inhibition of chromosome aberrations in animals
Báo cáo Y học: Inhibition of hyaluronan synthesis in Streptococcus equi FM100 by 4-methylumbelliferone doc
... quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72, 248–254 32 Laemmli, U.K (1970) Cleavage of structural proteins during the assembly of the ... activity of their membranes In order to examine whether possible metabolites of MU are involved in the inhibition of HA synthesis in intact cells, we performed some experiments using HPLC or ion-chromatography ... identifiable species In this regard, our most interesting result indicated that with increasing time of MU treatment there was a decrease in the proportion of smaller CL species and an increase in the larger...
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Báo cáo sinh học: " Improvement of cardiac contractile function by peptide-based inhibition of NF-B in the utrophin/dystrophin-deficient murine model of muscular dystrophy" potx
... and used for the following staining procedures Page of 10 For viewing of gross histology, sections were fixed in 100% ethanol and then stained with hematoxylin and eosin using standard procedures ... scars (Figure 6A) in the hearts of most of dko mice in this study regardless of treatment (5 of [71%] NBD treated mice, versus of Figure NBD is effective in inhibiting NF-B in cardiac muscles ... causes of death in DMD Clinical treatment of this debilitating aspect of DMD is paramount in extending Delfín et al Journal of Translational Medicine 2011, 9:68 http://www.translational-medicine.com/content/9/1/68...
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báo cáo hóa học: " Tumor necrosis factor-mediated inhibition of interleukin-18 in the brain: a clinical and experimental study in head-injured patients and in a murine model of closed head injury." pot
... corresponds to the time-point of maximal extent of intracerebral inflammation in the model of CHI used in this study [17] For assessment of intracerebral IL-18 levels, the murine brains were immediately ... effects of pro-inflammatory mediators, depending on the kinetic of their expression and posttraumatic regulation in the injured brain [3,12,13] However, the TNF-dependent regulation of IL18 in the injured ... quality of the blood-brain barrier has not been determined in this cohort of head-injured patients, due to the lack of matching serum samples for assessment of albumin levels, the source of elevated...
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Báo cáo hóa học: " Inhibition of histone deacetylation in 293GPG packaging cell line improves the production of self-inactivating MLV-derived retroviral vectors" pdf
... resulted in a significant increase in titer indicating that histone deacetylation is indeed implicated in suppression of retroviral RNA transcription in the SINCMV design resulting in reduced ... histone H4 as the dose of sodium butyrate increases Increase in titer of SINCMV producers with Trichostatin A treatment To determine if the resultant increase in SINCMV retroviral titers with sodium ... been proposed including disruption of the transcription initiation complex, or simply preventing its assembly, or changes in the higher-order structure of chromatin rendering it incompatible with...
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báo cáo hóa học:" Improvement of cardiac contractile function by peptide-based inhibition of NF-B in the utrophin/dystrophin-deficient murine model of muscular dystrophy" doc
... and used for the following staining procedures Page of 10 For viewing of gross histology, sections were fixed in 100% ethanol and then stained with hematoxylin and eosin using standard procedures ... scars (Figure 6A) in the hearts of most of dko mice in this study regardless of treatment (5 of [71%] NBD treated mice, versus of Figure NBD is effective in inhibiting NF-B in cardiac muscles ... causes of death in DMD Clinical treatment of this debilitating aspect of DMD is paramount in extending Delfín et al Journal of Translational Medicine 2011, 9:68 http://www.translational-medicine.com/content/9/1/68...
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ANALYSIS OF GENETIC VARIATION IN ANIMALS pdf
... with inbreeding coefficients in both populations and interpopulations 30 Analysis of Genetic Variation in Animals The inbreeding coefficient of the whole population (FIT = Factor of Inbreeding in ... be divided into: i) inbreeding coefficient of individuals in relation to a subpopulation which includes individuals (FIS = Factor of Inbreeding relative to subpopulation); ii) inbreeding coefficient ... analysis is done by individual genetic profiling (genetic fingerprinting), determining the interrelations between different individuals and evaluating their allele frequency in populations Microsatellite...
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Báo cáo sinh học: "A pericentric inversion of chromosome 4 in pigs" doc
... of boars was also analysed using a linear model including the following fixed effects: inversion (normal or inverted chromosome 4), boar nested within inversion, herd x year x season x type of ... was defined within each herd as a group of at least 15 animals of the same sex born within a 2-week period of time and tested at the same time) and of the inversion (normal or inverted chromosome ... Samples of blood and/or skin biopsies were taken from two generations of offspring of boar !1!, as well as on the parents of boar (2! The abnormality was then diagnosed again in karyotypes of two...
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Báo cáo y học: " Large-scale analysis of chromosomal aberrations in cancer karyotypes reveals two distinct paths to aneuploidy" ppsx
... aberrations The main challenges in adapting our methods for array-based data are assigning each sample with a set of aberrations (aka ‘aberration calling’), and handling intersecting aberrations (for ... 154 (71%) were chromosome gain pairs, and 47 (22%) were chromosome loss pairs The induced network split clearly into two disjoint parts: one dominated by chromosome gains and one by chromosome losses ... any mixed gain-loss pairs We also detected the trisomy of 1q [21], which appeared in all tumor categories in the associations involving gain of chromosome (Figure 2a; Figure S2a-d in Additional...
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Báo cáo y học: "Glutathione and growth inhibition of Mycobacterium tuberculosis in healthy and HIV infected subjects" pot
... were maintained in vitro in RPMI containing 5% AB serum, for days for differentiation to macrophages HMDM were infected with H37Rv at moi of 10:1 and maintained in media alone (Fig 1a) or in media ... treatment of HMDM with 10 mM NAC resulted in stasis in H37Rv growth in three out of six subjects (Fig 1b) Treatment of HMDM with NAC at mM and 15 mM induced growth inhibition of H37Rv, in one out of ... during TB infection Therefore, addition of NAC to HMDM caused growth inhibition of M tuberculosis by augmenting intracellular GSH levels These results suggest that growth inhibition of H37Rv in...
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Báo cáo y học: "Rapamycin-loaded nanoparticles for inhibition of neointimal hyperplasia in experimental vein grafts" pps
... 0.35) Rapamycin Pharmacokinetics Measurement of rapamycin levels in vein grafts demonstrated the presence of drug in vein grafts at days (after the vein being immersed in rapamycin-loaded NPs ... resulting in an intracellular drug delivery and thereby significantly inhibiting VSMCs proliferation An important finding was, long-term release of rapamycin in the vein until day 21 after grafting ... system of rapamycin in injured artery [23] Because RPLGA NPs can easily penetrate into the vessel wall and their sustained release of rapamycin into cell cytoplasm, the inhibition to the intimal...
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Báo cáo y học: "Array comparative genomic hybridisation-based identification of two imbalances of chromosome 1p in a 9-year-old girl with a monosomy 1p36 related phenotype and a family history of learning difficulties: a case report" pps
... arrowed), confirming a duplication of the clones within 1p32.3 (observed in a total of 10 cells) and identifying the distal location of the duplicated region within the p-arm of chromosome Additional ... of the genomic target sequences is interpreted using an integrated suite of bioinformatic tools In comparison to conventional cytogenetic techniques, aCGH enables a more precise examination of ... is evident by the association of a variety of neoplasms in patients with deletions of this chromosome location [8,9] Interstitial duplications of the short arm of chromosome are rare with a varied...
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Báo cáo y học: "EM703 improves bleomycin-induced pulmonary fibrosis in mice by the inhibition of TGF-β signaling in lung fibroblasts" doc
... by EM703 (Figure 6) The mechanisms of inhibition by EM703 of bleomycininduced pulmonary fibrosis in mice may involve the inhibition of TGF-β signaling, mediating fibroblast proliferation and extracellular ... anti-fibrotic effects of EM703 in the attenuation of bleomycin-induced pulmonary fibrosis Although there is a room for further investigation of the mechanism of EM703 inhibition of bleomycin-induced lung ... effects of EM703 on the inflammatory phase, we investigated bleomycin-induced changes in the cell populations in BAL fluid on day after bleomycin injection The increase in the number of macrophages...
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Báo cáo y học: " Reduced levels of reactive oxygen species correlate with inhibition of apoptosis, rise in thioredoxin expression and increased bovine leukemia virus proviral loads" potx
... leukemia in BLV-infected sheep using the VPA histone deacetylase inhibitor [21] Since we showed that VPA acts at least in part through induction of apoptosis, we investigated the involvement of ROS in ... thioredoxin system Our results thus provide evidence linking inhibition of apoptosis and reduced ROS levels resulting in a Experimental animals A total of 13 BLV-infected sheep and controls used in ... these kinetic experiments are useful to explain the accumulation of infected cells in vivo, further understanding of BLVinduced pathogenesis requires dissection of metabolic pathways in vitro In...
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Báo cáo y học: "Inhibition of early steps in the lentiviral replication cycle by cathelicidin host defense peptides" pptx
... Cathelicidins have since been identified in many other species including hCAP18/LL37 in humans [10], protegrins in swine [11-13], CRAMP in mice [14,15] and SMAP29 in sheep [16] Many of these peptides ... analysis of inhibition of lentiviral and retroviral vector infectivity Comparative analysis of inhibition of lentiviral and retroviral vector infectivity Percent luciferase activity of 293A target ... mechanism of inhibition of lentiviral vector infectivity, LL37 and PG-1 were added at different time points during infection: both HDPs were either preincubated with the vector preparation for 30 minutes...
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Báo cáo y học: " Identification of structural aberrations in cancer by SNP array analysis Stefan Heinrichs and A Thomas Loo" pot
... cell lines, showed a copy-number gain in a defined region of chromosome 3p Comparison of the geneexpression profiles of the six melanoma cell lines with the other lines identified a small set of ... analysis of loss of heterozygosity at individual loci A subset of four cases showed loss of heterozygosity of 11p solely as a result of UPD, indicating that cells might not tolerate the haploinsufficiency ... string of adjacent heterozygous SNPs, because homozygous germline genotypes are noninformative Most commonly, the loss of heterozygosity in tumor cells is a result of deletion of a region of a chromosome...
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Báo cáo sinh học: "Phenotypic plasticity of body pigmentation in Drosophila: A pericentric inversion of chromosome 4 in pigs" pot
... of boars was also analysed using a linear model including the following fixed effects: inversion (normal or inverted chromosome 4), boar nested within inversion, herd x year x season x type of ... was defined within each herd as a group of at least 15 animals of the same sex born within a 2-week period of time and tested at the same time) and of the inversion (normal or inverted chromosome ... Samples of blood and/or skin biopsies were taken from two generations of offspring of boar !1!, as well as on the parents of boar (2! The abnormality was then diagnosed again in karyotypes of two...
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Báo cáo sinh học: "Paracentric inversion involving NOR of chromosome 8 in a boar : studies of synaptonemal complexes under a light microscope" pdf
... disturbances in carriers of chromosome inversions the effect of position should also be taken into consideration The new gene neighbourhood at breakage/rejoining points can also cause activation or inhibition ... to crossing over within the loop and, in consequence, to the production of unbalanced gametes On the other hand, lack of loop formation results in supression of crossing over within the inverted ... RESULTS Mitotic chromosomes Chromosome analysis carried out by application of conventional and banding stainings showed in chromosome No an additional chromatin fragment within the nucleolar...
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Evaluation of the anti diabetic properties of averrhoa bilimbi in animals with experimental diabetes mellitus
... regulation of biosynthesis of the two insulin isoforms at the level of both transcription and translation This leads to an increase in the ratio of insulin I over insulin II in terms of both their ... sites of their uptake Steady-state levels for insulin mRNA appears to be important for regulation of insulin production Insulin mRNA levels varied with the change in demand for insulin in several ... al., 1995) The insulin gene is present as a single copy in most species However, in rats, two nonallelic insulin genes (Insulin I gene and Insulin II gene) are expressed (Clark and Steiner, 1969;...
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A study of genomic aberrations in gastric adenocarcinoma
... a sidebar on the chromosome 31 Fig 12 Screenshot of ACAVIS showing the chromosome profile of an individual sample Fig 13 Screenshot of ACAVIS showing the chromosome profile of 17 samples 32 Chapter ... of poor hybridizations 12 Screenshot of ACAVIS showing the chromosome profile of an individual sample 13 Screenshot of ACAVIS showing the chromosome profile of 17 samples 14 Histology from 40 micron ... for intestinal-type cancer and higher risk populations (3) The incidence of gastric cancer in Singapore has likewise been decreasing However, it remains firmly within the top five malignancies in...
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Báo cáo sinh học: " High Chromosome Number in hematological cancer cell lines is a Negative Predictor of Response to the inhibition of Aurora B and C by GSK1070916" potx
... http://www.upstate com using the KinaseProfiler to determine activity across a range of kinases including the ABL kinase oncogene Results In Vitro Response Data Based on proliferation, most of the hematological ... genetics of the hematological cell line panel was reviewed in relation to Aurora inhibition by GSK1070916 Expression profiles of Aurora A, B, and C were evaluated in terms of response to Aurora inhibition ... in the resistant group For instance, in our panel of B-cell lymphoma cell lines, of the cell lines were resistant to GSK1070916 and contained low chromosome number in the primary population of...
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