interpreting immunotoxicology data for risk assessment

... familiar? Risk wah wah wah risk wah Wah wah risk. ” – Miss Othmar, Peanuts Comics T here’s an ocean of information out there about risk You’re likely already feeling the pull of the tide for internal ... on risk management practices 77% Is the catalyst in forming risk management 48% 14% 38% Has active participation in implementing risk management 45% 20% 35% Participates as part of a formal risk ... in the data if a risk is not being successfully managed? Simply put: 1) Know your risks 2) Test data to ensure risks are identified and managed Also, be aware that what you don’t know is risky...

Ngày tải lên: 18/02/2014, 05:20

... Applica'on  these  ‘intake  or  inges'on’  TEFs  has  limited  toxicological   relevance  and  use for risk assessment  of  environmental  matrices   Aspects  reduced  bioavailability,  environmental ... for  ci*ng  us  although   oSen  with  the  wrong  scien*fic  ra*onale!   2010  Evalua*on   >1500  cita*ons   2010  Evalua*on   ~  500  cita*ons     14-­‐12-­‐11   Use  of  TEFs  and  TEQs for ...  towards  humans  been  less   sensiGve  (2-­‐10  *mes?)  than  rodents     For  DDT  most  countries  are  at  a  “safe  level” for  breasJed   infants         ...

Ngày tải lên: 16/04/2015, 08:52

... experimental setup and execution, methods for data analyses, and the reporting format for the test data Non-standard tests, on the other hand, are tests performed according to any other test method ... non-standard data for risk assessment purposes Method This study is divided into two parts: (1) an evaluation of the usefulness of four methods for reliability evaluation of test data that have ... done within the field of ecotoxicology and risk assessment is financed through tax payer’s money and to not find a way for use of this data in risk assessments would be an inefficient and irresponsible...

Ngày tải lên: 21/06/2014, 03:20

... well as the best fit to these data, with 95% confidence interval The risk assessment and sensitivity analysis for hotspot 1, 2, 3, and total risk are calculated for beta function at the mean ... (2000) While for Usum the level exceed the permitted level by (75) times and for 60Co by (5000) times and for 137Cs by (3850) times and for 90Sr (97) times The skewness coefficient for the distribution ... were analysis for gamma, beta and Alfa spectra Figure Soil samples locations 2.2 Risk Assessment One aspect is to use Crystal Ball (CB) software to simulate the data distribution for the selected...

Ngày tải lên: 05/09/2013, 16:10

... before the Subcommittee on Energy and Mineral Resources, Committee on Natural Resources, House of Representatives Data Management Problems and Reliance on SelfReported Data for Compliance Efforts ... and performance data by (1) reviewing the systems that MMS has in place to help ensure that the data were entered and calculated correctly, and (2) comparing the data to aggregate performance ... responsible for paying the royalties) with production data filed by operators (those responsible for reporting production volumes) • MMS’s compliance efforts not consistently examine data from...

Ngày tải lên: 08/03/2014, 14:20

... symposium equivalent genes for three species for a specific biologic process For risk assessment, gene ontologies provide an outstanding opportunity to use genomic information for cross-species comparisons ... Toxicity-Pathway-Based Risk Assessment: A Symposium Summary Leikauf continued, saying that evaluating genetic factors that affect pharmacokinetics or pharmacodynamics can provide valuable information for risk assessment ... Biographic Information on the Standing Committee on Risk Analysis Issues and Reviews 53 B Biographic Information on the Planning Committee for a Symposium on Toxicity-Pathway-Based Risk Assessment...

Ngày tải lên: 16/03/2014, 14:20

... note 15 35 require interactive data format information for the risk/ return summary? Should we require interactive data format information for any additional information contained in the proposed ... entity77 information? Would this information be useful in interactive data format? • Should we provide an opportunity for mutual funds to submit voluntarily in interactive data format information ... alter the requirements to provide risk/ return summary information with the traditional format filings.49 • Risk/ return summary information in interactive data format would be provided as exhibits...

Ngày tải lên: 16/03/2014, 14:21

... U.S for risk/ return summary information, as approved for use by the Commission.133 Interactive data is required for the entirety of the risk/ return summary information, including information for ... traditional format filing be the same as in the interactive data format.100 We have not changed this equivalency standard for risk/ return summary information provided in interactive data format as ... new ways for investors, analysts, and others to retrieve and use the information For example, users of risk/ return summary information will be able to download cost and performance information...

Ngày tải lên: 16/03/2014, 14:21

... Cataloging-in-Publication Data: Computational toxicology : risk assessment for pharmaceutical and environmental chemicals / edited by Sean Ekins p ; cm – (Wiley series on technologies for the pharmaceutical ... Institute for Bioinformatics, GSF–National Research Centre for Environment and Health, Ingolstädter Landstraße 1, D-85764 Neuherberg, Germany (itetko@vcclab.org) Weida Tong, Center for Toxicoinformatics, ... Agonists and antagonists for adrenocortical hormones have been described Oral contraceptives are risk factors for increased blood clotting and stroke Estrogens are risk factors for breast and uterine...

Ngày tải lên: 12/05/2014, 17:29

... and statistical power (for example, see the study of Wang and Riffel [34]) Also, when compiling information from the literature for a particular parameter for use in a risk assessment, it will remain ... the realism of model simulations, but also of higher tier risk assessments or the use of field studies in risk assessment Therefore, for a detailed evaluation of a population model, it may be ... therefore, the potential impact this uncertainty could have on the output of the model needs to be considered In some cases, not all data needed for a model may be available, for example, data for...

Ngày tải lên: 20/06/2014, 20:20

... and statistical power (for example, see the study of Wang and Riffel [34]) Also, when compiling information from the literature for a particular parameter for use in a risk assessment, it will remain ... the realism of model simulations, but also of higher tier risk assessments or the use of field studies in risk assessment Therefore, for a detailed evaluation of a population model, it may be ... therefore, the potential impact this uncertainty could have on the output of the model needs to be considered In some cases, not all data needed for a model may be available, for example, data for...

Ngày tải lên: 20/06/2014, 20:20

... the format of the data is character or numeric (Other data formats may be used for certain types of data Contact your data source for guidance in reading alternate data formats.) A variable format ... business data such as sales, balances, and minutes, is continuous data Reading Raw Data Data formats are used to read each column or data field in its most useful form The two most common formats ... cases are designed to provide you with ideas for creating your own risk modeling data sets Case 11— Credit Risk for Prospects Case 12— Fraud Risk for Customers AM FL Y High Street Bank has been...

Ngày tải lên: 21/06/2014, 13:20

... Now I have 22 forms of the variable estimated income I have 20 continuous forms and categorical forms I will use logistic regression to find the best form or forms of the variable for the final ... working with various forms of estimated income (inc_est3) I have created three forms for each model: inc_miss, inc_est3, and inc_low These represent the original form after data clean-up (inc_est3) ... powerful, (2) it is straightforward, and (3) it has a lower risk of over-fitting the data Logistic regression is an excellent technique for finding a linear path through the data that minimizes the...

Ngày tải lên: 21/06/2014, 13:20

... then 40 then risk_ adj = 50 then risk_ adj = 60 then risk_ adj = risk_ adj = 1.09; 1.01; 0.89; 0.75; do; 40 then risk_ adj = 1.06; | | | | do; Table 7.1 Average Net Present Value Calculation for Single ... variable transformations for inferred age (infd_ag) This step is repeated for all continuous variables in the model PROC UNIVARIATE creates the decile value (age10) needed for the binary form of age ... sort data = acqmod.audit; by pros_id; run; Finally, I merge each data set containing the transformations back together with the original data set (acqmod.audit) to create acqmod.audit2: data...

Ngày tải lên: 21/06/2014, 13:20

... strongest forms are the natural form, psy_sq and pamsy13 (pamsy < 13) These two forms will be candidates for the final model This process is repeated for the remaining 32 variables The winning transformations ... company information to develop a response model The company also purchased census information with local demographic data for each business on the list To build a response model, the data set ... the limited number of values for pamsy In the next step, I print out the values for the different deciles of pamsy to see why I have only groups: proc print data= psydata; run; Page 214 The following...

Ngày tải lên: 21/06/2014, 13:20

... managing risk Since payment behavior for a loan product is highly correlated with payment behavior for a product or service, Eastern plans to use the bank's data to predict financial risk over ... This step creates two temporary data sets, hr and lr, that are brought together in the final step to create the data set ch10.telco: data ch10.creddata; set ch10.creddata; if bkruptcy = or chargoff ... chargoff = or dayspdue => 90 then highrisk = 1; else highrisk = 0; run; TE data hr lr(where=(ranuni(5555) < 14)); set ch10.creddata; Team-Fly® Page 235 if highrisk = then do; smp_wgt=1; output hr;...

Ngày tải lên: 21/06/2014, 13:20

... can use both transactional data and demographic information as input Jesus Mena, in his book entitled Data Mining Your Website, described clustering analysis on a sample data set of 10,000 records ... transactional data, and demographic information and therefore can greatly contribute to the development of highly effective marketing strategies Market basket analysis is a clustering technique useful for ... history For customers, all of the above data sources could be used as predictors For registered users that are not customers, all but prior purchase history could be used and finally for non-registered...

Ngày tải lên: 21/06/2014, 13:20

... and statistical power (for example, see the study of Wang and Riffel [34]) Also, when compiling information from the literature for a particular parameter for use in a risk assessment, it will remain ... the realism of model simulations, but also of higher tier risk assessments or the use of field studies in risk assessment Therefore, for a detailed evaluation of a population model, it may be ... therefore, the potential impact this uncertainty could have on the output of the model needs to be considered In some cases, not all data needed for a model may be available, for example, data for...

Ngày tải lên: 21/06/2014, 17:20

... database to assess the risk and risk management of pesticides Activity/Output: (1) Complete analysis of data gathered on risk assessment, to produce integrated risk assessment for the catchment (2) ... environmental risk assessment at (1) PHTI July 2002 ELISA technology, risk & site selection (2) UAF July 2002 GC/HPLC validation and risk assessment (3) HUS October 2003 Integrated system Task: Develop risk ... and risk assessment (ii) Workshop (July 2002): demonstration of capacity to apply ELISA technology in field projects at two field sites conducted by UAF and HUS and to perform elementary risk assessment...

Ngày tải lên: 22/06/2014, 13:20

... technique for risk assessment in forestry – for example for the analysis of wind and snow damage (V, F 1999; J, M 2000) or for the occurrence of general forest damage ... be suitable for complex environmental risk assessment using generally available data References B M., L N., S-B H., L B.V (2001): Risk appraisal for forest management ... profound information for knowledge-based forest management While recognizing the aforementioned limitations, the proposed system based on the quantification of qualitative forest management data appears...

Ngày tải lên: 07/08/2014, 10:21