issues in bioequivalence and development of generic drug products

... also contains a GAL4 gene under the control of the GAL10 promoter The induction of the yeast, by galactose containing media, results in overexpression of GAL4, in turn inducing an increase of the ... expression is obtained in induced strains at 15 °C while the levels of Golf and Ga15 not change significantly In addition, the protein levels of I7 OR, Golf and Ga15 in strains from Fig 4A were ... odorants in two strains expressing either I7 OR and Golf, or I7 OR and Ga15 Strains were grown in minimal media with 2% glucose (uninduced) or subsequently in minimal media with 2% galactose (induced)...

Ngày tải lên: 07/03/2014, 16:20

... Prevalence and risk factors for developing K65R mutations among HIV-1 infected patients who fail an initial regimen of fixed-dose combination of stavudine, lamivudine, and nevirapine J Clin Virol ... are running behind A random sample survey is often the only way to assess treatment efficacy and the selection of drug resistance in treatment programs in Africa The information obtained from ... The interpretations of genotyping data and subtyping were performed using Smartgene™ HIV software packages (Integrated Database Network System, Smartgene, Zug, Switzerland) Selection of drug...

Ngày tải lên: 10/08/2014, 05:21

... Associate Researcher of Institute of Nuclear Energy Research He holds a PhD in environmental engineering, M.S and B.S in chemical engineering His research interests include biomass reforming, hydrogen ... reforming or partialoxidation reforming In the INER SOFC system, the reforming process is performed using a combination of these two methods by feeding both steam and an oxidant (air) into a ... afterburners provide an efficient means of ensuring the complete conversion of the SOFC off-gases during nominal operation and of pre-heating the cathode intake air during long-term operation Compared...

Ngày tải lên: 05/09/2013, 16:10

... coronal section and scheme of the coronal section at E14.5 in (F) (A) At E11.5, HSF2 is expressed in forebrain, midbrain and in hindbrain except for the midbrain, hindbrain midline Surprisingly, the ... basis of incorrect pairing of sister chromatids and of the lack of integrity of the synaptonemal complex in Hsf2) ⁄ ) spermatocytes is a pending question [62] Role of HSF1 in the quality control of ... importance of elucidating the mechanism discriminating various HSEs for HSF2 recruitment in development This latter study [73] underlines possible roles of HSF2 in the organization of chromatin and of...

Ngày tải lên: 18/02/2014, 04:20

... Importance of springs and groundwater in drinking water supply Springs comprise the main source of drinking water, estimated to supply up to 90 per cent of DRC’s rural population No inventory of springs ... understanding of the critical role of ecosystem services in securing national and MDG targets of providing people with safe and sustainable sources of water Enhancing environmental management and ... the sources of drinking water supply Confusion over land tenure, conflicting jurisdictional mandates and institutional weakness in applying an organized system of land use planning and management...

Ngày tải lên: 06/03/2014, 16:20

... concerning the rule of thirds by examining more positions between the quarter-line and mid-line positions studied in the present experiment, including ones that are precisely at the one-third and ... decidedly off center and facing out of the frame, violating these conventions to convey feelings of isolation, loneliness, and/ or longing Although such considerations are beyond the scope of the ... asymmetries in off-center compositions The genesis of this line of research appears to be an early claim by Wölf in (1928), as reported in Gaffron (1950), that aesthetically pleasing paintings generally...

Ngày tải lên: 07/03/2014, 17:20

Ngày tải lên: 09/03/2014, 17:20

... 470.—Form originating in basketry Fig 471.—Form originating in basketry Fig 472.—Form originating in basketry Basketry and other classes of woven vessels take a great variety of forms and, being generally ... with the use of clay and a capacity in handling it that, with advancing culture, brought all nature within the reach of the potter and made it assist in the processes of variation and development ... use by the Indians of the interior of the continent, is regarded as symbolic of the whirlwind, and it is probable that any symbol-using people will find in the features and phenomena of their environment,...

Ngày tải lên: 28/03/2014, 20:20

... worsening of an existing clinical condition (infectious or noninfectious) within months of initiation of ART Toxicity was graded according the system mentioned in the WHO ART scale-up guidelines ... from the grading system of Division of AIDS, National Institute of Allergic and Infectious diseases, USA) The regimen was discontinued (substituted with nonoffending ARV drugs) in cases of grade ... baseline and every months or as clinically indicated Creatinine clearance (CrCl) was calculated using the Cockroft-Gault formula Virologic failure was defined as inability to achieve or maintain...

Ngày tải lên: 20/06/2014, 08:20

... cultivation intensity of maize or OSR in the neighbourhood of each of the 7,338 NSG in Germany The combination of GC and CC resulted in a total of nine risk categories [RC], describing the potential ... contains relevant geodata and offers tools for integration of information of related environmental monitoring networks and tools for data analysis Such information platforms help in reducing GMP ... monitoring schemes covering approximately 4,000 species and 145 different habitat types and addresses of 239 monitoring coordinators and institutions Furthermore, the database contains information...

Ngày tải lên: 20/06/2014, 20:20

... staff in Science and Agriculture, extension of techniques to improve quality of seed and plant breeding, technologies of crop preservation and processing and quality inspection methods of finished ... all of the cattle manure and Lan super as well as 30% of Urea and 30% of Kali for treament before planting - Half of the remaining Urea and Kali lefts was fertilized 20-25 days after planting ... medium vine and leaves, deeply lobed leaves It is able to grow strongly and regenerate quickly and is suitable for trimming vines and leaves periodically The vines and leaves are soft and sweet...

Ngày tải lên: 21/06/2014, 04:20

... cultivation intensity of maize or OSR in the neighbourhood of each of the 7,338 NSG in Germany The combination of GC and CC resulted in a total of nine risk categories [RC], describing the potential ... contains relevant geodata and offers tools for integration of information of related environmental monitoring networks and tools for data analysis Such information platforms help in reducing GMP ... monitoring schemes covering approximately 4,000 species and 145 different habitat types and addresses of 239 monitoring coordinators and institutions Furthermore, the database contains information...

Ngày tải lên: 21/06/2014, 17:20

... Counting the number of roots for each content of these sweet potato roots The main treatment factor was the winter in Bac Giang (S1) and Weighing and grading roots: small Thanh Hoa (S3) influencing ... were determined for 30% of potassium for treatment roots of the sweet potato varieties at all of before planting locations in Bac Giang and Thanh Hoa, 2008 - Half of the remaining Urea and Kali ... lack of good cultivars and relevant technology for cultivation and processing of sweet potato means that this crop is not achieving its great potential for contributing to increasing income and...

Ngày tải lên: 22/06/2014, 13:20

... examining a piece of candy, putting it in one’s mouth, chewing it, and then spitting it out In play the object, to win, is recognized in advance At the end of play development, rules emerge; and ... covered in five steps The child, in wishing, carries out his wishes; and in thinking, he acts Internal and external action are inseparable: imagination, interpretation, and will are internal ... changes in needs and in consciousness of a much wider nature Play is the source of development and creates the zone of proximal development Action in the imaginative sphere, in an imaginary situation,...

Ngày tải lên: 23/06/2014, 09:52

... Carding Combing Draw frames Speed frames Ring frames Winding Rotor spinning Ply-winding Doubling and twisting Warping Sizing Weaving Soft package winding of yarn for wet processing Scouring Yarn ... team working, information gathering and maintaining records, maintaining the discipline while working relating to 30 Training and development of technical staff in the textile industry channelisation, ... reassembling of the machines for the purposes of scouring, cleaning, overhauling, etc., erection of new machines, shifting and re-erection of existing machines, ensuring breakdown free performance of...

Ngày tải lên: 28/06/2014, 17:20

... The outstanding characteristics of TTH climate are the highest rainfall of the whole country, a lot of floods in the narrow plain and difficult prevention of flooding 11 In terms of rain regime, ... preservation and promotion of cultural heritage in TTH province with distinctive characteristics of a province in the key Central economic zone including achievements, limitations, reason and issues ... restored and improved such as garden house system, landscape and additional plants in the buffer zones In particular, replanting the green corridor in King Minh Mang mausoleum, restoring and improving...

Ngày tải lên: 14/07/2014, 13:33

... structure and development of forest stands in national parks of Krkonoše Mts describes the stand of forest ecosystems before during and after the air pollution and subsequent ecological calamity including ... stands) and spruce stands, relict pine woods and stands in the ecotone of the upper forest limit in different site, stand, air-pollution and ecological conditions were examined The main attention ... predictions in year steps were conduced In selected stands with the absence of silver fir (PRP 6 and 28) virtual underplanting of this species was done and prediction of development after 25 and 50...

Ngày tải lên: 07/08/2014, 10:21

... smaller number of crop (selected) trees in the first thinning and thinning intensities, taking account of economical factors [46, 51] In Slovenia, selective thinning is the main type of thinning [34] ... of removed trees and of remaining trees; the more the thinning interferes in the middle and upper storey, the higher is qD In the T1 thinning subplot, a stronger intensity was carried out; in ... each within the thinned (T1 and T2) and the control stands (C1 and C2) in July 1994 All plant species 50 A Boncina et al Figure Development of stand basal area of the thinned (T1 and T2) and control...

Ngày tải lên: 07/08/2014, 16:20

... determination of protein concentration Refolding of proteins was performed using a Refolding kit (Novagen) following the manufacturers instructions The concentration of purified recombinant protein ... useful in detecting cattle with clinical paratuberculosis, the application of this procedure in identifying cattle in early stages of infection or in subclinical stages has proven to be of limited ... by variations in the stage of infection In the attempt to increase sensitivity, several modifications have been tried including using a combination of antigens or a single recombinant antigen...

Ngày tải lên: 07/08/2014, 17:22

... diagram of the processes involved in the growth and development of a tree in a stand ,and Inose (1982), a limited linear one Our context being more similar to that of the former author, to obtain a ... -In( FV/FV showing again a linear )), max relationship that appears in figure 6b) This analysis establishes the possibility of a linear fit to express In( BI) as a function of In (FV) and In( 1 -In( FV/FV ... Observations of crown profiles (fig 5) indicate that the lower part of the crown of a stand tree subject to competition from the surrounding crowns is almost cylindrical in shape (fig 4b and c); from...

Ngày tải lên: 08/08/2014, 23:22