insights from comparative genomics of parasitic protozoan

... nouns Spectrum of DSNs Spectral analysis refers to the systematic study of the eigenvalues and eigenvectors of a network Although here we study the spectrum of the adjacency matrix of the weighted ... ends of the second eigen247 across languages, different network construction policies, and corpora of different sizes and from various domains; (b) clustering of the words on the basis of eigenvector ... is inversely proportional to the logarithm of the number of target words it applies on The similarity of two target nouns is then computed as the sum of the feature weights they share For our...

Ngày tải lên: 17/03/2014, 02:20

... region of the bilayer, with the helical axis nearly parallel to the bilayer surface Interestingly, the tilt of the MSI-594 helix varied from 15° to 25° from the Insights from NMR structures of antimicrobial ... Insights from NMR structures of antimicrobial peptides S Bhattacharjya and A Ramamoorthy drugs using existing antibiotic scaffolds are often challenging, as a result of their inability ... binding and permeation of antimicrobial peptides into Gramnegative organisms [46–49] Structures of antimicrobial peptides derived from model membranes composed of synthetic lipids often show poor correlation...

Ngày tải lên: 29/03/2014, 22:21

... unveiling of cryptic epitopes following internalization of CD4 in complex with gp120 was proposed to explain the pathogenesis of this phenomenon [14,15] A further in vivo proof of principle of the ... formation of autoreactive CD8 T cells Apoptosis is an ordered state of cell death in which the structural components of the cell are carefully disassembled by the activity of a unique set of proteolytic ... diseases The depletion of the CD4 T lymphocytes is the hallmark of the progression of HIV infection and, in the absence of antiviral treatment, the main contributor to the development of opportunistic...

Ngày tải lên: 18/06/2014, 15:20

... http://www.virologyj.com/content/4/1/97 Figure the genome of 0305φ8-36 showing distribution of features Map of Map of the genome of 0305φ8-36 showing distribution of features The features are from ref [1] The scale is in ... made of the genomic organization and vertical descent of phage 0305φ8-36 in comparison with BtI1/BwK1 A central problem in comparative genomics analysis is to reconcile the high incidence of horizontal ... N terminus of a BtI1 gene Shades of red from bright to pale indicate assignment of homology with increasing reliance on positional information as described in the methods The size of a connector...

Ngày tải lên: 18/06/2014, 18:20

... http://www.virologyj.com/content/4/1/97 Figure the genome of 0305φ8-36 showing distribution of features Map of Map of the genome of 0305φ8-36 showing distribution of features The features are from ref [1] The scale is in ... made of the genomic organization and vertical descent of phage 0305φ8-36 in comparison with BtI1/BwK1 A central problem in comparative genomics analysis is to reconcile the high incidence of horizontal ... N terminus of a BtI1 gene Shades of red from bright to pale indicate assignment of homology with increasing reliance on positional information as described in the methods The size of a connector...

Ngày tải lên: 20/06/2014, 01:20

... is a close relative of E coli that has specialized in living as a human pathogen [24,25] As a result of the expansion of the human population from Neolithic times a number of more generalistic ... simulations, an upper limit of 20% was estimated for paralogs of xenologous origin Assuming that the extra members of a gene family from our paralog plots represent an upper limit of HGT for established ... fraction of the genome occupied by gene families and the genome size; that is, larger genomes had a larger proportion of redundant genes However, at the time of that analysis, the sequences of genomes...

Ngày tải lên: 09/08/2014, 20:20

... physiology of these soil microbes Results and Discussion Structure and comparative genomics of the D purpureum genome Genome assembly The genome of D purpureum strain DpAX1, an axenic derivative of QSDP1, ... protein of the slug that was fashioned out of hundreds of repeats of a bacterial Cna_B domain [1] CapA and CapB are two cAMP-binding proteins whose carboxy-terminal half is derived from a subunit of ... encoding cofilins, cofA and cofG Only cofA has a direct ortholog amongst the eight D discoideum genes An additional group of ADF domains is present in D purpureum that includes three proteins, one of...

Ngày tải lên: 09/08/2014, 22:23

... CERV 1/PTERV1 elements ranges from 97.1% to 99.7% Phylogenetic analysis of the LTRs from full-length elements of CERV 1/PTERV1 members indicated that this family of LTRs can be grouped into at ... since they diverged from the common ancestor (Tables and 4) reviews Comparative analyses of orthologous regions of the human and chimpanzee genomes has revealed a number of instances where relatively ... characterization and comparative genomics of chimpanzee endogenous retroviruses presented in this report should not only help contribute to our understanding of the functional significance of these elements...

Ngày tải lên: 14/08/2014, 16:21

... outside of the peak (total of 7,058 across 1,500 bp of 10,914 promoters) In humans, there is no indication of any clustering, and this element is also very rare (total of 1,015 across 1,500 bp of ... measure of the quality, or precise alignment, of the datasets, then the two human sets bracket the Drosophila set with respect to the accuracy of the positioning of the TSS Distribution of all ... embryonic and adult stages of Drosophila development that express different sets of genes Figure 11b presents a hierarchal clustering of mRNA expression for 89 samples from a survey of gene expression...

Ngày tải lên: 14/08/2014, 16:21

... representation of DNA microarray data as a circular map of the TT01/I genome Schematic Schematic representation of DNA microarray data as a circular map of the TT01/I genome Circle (from outside ... distinguish red secondary variants colonies from blue primary colonies [76] Because of the high level of pigmentation of Photorhabdus colonies, the use of color assays does not allow clear distinction ... was taken from this nematode During the course of a genetic study of the type III secretion system, we discovered that the bacterium isolated in 1998 is a genomic variant It differs from the TT01...

Ngày tải lên: 14/08/2014, 20:22

... biosynthesis of PUFAs goes through the desaturation and elongation of essential FAs taken from the diet, linoleic and a-linolenic (18:3 n-3) acids, which allow the production of n-6 and n-3 series of PUFAs, ... of linoleic acid (18:2) and 22:5 and 22:6 PUFAs, but lower levels of oleate (18:1) and C16 FAs than the human host Procyclic T brucei showed lower levels of 16:0 and 18:1, but higher ratios of ... histidine box has the QX2HH instead of the HX2HH motif present in other types of desaturases [18] The genome projects of trypanosomatids revealed the presence of front-end desaturase genes, tentatively...

Ngày tải lên: 07/03/2014, 12:20

... that the salt optima of the enzymes are fine-tuned to match the salinity of their environment The outer membrane and cell wall of Gram-negative bacteria not restrict passage of ions, and the periplasmic ... energy of activation Results from the thermodynamic calculations (Table 2) reveal that there is a slight difference in the free energy of activation between the two enzymes originating from both ... enzyme must sacrifice some of its stability It has previously been suggested that the lower thermal stability of cold-adapted enzymes is simply a consequence of the lack of selective pressure for...

Ngày tải lên: 19/02/2014, 05:20

... Rosene-Montella, 2009 Molecular Basis of Pulmonary Disease Insights from Rare Lung Disorders Edited by Francis X McCormack, MD Department of Internal Medicine, University of Cincinnati Medical Center, ... Department of Internal Medicine, University of Cincinnati School of Medicine and Cincinnati VA Medical Center, Cincinnati, OH, USA Bruce C Trapnell, MD Department of Pediatrics and Department of Internal ... gained from the study of PAP about the role of GM-CSF in the lung has sparked interest in the use of anti GM-CSF approaches to control both pulmonary and extrapulmonary inflammation in a variety of...

Ngày tải lên: 05/03/2014, 23:20

... composition of social networks over time could alter the relative availability and efficiency of different types of support because of changes in the availability of certain types of ties (Connidis ... participant loss.) Measures of Social Support The MacArthur battery included assessments of frequency of receipt of emotional and instrumental support, as well as the frequency of negative interactions ... goal of this study was to provide a detailed picture of how different types of social support from different support providers change over time SOCIAL SUPPORT IN OLDER ADULTS as a function of gender...

Ngày tải lên: 06/03/2014, 15:20

Ngày tải lên: 16/03/2014, 03:20

... the binding of the thiol sulfur of HS-CoM to the zinc atom of MtaA in a way that it replaces one of the nonsulfur ligands, possibly the oxygen of coordinated H2O or hydroxide EXAFS of two MtaA ... position of the absorption edge is the energy value corresponding to 0.65 units of normalized absorption (The value of 0.65 was chosen because it corresponds to roughly half of the magnitude of the ... slight decrease of Peak and strong increase of Peak (Fig 1A-II,III) Thus, already the visual inspection of the EXAFS data suggests that the number of sulfur atoms ligated to the zinc of MtaA increases...

Ngày tải lên: 17/03/2014, 23:20

... HIV-PTB co-infection rate of 5.2% from Lagos State, while Onipede et al.,18 reported 12.9% from Ile-Ife, Ogun State Okogun et al.,19 also reported a prevalence rate of 5.3% from Abeokuta and environs ... to produce sputum from a deep cough into one of the containers on the first day they visited the clinic (first spot specimen), and thereafter 2ml of venous blood was collected from each patient ... distribution of HIV-PTB co-infection among the various age groups is not statistically significant (P > 0.05) Table 4: Distribution of HIV and PTB by age groups of subjects in Benin City Number (%) of...

Ngày tải lên: 22/03/2014, 18:20

... occurs on formation of the ACE2 ES complex [26,29] Comparative molecular and biochemical studies of members of the ACE family are likely to provide new insights into the evolution of the ACE active ... from the IC50 value obtained by measuring initial rates of hydrolysis of the fluorogenic substrate Abz-YRK(Dnp)P (5 lM) in the presence of different concentrations of MKRSRGPSPRR b Estimated from ... of the two alanines of RXPA381 pack closely with Val372 of ACER, whereas in ANCE, the methyl group of the terminal alanine residue is orientated away from Thr364, reinforcing the importance of...

Ngày tải lên: 23/03/2014, 11:20

... folding (Fig 2) of HT c-552 from this thermophile closely resemble those of the 82-amino-acid cytochrome c-551 from a mesophile, Pseudomonas aeruginosa (PA c-551) Comparisons of the two proteins ... protein stability BIOGENESIS OF BACTERIAL CYTOCHROMES c Fig 3D structural comparison of HT c-552 and PA c-551 The main-chain folding of HT c-552 (red) is overlaid with that of PA c-551 (green) To confirm ... design resulting from careful structural comparison of HT c-552 and PA c-551 makes it possible to select a set of amino-acid residues that are completely responsible for the stability of a thermophilic...

Ngày tải lên: 24/03/2014, 03:21

... Because of economic hardships and marginalisation of the province in terms of educational infrastructures, the enrolment of children in primary school is one of the lowest in Kenya The objective of ... microcredit portfolio of Banco Caja Social represented 26,7% of the total Colombian microcredit portfolio 65% of the bank’s portfolio comes from clients with a monthly income of less than 1.4 million ... context of the Federal Government’s policy of decentralization of investments in culture, Caixa promotes free access for the population of all the Brazilian regions to cultural events and projects of...

Ngày tải lên: 29/03/2014, 08:20