issues in bioartificial liver support therapy for acute liver failure

... surfactant in children with acute respiratory failure: Duration of PICU stay ALI, acute lung injury; ARDS, acute respiratory stay distress syndrome; 95% CI, 95% confidence interval; PICU, paediatric intensive ... conducting clinical trials in infants and children with acute respiratory failure Am J Respir Crit Care Med 2003, 167:1334-1340 Royall JA, Levin DL: Adult respiratory distress syndrome in pediatric ... priori criteria for rescue therapy [13] Description of included trials Table describes the included trials Three trials enrolled exclusively infants with RSV-induced respiratory failure [20,21]...

Ngày tải lên: 13/08/2014, 03:21

... peptide vaccination therapy in combination with imatinib in a CML patient who could not acquire a major molecular response through the administration with a single agent of imatinib In addition, ... thereafter Imatinib was increased to a dose of 600 mg and continued for months, which caused adverse effects such as worsening of anemia and limb pain with increased CK Therefore the dose of imatinib was ... treatment for suppressing the function of regulatory T cells in combination with anti-tumor immunotherapy including tumor antigen peptide vaccination The present study showed that WT1 peptide vaccination...

Ngày tải lên: 26/10/2012, 09:39

... Health-related quality of life during post-induction chemotherapy in children with acute lymphoblastic leukemia in remission: An influence of corticosteroid therapy Int J Oncol 1997, 11(2):333-339 ... psychosocial) Items are scored using a four to six point Likert scale and converted to a to 100 point continuum, with higher scores indicating better QoL The original reference period of the CHQ ... scored using a four point Likert scale and reflect on the past week Higher scores indicate better QoL Analysis The Statistical Package for Social Sciences for Macintosh version 18.0 was used for all...

Ngày tải lên: 20/06/2014, 15:20

... to infarctive crises Thoracic bone infarction (usually in the ribs) in such patients leads to pain, splinting, hypoventilation, and the clinical signs of ACS In situ red blood cell sickling in ... included in the study e 32 patients were intubated for liver transplantation, 11 for other abdominal surgery, and 18 for respiratory distress f Mean g Interquartile range h Certain patients included ... noninvasive ventilation during acute lung injury Am J Respir Crit Care Med 2005, 172:1112-1118 40 Ambrosino N, Vagheggini G: Noninvasive positive pressure ventilation in the acute care setting:...

Ngày tải lên: 21/06/2014, 03:20

... excluding V1 Aspirin and thrombolysis administered within hours of onset of symptoms Age 21 to 85 years Ability to give informed consent At 90 minutes (±15 minutes) after the beginning of initial ... cause Administration of low-molecular-weight heparin within the previous 12 hours Definitions of trial end points Reinfarction During index admission: further chest pain lasting more than 30 minutes ... percutaneous coronary intervention (primary PCI) is a proven therapeutic approach in this setting5,6 and is used increasingly, intravenous thrombolysis remains the first-line therapy in 30 to 70 percent...

Ngày tải lên: 27/06/2014, 00:20

... S: Acute renal failure in an intensive care unit in India – prognostic factors and outcome J Nephrol 1999, 12:390-394 Brivet FG, Kleinknecht DJ, Loirat P, Landais PJ: Acute renal failure in intensive ... continuous versus intermittent dialysis for acute renal failure Kidney Int 2001, 60:1154-1163 45 Guerin C, Girard R, Selli JM, Ayzac L: Intermittent versus continuous renal replacement therapy for ... and initiation of renal replacement therapy (RRT) A trained research nurse and physician reviewed hospital medical records to obtain detailed clinical information using standardized data forms for...

Ngày tải lên: 12/08/2014, 23:20

... analysis and interpretation of data JAL, JN, FA, and MMP were involved in drafting the manuscript and revising it critically for important intellectual content All authors have given final approval ... Competing interests The authors declare that they have no competing interests References Bellomo R, Ronco C, Kellum JA, Mehta, RL, Palevsky P and the ADQI workgroup: Acute renal failure - definition, ... outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group Crit Care 2004,...

Ngày tải lên: 13/08/2014, 03:20

Ngày tải lên: 13/08/2014, 03:20

... within the first days in another [8] The timing of surfactant use was not stated in the remaining two trials [11] Patients with milder degrees of hypoxia (oxygenation index 5–7) were enrolled in ... good evidence for the benefit of surfactant in paediatric patients with hypoxic respiratory failure, therefore, many questions remain unanswered – such as the optimum timing of administration, ... and cons of using surfactant in each individual patient to decide whether the surfactant benefits outweigh the financial implications and risks in that particular patient Competing interests The...

Ngày tải lên: 13/08/2014, 03:21

... Liu et al in bleeding complications associated with administration of intravenous APC, the administration by the inhaled route is a novel approach that may allow for safer drug administration ... of recombinant human activated protein C for severe sepsis N Engl J Med 2001, 344:699-709 Looney MR, Matthay MA: Bench-to-bedside review: the role of activated protein C in maintaining endothelial ... mortality in acute lung injury Crit Care 2008, 12:R41 Ware LB, Camerer E, Welty-Wolf K, Schultz MJ, Matthay MA: Bench to bedside: targeting coagulation and fibrinolysis in acute lung injury Am...

Ngày tải lên: 13/08/2014, 16:20

... ACE inhibitors to 51.0%; angiotensin II receptor blockers, (accordingly to ADHF guidelines) in all centres [6], and digoxin and spironolactone in selected cases; and oxygen delivery to maintain ... confidence interval (CI) 3.49 to 10.97, P < 0.001) In multivariate analysis including both predictors and their interaction, the interaction term was not significant (P = 0.874) For an analysis including ... was performed on 247 patients Patients' follow-up was performed at 30, 90 and 180 days following discharge from ED In the 247 remaining patients, follow-up was performed by telephone interviews...

Ngày tải lên: 13/08/2014, 20:22

... of acute bacterial meningitis (by clinical diagnosis or culture of cerebrospinal fluid) Methods Types of interventions : • Fluid administered in the initial treatment of acute bacterial meningitis; ... found no difference in blood sodium levels Authors' conclusions • Some evidence supports maintaining intravenous fluids rather than restricting them in the first 48 hours in settings with high mortality ... given in the initial management of bacterial meningitis were eligible for inclusion Data collection and analysis • Three trials eligible for inclusion (415 children) • All trials were set in countries...

Ngày tải lên: 14/11/2016, 06:22

... contaminating blood cells, dissected from vessels and minced with scissors Minced adipose tissue was enzymatically digested using PBS containing 2% BSA and collagenase (0.2%) at 37°C for 45 minutes; ... Cruz Biotechnology, Inc., Europe) and CD20 (Santa Cruz Biotechnology, Inc., Europe) In addition, Sirus red staining was performed to examine the fibrosis percentage in the infarct area with an ... staining, with the red areas regarded as fibrotic The percentage of fibrotic area was analyzed in randomly chosen fields per slide in the infarct and periinfarct zone in a blinded manner in sections...

Ngày tải lên: 10/08/2014, 09:21

... induction chemotherapy consisting of CMOP regimen (cyclophosphamide, mitoxantone, vincristine and prednisone) and FLAG regimen (fludarabine, cytoarabine and granulocyte-cloning stimulating factor), ... transplantation [5] for Ph-positive CML In the present study, we reported a similar case which developed Ph-negative acute lymphoblastic leukemia following imatinib therapy for months It was thought ... peptides leading to clonal T-cell selection in CML are unknown, the change of TCR Vb clones might provide the information for host immune response After two courses of chemotherapy for Phnegative...

Ngày tải lên: 10/08/2014, 22:21

... contribution in analysing and interpreting the patient’s data during the ICU admission and has been involved in drafting the manuscript for the part concerning the ICU admission He gave final approval ... for a minimum of months following completion of therapy and prophylaxis for P jirovecii pneumonia is also suggested [7] The patient described in our report received four rituximab infusions in ... contribution in the manuscript drafting and in revising it critically for important intellectual content He gave final approval of the version to be published NP was a contributor in acquisition...

Ngày tải lên: 11/08/2014, 17:21

... published in English are included ACLF, acute- on-chronic liver failure; ALF, acute liver failure; ELISA, enzyme-linked immunosorbent assay; FACS, fluorescence-activated cell sorting; IL, interleukin; ... samples, and was involved in revising the manuscript AJ was involved in data analysis and in revising the manuscript CL performed the histological analysis and was involved in revising the manuscript ... studies that included patients with ACLF or acute liver failure reported a significant decrease of several cytokines in the course of MARS treatments [20,22,23,33] Finally, in a Chinese study in patients...

Ngày tải lên: 13/08/2014, 03:20

... KH: [Acute liver failure] Internist (Berl) 2001, 42(4):545-54, 556-62 Lee WM: Acute liver failure in the United States Semin Liver Dis 2003, 23(3):217-226 Bauer M, Winning J, Kortgen A: Liver failure ... significant influence was seen only for creatinine indicating that an additional renal failure respectively multiorgan failure was responsible for higher costs Other parameters expressing the severity ... liver support system MARS is a new emerging innovative medical technology used for the treatment of patients with liver failure Although in first randomized clinical trials the short-time clinical...

Ngày tải lên: 13/08/2014, 11:22

... recovery In the management of late presenters with APAP poisoning and APAPinduced liver failure, clinicians may have to consider individual case scenarios in tailor-making duration and dose of NAC therapy ... N-acetylcysteine does not protect HepG2 cells against acetaminophen-induced apoptosis Basic Clin Pharmacol Toxicol 2004, 94:213-225 Daly FF, Fountain JS, Murray L, Graudins A, Buckley NA: Guidelines for ... Future research on APAP-induced ALF patients could be in the direction of monitoring for biomarkers (for example, sFas and HGF) [19] for liver regeneration or apoptosis in order to establish whether...

Ngày tải lên: 13/08/2014, 16:20

... N, Tolwani A, Ronco C, for the Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) Investigators: Acute renal failure in critically ill patients: a multinational, multicenter ... Nursing time was determined by calculating the cost of additional nursing staff assigned to perform RRT or from the cost of changing ICU nurse staffing as a result of performing CRRT Nursing ... Collaborative Group for Treatment of ARF in the ICU: A randomized clinical trial of continuous versus intermittent dialysis for acute renal failure Kidney Int 2001, 60:1154-1163 Augustine JJ, Sandy...

Ngày tải lên: 13/08/2014, 20:21

... hemorrhage was noted in the single antiplatelet therapy group, and one subcutaneous hemorrhage was found in the combination therapy group As for the patient in the single antiplatelet therapy group ... Int J Med Sci 2010, with APS We therefore compared single antiplatelet therapy and a combination of antiplatelet and anticoagulation therapy for secondary prevention in ischemic stroke ... high-intensity warfarin (INR over 3.0) with or without low-dose aspirin (75 mg/day) was significantly more effective than low-intensity warfarin (INR under 3.0) with or without low-dose aspirin,...

Ngày tải lên: 26/10/2012, 09:48