insulin resistance syndrome in older people

... circulating aspirin esterase activities are mainly due to butyrylcholinesterase (BChE, pseudocholinesterase) and, in part, to albumin (6) Because of higher aspirin esterase activity leading to ... frailty Age Ageing 1990; 19: 128-30 12 Singh S, Nain CK, Verma M, et al Aspirin esterases in North-West Indians: the influence of age and nutrition Int J Clin Pharmacol Ther 2000; 38: 315-9 http://www.medsci.org ... has reported aspirin esterase activity to be increased in type diabetics and has shown the association to be modulated by circulating lipid metabolism (6) In addition, aspirin resistance has been...

Ngày tải lên: 26/10/2012, 09:39

... OF N URSI NG Settings Five trials reported the effect of interventions in A&E settings In two trials, the intervention was initiated within a hospital setting and continued in the community Two ... OF FALLS IN OLDER PEOPLE concealed (Crotty 2002; Ebrahim 1997; Rubinstein 1990; Shaw 2003) In the remaining five studies, information was inadequate to judge concealment (Close 1999; Kingston ... disability and the leading cause of mortality resulting from injury in people aged above 75 in the UK (Scuffham & Chaplin 2002) Furthermore, more than 400,000 older people in England attend accident...

Ngày tải lên: 28/03/2014, 16:20

... fronto-parietal networks by incrementing demand in a working memory task Cereb Cortex 1997, 7:465-471 Klingberg T: Limitations in information processing in the human brain: neuroimaging of dual task performance ... adults[6,7] Since a seminal study demonstrated that the inability to maintain a conversation while walking is a marker for future falls in older adults[8], walking while performing a secondary ... Washington, DC 4th edition 2000 Lawton MP, Brody EM: Assessment of older people: self-maintaining and instrumental activities of daily living Gerontologist 1969, 9:179-186 Morris JC: The Clinical...

Ngày tải lên: 19/06/2014, 08:20

... the following symptoms?" followed by a checklist including back/neck pain, hip pain, hand/wrist pain, knee/leg pain and foot pain Those who reported foot pain were then requested to indicate the ... between calcaneal spurs, heel pain, obesity, foot posture and osteoarthritis in a sample of older people In doing so, our objective was to provide further insights into the aetiology of calcaneal ... are over-represented in particular subgroups, including older people [3,5,8,9], females [4,5,7], people with osteoarthritis [3,9] and people with previous or current heel pain [2,4,6,10,11] The...

Ngày tải lên: 10/08/2014, 21:23

... have a broader affect on an individual A simple method for rating the severity of hallux valgus in the clinical setting is the Manchester Scale [21] This rating scale incorporates four comparative ... was to determine the association between the clinical appearance of hallux valgus (using the Manchester Scale) to the radiographic observations of hallux valgus in older people In addition, the ... cases Despite these limitations, these findings indicate that clinical observation of hallux valgus using the Manchester Scale provides useful insights into the progressive nature of the condition,...

Ngày tải lên: 10/08/2014, 21:24

... recruitment) Finally, all people visiting the general practice (for any reason) will be informed about the study by putting up posters in the waiting area of the GP clinics inviting patients to ... forefoot pain intensity scored by the participant on an 11-point pain numerical rating scale (PI-NRS, where = no pain and 10 = worst possible pain), foot function using the point Foot Function Index ... disabling foot pain Pain 2000, 85:107-113 18 Roddy E, Muller S, Thomas E: Defining disabling foot pain in older adults: further examination of the Manchester Foot Pain and Disability Index Rheumatology...

Ngày tải lên: 10/08/2014, 21:24

... mass index; CV: coefficient of variation; DXA: dual energy x-ray absorptiometry; IFN-γ: interferon-γ; IL-1β: interleukin-1β; IL-1α: interleukin-1α; IL-6: interleukin-6; JSN: joint-space narrowing; ... Burgess J, Jones G: Circulating levels of inflammatory markers predict change in bone mineral density and resorption in older adults: a longitudinal study J Clin Endocrinol Metab 2008, 93:1952-1958 ... IL-6, interleukin-6; CI, confidence interval; JSN, joint-space narrowing; BMI, body mass index; WHR, waist-to-hip ratio has been shown for IL-6 [29,55]; such an effect, if any, could explain in...

Ngày tải lên: 12/08/2014, 14:21

... analysis, suggesting a link between IMT, insulin resistance and dyslipidemia Insulin resistance is a common phenomenon and plays an important role in the cardio-cerebrovascular disease in obese population ... Short-term overeating induces insulin resistance in fat cells in lean human subjects Mol Med 2009; 15:228-34 Atabek ME, Pirgon O, Kivrak AS Evidence for association between insulin resistance and ... population [17,18] In our study, the obese and MetS group both demonstrated increased fasting insulin than control group rather than fasting blood glucose Meanwhile, fasting insulin and HOMA-IR levels...

Ngày tải lên: 25/10/2012, 11:40

... characterized by insulin resistance, and thus the inability of insulin to stimulate glucose utilization in skeletal muscle It has been proposed that insulin resistant individuals have a defect in GLUT4 ... immunohistochemistry In contrast, we did not find a significant increase in GLUT4 expression after resistance training This finding was also confirmed by immunohistochemistry, showing GLUT4 containing vesicles ... human SGLT3, an insulin- independent glucose transport system in skeletal muscle with resistance exercise training hSGLT3 action appears to be independent of the well known GLUT4, insulin- dependent...

Ngày tải lên: 31/10/2012, 17:08

... for older people in residential or nursing homes 41 Table Nutritional guidelines for community meals for older people 44 Table Example menus for older people living in residential or nursing ... protect against cataracts.60 Higher intakes of some nutrients including protein, vitamin A, carotenoids, vitamin C, niacin, thiamin and riboflavin during adulthood have been suggested as being protective ... cancer includes choosing a diet rich in plant-based foods, eating plenty of vegetables and fruits and choosing foods low in salt and fat In addition, maintaining a healthy body weight, drinking...

Ngày tải lên: 13/02/2014, 18:20

... older people, for example, those with physical or learning disabilities, those on very low incomes or living in social or rural isolation, including older people from minority ethnic groups In ... health? Maintaining mental wellbeing • sleep as an activity • keeping mentally active • memory Maintaining physical wellbeing • nutrition • pain • keeping physically active Occupation in the home ... (including older people from minority ethnic groups) How does the effectiveness of interventions depend on the characteristics of those delivering the intervention, the involvement of older people in...

Ngày tải lên: 05/03/2014, 18:20

... model assessment of insulin resistance (HOMA-IR) index (calculated from fasting glucose and fasting insulin levels: fasting glucose · fasting insulin ⁄ 22.5) was decreased in both HFD-O mice and ... is implicated in insulin resistance As shown in the present study, palmitic acid indeed impaired insulin signaling in C2C12 cells, which is in line with numerous studies addressing the effect ... Protein name Protein TSC21 (Testis-specific conserved protein of 21 kDa) Calreticulin Thioredoxin domain-containing protein precursor Prohibitin Tubulin beta-5 chain Tubulin alpha-1C chain 60...

Ngày tải lên: 06/03/2014, 09:22

... reduce postoperative insulin resistance Insulin resistance in type diabetes Tyrosine phosphorylation of the insulin receptor increased over the same concentration range of insulin in cells from patients ... sensitivity to insulin was invariably improved The fact that even minor surgery produces insulin resistance [8] indicates that it is difficult to obtain control tissue to study traumainduced insulin resistance, ... incubated with indicated concentration of insulin for 10 Mean ± SE, n ¼ subjects In this and the following figures, the insulin- stimulated effect was obtained by setting the value with no insulin to 0%...

Ngày tải lên: 07/03/2014, 16:20

... frail older people [55,56], our findings underscore the need for research along this line employing also QOL measures such as the OPQOL Page of 10 Conclusions In an older outpatient population in ... Activities of Daily Living (BADL) (i.e transferring, eating, bathing, dressing, toileting, continence) [24] Comorbidity was assessed by means of the Cumulative Illness Rating Scale morbidity (CIRS-m) ... communitydwelling older persons in two studies - one in Taiwan [18] and the other in Spain [19] - but this association was not adjusted for the frailty syndrome [18,19] An Italian longitudinal study...

Ngày tải lên: 20/06/2014, 15:20

... (HOMA), using the following formula: insulin (µU/ml) × glucose (mmol/l)/22.5 Insulin sensitivity was estimated using the Quantitative Insulin Sensitivity Check Index (QUICKI), using the following formula: ... in IA patients with insulin resistance and/or dyslipidemia, the use of DMARD in combination with dietary intervention was associated with a marked improvement in insulin resistance and sensitivity, ... Homeostatis Model Assessment for Insulin Resistance; LDL, low-density lipoprotein; NSAID, nonsteroidal anti-inflammatory drug; QUICKI, Quantitative Insulin Sensitivity Check Index; RA, rheumatoid arthritis...

Ngày tải lên: 09/08/2014, 06:22

... capable of triggering TLR4 signaling by trasducing production of proinflammatory markers in macrophages, adipocytes, and liver leading to insulin resistance Insulin resistance is a main pathological ... obesity and insulin resistance Diabetes 2007, 56:1986-1998 Shi H, Kokoeva MV, Inouye K, Tzameli I, Yin H, Flier JS: TLR4 links innate immunity and fatty acid-induced insulin resistance J Clin Invest ... the intestinal barrier allowing translocation of microbial products leading to the activation of TLR4 independent pathways associated with inflammation, dyslipidemia, hyperinsulinemia, insulin resistance, ...

Ngày tải lên: 11/08/2014, 03:20

... research findings in research reports, they will not use research findings in practice Being aware of relevant research is the first stage in implementing findings according to Rogers' Innovation-Decision ... Wallin L: Registered nurses' use of research findings in the care of older people Journal of clinical nursing 2008, in press: Wallin L, Bostrom AM, Wikblad K, Ewald U: Sustainability in changing ... working in hospitals In the care of older people RNs have a supervising role, performed through visiting the clients/patients in their home, making assessments, planning care, and evaluating...

Ngày tải lên: 11/08/2014, 05:21

... capable of triggering TLR4 signaling by trasducing production of proinflammatory markers in macrophages, adipocytes, and liver leading to insulin resistance Insulin resistance is a main pathological ... obesity and insulin resistance Diabetes 2007, 56:1986-1998 Shi H, Kokoeva MV, Inouye K, Tzameli I, Yin H, Flier JS: TLR4 links innate immunity and fatty acid-induced insulin resistance J Clin Invest ... the intestinal barrier allowing translocation of microbial products leading to the activation of TLR4 independent pathways associated with inflammation, dyslipidemia, hyperinsulinemia, insulin resistance, ...

Ngày tải lên: 11/08/2014, 06:22

... Dexamethasone-induced insulin resistance shows no gender difference in healthy humans Diabetes Metab 2004, 30:321-6 Saad MJ, Folli F, Kahn CR: Insulin and dexamethasone regulate insulin receptors, insulin ... Results in BioMedicine 2006, 5:14 Median (interquartile range) are shown A decrease in HOMA-S and ISI is indicative of a reduction in insulin sensitivity * Changes in insulin sensitivity in this ... variation in dexamethasone induced insulin resistance [16] Hence, this disordered NEFA metabolism reported with dexamethasone-induced insulin resistance may be consequential of changes involving signal...

Ngày tải lên: 11/08/2014, 08:20

... of insulin action but not insulin signaling in human skeletal muscle is reduced by exercise Diabetes 2002, 51:583-590 69 Yu S, Castle A, Chen M, Lee R, Takeda K, Weinstein LS: Increased insulin ... skeletal muscle insulin resistance and developmental genes Given the chronic nature of skeletal muscle insulin resistance in diabetes and the role of satellite cells in maintaining long-term physiological ... human microarray studies examining insulin resistance in skeletal muscle paint a remarkably similar picture - one of no striking change in protein coding mRNA abundance In the Patti et al study [2],...

Ngày tải lên: 11/08/2014, 12:20