ... model the branch-point between the methionine and threonine biosynthesis pathways in Arabidopsis the following procedure was used Firstly, the kinetic links inside the branch-point and between the...

Ngày tải lên: 20/02/2014, 02:21

... enzyme genes adjacent to the target missing enzyme using the original candidate score, and select genes based on the enzyme Prediction of missing enzyme genes commission (EC) numbers of the target ... j is defined by the number of nucleotides between the end of the i-th gene and the start of the j-th gene along the chromosomes We then derived a distance kernel using the formula Kposition (xi,xj) ... the i¼1 number of genes For the gene position data, we computed all the pair-wise distances between genes along the chromosome, where the distance dij between gene i and gene j is defined by the...

Ngày tải lên: 07/03/2014, 09:20

... antibody to His The sizes of the molecular mass standards are shown in kDa GMD homologues the expression of proteins of  50 kDa, whereas in the case of the different forms of GER the proteins were ... in the study using rrf-3 worms, so neither the relative importance of the two genes nor the biological significance of the alternative splicing of gmd-1 can be surmised at present Owing to the ... present, and that the concentration of GDP-4-keto-6-deoxymannose produced in the presence of GMD isoforms alone was greater than the conversion of GDP-Man into products in the presence of both...

Ngày tải lên: 16/03/2014, 13:20

... rather reflects synchrony to other events of the spermatogenesis For instance, the mechanisms unleashing the pass of the haploid germ cells through the tight junctions from the adluminal to the ... corresponds to the purge of the column and shows a trace of antigen Track and contain 572 ng and 0.425 ng of purified protein, respectively (C) Preabsorption of anti-Stk33 IgG in testis slides with the following ... involved in the normal development of heart and other organs in embryonic and fetal stages The third highest signal in the cDNA dot-blot corresponds to fetal heart and the sixth highest to the interventricular...

Ngày tải lên: 16/03/2014, 23:20

... AIFMs that are significant in terms of their size or the size of the AIFs they manage, their internal organisation and the nature, the scope and the complexity of their activities to establish a ... determine types of AIFM, where relevant in the application of the AIFMD, and to ensure uniform conditions of application of the AIFMD The different types of AIFM will manage a variety of AIF legal ... that some of the issues related to the topics covered by the regulatory technical standards to be developed under Article 4(4) of the AIFMD may merit the development of further guidelines and recommendations...

Ngày tải lên: 30/03/2014, 14:20

... the right sides of the gels these of the two other isoforms (Fig 6) These results correlate to the protein bands of  38 kDa (Plf1) and 27 kDa (Mrp4) [27], which were detected in the western blot ... Wnt target genes and the regulation of their promoters Fig Northern blot analysis of expression of candidate target genes in C57MG cells after treatment with 20 mM LiCl The relevant bands are indicated ... rates of the genes Fos, Fabp5, Slc7a2, Ccl2, Pedf and Fas, and to decreased rates of the genes Mrp ⁄ Plf and Ramp3 (Fig 4) These experimental results are consistent with the microarray results and...

Ngày tải lên: 30/03/2014, 16:20

... data in the study and takes responsibility for the integrity of the data and the accuracy of the data analyses Study concept and design: CA and OB Acquisition of data: CA and OB Analysis and interpretation ... [35] Selection of these strategies depends, apart from the nature of the disturbance, on the subject’s state of attention and previous experience [31,36] Maintenance of posture and balance during ... influences the occurrence and mechanism of the fall and its consequences due to its action on postural balance system - i.e., CNS and muscles - would then be feasible Evidence of the effectiveness of...

Ngày tải lên: 19/06/2014, 08:20

... expression and production of IL-6 deserves special attention in the view of recent success of the neutralization of IL-6 for alleviation of RA [35] These observations support the regulatory role of survivin ... joints, and metatarsophalangeal joints The presence of one erosion was sufficient to fulfil the requirement of an erosive disease We considered the presence of rheumatoid factor (RF) of any of the ... expressed the level of survivin and antibodies against survivin in the blood, in synovial fluid samples, as well as in cell lysates as the mean ± standard error of the mean The survivin levels in the...

Ngày tải lên: 09/08/2014, 06:22

... background on the generation of Th17 cells, which are the main producers of IL-17 We then discuss the biologic effects of Th17 and IL-17 in the context of RA, and the direct Page of 14 (page number ... role in the regulation of immune central and peripheral tolerance, and hence in autoimmune reactivity of the immune system Autoimmunity Autoimmunity is the result of a loss of tolerance (the ability ... lymph nodes and spleen) Several authors have shown that NF-κB is required for the development of mTECs and organization of the thymic stroma, and the development and differentiation of DCs [38-43]...

Ngày tải lên: 09/08/2014, 10:23

... polypeptide synthesis is only one aspect of the control of the tryptophan pathway Besides these, there are two other levels of control that affect the amount of tryptophan synthesis within the cell The ... examining the evolution of the trp genes and the relationships between various species is the analysis of genes not involved in tryptophan biosynthesis that either neighbor the trp genes or are ... of these is feed-back inhibition which influences the activity of the first two reactions [22], and thereby the amount of metabolites flowing through the pathway The second is the formation of...

Ngày tải lên: 14/08/2014, 08:20

... 1.1.1 The structure of the A influenza virus 1.1.2 The structure of the genome A influenza virus 1.1.3 Structure and function of RNA segments of the genome the A influenza virus 1.1.4 Structural and ... characteristics of PB2, PB1 and PA genes 1.1.5 The polymerase complex of the A influenza virus 1.1.6 Genetically variation characteristic of genes and the genome A influeza virus 1.2 A INFLUENZA PANDEMIC AND ... nucleotide and 96% – 100% of the amino acid 3.3 Phylogenetic construction and determining relationships of PB2, PB1 and PA of A/H5N1 strains in this study The sequence of PB2, PB1 and PA genes of A/H5N1...

Ngày tải lên: 27/08/2014, 16:21

... the major genes regulating atopic diseases Candidate genes Positional candidate genes Identify candidate genes Determine functional relevance of polymorphisms in candidate genes Assess role of ... The other is nature of the disease will suggest 22 possible candidate genes Recent advances in understanding of the molecular biology of atopy have suggested a number of plausible candidate genes ... OF THE IMPACT OF POLYMORPHISMS ON CANDIDATE GENES OF ALLERGIC RHINITIS AND ASTHMA ON DISEASE OUTCOMES IN THE SINGAPORE POPULATION LIANG XIAOHUI (BACHELOR OF MEDICINE) A THESIS SUBMITTED FOR THE...

Ngày tải lên: 12/09/2015, 10:58

... Accordingly, the great and urgent need presently is to investigate the role of each of the plenitude of genes and proteins important in the progression of cancer NUCLEAR RECEPTORS The nuclear ... Conventional drugs and the pathways they influence have been the subject of immense interest to biologists, and there has been some headway in understanding the signal transduction pathways these drugs ... Pervaiz, Professor, Department of Physiology, Yong Loo Lin School of Medicine, NUS Their encouragement and guidance and their critique has been of paramount importance in directing the course of the...

Ngày tải lên: 14/09/2015, 14:04

... in this thesis is intended to improve our understanding of the regulation of the transcription of the oxytocin and vasopressin genes The information necessary for correctly regulating the expression ... works and how the machinery itself evolves In this introduction, I describe in some detail the oxytocin and vasopressin peptides, and the structure and evolution of the genes encoding them Then ... bars represent mm and Insel 2002; Goodson and Bass 2001) On the other hand, the main role of vasopressin is maintenance of blood osmolarity and volume homeostasis (Orloff and Handler 1967) Oxytocin...

Ngày tải lên: 15/09/2015, 22:13

... Following the suggestions of scientific literature on the advantages of the compactness, reliability, ease of use and affordability of the 980 nm Diode Lasers, we evaluated the efficacy and safety of ... are reduced [17,18] The lasers normally adopted offer the enormous advantage of being conveyed in a fibre, which serves as the working tip at the end of the handpiece The use of flexible, length-adjustable ... question the efficacy of the 980nm Laser for photosclerosis of lesions and areas with little melanin and hemoglobin pigmentation [7] Furthermore, to avoid exaggerated fluences and thermal damage to the...

Ngày tải lên: 26/10/2012, 09:48

... (CO2), ammonia (NH3) and methane (CH4) into the atmosphere ♦ Most of the H2O vapor condensed to form the oceans ♦ As a result of three key processes (outlined on the next slide), the air ended up ... key processes (outlined on the next slide) completely altered the atmosphere, enabling plants and animals to leave the oceans, and survive and evolve on land ♦ Between 450 million years ago and ... Multi-celled organisms appeared, and some of these evolved into soft-bodied worm-like animals with a variety of organs, and still later into the first hard-shelled creatures capable of leaving fossils ♦...

Ngày tải lên: 04/04/2013, 10:51

... techniques The report then describes the recent status of each of the issues RESEARCH AND DEVELOPMENT IN INCREASING OZONE CONCENTRATION Ozone generation Method and scale of use Table summarizes the ... concentration and decomposition RESEARCH AND DEVELOPMENT IN OZONATION TECHNOLOGY Objectives of ozonation The main objectives of ozonation are to reduce trihalomethane and to remove taste and odor These ... treate the cryptosporidium parvum by chlorine disinfection, the turbidity at the exit of the sand filtration basin is set to a turbidity of 0.1 degrees or less However, this method is neither safe...

Ngày tải lên: 05/09/2013, 08:40

... proposed the necessity of city-wide recycling system and other measures The fluctuation of water consumption in this period reflects the people’s consideration on the WCP introduced The people ... relocation of large-scale factories in Tokyo such as Toyosu Gas, Ebisu Brewery, Kirin Beer and others to the outskirts of Tokyo Another major factor was the reduction of water use in the factory ... conservation They also continuously make efforts to promote the utilization of SWT devices including the distribution of free SWT-tap developed by them as shown in Fig.7 On the other hand, for triggering...

Ngày tải lên: 05/09/2013, 10:17