invasive fungal infection in solid organ transplant patients

... Cytomegalovirus infections in solid organ transplant recipients 1.3 Clinical findings associated with human cytomegalovirus infections 1.3.1 Infections in immunocompetent hosts CMV infection in normal ... Cytomegalovirus infections in solid organ transplant recipients Recurrent infections may consist of either reactivation of the virus strain causing primary infection or reinfection by a new virus strain Recurrent ... useful in monitoring CMV infection in immunocompromised patients for several years However, problems arose in interpretation when rising levels of 24 Cytomegalovirus infections in solid organ transplant...

Ngày tải lên: 13/09/2015, 19:41

... patients) is presented in Table Characteristics of fungal infection In all 90 patients with IFI, 100 episodes of invasive fungal infection were identified, including 58 involving Candida albicans ... evidence [14] indicates that the incidence of fungal infection in septic patients is increasing Fungal organisms are common pathogens in surgical patients and patients suffering from severe sepsis Raymond ... et al Introduction Invasive fungal infection (IFI) is a severe clinical complication in immunocompromised patients, such as neutropenic patients, recipients of bone marrow or solid organ transplants,...

Ngày tải lên: 13/08/2014, 08:21

... was no increased preponderance of fungal infection in patients in the treatment arms compared to placebo, this finding is not necessarily at odds with evidence of increased prevalence of fungal ... Rules for identifying patients at increased risk for candidal infections in the surgical intensive care unit: approach to developing practical criteria for systematic use in antifungal prophylaxis ... fungal infection rates but not mortality [22] Synthesising this evidence into a practical management algorithm would suggest that there are limited grounds for routine antifungal prophylaxis in patients...

Ngày tải lên: 13/08/2014, 03:20

... and interpreted the patient’s data and was involved in writing the manuscript CSJ was involved in drafting the manuscript Competing interests The author declares that they have no competing interests ... any signs of disseminated infection At the last follow-up appointment, he had no symptoms of any disseminated fungemia Amphotericin Conclusion Opportunistic infections in transplant recipients ... Opportunistic fungal infection by Fusarium oxysporum in a renal transplant patient Sabouraudia 1979, 17:219-223 Guarro J, Gené J: Opportunistic fusarial infections in humans Eur J Clin Microbiol Infect...

Ngày tải lên: 11/08/2014, 00:23

... studies in transplantation is to find non -invasive biomarkers of transplant patho­ logies using patient urine or blood that indicate changes at the molecular level, before the development of a clinical ... urine-based test to distinguish between these entities is a major advance for the renal transplant field, especially with the increasing incidence of BK virus infection in transplant recipients ... allograft rejection Advances in immunosuppressive therapy and improved patient monitoring have decreased the incidence of AR in solid organ transplantation However, the lack of noninvasive biomarkers...

Ngày tải lên: 11/08/2014, 12:21

... through transfusion of infected blood, transplantation of infected organs, and sharing injection drug equipment [3] Diagnosis The diagnosis of HCV infection can be made by detecting either anti-HCV ... transfusion to the HCV infection with 21.8% as against 16.7% in intravenous drug users, while 10.2% against 5.5% prevalence was observed between blood donors and diabetes patients with CV infection respectively ... higher frequency of diabetes mellitus type in this group of patients This study also shows that the prevalence of HCV infection in type diabetes patients within the status had no significant difference...

Ngày tải lên: 12/08/2014, 04:21

... through transfusion of infected blood, transplantation of infected organs, and sharing injection drug equipment [3] Diagnosis The diagnosis of HCV infection can be made by detecting either anti-HCV ... transfusion to the HCV infection with 21.8% as against 16.7% in intravenous drug users, while 10.2% against 5.5% prevalence was observed between blood donors and diabetes patients with CV infection respectively ... higher frequency of diabetes mellitus type in this group of patients This study also shows that the prevalence of HCV infection in type diabetes patients within the status had no significant difference...

Ngày tải lên: 12/08/2014, 04:22

... of invasive fungal infection on outcomes of severe sepsis: a multicenter matched cohort study in critically ill surgical patients Crit Care 2008, 12:R5 Blot S, Vandewoude K: Management of invasive ... Colardyn F, Vogelaers D: Invasive aspergillosis in critically ill patients: attributable mortality and excesses in length of ICU stay and ventilator dependence J Hosp Infect 2004, 56:269-276 Vandewoude ... Critical Care Vol 12 No Blot et al Competing interests The authors declare that they have no competing interests References Xie G-H, Fang X-M, Fang Q, Wu X-M, Jin Y-H, Wang J-L, Guo QL, Gu M-N, Xu...

Ngày tải lên: 13/08/2014, 08:21

... cephalosporin; CI, calcineurin inhibitor; FQ, fluoroquinolone; GVHD, graft-versus-host disease; ICU, intensive care unit; MMF, mycophenolate mofetil; MV, mechanical ventilation; NIV, non -invasive ... H1N1 influenza in Australia and New Zealand N Engl J Med 2009, 361:1925-1934 Vilchez RA, McCurry K, Dauber J, Lacono A, Griffith B, Fung J, Kusne S: Influenza virus infection in adult solid organ ... Published: 14 April 2010 References Fishman JA: Infection in solid- organ transplant recipients N Engl J Med 2007, 357:2601-2614 Kumar A, Zarychanski R, Pinto R, Cook DJ, Marshall J, Lacroix J, Stelfox...

Ngày tải lên: 13/08/2014, 20:21

... protein binding of MPA .76 3.3.3.2 Human plasma protein binding of MPAG 76 3.3.3.3 Effect of MPAG on human plasma protein binding of MPA77 3.3.3.4 Effect of MPA on human plasma protein binding ... rejection Cyclosporine (Sandimmune®, Neoral®) Binds to cyclophilin, resulting in cyclophilin-cyclosporine complex which inhibits calcineurin phosphatase and Tcell activation Maintenance immunosuppression ... and Drug Administration (FDA) for the prophylaxis of organ rejection in patients receiving allogeneic renal, cardiac or hepatic transplants It is used in combination with a calcineurin inhibitor...

Ngày tải lên: 12/09/2015, 08:18

... and Fitzsimmons, 1996) In an investigation to determine the clinical utility of monitoring Tac blood concentrations in liver transplant patients involving 111 subjects from transplant centres evaluated ... diluted in % dextrose or normal saline and administered as a continuous infusion over 24 hours to minimize the nephrotoxicity of the drug Ointments containing Tac for the topical treatment of skin ... tsukubaensis, referring to the origin of the soil (Kino et al., 1987) In 1994, Tac was approved for the prophylaxis of organ rejection in patients receiving allogeneic liver transplants in the United...

Ngày tải lên: 12/09/2015, 10:19

... of a combination of a calcineurin inhibitor (tacrolimus) with a purine inhibitor (mycophenolate mofetil or azathioprine) and a steroid (prednizolone) Tacrolimus was given twice a day in individually ... conditions were 1min at 94οC, 40 cycles of 1min at 94οC (template denaturation), 1min at 55οC (primer annealing), 1min at 72οC (primer extension) and finally, 7min at 72οC (final elongation) The ... http://www.medsci.org Int J Med Sci 2010, carries increased risk of side effects or insufficient treatment Taking into account the critical clinical condition of renal transplant recipients and...

Ngày tải lên: 26/10/2012, 09:32

... being least in patients transplanted with fulminant hepatitis B (17%) and greatest in cirrhotics (67%) [9] The rate of reinfection in patients receiving HBIG who were transplanted with fulminant hepatitis ... for a minimum of months post-OLT After one year, reinfection occurred in 20% of patients in each group, but the finding of circulating HBV DNA by PCR in of 11 receiving HBIG and of 10 receiving ... been implicated in allograft reinfection: 1) rapid reinfection by HBV in the circulation of the recipient and/or 2) reinfection from HBV replicating in extrahepatic sites [29] Since the former...

Ngày tải lên: 02/11/2012, 11:17

... stable, slightly increasing tendency during the observation period, which was interpreted as a positive effect of the TB treatment This finding is in line with results obtained from patients from ... HIV infected TB patients indicate that these were patients with only moderately progressed HIV infection reflecting that the study population was enrolled from outpatient clinic settings, not including ... Scarpellini P, et al: Impaired CD4 T-cell count response to combined antiretroviral therapy in antiretroviral-naive HIV-infected patients presenting with tuberculosis as AIDS-defining condition Clin...

Ngày tải lên: 06/03/2014, 04:20

... number of male patients was higher in the index cases, but the number of female patients was higher in contacts determined active disease In our opinion, the reason of this findings were that ... according to WHO guideline [2] Household contacts above 15 years old were evaluated by obtaining a microfilm in every control Acid Fast Bacilli (AFB) in sputum examination was searched times in ... Chee et al detected a rate of 0.9% TB patients in investigation of 5699 close contacts of 1374 index case in Singapore [8] In their study which they detected TB in 36 children younger than years...

Ngày tải lên: 29/03/2014, 03:20

... efforts to prevent mixed infections (superinfection or co-infections) in patients with chronic hepatitis B should not be overlooked, especially in areas endemic for HBV infection Since a small number ... mixed infections We conclude that HBV mixed genotype infections could probably be of clinical significance in HBV-induced liver diseases In light of the prevalence of mixed A/D genotype infections ... patients infected with genotype D strains had more severe chronic liver disease In contrast, Gandhe et al [27] could not find that genotype D influenced the outcome of chronic HBV infection in...

Ngày tải lên: 18/06/2014, 18:20

... efforts to prevent mixed infections (superinfection or co-infections) in patients with chronic hepatitis B should not be overlooked, especially in areas endemic for HBV infection Since a small number ... mixed infections We conclude that HBV mixed genotype infections could probably be of clinical significance in HBV-induced liver diseases In light of the prevalence of mixed A/D genotype infections ... patients infected with genotype D strains had more severe chronic liver disease In contrast, Gandhe et al [27] could not find that genotype D influenced the outcome of chronic HBV infection in...

Ngày tải lên: 20/06/2014, 01:20

... the original reports, into infections of: the gastrointestinal tract; the central nervous system; lungs; eyes; or skin In addition, categories of CMV infections characterized as severe included ... shown in our review severe CMV infections in immunocompetent patients can affect almost every system In a decrescendo order of frequency, severe organ involvement in the herein reviewed reports included: ... symptoms, including fatigue, fever, abdominal or chest pain, headache, pain in the extremities, numbness of the hands, darkening of urine due to the presence of haemoglobin, epistaxis, easy bruising,...

Ngày tải lên: 20/06/2014, 01:20

... Gender against patient outcome Discussion The increasing incidence of MRSA colonisation in patients from institutional settings is well documented and rates of nosocomial MRSA infection have increased ... Gender Deep wound/intraoperative swabs Figure Classification of MRSA Infections/Colonisation Past studies have suggesting a higher incidence of postoperative MRSA infections in males [4] 38% of ... surgical intervention Of these, there were 404 MRSA post-operative wound infections and an additional 254 patients were noted as being ‘colonised’ by MRSA Overall incidence of MRSA wound infection...

Ngày tải lên: 20/06/2014, 04:20

... canker extension only in the inoculated branches Canker length increased during the first months after inoculation, decreasing thereafter in association with the beginning of callus tissue formation ... of pre-dawn ones in Q ilex [17] Data were corrected for changes in measuring light intensity induced by temperature changes in the Mini Pam Correction was calculated by monitoring the fluorescence ... leaf gas-exchange and chlorophyll a recording at the first stages of infection by C parasitica or Phomopsis spp During the first nine months following inoculation, (April 1997–January 1998), photosynthetic...

Ngày tải lên: 08/08/2014, 14:21