introduction and rationale for nanotechnology in cancer therapy

nanotechnology for cancer therapy, 2007, p.810

Ngày tải lên : 04/06/2014, 14:30

... Grodzinski for providing the Foreword Drs Fredika Robertson and Mauro Ferrari have done a superb job in laying the foundation by providing a chapter entitled Introduction and Rationale for Nanotechnology ... continue to have promise in cancer nanotechnology q 2006 by Taylor & Francis Group, LLC Introduction and Rationale for Nanotechnology in Cancer Therapy Another class of nanovectors described in ... doxorubicin in advanced breast cancer: Phase II study, J Natl Cancer Inst., 82(21), 1706–1710, 1990 q 2006 by Taylor & Francis Group, LLC Introduction and Rationale for Nanotechnology in Cancer Therapy...

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báo cáo hóa học: " In vitro and in vivo pre-clinical analysis of a F(ab’)2 fragment of panitumumab for molecular imaging and therapy of HER1-positive cancers" pot

Ngày tải lên : 21/06/2014, 02:20

... colorectal carcinoma with disease progression while on or following fluoropyrimidine-, oxaliplatin-, or irinotecan-containing chemotherapy regimens [22] Panitumumab has been well tolerated in clinical ... cells in 0.2 mL of media containing 20% Matrigel ™(Becton Dickinson, Bedford, MA, USA) or intraperitoneal (i.p.) injections of × 10 cells in mL of media Animals bearing s.c tumors were used for ... calculated for each of the samples and the average with the standard deviation plotted for each time point Imaging g-Scintigraphy was performed with tumor bearing mice to further validate the 111 In- CHX-A"-panitumumab...

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Surface functionalization of superparamagnetic iron oxide nanoparticles for potential cell targeting, imaging, and cancer therapy applications

Ngày tải lên : 09/09/2015, 10:14

... PBS, and artificial urine at 37 oC Inset shows the release profile in the first 10 h Figure 6-9 Size increase of a mixture of Pt-Fe-PNs and mucin after incubation at 37oC for h Pure mucin and ... an alternative method for synthesizing FA-conjugated SPIONs for minimizing uptake by macrophages and enhancing the selectivity in targeting of cancer cells ATRP of GMA and poly(ethylene glycol) ... molecular imaging modalities, MRI is one of the best imaging modalities in both research and clinical fields for injury and disease diagnosis as it offers high spatial and temporal information with...

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Molecular Imaging: An Essential Tool in Preclinical Research, Diagnostic Imaging, and Therapy potx

Ngày tải lên : 29/06/2014, 11:20

... established for investigating protein-protein interactions in cultured cells and several are now being validated for use in living animals, including the two-hybrid system and protein fragment ... separated into discrete DNA-binding and activation domains (Fields and Song 1989) Proteins of interest are expressed as fusions with either a DNA-binding domain (BD) or activation domain (AD), creating ... imaging of protein-protein interactions in vivo by PET and fluorescence imaging, we engineered a fusion reporter gene comprising a mutant herpes simplex virus thymidine kinase Imaging Protein-Protein...

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The use of gold nanostructures in the imaging and therapy of cancer

Ngày tải lên : 11/09/2015, 09:02

... absorption or scattering and offer promising clinical application especially in the area of cancer imaging by increasingly proving themselves to offer alternative angles in examining the same biological ... tyrosine kinase found in cellular surface The EGFR is a 170 kDa plasma membrane glycoprotein containing an extracellular ligand-binding domain, a single transmembrane region, a cytoplasmic domain ... advice in developing the OCT theoretical curve fitting for extraction of gold nanoshells concentration in tissue I also wish to thank Kin San for his assistance in performing the small animal imaging...

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Báo cáo hóa học: " Both FA- and mPEG-conjugated chitosan nanoparticles for targeted cellular uptake and enhanced tumor tissue distribution" docx

Ngày tải lên : 20/06/2014, 22:20

... advantage that it is nontoxic and non-immunogenic, leading to approved by the FDA for internal use in humans and inclusion in the list of inactive ingredients for oral and parenteral applications ... images in animals and participated in its design and coordination All authors read and approved the final manuscript Competing interests The authors declare that they have no competing interests ... red intensity of rhodamine B Nevertheless, in case of mPEG-NPs, rhodamine B was significantly localized probably in the outside of the cells instead of a distribution in the endosomes, indicating...

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Báo cáo y học: "Rasburicase represents a new tool for hyperuricemia in tumor lysis syndrome and in gout Lisa Cammalleri and Mariano Malaguarnera"

Ngày tải lên : 31/10/2012, 14:59

... synthesis, and inosine that will be degraded into hypoxanthine and xanthine and finally into uric acid Hypoxanthine and guanine may enter in a salvage pathway, using hypoxanthine-guanine phosphoribosyltranferase ... hypoxanyhine into xanthine and this latter into uric acid During this reaction an active metabolite, deriving by enzymatic action on allopurinol, oxypurinol, inhibits xanthine oxidase and probably ... tendency to lowering of pH in patients with vomiting and diarrhoea It increases solubility and renal excretion of uric acid and xanthine, maintaining urinary pH between 7.0 and 7.3 Nevertheless, if...

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Báo cáo khoa học: Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis pptx

Ngày tải lên : 15/03/2014, 23:20

... heparanase in human cancer by focusing on head and neck carcinoma and multiple myeloma as examples of solid and hematological malignancies Heparanase in head and neck carcinoma: signaling in motion ... established clinically [23,25,31] and in several in vitro and in vivo model systems, including wound healing [29,57], tumor xenografts [52,55], Matrigel plug assay [57] and tube-like structure formation ... protein-coding genes contain introns that are removed in the nucleus by RNA splicing and are often alternatively spliced Alternative splicing increases the coding capacity of the genome, generating...

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adobe digital imaging how-tos 100 essential techniques for photoshop cs5, lightroom 3, and camera raw 6

Ngày tải lên : 30/05/2014, 23:16

... primary focus for this chapter The Library module in Lightroom provides robust tools for importing photos; categorizing and applying attributes; comparing similar images in detail; and exporting files ... Adobe training tutorials, including Image Retouching & Adjustment with Photoshop CS5 and Core Lightroom His articles have been featured in photo technique magazine, Photoshop User Magazine, and on ... transmitted in any form by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior written permission of the publisher For information on getting permission for reprints...

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patel, chellapa - sparse representations and compressive sensing for imaging and vision

Ngày tải lên : 05/06/2014, 12:05

... compressive sensing or compressed sensing V.M Patel and R Chellappa, Sparse Representations and Compressive Sensing for Imaging and Vision, SpringerBriefs in Electrical and Computer Engineering, DOI ... allows for imaging in wider swaths and possible reduction in antenna size 3.4 Compressive Passive Millimeter Wave Imaging Interest in millimeter wave (mmW) and terahertz imaging has increased in ... Compressive Sensing for Imaging and Vision, SpringerBriefs in Electrical and Computer Engineering, DOI 10.1007/978-1-4614-6381-8 4, © The Author(s) 2013 41 42 Compressive Sensing for Vision of CS in order...

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báo cáo hóa học:" Comparative study of 64Cu/NOTA-[D-Tyr6,beta-Ala11,Thi13,Nle14]BBN(6-14) monomer and dimers for prostate cancer PET imaging" potx

Ngày tải lên : 21/06/2014, 17:20

... two BBN(6-14) ligands and the chelator In vitro GRPR-binding affinities were determined with competitive binding assays on PC3 human prostate cancer cells In vivo stability and biodistribution ... used lysine side chain or a 6-aminohexanoic acid spacer for their homodimer and obtained promising in vitro results We used one and two PEG spacers between the binding sequences to fine-tune ... 64 Cu/NOTA-dimer after final formulation (green line), 24 h incubation in mouse plasma (red line), h in vivo (blue line), 24 h in vivo (purple line) and free 64Cu (black line) Figure Bio-distributions...

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Báo cáo y học: "Autologous chondrocyte implantation for cartilage repair: monitoring its success by magnetic resonance imaging and histology" ppt

Ngày tải lên : 09/08/2014, 01:21

... meniscus, in contrast, had much staining for types I and III collagens, patchy staining for type II collagen, and a little for type VI collagen Most glycosaminoglycan staining was for chondroitin-4-sulfate, ... poly-Llysine-coated slides and stained with haematoxylin and eosin (H&E) and safranin O (0.5% in 0.1-M sodium acetate, pH 4.6, for 30 s) for general histology, measurement of cartilage thickness, and ... morphology was predominantly hyaline (> 90%) in five of the biopsy specimens and predominantly fibrocartilage in seven, and the remaining 11 biopsy specimens had areas with both hyaline and fibrocartilage...

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Báo cáo khoa học: "Preoperative Y-90 microsphere selective internal radiation treatment for tumor downsizing and future liver remnant recruitment: a novel approach to improving the safety of major hepatic resections" docx

Ngày tải lên : 09/08/2014, 04:21

... treatment that offers meaningful improvement in survival in patients with colorectal cancer liver metastases (CRCLMs) Indications for surgical resection continue to expand An increasing number of patients ... by standard MIRD technique Written informed consent was obtained from the patient for publication of this case report Competing interests The authors declare that they have no competing interests ... portal vein diameter and spleen volume by 12 months after treatment The increase in spleen volume and portal vein size was thought to be due to portal hypertension resulting from scarring within the...

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Báo cáo y học: "Expression of ADAM15 in rheumatoid synovium: up-regulation by vascular endothelial growth factor and possible implications for angiogenesis" ppt

Ngày tải lên : 09/08/2014, 07:20

... cycle was minute at 94°C, minute at 62°C for ADAMs 8, 9, 10, 12, 17, 20, 21, 28 and 30, 67°C for ADAM15, 64°C for VEGFR-1, 63°C for VEGFR-2 and neuropilin-1 and 65°C for β-actin, and minute at ... (Wako Pure Chemical Industries, Osaka, Japan) After washing once in 2× standard saline citrate and twice in 0.2× standard saline citrate and blocking nonspecific binding with blocking solution (DakoCytomation ... in the angiogenesis in RA synovium [13,14] All these VEGF isoforms bind to high-affinity receptors, namely VEGFR-1 (fms-like tyrosine kinase; Flt-1) and VEGFR-2 (kinase insert domain-containing...

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Báo cáo khoa học: "Planning target volume margins for prostate radiotherapy using daily electronic portal imaging and implanted fiducial markers" docx

Ngày tải lên : 09/08/2014, 09:20

... 2a) and the S-I and L-R (Figure 2b) axes Summary statistics are shown in Table 2, in the right-hand columns ("during treatment”) In the figures, any deviation of individual points from the intersection ... a): S-I and A-P axes, and b): S-I and L-R axes Ellipse shows 95% confidence intervals for CTV coverage in each direction PTV margins, from 0.57 cm, 0.79 cm and 0.77 cm to 0.36 cm, 0.37 cm and 0.37 ... C, Herman M, Davis B: Planning target margin calculations for prostate radiotherapy based on intrafraction and interfraction motion using four localization methods Int J Radiation Oncology Biol...

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Báo cáo khoa học: "Value of diffusion weighted MR imaging as an early surrogate parameter for evaluation of tumor response to high-dose-rate brachytherapy of colorectal liver metastase" docx

Ngày tải lên : 09/08/2014, 09:20

... the study and participated in its design and coordination All authors have read and approved the final manuscript Competing interests The authors declare that they have no competing interests ... decreased significantly A slight increase in TV accompanied the decrease in ADC (compare Figures and 6) How may this decrease in mean tumor ADC and increase in TV be explained? Current models of tumor ... are well in agreement with the current understanding of therapy induced changes assessed by DWI: effective anticancer treatment results in tumor lysis, loss of cell membrane integrity, increased...

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Báo cáo khoa học: "Stereotactic body radiotherapy for stage I lung cancer and small lung metastasis: evaluation of an immobilization system for suppression of respiratory tumor movement and preliminary results" ppsx

Ngày tải lên : 09/08/2014, 09:22

... be confirmed with CTguided biopsy in patient, this case was included in the study considering the positive FDG-PET finding and the increase in tumor size during observation period Of the 55 lesions, ... cm, and 52 Gy in fractions for those larger than The tumor movement was defined as increased and decreased when the amplitude in condition B minus the amplitude in condition C or D exceeded - and ... measured setup errors for 40 times in the first 10 patients Absolute setup errors were ≤ mm in 93%, 90% and 78%, and ≤ 10 mm in 100%, 100% and 98% in lateral (right-to-left, RL), AP and craniocaudal...

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Báo cáo khoa học: " Ipsilateral irradiation for well lateralized carcinomas of the oral cavity and oropharynx: results on tumor control and xerostomia" pot

Ngày tải lên : 09/08/2014, 10:20

... promising, these findings require validation in a larger patient cohort, especially for oral cavity cancer 13 14 15 16 Competing interests The authors declare that they have no competing interests ... treated in the adjuvant setting For elective radiotherapy, 50 Gy was administered to the ipsilateral regions at risk of subclinical disease (PTV2), both for radical and postoperative radiotherapy ... cavity cancer Oral cavity cancer Patient with a pT2N0M0 carcinoma of the left lateral border of tongue treated with postoperative radiation therapy for close margin and perivascularperineural invasion...

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Báo cáo khoa học: " Kinetic modeling of tumor growth and dissemination in the craniospinal axis: implications for craniospinal irradiation" pps

Ngày tải lên : 09/08/2014, 10:21

... suspend treatment of the spine temporarily while treatment of the brain continues Since the brain and spine are in communication via the cerebrospinal fluid, holding treatment in one compartment may ... γf and γt, as described above The value for Qf, the volumetric flow rate and the spine and brain CSF volumes are taken from Bergsneider [12] The values used for the volumes of the brain and spine ... kshedNb,t,i+γfkadhNb,f,i)] where Ds and Db are the doses administered in a single fraction to the spinal and brain compartments, respectively Scenario I In this scenario (Figure 3), results following a standard course...

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