integrins in prostate cancer invasion and metastasis
Báo cáo khoa học: "The Akt-inhibitor Erufosine induces apoptotic cell death in prostate cancer cells and increases the short term effects of ionizing radiation" pot
... inhibitors of the PI3K/Akt pathway in prostate cancer cells Combined effects of ErPC3 and ionizing radiation in prostate cancer cell lines Up to now our data revealed that ErPC3 is a potent inhibitor ... ErPC3, in preclinical and clinical investigations is based on their ability to induce apoptosis in tumor cells and their ability to increase cytotoxic efficacy of chemotherapy and radiotherapy in ... inactivated in a variety of solid human tumors, including prostate cancer Increased levels of PIP3 trigger the recruitment of phosphatidylinositide-dependent serine/threonine kinase (PDK1) and Akt...
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báo cáo hóa học:" Aberrant expression and potency as a cancer immunotherapy target of alpha-methylacyl-coenzyme A racemase in prostate cancer" pptx
... liver and pancreas by immunohistochemical staining In contrast, PSA was stained in both prostate cancer tissue and non-cancerous tissue (Figure 2C) These data indicated that AMACR had a mostly cancer- specific ... Immunostaining of prostate cancer tissue with antibodies against AMACR and PSA Immunostaining of prostate cancer tissue with antibodies against AMACR and PSA Surgically resected prostate cancer tissue ... was detected in three prostate cancer cell lines (LNCaP, DU145 and PC-3) C Expression of AMACR in cancer tissues and noncancerous tissues from surgical specimens of two prostate cancer cases...
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Báo cáo hóa học: " Ezrin promotes invasion and metastasis of pancreatic cancer cells" ppt
... of ezrin in intercalated duct cells, the tubular complexes of CP and PanINs (A) Staining of ezrin in the intercalated duct cells in the paraneoplastic tissues (B-D) Ezrin-positive staining in the ... cells, such as increased protrusions and microvilli Ezrin overexpression inducing Erk1/2 activation The results described above indicate that ezrin is involved in the motility and invasion of MiaPaCa-2 ... lesions (n = 34) and CP (n = 28) were assessed and graded in the pancreatic tissues adjacent to the tumor in hematoxylin and eosin-stained slides Immunostaining for ezrin was performed using the primary...
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Báo cáo khoa học: "Early prediction of response to radiotherapy and androgen-deprivation therapy in prostate cancer by repeated functional MRI: a preclinical study" pptx
... training, testing and validating the network showed curve flattening after a few training epochs, this indicated that no overtraining occurred However, if such a model is to be applied on clinical ... preclinical study in prostate cancer xenografts, and suggest that the combination of functional MRI parameters, in addition to standard clinical parameters, increases the power of predicting therapeutic ... prediction, wherein different pre-treatment and early in- treatment functional imaging parameters may be combined with standard clinical parameters in order to increase the prediction of how individual...
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Báo cáo khoa học: "The evolution of rectal and urinary toxicity and immune response in prostate cancer patients treated with two three-dimensional conformal radiotherapy techniques" ppt
... becoming one of the most significant issues in treatment decision-making, in general, and more so in prostate cancer [1] Thus late rectal and urinary damage became a major concern in prostate cancer; ... radiotherapy-irradiation of prostate, seminal vesicles, and lymph nodes followed by a prostate boost (116 patients, 59%); and prostate- only (PO) radiotherapy-irradiation of prostate and seminal vesicles (81 ... volume and critical normal structure definition Treatment planning and irradiation were performed with the patients in supine position (using knee and ankle supports) with an emptied rectum and...
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Báo cáo khoa học: "In vitro studies on the modification of low-dose hyper-radiosensitivity in prostate cancer cells by incubation with genistein and estradiol" pot
... several protein tyrosine- and histidine kinases [810], and inhibits topoisomerase I and II [11] These effects result in alterations of several intracellular and extracellular pathways including cell ... radiosensitivity in the androgen independent PC cell line PC-3 has been demonstrated in vitro and in vivo [26,27] Our study analyzes the interactions of irradiation and genistein or estradiol incubation in androgen ... anti -prostate cancer activity in vitro and in vivo Clin Cancer Res 2004, 10:5282-5292 Ouchi H, Ishiguro H, Ikeda N, Hori M, Kubota Y, Uemura H: Genistein induces cell growth inhibition in prostate...
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Báo cáo khoa học: "Acute and late toxicity in prostate cancer patients treated by dose escalated intensity modulated radiation therapy and organ tracking" pps
... Kemmerling L, Born EJ, Mini R, Greiner RH, Aebersold DM: Daily organ tracking in intensitymodulated radiotherapy of prostate cancer using an electronic portal imaging device with a dose saving acquisition ... abdomen and pelvis and a total-body bone scan When clinically indicated a chest x-ray and/ or thoracic CT was performed Based on these examinations clinical staging was defined according to the ... summarized in Table Incidence of single symptoms (diarrhea, rectal pain, rectal bleeding) as well as the highest toxicity occurred in a given patient concluding all single symptoms but counting only...
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Báo cáo khoa học: " Potentials of on-line repositioning based on implanted fiducial markers and electronic portal imaging in prostate cancer radiotherapy" docx
... 23 patients) in Table and the mean standard deviations (mean random error) in Table Then, we determined means and standard deviations from control EPIs for each patient resulting in the same error ... values10%variability, prostate line), format, Measured deviations in and Measured deviations in LR, SI and AP directions in a box plot format, showing the mean values (black squares), the median values (lines in ... issue indicate that a 3mm planning target margin is in most cases sufficient to account for intrafractional motion [39] Both uncertainties, setup error and target motion can be split into random and...
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báo cáo khoa học: " XAF1 expression and regulatory effects of somatostatin on XAF1 in prostate cancer cells" docx
... somatostatin and Octreotide in prostate cancer cell lines To examine the regulatory effects of somatostatin and Octreotide on XAF1 mRNA and protein expression, prostate cancer cell lines (LNCaP, ... somatostatin indicates a promising strategy for prostate cancer therapy Materials and methods Cell lines and cell culture A human prostate epithelial cell line (RWPE-1) and prostate cancer cell lines ... in prostate cancer cell lines We found that somatostatin and Octreotide up-regulated XAF1 mRNA and protein expression in prostate cancer cell lines The enhanced XAF1 expression by somatostatin...
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Báo cáo y học: "Identification of candidate predictive and surrogate molecular markers for dasatinib in prostate cancer: rationale for patient selection and efficacy monitoring" doc
... with prostate cancer invasion, metastasis and poorer survival in prostate cancer [36,37] and its value as a prognostic marker has been well established in breast cancer [38,39] We found in our ... JS: RNA interference-directed knockdown of urokinase plasminogen activator and urokinase plasminogen activator receptor inhibits prostate cancer cell invasion, survival, and tumorigenicity in vivo ... targeted therapeutics for prostate cancer candidate predictor of efficacy in both prostate and breast cancer Finally, the observed sensitivity to dasatinib of prostate cancer cell lines with expression...
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CHEMICAL AND BIOLOGICAL CHARACTERIZATION OF TRACE AMOUNT OF SEX HORMONE RECEPTOR ACTIVE COMPOUNDS IN PROSTATE CANCER RELATED BIOLOGICAL SAMPLES
... Occurrence of Prostate Cancer (PCa) in Men 2-3 1.2 Prostate and its Importance 1.3 Signs & Symptoms and Detection of Prostate Cancers 1.4 Treatment Options for Prostate Cancer 1.4.1 Hormone or Androgen ... 113 4.2.1.4.6 Standardisation via checking on β-actin 114 4.2.2 Determination of Saturating Doses of Known AKR1C3 Inhibitor and Dimethoxycurcumin and its Potential as AKR1C3 Enzyme Inhibitor 4.2.2.1 ... using non-androgenic ligands such as estrogens for activation also seemed to play a role in maintaining proliferation of these cells AKR1C3 is the critical enzyme to synthesise T and DHT in prostate...
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Prostate cancer: diagnosis and treatment docx
... unit and Surveillance (WCISU) Between 1996 and 2004 the age standardised incidence rate of prostate cancer increased in all cancer networks in England and Wales1 In England the average increase ... evidence incorporating health economic evidence distilling and synthesising the evidence and writing recommendations agreeing the recommendations structuring and writing the guideline updating the ... risks (including the increased chance of having to live with the diagnosis of clinically insignificant prostate cancer) and benefits of prostate biopsy If the clinical suspicion of prostate cancer...
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Prostate cancer - Diagnosis and treatment pot
... used in this guideline .38 Introduction Prostate cancer is one of the most common cancers in men Every year there are 34,986 new cases in England and Wales and 10,000 deaths Prostate cancer ... (including the increased chance of having to live with the diagnosis of clinically insignificant prostate cancer) and benefits of prostate biopsy 1.2.3 If the clinical suspicion of prostate cancer ... (for example, UK Prostate Link – www .prostate- link.org.uk), local and national cancer information services, and from cancer support groups 1.1.4 Before choosing or recommending information resources...
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European guidelines for quality assurance in breast cancer screening and diagnosis pot
... continuing advances in technical and professional knowledge Certain principles remain just as important in diagnosis as they are in screening Training, multidisciplinary teamwork, monitoring and ... screening should be established in line with the routine screening interval, taking into consideration that most programmes not succeed in keeping the routine screening interval for each individual ... screening should be established in line with the routine screening interval, taking into consideration that most programmes not succeed in keeping the routine screening interval for each individual...
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ADVANCES IN PROSTATE CANCER docx
... Integrins in Prostate Cancer Invasion and Metastasis 619 Paulynn Chin Suyin, Joanne Louise Dickinson and Adele Frances Holloway Chapter 26 The Role of E-Cadherin-Catenin Complex in Prostate Cancer ... of all prostate cancer cases The risk of getting prostate cancer increases nearly exponentially with increasing age This makes prostate cancer one of the most distinctive cancers in aging popu‐ ... Stovall and Guangchao Sui Chapter 24 The Role of PARP Activation in Prostate Cancer 589 Luis A Espinoza VII VIII Contents Section Cell Adhesion Proteins in Prostate Cancer 617 Chapter 25 Integrins in...
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prostate cancer, methods and protocols
... serial reinjection into the prostate of prostate cancer cell lines or by growing Human Prostate Cancer 23 Table Profile of Established Human Prostate Cancer and Immortalized Cell Lines Cell line PC-93 ... carcinoma Int J Cancer 29, 611–616 Giles, G G and Ireland, P (1997) Diet, nutrition and prostate cancer Int J Cancer 74, 1–5 Smith, D P and Armstrong, B K (1998) Prostate- specific antigen testing ... human-papillomavirus infection and risk of prostate cancer Int J Cancer 75, 564–567 60 Rotkin, I D (1977) Studies in the epidemiology of prostatic cancer: expanded sampling Cancer Treatment Reports...
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báo cáo hóa học:" Can urinary exosomes act as treatment response markers in prostate cancer?" ppt
... produced by LNCaP -prostate cancer cell line Prostate cancer cell lines (LNCaP and DU145), as indicated, were maintained in culture as a source of positive-control prostate cancer exosomes (for ... loading Bands for prostate- derived proteins PSA or PSMA were evident in patients (p1, p7, p8, p9, p10), indicating that at least some of the exosomes present in the urine were of prostate origin ... advances are being made in understanding the biology underlying this disease, and in many respects in its treatment, there remains a need for better tools for PCa diagnosis and monitoring Disease-related...
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Báo cáo sinh học: " Downregulation of APOBEC3G by Xenotropic Murine Leukemia-Virus Related Virus (XMRV) in Prostate Cancer Cells docx
... in prostate epithelial cell lines specifically in LNCaP cells [3,18] In addition, the prostate cancer cell line 22Rv1 has been shown to be chronically infected with XMRV and produces highly infectious ... replicate in these cells Findings This report builds on and challenges the published data on the absence of A3G protein in prostate epithelial cells lines We demonstrate the presence of A3G in prostate ... immunoblotting using anti-ApoC29 to assist in A3G identification in the gel for mass spectrometry The gel bands corresponding to A3G protein were excised and were subjected to in- gel trypsin digestion...
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Báo cáo sinh học: " Prostate transglutaminase (TGase-4) antagonizes the anti-tumour action of MDA-7/IL-24 in prostate cancer" potx
... TGase-4 and MDA-7/IL-24 in prostate cancer cells We have stained MDA-7 in prostate cancer cells Shown in Figure 5A, PC-3 wild type cells stained for MDA-7, mostly in the cytosolic region and perinucleus ... TGase-4 is linked to the invasiveness of prostate cancer cells [12] and participates in the regulation of the interactions between prostate cancer cells and endothelial cells, the later involving the ... co-localize in normal and malignant human prostate tissues Shown in Figure (B, C and D), strong staining of TGase-4 was seen in the matrix and epithelial cells Prostate tissues also showed staining of...
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