... (normalized cDNA peak heights of targeted vs. non-targeted allele of rs1800222) 72 hours post-transfection with three dif-ferent concentrations of siRNA3. Colours of bars indicate the SNP used ... severity of this disease. The principle of allele specific silencing of Collagen type I genes has been explored previously by Millington-Ward (14) who reported allele-preferential silencing of COL1A1 ... silencing of the Collagen 1 alpha genes, can be tested in clinical trials. The efficiency and specificity of RNA interference using siRNAs is heavily dependent on the base composition of target...
... According to the Council of Europe Committee of Experts for the Development of Human Rights (DH-DEV) “at the core of the examination of any interference in the exercise of freedom of opinion is therefore ... Assembly of Member Nations of the Commonwealth of Independent States – Model Law on the Principles of Internet Regulation, adopted at the 36th plenary meeting of the Interparliamentary Assembly of ... contradictory to the conclusions of the Final Document of the Moscow Meeting of the Conference on the Human Dimension of the CSCE and in breach of Article 19 of the International Covenant on...
... F.100.a and L.100.a) show estimates of annual flows and year-end outstandings of nonprofit organizations.(2) See table F.10 for derivation of alternative measures of personal saving.(3) Railroad ... Flow of Funds Accounts, Third Quarter 2012 This publication presents the Flowof Funds Accounts for 2012:Q3. The statistics in the attached tables reflect the use of new or ... analysis of particular relationships over time. Specifically, outstandings in the Flowof Funds Accounts are related to flows in the following way: Outstanding BtB = Outstanding Bt-1B+ Flow...
... direction of research appeared in thelast decade, taking full advantage of the ”wisdom of crowds” (Surowiecki, 2004). In simple words, wis-dom of crowds enables parallel acquisition of opin-ions ... LinguisticsModeling Wisdom of Crowds Using Latent Mixture of Discriminative ExpertsDerya Ozkan and Louis-Philippe MorencyInstitute for Creative TechnologiesUniversity of Southern California{ozkan,morency}@ict.usc.eduAbstractIn ... opinions of multiple an-notators/experts, which is referred to as ”wis-dom of crowds”. In this paper, we propose anew approach for modeling wisdom of crowdsbased on the Latent Mixture of Discrimina-tive...
... AnalysisWe investigated a number of errors and concludedthat there were mainly three types of errors.One is the ambiguity of word senses. For exam-ple, one of the glosses of “costly”is “entailing ... :¯xnewi=xixiexpβxijwij¯xoldjxiexpβxijwij¯xoldj. (7)4 Extraction of Semantic Orientation of Words with Spin ModelWe use the spin model to extract semantic orienta-tions of words.Each spin has a direction taking one of two values:up or ... expressions. For exam-ple, although “brag” means “show off”, neither of “show” and “off” has the negative orientation. Id-iomatic expressions often does not inherit the se-mantic orientation from...
... analyzed using Conexor parser, and various statistics are extracted: 1) frequency, tf.idf of the disease names, 2) distribution of modifiers of the disease names, 3) frequency, tf.idf of unit ... Library of Medicine, USA. (http://www.nlm.nih.gov) Contextual information is distribution of sur-rounding words of target terms. For example, the distribution of co-occurrence words of the ... specificity of domain-specific terms. The preci-sion of 82.0% is good performance compared to upper bound of 87.4%. 4.2. Error Analysis One reason of the errors is that the names of some internal...
... and suggestions were of inestimable value for ourstudy using GC-A knockout mice, to Professor Misono of the University of Nevada School of Medicine, and tothe reviewers of the FEBS Journal, ... pathophysiologicalroles of the natriuretic peptides ⁄ receptor signalingpathways in the regulation of blood pressure ⁄ volume,maintenance of the cardiovascular system, and devel-opment of the longitudinal ... potential importance of the natriuretic peptide sys-tem in humans.AcknowledgementsOur heartfelt appreciation goes to the late Dr Garbers, aformer professor of the University of Texas, whose com-ments...
... FEBS 3279 consequence of the use of D2O buffer. This is the con-sequence of the H–D exchange that takes place when using D2O buffer, a range of that was quantified using two different procedures. ... 344have been solved [19]. The catalytic domain of PKChpossesses a high degree of homology ( 80%) with thecatalytic domain of other isoforms of PKC belongingto the classical or novel subfamilies. ... case of the catalytic domain of PKB [42] (PDB code1MRV), the homology with cat-f is 48%, It is notice-able that for the catalytic domain of PKCi, the degree of sequence homology with that of...
... of enzyme was added to release 15 nmol of MCAin the 1 min enzyme reaction. For determination of theinhibitory activity, a fixed amount of enzyme was first incu-bated with different amounts of ... isoforms of this peptideinhibited the enzyme with Kivalues of 1.2 · 10-7mand 4 · 10)8m [24].A backbone-cyclized, potent trypsin inhibitor, sun-flower trypsin inhibitor-1 (SFTI-1), of ... Journal compilation ê 2006 FEBS 3913 Template-assisted rational design of peptide inhibitors of furin using the lysine fragment of the mung beantrypsin inhibitorHu Tao1,2,*, Zhen Zhang2,*,...
... Wepropose a new set of benchmarks and evaluation methodsfor the next generation ofoptical flow algorithms. To thatend, we contribute four types of data to test different as-pects ofoptical flow algorithms: ... ImagerySynthetic scenes generated using computer graphics are of- ten indistinguishable from real ones. For the study of optical flow, synthetic data offers a number of benefits. In particu-lar, it ... diverse, offering a number of insights into the choice of the most appropriate metrics and statistics (Sect. 5.2),the effect of the datatype on the performance of algorithmsand the difficulty of the...
... PL intensity of the porous aluminafilm fabricated using oxalic acid and annealed above400◦C is stronger than that of porous silicon. The PLintensity of porous alumina fabricated using oxalicacid ... oxidation of aluminum by means of sucha self-organization method, yielding highly ordered arrays of nanoholes several hundreds down to several tens of nanometers in size. This paper is an overview of ... nm)Figure 11. TEM cross-section ofporous alumina and Co particlesat the bottom of pores (Sun M. et al., 2001).have an out -of- plane anisotropy. Thus, the magneticanisotropy of ferromagnetic rods is...
... coefficient on concentration of impurities. when concentration of impurities Dn tend toward zero, value of the parametric transformation coefficient of acoustic and optical phonons in doped ... transformation of acoustic and optical phonons in doped superlattices is theoretically studied by using a set of quantum kinetic equations for the phonons. The analytic expression of parametric ... approximately coincides, with the frequency ofoptical phonon,qυr , optical phonons will appear. These optical phonons cause a CDW with a combination frequency of qlυ±Ωr, and when qqlυω±Ω≅rr,...