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... lysozyme (LYS) [3] LYS and a-lactalbumin are two related proteins of 129 and 123 amino acid residues, respectively, which share a similar three-dimensional structure, including four disulfide bonds ... specific calcium-binding site) Interestingly, the formation of spherical particles containing the two proteins in an equimolar ratio was favoured at pH 7.5 under conditions in which apo a-LA adopts ... (driving forces, nature and energy of the interactions) leading to different supramolecular structures [3], and for the control and orientation of protein interactions and cluster formation We are...

Ngày tải lên: 23/03/2014, 07:20

... promoter, are essential for both basal and PMA-mediated induction of DNase II transcription These sites bind Sp1 and Sp3, and protein levels and binding of Sp1 and Sp3 are increased in PMAtreated ... mediate the PMA-induced transcription of lysosomal acid lipase and acid sphingomyelinase in THP-1 cells In this study, we show that Sp1 is involved in PMA-induced expression of DNase II in HL-60 cells ... DNA–protein complexes formed with probe I (Fig 4A, lanes and 9) These results suggest that both Sp1 and Sp3 are able to bind to the GC boxes and that binding of Sp1 forms complex C1 and binding of...

Ngày tải lên: 23/03/2014, 17:21

... http://www.virologyj.com/content/7/1/141 and, in some cases, gastrointestinal disorders Both viruses have been detected in feces [11,12] and their role in the etiology of respiratory infections has recently been ... polyomaviruses in environmental matrices Competing interests The authors declare that they have no competing interests Authors' contributions SBM coordinated the study, concentrated urine samples and nucleic ... positions are referred to strain EU375803 d The sequence positions are referred to strain K02562 a The others and from strain EU375803 although it does not produce any change in the derived protein...

Ngày tải lên: 12/08/2014, 04:20

... significance of Hb and its subchains have not been investigated in lung diseases In this study, Hba and Hbb monomers and complexes were investigated in more detail in normal lung and lung specimens ... higher in the control than in the IPF lungs (1.6 fold) in the standard Western blot In addition, the levels of Hbb complexes were higher in the standard and nonreducing Western blots (4.6 and 5.1 ... analysis and participated in creating the figures VLK conceived the study, and participated in its design and coordination and helped to draft the manuscript All authors have read and approved the final...

Ngày tải lên: 12/08/2014, 11:22

... maximum PINP and PIIINP and maximum lactate level (P < 0.001 for both PINP and PIIINP) and PINP and PIIINP and liver and kidney-specific SOFA scores ROC curve analysis of maximum PIIINP for liver ... compared In addition, the maximum PIIINP, PINP and ICTP values of the surgical and medical, survivors and non-survivors, and MODS and MOF patients during the first 10 days of the study were compared ... assay, the inter- and intra-assay of CVs were 3.1 to 9.3% for values within the reference intervals For serum PIIINP assay, inter- and intra-assay of CVs were 3.0 to 7.2% for values ranging from...

Ngày tải lên: 13/08/2014, 16:20

... inhibitor-kappaB kinase (IKK)α/β/γ and casein kinase complexes modulating NFκB1, RELA and cREL, and alternative pathways involving NF-κB inducing kinase and IKKα modulating NFκB2 and RELB [1,2,11,24-26] ... direct and indirect physical and functional interactions from peer-reviewed publications The relationships in the network include protein-protein interactions, protein binding to DNA or RNA, protein ... Yan et al R53.15 Binding activityprevious page) of RELA and NFκB1 Figure (see and motif logo Binding activity and motif logo of RELA and NFκB1 (a) The basal and inducible binding activity of RELA...

Ngày tải lên: 14/08/2014, 08:20

... maintained in a 5% CO2 incubator at 37°C using MEM (Mediatech, Inc Herndon, VA) for AS and S cell lines and LHC-8 media (Biosource, Camarillo, CA) for IB3-1 and S9 cell lines All media contained ... we investigated the following two hypotheses: 1) To determine if the signaling pathway going through the MAPKs: p38, extracellularregulated protein kinase (ERK), and Jun-N terminal protein kinase ... Clinical sample CFTR-Inhibitor 172: CFTRinh-172 Competing interests The authors declare that they have no competing interests Authors’ contributions MB and AS participated in the conception and...

Ngày tải lên: 11/08/2014, 03:20

... that FcgRIIa and FcgRIIb on human monocytes are differentially regulated by Th1/Th2 cytokines, with interferon-gamma favoring the activator receptor and interleukin-4 favoring the inhibitory receptor ... participated in the conception and design of the study and in the interpretation of data and helped to draft the manuscript All authors read and approved the final manuscript Competing interests ... IgG-containing immune complexes; FITC: fluorescein isothiocyanate; MCV: modified and citrullinated vimentin; MFI: mean fluorescence intensity; PE: phycoerythrin; RA: rheumatoid arthritis; SD: standard...

Ngày tải lên: 12/08/2014, 12:20

... focus of interest The philosophers are interested in understanding the relations between linguistic expressions and what they refer to in the real world, and in evaluating the truth value of linguistic ... is a collocation and which is an idiom? That is the problem raised in using collocations and word combination in lexical relatives The problems can be explained and investigated in semantic field ... basic area of study is the meaning of signs, and the -5study of relations between different linguistic units: homonymy, synonymy, antonym, polysemy, hypernymy, hyponymy, meronym, metonymy, holonymy,...

Ngày tải lên: 14/10/2014, 01:01

... Hồ Thị Tuyết Nhung Marketing definition I Marketing is the activity, set of institutions, and processes for creating, communicating, delivering, and exchanging offerings that have value for customers, ... marketing efforts All business owners understand the importance of marketing but they can’t distinguish between marketing and advertising Marketing has vast boundaries and advertising is just a part ... That’s the reason business owners invest in marketing You have Page | to use marketing strategies to create product awareness If a company wants to increase the sales percentage and increase production,...

Ngày tải lên: 15/05/2015, 12:39

... proliferation and promotion of apoptosis in this model Dietary supplement containing Schisandra chinensis has been shown to reduce prostate cancer cell growth and induce apoptosis by inhibiting androgen ... contain various anti-carcinogenic compounds including lunasin and lectins that were shown to induce apoptosis in malignant cells [13] As CKBM contains these compounds, this would partially explain ... including TNF-α in these animals and inhibit tumor growth However, further study is needed to determine how they are induced and the mechanisms they inhibit cancer cell growth in vivo In summary,...

Ngày tải lên: 03/11/2012, 09:54

... quality of information (input data) needed and difficulty in obtaining them, ability to handle uncrtaines and availability of user friendly software were also concerns” Ref [17] have indicated ... required as an input, easiness to understand and use, and so forth The most essential factors for choosing the MCA technique is the easiness of understanding by the analyst, the stakeholders and use ... university academics, and private consultants and engineers There were two scenarios for assigning ordinal scores When the ordinal scales of “high” and “very low” indicates the best and worst performance...

Ngày tải lên: 05/09/2013, 16:11

... values in connectors include Insertion Loss, Reflectance, Core Alignment (Apex Offset), and End Face Polishing Insertion Loss is the measure of reduction in signal caused by inserting a component, ... selecting high performance polishing techniques and/ or utilizing Angled Physical Contact (APC) connectors Obviously not all connectors are created equal Beside field termination polishing, which ... resulting in increased attenuation and loss of signal strength To improve upon the physical performance values at the connection point, there are several options to choose from One of the best...

Ngày tải lên: 21/12/2013, 08:17

... just click Finish, and the final mailing label report is created (see Figure 10.24) Figure 10.24 These appear in nice mailing label format when they're viewed on a form Controlling the Sort ... level You this first when you're loading up a combo box with fields that are being used in the report The following lines of code accomplish this: For Each dfCurr In Me.rdHowTo10_6.Database.Tables.Item(0).Fields ... FieldDefinition object, which means it is a field definition for a given field in the report The other object that will be used from the Report definition is the DataDefinition object, and the...

Ngày tải lên: 26/01/2014, 11:20

... staining of sPLA2-IIE was observed in two inactive RA sections (Fig 4A), it was intense in VSMC in three distinct active RA sections (Fig 4Ba– c) In contrast, staining of synovial lining cells and ... sporadic and weak staining in individual cells (Fig 4Ca,b), and a few interstitial cells provided intense staining in one sample (Fig 4Cb) In two active RA sections, scattered staining of sPLA2-IIF ... staining for sPLA2-IIA (Fig 2A), whereas the enzyme was intensely expressed in synovial lining cells in the section from a patient with active RA (Fig 2B,C) Staining of the synovial sublining area...

Ngày tải lên: 19/02/2014, 16:20

... Joanis15 and 9-fold for Levin48 We use a balanced training set, which contains 20 verbs from each class in Joanis15, but only verbs from each class in Levin48 We also tried Chang and Lin (2001)’s ... the linguistic conditions which are crucial for lexical semantic classification of verbs We develop feature sets that combine syntactic and lexical information, which are in principle useful ... Again, for each trial, each feature set is trained and tested on the same training/test split The results for Levin48 are presented in table 6, which clearly reveals the general applicability and...

Ngày tải lên: 20/02/2014, 09:20

... cystein, methionine and serine (Fig 2) Mutants containing asparagine, aspartic acid, glycine, lysine or valine were nonfunctional (Fig 2) Clones expressing eEF2 in which the adjacent threonine ... protein (MAP) kinase and mTOR-signalling pathways [17] These signalling pathways activate the eEF2 kinase in response to mitogens and other stimuli that increase the cellular energy demand [18– ... position of threonines T56 and T58 (yeast numbering) are indicated by arrows Amino acid sequences from (accession numbers in parenthesis) Saccharomyces cerevisiae (NP_014776), Saccharomyces castellii...

Ngày tải lên: 07/03/2014, 05:20

... residues in all proteins or in two species are indicated as black and gray boxes, respectively Both elements of the RRM are squared (C) Autoradiography of [35S]Met incorporation in in vitro transcription/translation ... Dm-eIF4B-L in Drosophila cell cultures and in developing tissues provided interesting insights into the function of eIF4B In mammalian cell cultures, a 50-fold overexpression of eIF4B resulted in the inhibition ... Drosophila Ultrabithorax and caudal mRNA As shown in Figs 3B and 4C, both RNAs are cross-linked to Dm-eIF4B recombinant proteins, but not to GST Preliminary evidence for cross-linking of endogenous...

Ngày tải lên: 07/03/2014, 15:20