... binding to human TK1 In the first crystal structure of TK1-type enzymes of human and mycoplasmic origin [14], the feedback inhibitor dTTP was bound in the substrate pocket, similar to the binding ... hTK1 at serine 13 has been proposed to be involved in this regulation, preventing ATP-induced transformation to the highactive tetramer [13] 572 The structure of human TK1 was solved in 2004 [14], ... Valine, not methionine, is amino acid 106 in human cytosolic thymidine kinase (TK1) Impact on oligomerization, stability and kinetic properties J Biol Chem 275, 32187–32192 Frederiksen H, Berenstein...
Ngày tải lên: 18/02/2014, 12:20
... development [24] Heparin-like glycosaminoglycans that contain galactose and N-acetylgalactosamine residues are involved in the wingless signaling [25] The DmUGT protein was localized in the Golgi region ... nucleotide sugars To identify the transport substrate of DmNST, a DNA fragment containing the entire coding region was ampli®ed by PCR and inserted into the expression vector pMKIT-neo utilizing the EcoRI ... system HA-tagged DmUGT cDNA was inserted into the copperinducible yeast expression vector pYEX-BESN and transfected into S cerevisiae YPH500, and a transformant was obtained We prepared the microsomes...
Ngày tải lên: 21/02/2014, 15:20
Conclusion - In praise of human rights nihilism
... emotionally intense I used to tell them that 275 276 Who Believes in Human Rights? I was hoping that they would remember our class discussions when, in the future, they might be in a position to make ... ‘system of persuasion’, a ‘kind of rhetoric’, an ‘expression of the will to power – even to domination – of those making the [human rights] truth-claims over those who are being addressed by them’.21 ... aspect’.24 In his view, realism’s barrenness needs to be corrected by its contrary, utopianism.25 In his words, [T]he realist, in denying any a priori quality to political [values], and in proving them...
Ngày tải lên: 01/11/2013, 10:20
HUMAN PAPILLOMAVIRUS AND RELATED DISEASES – FROM BENCH TO BEDSIDE A DIAGNOSTIC AND PREVENTIVE PERSPECTIVE potx
... applied In last years, RT-PCR is being introduced in clinical microbiology laboratories 3.3 Full spectrum genotyping About 40 different HPV types (involved in human genital infections) have been ... possible to distinguish the various types [74, 76] In any case, genotyping is a technology that has to be incorporated in the HPV surveillance Waiting for massive sequencing, now the most promising ... and Related Diseases – From Bench to Bedside A Diagnostic and Preventive Perspective Addition of new technologies into existing, highly efective screening programs are considered according to...
Ngày tải lên: 08/03/2014, 19:20
HUMAN PAPILLOMAVIRUS AND RELATED DISEASES – FROM BENCH TO BEDSIDE RESEARCH ASPECTS pdf
... cancer have been proposed, including vaccination in younger women and improved HPV screening in older women (25) Two HPV vaccines have been generated from the recombinant L1 protein into non-infectious ... 22% 26 Human Papillomavirus and Related Diseases – From Bench to Bedside – Research Aspects Table Incidence of HPV infection related to ICC, HSIL and LSIL in China, Hong Kong and Taiwan Human ... cervical cancer in Taiwan (15) As shown in Table 4, the frequency of HPV in HSIL, ICC, and CIN3 samples is higher than in ASCUS, LSIL, CIN1, and CIN2 In Beijing, 85.7% of CIN3 patients have been diagnosed...
Ngày tải lên: 27/06/2014, 13:20
HUMAN PAPILLOMAVIRUS AND RELATED DISEASES – FROM BENCH TO BEDSIDEA CLINICAL PERSPECTIVE potx
... have been proposed to explain this p53 inactivation: The first is inhibiting the binding of p53 to its target sequence in the genome; second, E6 may be able to inhibit p53 signaling by maintaining ... 2007) In addition to increasing the expression of hTERT, E6 also interacts with other proteins involved in maintaining chromosomal stability within the HPV-infected cell, for example, the minichromosome ... domain (Tungteakkhun et al., 2008), it is possible that other E6 proteins may inhibit these extrinsic pathways HPV E6 proteins have been shown to inhibit intrinsic apoptotic pathway binding to...
Ngày tải lên: 27/06/2014, 15:20
Báo cáo y học: "Midregional pro-Adrenomedullin in addition to b-type natriuretic peptides in the risk stratification of patients with acute dyspnea: an observational study" ppt
... Beta-blockers 39 Angiotensin-converting enzyme inhibitor/Angiotensin-II-receptor blockers 49 Loop diuretics 52 Calcium antagonists 18 Digoxin Spironolactone Laboratory findings Serum creatinine, ... Autocrine/ paracrine role of inflammation-mediated calcitonin generelated peptide and adrenomedullin expression in human adipose tissue Endocrinology 2005, 146:2699-2708 Hirata Y, Mitaka C, Sato ... seems to be even better than the natriuretic peptides regarding short-term mortality • MR-proADM used in addition to natriuretic peptides helps to better risk stratify patients Competing interests...
Ngày tải lên: 13/08/2014, 18:22
In order to become competent in a foreign language
... According to Thomas (1998) a speaker can say one thing and manage to mean something else or something more by exploiting the fact that he may be presumed to be cooperative, in particular, to be ... should be guided to effectively communicate by using various kinds of questioning and responding strategies They should be trained how to negotiate the utterance meaning in a conversation, how to ... must be consistent with certain beliefs and behaviors For example to offer a guest a drink at a party, you need to be the host (or otherwise have the right to make the offer) and there needs to be...
Ngày tải lên: 09/04/2013, 08:49
In order to become competent in a foreign language, it is important for language learners not only to acquire new vocabularies and a new set of phonological and syntactic rules but also to learn what Wilson (1986)
... môi trường hoàn to n Sinh hoạt sản xuất Nam Bộ gắn bó với đổi thay, biến động nước, dòng sông thủy triều Những biểu văn minh sông nước thể rõ phương thức lao động, nhòp sống sinh hoạt, tín ngưỡng, ... ngữ to n dân đòa phương cụ thể với nét khác biệt so với ngôn ngữ to n dân hay với phương ngữ khác “[8; 24] Ở đây, thấy cần phân biệt ngôn ngữ to n dân phương ngữ Phương ngữ biến thể ngôn ngữ to n ... lớn nước Ven biển có rừng ngập mặn rộng lớn Từ Cà Mau đến Kiên Giang có rừng nguyên sinh U Minh Thượng, U Minh Hạ Rừng có nhiều loài động thực vật quý Hình ảnh quen thuộc sân chim, kèo ong, sếu...
Ngày tải lên: 17/04/2013, 16:09
Báo cáo y học: "Burns: learning from the past in order to be fit for the future" pps
... Prevention of inadequate perfusion, due to burn fluid loss, remains the top priority for initial management Advances in fluid management have led to a marked decrease in fatal burn shock and its related ... challenge concerning resuscitation is to provide enough fluid to maintain perfusion without causing overload [3,12,13] Without effective and rapid intervention, hypovolemia will develop A delay in fluid ... physiologic endpoints such as urinary output and other measurements, so the trend in burn resuscitation is shifting the focus from fluid formulas to adequate endpoint monitoring, edema control...
Ngày tải lên: 13/08/2014, 20:21
báo cáo hóa học:" Imprisoned and imperiled: access to HIV and TB prevention and treatment, and denial of human rights, in Zambian prisons" ppt
... and Human Rights Watch prior to undertaking this study, and all interviewers were trained in human participant protection and information security The study protocol, including detailed information ... care In addition to calling upon, and supporting, Zambia to respect its human rights obligations to prisoners, international donors should examine their own portfolios of health grant-making International ... periods before being tried, a phenomenon confirmed by additional human rights monitors [18] Two inmates reported having been held on remand for six years [inmates Elijah and Mumba at Mukobeko Maximum...
Ngày tải lên: 20/06/2014, 08:20
báo cáo khoa học: "Local suffering and the global discourse of mental health and human rights: An ethnographic study of responses to mental illness in rural Ghana" pptx
... Another man was chained to a log to prevent him from preaching loudly during the night and attempting to stop speeding traffic In a few cases, some informants reported being injured by their relative, ... brother had to be restrained by seven men in order to bring him to the shrine for treatment This family paid the police who used their handcuffs to restrain the man and bring him to the shrine in a ... and healing practitioners within rural communities in Ghana, to gain an understanding of how practices such as the chaining and beating of those with mental illness are embedded within sociocultural...
Ngày tải lên: 11/08/2014, 14:21
The road from principles to practice todays challenges for business in respecting human rights
... Defining human rights in relation to business In this report, and the online survey underlying it, some questions refer to human rights in the context of 11 clusters, or areas of activity In the ... is to learn in a very complex field The road from principles to practice: Today’s challenges for business in respecting human rights Introduction An inescapable encounter A rapid increase in ... communications business He says that the key to embedding human rights thinking across his company has been to understand the importance of those rights to the firm’s stated overarching mission, to “transform...
Ngày tải lên: 04/12/2015, 00:23
Cambridge.University.Press.Who.Believes.in.Human.Rights.Reflections.on.the.European.Convention.Oct.2006.pdf
... rights belong to every human being in every human society: all human beings have them, equally and in equal measure Implied in one’s humanity, human rights are generally presented as being inalienable ... human rights Human rights as an article of faith According to a standard definition, human rights are those rights one has by virtue of being human. 1 This definition suggests that human rights belong ... rights, or because human rights cannot be what they are said to be, making the concept invalid In other words, critiques of human rights can either require human rights to be true to their word or...
Ngày tải lên: 21/09/2012, 11:02
Introduction of Who Believes in Human Rights
... rights, or because human rights cannot be what they are said to be, making the concept invalid In other words, critiques of human rights can either require human rights to be true to their word or ... experience of human rights violations is confined to being served a bad bottle of wine In the process, human rights have been turned from a discourse of rebellion and dissent into that of state ... scathing than Bentham in his critique of human rights While he did not regard human rights as a panacea, Marx Who Believes in Human Rights? nonetheless welcomed their introduction as a step towards...
Ngày tải lên: 01/11/2013, 10:20
The human rights creed in four schools
... believe in, but are committed to, human rights: The deliberative scholars Natural and protest scholars believe in human rights Deliberative scholars are committed to human rights without believing in ... see injustice (human rights abuses) and want to fight it This is the more so since they are inclined to consider human society globally, taking into account North-South 243 244 Who Believes in Human ... no rest Because human rights cannot be reserved to a few, uninterested in the fate of others,19 it follows that nothing could be more demanding than to attempt to follow the human rights inspiration...
Ngày tải lên: 01/11/2013, 10:20
Tài liệu Embedding Human rigHts in business Practice iii ppt
... effective in managing human rights risks and realizing business opportunities from supporting human rights? How can companies ensure that respect for human rights is incorporated into day-today business ... corporate responsibility is to respect human rights, that is, not to infringe human rights OMV subscribes to the concept of respecting human rights and remedying human rights abuses, but it also ... to offer information on its own culture to host country staff The human rights e-learning tool, to be introduced in 2009, will help to ensure that every OMV staff member is trained on human rights...
Ngày tải lên: 18/02/2014, 00:20
HUMAN RIGHTS AND GENDER EQUALITY IN HEALTH SECTOR STRATEGIES pdf
... A GETTING TO KNOW THE TOOL A GETTING TO KNOW THE TOOL HUMAN RIGHTS AND GENDER EQUALITY IN HEALTH SECTOR STRATEGIES – HOW TO ASSESS POLICY COHERENCE GETTING TO KNOW THE TOOL A A GETTING TO KNOW ... human rights of women and girls are inalienable, integral and indivisible parts of universal human rights and that the equal status and human rights of women should be integrated into the mainstream ... guidance to interventions and processes Key human rights principles in relation to health are the following: • The principle of equality and non-discrimination All individuals are equal as human beings...
Ngày tải lên: 05/03/2014, 13:20
Human Rights Related Trade Measures under International Law potx
... Linking Trade and Human Rights United States Treaty Linkage of Trade and Human Rights European Union – Mechanisms Linking Trade and Human Rights European Union Regulations Linking Trade and Human ... Rights Holders of Human Rights under International Law Individual and Group Human Rights Corporations and Human Rights Addressees of Human Rights Obligations under International Law States, Individuals ... Chapter Developing States, the WTO and Human Rights Related Trade Measures Trade Related Intellectual Property Rights, Agriculture and Human Rights Developing States and the Human Right to Health...
Ngày tải lên: 07/03/2014, 10:20
Can’t Shake that Feeling: Event-Related fMRI Assessment of Sustained Amygdala Activity in Response to Emotional Information in Depressed Individuals pptx
... the beginning of the trial To simulate the pretrial interval the network’s input was set to a mask of noise To simulate the presentation of a stimulus, input was set to a single input unit being ... minutes to hours Potentially, the same mechanisms underlying sustained processing, which begin in the seconds following emotional information, are involved in the experience of depressive rumination ... subscales for thinking about depressive affect in relation to a negative event [MRQ-Emots], thinking about what can be done in response to it [MRQ-Inst], and searching for meaning in the event [MRQ-Srch];...
Ngày tải lên: 07/03/2014, 17:20