ischemia reperfusion injury in the rat retina
Báo cáo y học: "Beneficial effect of the oxygen free radical scavenger amifostine (WR-2721) on spinal cord ischemia/reperfusion injury in rabbits" docx
... during radiotherapy and chemotherapy, particularly in combination with cisplatin administration [10] To the best of our knowledge, there have been no other studies investigating the direct or indirect ... Amifostine in spinal cord cells during ischemia- reperfusion injury Experimental Design/Groups The animals were divided into three groups Group I the control group (n = 6): The animals underwent the ... under the animal and exposing it to a heat lamp maintained animal body temperature min) intra-aortically via the Peripheral Dilatation Catheter line, by the onset of reperfusion After 75 of reperfusion...
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Báo cáo y học: "Antioxidant effects of ethyl acetate extract of Desmodium gangeticum root on myocardial ischemia reperfusion injury in rat hearts" pps
... effect of the extract was determined by administering the rats with Desmodium gangeticum orally for 30 days and then sacrificing them for reperfusion- induced ischemic injury Lipid peroxidation in drug ... scavenged by the test compounds in a concentration-dependent manner within the given range of concentrations in all the models The half maximum inhibitory concentration (IC50) in the DPPH, superoxide ... during ischemia reperfusion of the isolated rat heart Reperfusing the ischemic heart with KH buffer did not recover the mean arterial pressure and heart rate in the early reperfusion stage of the...
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Báo cáo khoa học: "Immunohistochemical study of caveolin-1 and -2 in the rat retina" pps
... ot degufirtnec neht dna )nitpepuel lm/gµ 01 ,ninitorpa lm/gµ 01 ,FSMP Mm ,4OV3aN Mm ,04 tedinoN %1.0 ,lCaN Mm 021 ,sirT Mm 04( reffub sisyl ni dezinegomoh yletarapes erew star morf straeh dna ... detceted ylesnetni ,revewoh saw gniniatsonummi 2-niloevaC )A3 giF( rekaew hcum saw tub ,1-niloevac fo taht sa emas eht ylegral saw aniter eht ni 2-niloevac fo nrettap gniniatsonummi ehT )F2 giF( senoc ... ssecorp eht ni dnuof saw gniniatsonummi-2-niloevaC )B( reyal mrofixelp renni eht ni deniats ylesuffid saw 2-niloevaC )A( )daehworra( sllec lailg fo sessecorp eht ni nees saw gniniats kaew elihw ,)worra(...
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Báo cáo y học: "Neurturin enhances the recovery of erectile function following bilateral cavernous nerve crush injury in the rat" ppsx
... procedures [2] The emerging concept of neuromodulatory therapy recognizes that although the peripheral nervous system demonstrates an intrinsic ability to regenerate after injury, this innate response ... synthesized in urogenital tissues including the penis and may also be secreted by glial cells within the ganglion or glia associated with the injured axon(s) [3] Known receptors for neurturin include the ... treatment strategies offering the potential to facilitate recovery are currently under investigation in animal models, including neurotrophins, immunophilin ligands, phosphodiesterase-5 inhibitors,...
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Báo cáo y học: "Ipsilateral common iliac artery plus femoral artery clamping for inducing sciatic nerve ischemia/reperfusion injury in rats: a reliable and simple method" doc
... microscope at the distal site of clamping after removing the clips Using a rectal probe inserted cm into the rectum, the deep rectal temperature was monitored and maintained at 36.5 ± 1°C by a thermal ... drafting the manuscript SMR participating in setting up the method ABF participating in setting up the method FAA carried out pathologic assessment ARD participated in the design and cordination ... used in experimental studies designed to evaluate the effect of therapeutic candidates on I/R injury in peripheral nerves Competing interests The authors declare that they have no competing interests...
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Báo cáo y học: " Anti-inflammatory treatment strategies for ischemia/reperfusion injury in transplantation" ppt
... Posttransplant strategies to reduce I/R injury include the administration of substances that interfere with the inflammatory process mainly with the action of chemokines, cytokines, or leukocyte infiltration ... receptors or the complement system also participate in the development of I/R injury Evidence exists that the temperature during ischemia differentially affects tissue injury as in liver ischemia ... also been demonstrated that the missing expression of Toll-like receptors on the injured tissue rather than on the infiltrating immune cells is the responsible mechanism for the protective effects...
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Báo cáo y học: " tài: Anti-inflammatory treatment strategies for ischemia/reperfusion injury in transplantation" potx
... Posttransplant strategies to reduce I/R injury include the administration of substances that interfere with the inflammatory process mainly with the action of chemokines, cytokines, or leukocyte infiltration ... receptors or the complement system also participate in the development of I/R injury Evidence exists that the temperature during ischemia differentially affects tissue injury as in liver ischemia ... also been demonstrated that the missing expression of Toll-like receptors on the injured tissue rather than on the infiltrating immune cells is the responsible mechanism for the protective effects...
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Báo cáo y học: "CXC-chemokine regulation and neutrophil trafficking in hepatic ischemia-reperfusion injury in P-selectin/ICAM-1 deficient mice" docx
... that P-selectin might participate in I/R injury through its role in platelet aggregation and binding to the neutrophils [25] Other factors such as swelling of the endothelial lining cells, vasoconstriction ... pathways in neutrophil infiltration in I/R-induced hepatic injury remains unclear Further, other proteins are recognized to act as ligands for β2-integrins such as those produced during coagulation ... liver injury Further, other inflammatory mediators may have been involved in neutrophil infiltration (e.g C5a, LTB4) Finally, the nature of hepatic sinusoidal endothelium, which is fenestrated,...
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Báo cáo y học: "Low-dose vasopressin infusion results in increased mortality and cardiac dysfunction following ischemia-reperfusion injury in mice" potx
... result in predominant vasoconstriction in the injured heart, potentially worsening cardiac ischemia and resulting in dysfunction In addition to a decline in cardiac contractility, vasopressin resulted ... in rodents the intraperitoneal route of administration for AVP increases plasma AVP levels in a manner very similar to intravenous dosing in humans [34,35] At least five mice per time point in ... decreasing OTR expression in the heart, may result in vasopressin-inducing vasoconstriction and cardiac dysfunction in the injured heart Conclusions AVP infusion significantly depressed the myocardial...
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Báo cáo y học: "Ischemic preconditioning reduces the severity of ischemia-reperfusion injury of peripheral nerve in rat" pptx
... This finding was concominant to the finding of decreased oxidative injury (i.e decreased MDA levels in nerve tissue) seen in IP pretreated group Previously protective effects of IP in intestine, ... blunt injury to the abdominal aorta J Trauma -Injury Inferction and Critical Care 2003, 55:795-799 Murry CE, Jennings RB, Reimer KA: Preconditioning with ischemia: a delay of lethal cell injury in ... Peripheral Nerve Injury 2006, 1:2 with reperfusion [6] An aggrevated reperfusion injury in Streptozocine induced diabetic rats could be seen with less severe ischemic times [7] Clinical experience...
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Báo cáo khoa học: "Attenuation of ischemia-reperfusion injury by ascorbic acid in the canine renal transplantation" pps
... csavoidraC ecnaveler lacinilc dna ,smsinahcem ,snoitatsefinam :yrujni decudni noisufrepeR R illoB ,JD esraeH 01 216-506 ,243 ,0002 deM J lgnE N 6991 ot 8891 ,setatS detinU eht ni noitatnalpsnart ... erofeb nim 02 )aeroK ,mrahP naH iaD ;VI ,gk/g 1( lotinnam deretsinimda erew sgod ehT )VI ,h/gk/lm 01( noitulos etylortcele decnalab a deretsinimda erew sgod eht llA erudecorp eht gnirud ylppus ... selpmas eussit ehT ld/gm 8.1< ot dezilamron dah seulav eninitaerc mures eht fi keew tnalpsnart-tsop driht eht retfa seninac gnivivrus eht gnizinahtue rof dellac locotorp yduts ehT noitanimaxe lacigolohtapotsiH...
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Báo cáo y học: "Effects of ischemic pre- and postconditioning on HIF-1a, VEGF and TGF-b expression after warm ischemia and reperfusion in the rat liver" ppsx
... apoptosis was increased in rats subjected to 120 of warm liver ischemia compared to non -ischemia [32] Another study supporting the conclusion in the present paper is that by Feinman et al [33] They used ... conditioning seems to prevent HIF-1a mRNA induction in the rat liver after ischemia and reperfusion This suggests that the protective effects of ischemic conditioning not involve the HIF-1 system On the ... of preconditioning, postconditioning and combined therapy against hepatic ischemia/ reperfusion injury Chin J Traumatol 2007, 10:223-227 17 Schofield CJ, Ratcliffe PJ: Oxygen sensing by HIF hydroxylases...
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Báo cáo khoa học: Inhibition of the mitochondrial calcium uniporter by the oxo-bridged dinuclear ruthenium amine complex (Ru360) prevents from irreversible injury in postischemic rat heart docx
... mitochondrial state respiratory rates and RC changed during reperfusion, indicating alterations in mitochondrial integrity Reperfusion sensitized mitochondria to the opening of the mPTP, in remarkable contrast ... in assessing the relevance of mPTP in I ⁄ R injury in the intact heart is the 3483 Mitochondrial Ca2+ uniporter and reperfusion injury contradictory finding that CsA, the most potent inhibitor of ... normalized in each group (C) Specific [3H]ryanodine binding was determined in a medium containing 100 lM free Ca2+ to maintain the calcium release channel in sarcoplasmic reticulum (RyR) open and in medium...
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Báo cáo khoa học: Modulation of the endocannabinoid system by focal brain ischemia in the rat is involved in neuroprotection afforded by 17b-estradiol pdf
... reported in the whole brain of rats following transient focal brain ischemia [15] However, in that study, no information was collected about the alterations induced by the ischemic insult in different ... 609, included in D.M 116 ⁄ 1992 of the Italian Ministry of Health Focal cerebral ischemia Brain ischemia was induced by MCAo in male Wistar rats (280–320 g) by intraluminal filament, using the ... However, the modulation of the endocannabinoid system by estrogen in the brain has been poorly investigated In the present study, we aimed to evaluate the effect of MCAo-induced brain insult on...
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Báo cáo sinh học: "The combined transduction of copper, zincsuperoxide dismutase and catalase mediated by cell-penetrating peptide, PEP-1, to protect myocardium from ischemia-reperfusion injury" ppt
... cooperatively protected heart against ischemia- reperfusion injury by removing OFR Ischemia- reperfusion injury induces myocardial apoptosis [28,29] OFR produced during the reperfusion turns on mitochondrial ... ischemia- reperfusion injury To observe whether transduced PEP-1-SOD1 and PEP-1CAT protect myocardial ischemia- reperfusion injury in Page of 11 vivo, we established the model of myocardial ischemiareperfusion injury ... did not stain the infarcted myocardium, thus showing white in color while non-ischemic myocardium was stained by TTC and showed brick-red in color In the ischemia- reperfusion hearts, the left ventricle...
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báo cáo hóa học: " Inhibition of NF-κB activation by 5-lipoxygenase inhibitors protects brain against injury in a rat model of focal cerebral ischemia" docx
... expression in neurons and microglia/macrophage in brain after IR injury. As inferred from the data above (Fig 1E, a–c), there is an increase in the expression of 5-LOX enzyme after IR injury To determine ... p65 translocation in brain after IR injury As concluded from the data above (Figs 1E and 2), there is an increased expression of 5-LOX enzyme in the brain after IR injury Growing evidence suggests ... removed The animals were then allowed to recover from anesthesia During surgery, the whole body temperature was maintained at 37.0 ± 0.5°C using a heating pad, and monitored using a rectal temperature...
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Báo cáo khoa học: " Influence of ascorbic acid on BUN, creatinine, resistive index in canine renal ischemia-reperfusion injury" pps
... tnereffid tnacifingis ton erew ,noitcnuf yendik fo xedni na sa derusaem ,slevel rC mureS stnemirepxe eht gnirud aimeru fo sngis lacinilc on dah spuorg htob fo sgod llA stluseR tnacifingis yllacitsitats ... detartsnomed erew slevel rC ni segnahc tnacifingis on ,M adaraH ,M awakayaH ,K arumukO ,H ianasO 3101-7001 ,58 ,0002 tnI UJB edixo cirtin fo elor eht :gninoitidnocerp cimehcsi laner yb yrujni noisufreper ... evitsiser fo tnemerusaem htiw )aeroK ,nosideM( yhpargonos relppoD roloC derusaem erew negortin aeru doolb dna eninitaerc mures dna ,)syad 41 ,7 ,5 ,3 ,1( slavretni emit tnereffid ta ylevitarepo-tsop...
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Role of cyclic AMP signalling mechanisms in heart protection against ischemia reperfusion injury
... (adenosine) results in an extraordinary cardioprotective effect during normothermic (37°C) ischaemia and reperfusion Khaliulin I et al Cardiovasc Res 2010;88:324-33 Initial rate of swelling A520.105 ... depletes glycogen in myocardium This promotes binding of Hexokinase II to the mitochondrial membrane and inhibition of mitochondria permeability transition pore (MPTP) opening Cyclic AMP-induced activation ... effectively protects heart against ishaemia /reperfusion injury PKA and Epac act synergicaly in the cardioprotective effect of cAMP Scheme of Signal Transduction of the cAMPInduced Cardioprotection...
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Báo cáo khoa học: Oxidative stress induces a reversible flux of cysteine from tissues to blood in vivo in the rat pptx
... before and during the experiments Rats received infusions of diamide in saline (7.73 lmol Æmin)1Ækg)1 unless otherwise specified) via the cannula implanted in the femoral vein The infusion was ... cysteine in ux to the blood during diamide infusion In both cases, a decrease of 25–30% in the hematic levels of cysteine was observed The effect was strengthened by concurrent administration ... homocysteine tended to increase during the diamide infusion and remained higher than the basal concentration during the whole experiment (Fig 1C) Conversely, the CysGly redox balance was minimally in uenced...
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