k channels in the immune system
Báo cáo sinh học: "Beyond toxicity: aryl hydrocarbon receptor-mediated functions in the immune system" docx
Ngày tải lên :
06/08/2014, 19:21
... promoting (though not in initiating) the differentiation of TH17 cells, and more importantly, in inducing them to secrete the cytokine interleukin (IL)-22 (a cytokine implicated in the defense of mucosal ... subsets, distinguished by the different cytokines they produce (indicated under each CD4 T cell type): the cytokines act on other immune cells, activating them in turn The four known subsets ... for their suppressive effect in this autoimmune model with a view to future application in treatment of the disease While the role of AhR in the induction of the cytokine IL-22 is now defined in...
- 3
- 335
- 0
Báo cáo y học: "Gene regulation and signal transduction in the immune system" pptx
Ngày tải lên :
14/08/2014, 20:22
... USA) hinted that he might have an explanation of Kawamoto’s findings Singh presented data on the role of the transcription factor Ikaros in B-cell fate determination in mice He showed that Ikaros ... the immunoglobulin heavy-chain locus Interestingly, Ikaros was found to bind at pericentromeric satellite DNA and could therefore play a role in the silencing of genes encoding key developmental ... in CTNNBL1 binding retains deamination activity but is impaired in class switching, suggesting that CTNNBL1 may specifically regulate AIDdependent class switching Cell-fate determination in the...
- 4
- 268
- 0
Báo cáo Y học: A new siglec family member, siglec-10, is expressed in cells of the immune system and has signaling properties similar to CD33 docx
Ngày tải lên :
24/03/2014, 04:21
... plasmid and the integrity of the insertion was validated by digesting the plasmid construct with either HindIII/Nco I to check the extracellular domain of siglec or with HindIII/Xba I to check the entire ... underlined, the transmembrane domain is in bold and amino acids in the ITIM motifs in the cytoplasmic domain are boxed The intron/exon boundaries as determined from accession no AC008750 are indicated ... cytoplasmic domain with major signaling molecules in the cell, kinase assays were performed using representatives of the four major types of tyrosine kinases (Lck, Jak3, Emt and ZAP-70) known to associate...
- 14
- 540
- 0
Báo cáo y học: "Regulating the immune system: the induction of regulatory T cells in the periphery Jane H Buckner1 and Steven F Ziegler2" pot
Ngày tải lên :
09/08/2014, 01:24
... transiently then die, whether they persist in the body as TR cells, or whether they return to their previous role as nonregulatory resting T cells remains unknown The balancing act required by the immune ... inducing tolerance These subsets have been isolated from a variety of tissues, including the liver, the lung, and the intestine, and they appear to function via IL10 secretion [32,38–40] Wakkach ... [56].Yet, in humans, it is impossible to prove whether the TR cells isolated from peripheral blood originate in the thymus, and are expanded in the periphery, or whether they have been generated in the...
- 8
- 478
- 0
ROLE OF THE IMMUNE SYSTEM IN TUMOR PROGRESSION 1
Ngày tải lên :
10/09/2015, 15:50
... by the histologically defined layers of the skin However, this can be inaccurate as the thickness of the different layers of the skin can vary between individuals The Breslow’s thickness is the ... of the cross-talk between cancer cells and the immune system must be analyzed in the context of the organ in which the tumor exists and the type of cells that the tumor recruits Melanoma In Singapore, ... Laboratory in the Singapore Immunology Network (SIgN) Special thanks go to Karen Khoo, Jeremy Wang and Jo Keeble for their help and discussions about the work presented in this thesis Next, I would like...
- 173
- 528
- 0
ROLE OF THE IMMUNE SYSTEM IN TUMOR PROGRESSION 2
Ngày tải lên :
10/09/2015, 15:50
... expression in the lungs of control vs PMNMDSC-depleted mice, k c is the fraction of proliferating cells in the lungs of control mice and k d is the fraction of proliferating cells in the lungs ... experiment, N is the number of melanoma cells at the onset of the experiment, k is the fraction of proliferating cells, t is the duration of the experiment (6 weeks), τ is the duration of the cell cycle ... cells at the end of the experiment, N is the number of melanoma cells at the onset of the experiment, k is the fraction of proliferating cells, t is the duration of the experiment (6 or 19 weeks),...
- 10
- 278
- 0
Báo cáo khoa học: Crystal structure of salt-tolerant glutaminase from Micrococcus luteus K-3 in the presence and absence of its product L-glutamate and its activator Tris pdf
Ngày tải lên :
06/03/2014, 09:22
... 428 aa; nine aa in total) were located near the interface of the physiological dimer The Cterminal domain may contain structural features involved in protein–protein interactions to form the physiological ... differences in the interactions across the domain interface All the residues involved here seem to be unrelated to the Trisbinding site residues (including Arg223 and Ser227), either directly or indirectly ... Similarly, the 33 ordered residues in the T structure (that are disordered in the N form) are not related to the Tris-binding site residues in any way Thus, the effect of Tris binding on the glutaminase...
- 11
- 521
- 0
Paradoxical roles of the immune system during cancer development docx
Ngày tải lên :
15/03/2014, 01:20
... However, in these studies deletion of the inhibitor of NFκB kinase (IKKβ) — a key intermediary of NFκB — in intestinal epithelial cells did not decrease intestinal inflammation, as measured by inflammatory ... infiltration of innate immune cells in the stromal tissue25,26 (FIG 2) Interestingly, the profile of infiltrating inflammatory cells in skin is distinct from that in cervix — pre-malignant skin ... are continually fine-tuned as tissue microenvironments are altered Therefore, the immune system is integrally involved in maintaining tissue homeostasis as well as being implicated in the pathogenesis...
- 17
- 527
- 0
Environmental Injustice and Human Rights Abuse: The States, MNCs, and Repression of Minority Groups in the World System pptx
Ngày tải lên :
15/03/2014, 23:20
... firms to the town of Koko in Nigeria; and several other similar cases involving a systematic dumping of hazardous wastes to these regions (the case of Koko is discussed in more detail later in this ... the murder of Wilson Pinheiro and Francisco “Chico” Mendes in the Amazon rain forest, the massacre of Father Nery Lito Satur and several others in the Philippines, and the public hanging of Ken ... Nigeria involved the skillful, strategic pursuit of political dominance by the numerical majority following the independence in the 1960s As explained by Naanen (1995, 49), the political power gained...
- 21
- 683
- 0
Báo cáo khoa học: Thermal behaviour of cubic phases rich in 1-monooleoyl-rac-glycerol in the ternary system docx
Ngày tải lên :
17/03/2014, 09:20
... A showing (A) without and (B) with the extra peak The dots above the peaks indicate the calculated positions obtained for the Pn3m structure based on the first peak in the diffractogram In samples ... wedge-like shape To put it another way, with increasing temperature the bilayer gets thinner, with the minimal and the parallel surfaces of the polar/nonpolar interface approaching each other, again ... and E a rather drastic broadening in the line shape of the peaks indexed to the Ia3d structure occurs just below 40 °C, indicating the occurrence of a more disordered structure Also, the lattice...
- 10
- 406
- 0
Báo cáo khoa học: "THE RESOLUTION OF QUANTIFICATIONAL AMBIGUITY IN THE TENDUM SYSTEM" docx
Ngày tải lên :
24/03/2014, 01:21
... call the strong group readinq of the sentence, and the other one the weak group reading On the strong group reading the quantifier 'twelve' has a double function: it indicates both source involvement ... determiner the source is the denotation of the head noun For the indication of the quantity or fraction of that part of the source that is involved in a predication I will use the term source involvement ... will now indicate how representations of the form (14) are constructed in the TENDUM system The crane lifted the tubes there is no indication as to whether the tubes were lifted one by one (individual...
- 4
- 304
- 0
Báo cáo khoa học: Probing the access of protons to the K pathway in the Paracoccus denitrificans cytochrome c oxidase pdf
Ngày tải lên :
30/03/2014, 15:20
... different kinetic properties In the case of the Paracoccus wild-type enzyme, the observed fitted rate constant relative to the major kinetic phase ( 19 s)1 corresponding to 70% of the reaction ... spectral contributions from the mediators in the visible and infrared range could be detected in control experiments with samples lacking the protein, except for the PO modes of the phosphate buffer ... G, Jasaitis A, Svensson-Ek M, Laakkonen L, Puustinen A, Iwata S & Wikstrom M (2000) The structure of the ubiquinol oxi¨ dase from Escherichia coli and its ubiquinone binding site Nat Struct Biol...
- 9
- 367
- 0
scientific american - 1993 09 - special issue - life, death, and the immune system
Ngày tải lên :
12/05/2014, 14:50
... protein in the body They must be able to distinguish the hemoglobin found in blood from the insulin secreted by the pancreas from the vitreous humor contained in the eye from everything else They ... generate lymphokines, chemicals that boost the activity of other cells in the immune system the junctions between the V and D or D and J segments when they interlink, which further increases the number ... successive kinds of T cells that populate the lining (epithelium) of the skin, various oriÞces (such as the mouth and vagina) and the organs that connect with them (the gastrointestinal tract,...
- 119
- 910
- 1
Báo cáo hóa học: " Research Article Blind Identification of FIR Channels in the Presence of Unknown Noise" docx
Ngày tải lên :
22/06/2014, 23:20
... of Ziη H K computation of Mi − (K+ L) Z j Z j j= computation of ED Total Mi K − (K+ L) j =1 N(M1 + M2 )2 K M1 K 3 M2 K 2 M1 M2 K + M1 M2 K 3 3 O M1 K , M2 K 2 Mi K Mi K − (K + L) Mi K − (K + L) Mi2 ... M1 + M2 K M1 K 3 M2 K 2 M1 M2 K + M1 M2 K 3 3 O M1 K , M2 K 2 Mi K (K + L) Mi Mi − Mi Mi − Mi2 K × (K − L) + Mi K × (K − L) 2 Mi Mi − O (K − L) 2 Mi Mi − Mi Mi − (K + L) Mi (L + 1) (K − L) + ... the volume of the [MK − (K + L)]dimensional parallelepiped whose edges are the [MK − (K + L)] vectors {ηm } involved in the principal minor Now, since the determinant of the rank deficient matrix...
- 14
- 246
- 0
Báo cáo sinh học: "Parasite immunomodulation and polymorphisms of the immune system" ppsx
Ngày tải lên :
06/08/2014, 19:20
... showing greatest variability included some encoding cytokines controlling both innate immune responses (such as the IL-1 family) and adaptive Th2 responses (such as IL-4 and IL-4R) Strikingly (in ... targeting innate immune responses, the parasite is also reducing cytokine-based stimulation of the adaptive immune system Moreover, similar effects were exerted by ectoparasites, in particular the ... [3] In an analysis of nearly 100 human interleukin genes, they found the highest single nucleotide polymorphism (SNP) frequencies in geographical areas with the highest number of endemic helminth...
- 4
- 386
- 1
Báo cáo khoa học: "The use of crossreactive monoclonal antibodies to characterize the immune system of the water buffalo (Bubalus bubalis)" pdf
Ngày tải lên :
07/08/2014, 15:20
... evaluate the immune responses of water buffalo to infectious agents and potential vaccines, it is necessary to characterize the immune system of the water buffalo and elucidate the changes in the immune ... containing either 50 µl of PBS-HS (negative control) or µg of mAb in 50 µl of PBS-HS and incubated for 30 minutes at 4oC Cells were washed times (800 × g/3 min) in PBS-HS, then incubated in the ... used to make the mAbs [7] In the present study, we screened a set of anti-bovine mAbs developed in our laboratory and also mAbs submitted to the first international workshop on ruminant leukocyte...
- 7
- 388
- 0
Báo cáo khoa học: " Characterization of the Recombinant Proteins of Porcine ircovirus Type 2 Field Isolate Expressed in the Baculovirus System" potx
Ngày tải lên :
07/08/2014, 15:20
... showing strong positive reaction in the cytoplasm of the PCV ORF1 gene inserted recombinant baculovirus infected insect cells The PCV ORF2 gene containing recombinant baculovirus infected insect ... capture the recombinant protein bound swine IgG The membrane was washed and agitated into chemiluminascence(Intron, Korea) for Then the membrane was exposed to X-ray film and developed Tunicamycin ... recombinant protein expressed in the baculovirus system did not show any noticeable changes in the molecular mass by tunicamycin treatment This may indicate that the ORF2 of the PCV has minor...
- 5
- 159
- 0
Báo cáo toán học: "A Rainbow k-Matching in the Complete Graph with r Colors" pdf
Ngày tải lên :
07/08/2014, 21:21
... Since n = |V (H)| + 2|M| = h + 2 (k − 1), that is h = n − 2k + 2, we have k − k + + (k − 2)(n − 2k + 2) 2 = k − k + + (k − 2)(n − k + 2) 2 < k − k + + (k − 2)(n − k + 2) 2 k 2 = + (k − 2)(n − k ... rainbow kmatching, if r ≥ max{ 2k 3 + 2, k 2 + (k − 2)(n − k + 2) + 2}, k ≥ 2, and n ≥ 2k + 2 If n = 2k then there exists an exactly r-edge-coloring with r = 2k 3 + for k ≥ or r = 2k 3 + for k ... there is no rainbow k- matching (See Figure 2.) Figure 2: ( 2k 3 + or +3)-Colorings without rainbow k- matchings In the coloring (a) of Figure 2, a complete subgraph K2 k−3 of G is rainbow and the...
- 13
- 371
- 0
Báo cáo lâm nghiệp: "Morphological and functional variability in the root system of Quercus ilex L. subject to confinement: consequences for afforestation" ppt
Ngày tải lên :
08/08/2014, 00:22
... estimating the following parameters using the software WhinRhizo v.4.1: number of exterior root links (or magnitude, µ); number of root links in the longest unique path from the base link to ... shortening its length to the depth of the container and preventing the development of replacement taproots The confining of lateral roots in the container and their downward growth lead to the generation ... exterior link (or altitude, a); and sum of links in all possible unique paths from the base link to all exterior links (or total exterior path length, pe ) The following topological Root system...
- 6
- 371
- 0