iv— mechanisms of impaired smooth muscle contractility and relaxation
DIFFERENTIATION AND CONTRACTILITY OF COLON SMOOTH MUSCLE UNDER NORMAL AND DIABETIC CONDITIONS
... Structure and functions of the colon Regulation of colonic contractility .2 Differentiation and development of the colon smooth muscle Smooth muscle contractile and regulatory ... Examples of smooth muscle- specific proteins include smooth muscle α and γ actin, SM-MHC, caldesmon, SM22α, telokin and calponin Although all of these proteins are expressed in smooth muscle some of ... proliferation and differentiation of fibroblasts [14] Smooth muscle contractile and regulatory proteins All differentiated smooth muscle is characterized by the presence of unique isoforms of contractile...
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THE EFFECT OF OMEGA-3 FATTY ACIDS ON AIRWAY INFLAMMATION, HYPERPNEA-INDUCED BRONCHOCONSTRICTION, AND AIRWAY SMOOTH MUSCLE CONTRACTILITY IN ASTHMA
... society in terms of lost productivity and healthcare costs Airway Smooth Muscle Contractility As airway narrowing and hyperresponsiveness are key features of asthma, airway smooth muscle contraction ... Fatty Acids and Smooth Muscle Contractility Conflict exists in the current literature regarding the association between the exposure to fish oil or one of its components and smooth muscle contractility ... due to airway smooth muscle contraction Research on fish oil and airway smooth muscle tissue contractility is limited It is hypothesized that fish oil treatment of tracheal smooth muscle tissue...
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Báo cáo khoa học: " Science review: Mechanisms of impaired adrenal function in sepsis and molecular actions of glucocorticoids" pdf
... deficiency in thyroid and growth hormones and in vasopressin Necrosis or haemorrhage of the hypothalamus or of the pituitary gland have been reported in sepsis as a result of prolonged hypotension ... treatment [12] The duration of suppression of the hypothalamic–pituitary axis after a single dose of a glucocorticoid depends on the anti-inflammatory potency and duration of the glucocorticoid preparation, ... the renal artery and the aorta form rich plexuses in the cortex and supply the gland The plexuses are continuous with the sinuses of the medulla, which drain into the central vein of the medulla...
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Báo cáo khoa học: Mechanisms of amyloid fibril self-assembly and inhibition Model short peptides as a key research tool pptx
... century because of a gradual increase in life expectancy The genuine understanding of the mechanisms leading to the formation of amyloid fibrils and its inhibition is therefore of high clinical ... presence of aromatic residues in specific structural contexts can accelerate this process by several orders of magnitude Therefore, from the practical point of view, understanding of the mechanism of ... one of the key parameters for predicting the rate of the fibrillization process [36] Molecular dynamics simulations of the stability of preformed amyloid fibrils clearly demonstrated the role of...
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Báo cáo Y học: Expression of uncoupling protein-3 in subsarcolemmal and intermyofibrillar mitochondria of various mouse muscle types and its modulation by fasting docx
... soleus muscle (1.7-fold and 2.1-fold, respectively) Therefore the relative amounts of UCP3 protein and mRNA in the three muscles are comparable Effect of fasting on UCP3 protein expression We and ... in SS and IMF mitochondria of gastrocnemius muscle in 24 h-fasted mice Figure illustrates the effects of 24-h fasting on the expression of muscle UCP3 and COX per mg of protein in both mitochondria ... density of UCP3 protein (i.e the intensity of the signal expressed per mg of proteins) was similar in the SS mitochondria of the two glycolytic muscles, tibialis anterior and gastrocnemius, and higher...
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Caldesmon regulates the motility of vascular smooth muscle cells by modulating the actin cytoskeleton stability doc
... cells and the Page of 12 control cells Apparently both MAPK and PAK contribute to the motility of A7r5 cells and these effects are comparable and additive Effect of phosphomimetic mutation of CaD ... to that of untransfected cells The relative migration activity for the A1234-transfected cells was about 13% of the control cells (EGFP), and the ratios of A1A2 and A3A4 were 49% and 47% of the ... discussion at the early phase of this project, and Dr Chan Young Park and Professor Jeffrey Fredberg (of Harvard School of Public Health) for their help in performing and analyzing the traction...
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báo cáo khoa học: "The immunoregulatory mechanisms of carcinoma for its survival and development" docx
... as Fas L and RCAS1 may directly induce anticarcinoma immune cell death Secretion of TGF-beta1 and Gal-1, expression of immune inhibitor ligands (B7-H1 -H3 and -H4), upregulation of IDO and/ or ARG ... Loss of classical and/ or up-regulation of non-classical HLA class I expressions may be able to avoid the stimulation of cytotoxic CD8+ T cells and NK cells; Up-regulation of pro-apoptotic ligands, ... Induction of TIC apoptosis by expression of pro-apoptotic ligands Fas ligand (FasL) FasL binding to death receptor Fas triggers apoptosis of Fas-expressing cells including TICs Two patterns of FasL...
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Báo cáo y học: " TGF-β1 increases proliferation of airway smooth muscle cells by phosphorylation of map kinases" potx
... microscopy for appearance of "hill and valley formation" and by immunocytochemistry staining for α -smooth muscle actin and smooth muscle- specific myosin heavy chain (SM1 and SM2) For the experiments, ... proliferation of epithelial and hematopoietic cells [19]; however, TGF-β1 induces proliferation of the mesenchymal phenotype of cells such as fibroblasts, smooth muscle cells, and myofibroblasts ... airways or within the smooth muscle cells of the airways The release and persistent presence of TGF-β1 in asthmatic airways may gradually induce airway smooth muscle hypertrophy and hyperplasia Moreover,...
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Báo cáo y học: "Evidence that CFTR is expressed in rat tracheal smooth muscle cells and contributes to bronchodilation" pptx
... 0.00 Figure of Analysis chloride transports in rat airway smooth muscle cells Analysis of chloride transports in rat airway smooth muscle cells A Immunofluorescence study of α -smooth muscle actin ... (COPD) and cystic fibrosis (CF), it is important to understand the mechanisms underlying control of the bronchoconstriction and dilatation Ion channels in epithelial, glandular and smooth muscle ... Pharmacological inhibition and immunolocalisation of CFTR in rat tracheal smooth muscle cells Pharmacological inhibition and immunolocalisation of CFTR in rat tracheal smooth muscle cells A Iodide...
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Báo cáo y học: "Autocrine regulation of asthmatic airway inflammation: role of airway smooth muscle" doc
... induce proliferation of fibroblasts and smooth muscle cells in vitro, possibly leading to the observed increase in smooth muscle mass in the asthmatic airway CC chemokines Secretion of other cytokines ... fibroblasts and vascular smooth muscle cells in vitro and is described as mitogenic for cells of mesenchymal origin Page of 13 (page number not for citation purposes) Respiratory Research Vol No McKay and ... Tagoe S, Costello J, Page C: Stimulation of airway smooth muscle cell mitogenesis by transforming growth factor beta and inhibition by heparin and smooth muscle explant-conditioned media [abstract]...
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Báo cáo y học: "Mechanisms of HIV non-progression; robust and sustained CD4+ T-cell proliferative responses to p24 antigen correlate with control of viraemia and lack of disease progression after long-term transfusion-acquired HIV-1 infection" pdf
... genetic data JJZ and ADK assisted with analysis of T cell immunity data, and DM and PRG provided commentary on neutralising antibody and viral evolution and helped edit the manuscript AFG and JSS contributed ... responses, regardless of the strength and breadth of the CTL response A decline in this protective p24 response preceded or correlated with loss of non-progressor status and/ or signs of disease progression ... cells/μl, and no history of ART [27,28] Subsequently, loss of LTNP status was defined by any of the following events: a consistent decline in CD4 T cell counts below 500/μl, commencement of ART, and...
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Báo cáo y học: " Central and peripheral mechanisms of narcotic antitussives: codeine-sensitive and -resistant coughs" ppt
... nerves in the smooth muscle layer of the trachea and bronchi were less abundant in rat and cat than in guinea-pig [97] In addition, as in the cases of animal models, the density of SP-immunoreactive ... activation of µ-opioid and inhibition of neurokinin receptors can help in the suppression of some varieties of chronic cough In a preliminary study, we found that coadministration of codeine and a ... doses Further studies are needed to clarify the pharmacology and mechanisms of antitussive effects of opiates, and to elucidate mechanisms of opiate-resistant coughs Furthermore, it is very important...
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MECHANISMS OF HEXOSAMINE-INDUCED CHOLESTEROL ACCUMULATION AND THERAPEUTIC ACTIONS OF CHROMIUM
... rise above 140 mg/dL The focus of this thesis is to understand the molecular mechanisms of insulin-mediated glucose transport into adipose tissue and skeletal muscle and how this process becomes ... regulation of GLUT4 exocytosis and is particularly abundant in skeletal muscle (58, 59) The tissue-specific isoforms of Rab proteins targeted by AS160 and TCB1D1 are currently under study Rab8A and ... brief history of Cr3+ and its impact on glucose and lipid metabolism in 31 health and disease It will also outline several proposed mechanisms for Cr3+ action in adipose and skeletal muscle tissue...
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Molecular mechanisms of mechanosensing at cell cell and cell matrix adhesion 2
... question: Mechanosensing mechanisms of talin and αcatenin 16 Strategies and Methods 2.1 19 Theory of force induced structural transitions of protein 20 2.1.1 2.1.2 ... study the mechanical stability of the rod domains of talin and central domain of α-catenin using both wild type and mutant constructs Both talin vii rod domain and α-catenin central domain undergo ... responses of talin rod domain and αcatenin central domain to show that vinculin binding to talin and α-catenin only upon application of force and vinculin binding inhibits the refolding of these...
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Tài liệu Báo cáo khoa học: Thermal unfolding of smooth muscle and nonmuscle tropomyosin a-homodimers with alternatively spliced exons docx
... comparison of Tm5a with smTm allows study of the effects of replacement of muscle exons 1a and 2a by nonmuscle exon 1b, and comparison of Tm5a with Tm5b allows the effects of exchange of exon to ... of the a-Tm molecule For this purpose, we have used the smooth muscle a-Tm (smTm) and the two a-Tm fibroblast isoforms Tm5a and Tm5b, as shown in Fig All of these a-Tm isoforms have a smooth muscle- like ... Fig Exon structure of smooth muscle a-Tm and the two fibroblast isoforms Tm5a and Tm5b with constitutive exons are shown in white, smooth muscle exons in light grey, and nonmuscle exons in dark...
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Tài liệu Báo cáo khoa học: Regulation of connective tissue growth factor (CTGF/CCN2) gene transcription and mRNA stability in smooth muscle cells Involvement of RhoA GTPase and p38 MAP kinase and sensitivity to actin dynamics docx
... Regulatory mechanisms of the CTGF/CCN2 gene (Eur J Biochem 271) 4437 TGF-b Consistent with this, the expression of CTGF/ CCN2 is either not or minimally affected upon stimulation of cultured smooth muscle ... via increased transcription and/ or by stabilization of the CTGF transcripts and the role of RhoA GTPase and p38 signaling in such a regulation, nuclear run-on assays and message stability analyses ... transcription rate of the CTGF/CCN2 gene was determined upon stimulation of the cells with S1P, anisomycin or FBS in the absence and in the presence of RhoA GTPase and p38 inhibitors (Y-27632 and SB-203580,...
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Tài liệu Báo cáo khoa học: Modulation of cyclin D1 and early growth response factor-1 gene expression in interleukin-1b-treated rat smooth muscle cells by n-6 and n-3 polyunsaturated fatty acids pdf
... Modulation of smooth muscle cell (SMC) proliferation and retinoblastoma protein (Rb) phosphorylation after supplementation with n-3 and n-6 polyunsaturated fatty acids (PUFAs) (A,B) Effects of n-3 and ... control of SMC proliferation 4466 S Bousserouel et al (Eur J Biochem 271) Modulation of cyclin D1 synthesis and hyperphosphorylation of Rb by n-3 and n-6 PUFAs Induction of cyclin D1 is one of the ... proliferation of vascular smooth muscle cells through modulation of various steps of growth signals Lipids 31 (Suppl ), S301–S304 16 Pakala, R., Sheng, W.L & Benedict, C.R (2000) Vascular smooth muscle...
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Tài liệu Báo cáo Y học: Enhancement by a-tocopheryl hemisuccinate of nitric oxide production induced by lypopolysaccharide and interferon-c through the upregulation of protein kinase C in rat vascular smooth muscle cells docx
... induction Effects of a-T and its derivatives on the enhancement by TS of LPS/IFN-induced NO production We compared the effects of a-T and its derivatives TA and TN with that of TS on LPS/IFN-induced ... production with Ro31-2880 and GF109203X were approximately 70 and 30%, respectively Effects of TS on the amount of PKCa We further examined the effects of TS on the amounts of PKCa and PKCb by Western ... upregulation of PKCa DISCUSSION Fig Effects of PKA inhibitors (KT-5720 and H8) and PKC inhibitors (Ro31-8220 and GF109203X) on the enhancement by TS of LPS/IFNinduced NO production in VSMC (A), and Western...
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Báo cáo khoa học: Endogenous mono-ADP-ribosylation mediates smooth muscle cell proliferation and migration via protein kinase N-dependent induction of c-fos expression potx
... both the number of bands and the labeling intensity were increased in growing cells The most prominent increases were in bands of 140, 133, 116, 95, 82, 73 and 56 kDa (Fig 4) Other bands also showed ... Campbell, J.H (1986) Replication of smooth muscle cells in vascular disease Circ Res 58, 427–444 Owens, G.K (1995) Regulation of differentiation of vascular smooth muscle cells Physiol Rev 75, 487–517 ... inhibits the proliferation of human and rat vascular smooth- muscle cells Biochem J 283, 403–408 Saward, L & Zahradka, P (1997) Coronary artery smooth muscle in culture: migration of heterogeneous cell...
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Báo cáo Y học: Cloning and characterization of novel snake venom proteins that block smooth muscle contraction pptx
... obtained mg of triflin and mg of latisemin from 500 mg of crude venom, respectively The predicted amino-acid sequences of triflin and latisemin are homologous to that of ablomin (83.7 and 61.5%, ... shown on the left Lanes and show ablomin (26 and 29.7 kDa), lanes and show triflin (23 and 29 kDa), lanes and show latisemin (28 kDa each), and lanes and show tigrin (28 and 30 kDa) The numbers ... and cloning of tigrin and ablomin During the isolation process of a prothrombin activator from the Duvernoy’s gland of Yamakagashi snake (R tigrinus tigrinus), we identified a large quantity of...
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