iron metabolism quinone dependent and independent mechanisms
Tài liệu Báo cáo khoa học: Platelet factor 4 disrupts the intracellular signalling cascade induced by vascular endothelial growth factor by both KDR dependent and independent mechanisms ppt
Ngày tải lên :
19/02/2014, 16:20
... contrast, PF-4 strongly inhibited the Raf1, MEK1/2 and ERK1/2 activation stimulated by both VEGF165 and VEGF121 Thus, PF-4 inhibited the MAP kinase pathway independently of KDR activation, showing that ... obtained ` through local maternity units (Lariboisiere Hospital and Saint Isabelle Clinic) under approval, and with appropriate understanding and consent of the subjects DNA synthesis HUVEC were seeded ... obtained with VEGF165 (––) and VEGF121 (- - -) (B) Values are means ± SD of four independent experiments performed in triplicate effect of PF-4 on KDR activation VEGF165 and VEGF121 (10 ngÆmL)1)...
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Báo cáo sinh học: " Human herpesvirus 6A induces apoptosis of primary human fetal astrocytes via both caspase-dependent and -independent pathways" potx
Ngày tải lên :
18/06/2014, 18:20
... and WXH designed and directed studies, and were involved in the interpretation of the data and writing of manuscript BG, GFZ and FZ carried out the cells culture and HHV-6 infection BG, JFW and ... molecules including cytochrome c, Smac/Diablo, and AIF to induce apoptosis via the caspase -dependent and independent pathways [24-26] We separated the cytosolic and mitochondrial fractions to examine ... caspasedependent and -independent apoptosis pathways, as evidenced by (1) activation of caspase-3, -8 and -9; (2) increasing the ratio of Bax/Bcl-2; (3) increasing the presence of Smac/Diablo, AIF and...
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Báo cáo y học: "VLA-4-dependent and -independent pathways in cell contactinduced proinflammatory cytokine production by synovial nurselike cells from rheumatoid arthritis patients" potx
Ngày tải lên :
09/08/2014, 06:22
... factor-1- and CD106 (VCAM-1 )dependent mechanism J Clin Invest 2001, 107:305-315 Toyama-Sorimachi N, Miyake K, Miyasaka M: Activation of CD44 induces ICAM-1/LFA-1 -independent, Ca2+, Mg2+ -independent ... alternative ligand(s) for VLA-4 Other investigators have also reported the involvement of a VLA-4 -dependent/ VCAM-1 -independent adhesion pathway in the interaction between bone marrow stromal cells and leukocytes ... streptomycin, and 10% heat-inactivated FCS (Hyclone Laboratories, Logan, UT, USA) After four to five passages, leukocytes and macrophages were removed from the culture and only the adherent, and apparently...
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Báo cáo y học: "Hypoxia regulates human lung fibroblast proliferation via p53-dependent and -independent pathways" ppsx
Ngày tải lên :
12/08/2014, 14:20
... desferroxamine (DFX) DFX is known as an iron chelator which depletes iron and inhibits oxygen, Fe2+-, and oxoglutaratedependent dioxygenases [36] Methods Chemicals Chemicals and materials were obtained from ... laboratory measurements and drafted the manuscript HB and NV participated in the revision of the manuscript YU and MK participated in the laboratory measurements and data analyses SA and IM participated ... Each assay was replicated in four independent experiments Transfection of small interfering RNA (siRNA) into NHLF p21, p27, p53 and control siRNAs were designed and synthesized by B-Bridge International...
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Báo cáo y học: "House dust mite major allergens Der p 1 and Der p 5 activate human airway-derived epithelial cells by protease-dependent and protease-independent mechanisms" docx
Ngày tải lên :
13/08/2014, 13:22
... protease -dependent and protease -independent Protease -dependent activation results in morphological changes, cell-desquamation and production of proinflammatory cytokines Protease -independent ... (pg/ml) 100 Der p 1- and Der p 5-induced cytokine release are protease -dependent and protease -independent, respectively Next, we determined the effects of heat treatment and protease inhibitors ... House dust mite extract and Der p induce morphological changes and cell desquamation in A549 cultures As summarized in table I, both HDM extract and purified natural Der p dose-dependently induced...
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Báo cáo khoa học: Amino acid limitation regulates the expression of genes involved in several specific biological processes through GCN2-dependent and GCN2-independent pathways ppt
Ngày tải lên :
07/03/2014, 03:20
... We chose to study the regulation of chemokine (C-XC motif) ligand 10 (Cxcl10), Egr1 (partially GCN2 independent) and Dusp16 (GCN2 independent) because the structures of these genes were known In ... GCN2 independent and 21% were partially GCN2 dependent (Table S1) As the GCN2 pathway regulates gene expression via transcription factor ATF4, we determined the ATF4 dependence of a few GCN2 -dependent ... extracted and the gene expression levels were quantified by quantitative RT-PCR Oligonucleotide sequences are given in Materials and methods Two independent experiments were performed Trb3, Chop and...
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Báo cáo khoa học: Okadaic acid induces DNA fragmentation via caspase-3-dependent and caspase-3-independent pathways in Chinese hamster ovary (CHO)-K1 cells pot
Ngày tải lên :
22/03/2014, 21:20
... caspase -dependent and caspase -independent [22,25] In the case of CHO-K1 cells, OA appears to induce DNA fragmentation by at least three different pathways: caspase-3 and other caspase activationdependent ... involving DEVDase activity; caspase-3 -dependent and other caspase activation -independent pathways not involving DEVDase activity; and other caspase activation -dependent pathways involving DEVDase ... apoptosis proteins and caspase -independent cell death [28,29] In this study, TPCK and TLCK could not inhibit caspase-3 cleavage, and thus subsequently induce PARP degradation and DNA fragmentation...
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báo cáo hóa học:" CCR9 interactions support ovarian cancer cell survival and resistance to cisplatin-induced apoptosis in a PI3K-dependent and FAK-independent fashion" pdf
Ngày tải lên :
20/06/2014, 07:20
... death We also report that CCL25 promotes proliferation and CCR9 -dependent anti-apoptotic signalling via the PI3K/Akt/GSK/FKHR pathway and independent of FAK These studies suggest expression of ... PI3K/Akt pathway and its downstream mediators, FKHR and GSK-3β Moreover, PI3K inhibition completely abrogated CCL25-mediated and CCR9 -dependent cisplatin resistance, Akt, GSK-3β, and FKHR phosphorylation ... the manuscript RS and CJH assisted with experiments and manuscript preparation WEG, EEP, JWL and SS conceptualized, edited, and/ or revised the manuscript All authors have read and approved the...
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báo cáo khoa học: "CCR9-CCL25 interactions promote cisplatin resistance in breast cancer cell through Akt activation in a PI3K-dependent and FAK-independent fashion" pptx
Ngày tải lên :
09/08/2014, 01:24
... contributions All authors conceived of the study, and participated in its design and coordination and helped to draft the manuscript All authors read and approved the final manuscript Competing interests ... ischemic and necrotic tissue Denatured proteins bind specifically to phosphate Page of ions and thereafter react with calcium ions to form calcium phosphate precipitates The relatively alkaline environment ... gastric cancer: mucin pool calcifications, psammomatous calcifications, and heterotopic ossification [9,12] In addition, four mechanisms of calcification within tumor have been suggested: (a) calcified...
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Tài liệu Báo cáo khoa học: 3T3-L1 adipocyte apoptosis induced by thiazolidinediones is peroxisome proliferator-activated receptor-c-dependent and mediated by the caspase-3-dependent apoptotic pathway doc
Ngày tải lên :
16/02/2014, 09:20
... through PPARgamma -dependent and PPARgamma -independent signal pathways Mol Cancer Ther 5, 430–437 Kliewer SA, Lenhard JM, Willson TM, Patel I, Morris DC & Lehmann JM (1995) A prostaglandin J2 metabolite ... proliferation via a PPARc -dependent Akt-1 signaling pathway, as well as by a PPARc -independent AMPactivated protein kinase pathway [28] Only the inhibitory effect through the PPARc -dependent Akt-1 signaling ... 30821065 and 30870559 from the China National Nature Sciences Foundation, 2006CB910703 from the Ministry of Sciences and Technology of China, and 07dz05907 from the Committee of Sciences and Technology...
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IRON METABOLISM Edited by Sarika Arora pptx
Ngày tải lên :
05/03/2014, 23:20
... Dysregulation of Iron Metabolism and Anemia of Chronic Diseases 129 Bhawna Singh, Sarika Arora, SK Gupta and Alpana Saxena Section Iron Metabolism in Pathogens 145 Chapter Iron Metabolism in Pathogenic ... review and summarize recent developments in our understanding of iron transport and storage in living systems and how iron metabolism may be affected in anemias associated with chronic diseases and ... regulated by iron metabolism in a coordinated way 28 Iron Metabolism Fig The iron- regulatory protein /iron- responsive element (IRP/IRE) regulatory system IRP1 and IRP2 bind to IREs in iron- deficient...
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Báo cáo khoa học: Enzymes of creatine biosynthesis, arginine and methionine metabolism in normal and malignant cells Soumen Bera1, Theo Wallimann2, Subhankar Ray1 and Manju Ray1 potx
Ngày tải lên :
07/03/2014, 04:20
... EAC and S180 cells, mice muscle, sarcoma tissue and the kidney of normal and sarcoma-bearing mice Mitochondria from EAC and S180 cells were prepared according to Moreadith and Fiskum [47] and ... in EAC and S180 cells and in sarcoma tissue indicates that the upregulated proteins are entirely tumor-cell specific On the other hand, the influx and efflux rate of creatine in both EAC and S180 ... normal and sarcoma-bearing mice, as well as from EAC and S180 cells In addition, ornithine and GAA were estimated also from the kidney of normal and sarcoma-bearing mice Enzyme assay AGAT and mitochondrial...
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Báo cáo khoa học: The stop transfer sequence of the human UDPglucuronosyltransferase 1A determines localization to the endoplasmic reticulum by both static retention and retrieval mechanisms docx
Ngày tải lên :
07/03/2014, 16:20
... reticulum localization of Sec12p is achieved by two mechanisms: Rer1p -dependent retrieval that requires the transmembrane domain and Rer1p -independent retention that involves the cytoplasmic domain ... residues of human UGT1A6 (1593–1576) followed by a stop codon and XhoI site The PCR product was cut with BamHI and XhoI and cloned into BamHI and XhoI sites of pTM1 expression vector in frame with CD4 ... in a band with a molecular mass similar to that of the nontreated polypeptide as well as a band of kDa smaller corresponding to the nonglycosylated form (Fig 3A) The high molecular mass band was...
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Báo cáo khoa học: Aspartate transcarbamylase from the hyperthermophilic archaeonPyrococcus abyssi Insights into cooperative and allosteric mechanisms docx
Ngày tải lên :
16/03/2014, 19:20
... specific activity [50,51] A minimum of two independent experiments was carried out at each temperature (at least three independent experiments at 37 and 55 °C) Aspartate saturations in the presence ... coefficient of the unliganded enzyme Ds is defined as the difference between the sedimentation coefficient of the unliganded enzyme (s0) and the sedimentation coefficient of the PALA-liganded enzyme SEM ... activated by ATP (270%) and inhibited by CTP and UTP (50 and 40%, respectively) The amplitudes of the responses to the different allosteric effectors not change between 37 and 55 °C Competition...
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IRON METABOLISM pdf
Ngày tải lên :
22/03/2014, 09:20
... Dysregulation of Iron Metabolism and Anemia of Chronic Diseases 129 Bhawna Singh, Sarika Arora, SK Gupta and Alpana Saxena Section Iron Metabolism in Pathogens 145 Chapter Iron Metabolism in Pathogenic ... review and summarize recent developments in our understanding of iron transport and storage in living systems and how iron metabolism may be affected in anemias associated with chronic diseases and ... regulated by iron metabolism in a coordinated way 28 Iron Metabolism Fig The iron- regulatory protein /iron- responsive element (IRP/IRE) regulatory system IRP1 and IRP2 bind to IREs in iron- deficient...
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Báo cáo khoa học: Proteolysis of the tumour suppressor hDlg in response to osmotic stress is mediated by caspases and independent of phosphorylation pot
Ngày tải lên :
23/03/2014, 06:20
... attached and apoptotic cells after sorbitol treatment (A) Cell attachment and (B) caspase activation were measured as indicated in Materials and methods, at the times indicated – (A) and h or (B) and ... analysed by immunoblotting (lower) and the percentage of protein level quantified (upper) as described in Materials and methods Values are means (± SE) of three independent experiments (C) HeLa cells ... (upper and lower) or h (lower) Endogenous levels of hDlg were analysed as described previously and the percentage of hDlg protein was quantified (lower) Values are means (± SE) of two independent...
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PROGRESS I N BRAIN RESEARCH VOLUME 36 BIOCHEMICAL AND PHARMACOLOGICAL MECHANISMS UNDERLYING BEHAVIOUR doc
Ngày tải lên :
29/03/2014, 13:20
... ChAc AND ACh SYNTHESIS 27 WHITTAKER, P (1970) The vesicle hypothesis In Excitatory Synaptic Mechanisms, P ANDERSEN V AND J K S JANSEN (Eds.), pp 67-76 WHITTAKER, P., MICHAELSON, A AND KIRKLAND, ... Isolation and characterisation of membranes H W W AND from rat cerebral cortex In Drugs and Cholinergic Mechanisms in the CNS, E HEILBRONN A WINTER (Eds.), Res Inst of Natl Def., Stockholm Almqvist and ... A., DOWDALL, ESSMAN, B AND WHITTAKER, P (1970) In Drugs and Cholinergic Mechanisms in the CNS, E HEILBRONN A WINTER AND (Eds.), Res Inst of Natl Def., Stockholm, 4lmqvist and Wiksell, Stockholm,...
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cooperation in primates and humans mechanisms and evolution - peter m. kappeler
Ngày tải lên :
08/04/2014, 12:58
... Cooperation in Primates and Humans Mechanisms and Evolution Peter M Kappeler Carel P van Schaik (Eds.) Cooperation in Primates and Humans Mechanisms and Evolution With 61 Figures and 18 Tables 123 ... sharing and other relevant topics (2) The range of behavioral mechanisms underlying cooperative behavior in primates and humans is documented and critically assessed to identify mechanisms of, and ... economics and analyzed the outcomes of evolutionary games in which frequency -dependent selection acts on genotypes Anthropologists, economists and political scientists, on the other hand, have...
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inorganic biochemistry of iron metabolism
Ngày tải lên :
11/04/2014, 09:48
... Interactions with Iron, and Evolution Copper Chaperones Iron and Copper Interactions in Mammals and Man 12.2.2 Iron and Zinc Introduction Zinc Chemistry and Biochemistry Iron and Zinc Interactions ... Contents 12.3 xiii Iron and Toxic Metals 12.3.1 12.3.2 12.3.3 Iron and Aluminium Introduction Aluminium Chemistry and Biochemistry Iron Aluminium Interactions and Aluminium Toxicity Iron and Lead Cadmium ... Prevalence and Global Distribution of Iron Deficiency Acquired Iron Deficiency Genetic Forms of Iron Deficiency Clinical Stages of Iron Deficiency Symptoms and Signs of Iron Deficiency Treatment of Iron...
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