Particle development for drug delivery

Particle development for drug delivery

Ngày tải lên : 17/09/2015, 17:19
... Process 76 B1.1.1 Influence of Beater Rotational Speed 79 B1.1.2 Influence of Classifier Wheel Rotational Speed 79 B1.1.3 Influence of Airflow Rate 79 B1.1.4 Influence of the Length of Grinding Zone ... Plots of D99 against beater rotational speed at (a) classifier wheel rotational speed of 5000 rpm, airflow rate of 80 m / h and long grinding track; (b) classifier wheel rotational speed of 15000 ... rate of 80 m3 / h and long grinding track; (c) classifier wheel rotational speed of 5000 rpm, airflow rate of 90 m3 / h and long grinding track and (d) classifier wheel rotational speed of 5000...
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Research " Essays on the Equilibrium Valuation of IPOs and Bonds " pdf

Research " Essays on the Equilibrium Valuation of IPOs and Bonds " pdf

Ngày tải lên : 07/03/2014, 02:20
... securities) of IPOs IPO residual risk acts as a source of systematic risk and is priced in equilibrium From the point of view that innovation is the source of sustained economic growth and economic ... presents a number of testable implications to facilitate future empirical work Section 2.4 concludes and discusses limitations and possible future extensions of the static and dynamic models ... is de…ned as the negative of the ratio of the total number of shares available for short sale over the total number of shares outstanding IPO shares available Mauer and Senbet (1992) provide...
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Báo cáo khoa học: Equilibrium distribution of skeletal actin–tropomyosin– troponin states, determined by pyrene–tropomyosin fluorescence potx

Báo cáo khoa học: Equilibrium distribution of skeletal actin–tropomyosin– troponin states, determined by pyrene–tropomyosin fluorescence potx

Ngày tải lên : 07/03/2014, 09:20
... inactive state in the absence of Ca2+ and bound S1 Both Ca2+ and Distribution of actintropomyosintroponin states S1ADP bind more tightly to the active state of actin than to the inactive state, and stabilize ... and p2 are fractions of actin units in the inactive and active states, respectively; hI and h2 are fractions of actin containing bound S1 in the inactive and active states, respectively; K1 and ... methods of determining the state of actin in real time This manuscript explores, in detail, a well-known method of monitoring the state of regulated actin The fraction of actin in the active state...
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An Equilibrium Model of Rare-Event Premia and Its Implication for Option Smirks potx

An Equilibrium Model of Rare-Event Premia and Its Implication for Option Smirks potx

Ngày tải lên : 07/03/2014, 10:20
... types of random shocks One is a standard diffusive component, and the other is pure jump, capturing rare events with low frequency and sudden occurrence While the probability laws of both types of ... include Gilboa and Schmeidler (1989), Epstein and Wang (1994), Anderson, Hansen, and Sargent (2000), Chen and Epstein (2002), Hansen and Sargent (2001), Epstein and Miao (2003), Routledge and Zin (2002), ... coefficient and 1/d is the elasticity of intertemporal substitution When d ¼ g, the utility function reduces to the standard time -and- state additive power utility and r is the constant discount...
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Báo cáo khoa học: Monomeric molten globule intermediate involved in the equilibrium unfolding of tetrameric duck d2-crystallin pdf

Báo cáo khoa học: Monomeric molten globule intermediate involved in the equilibrium unfolding of tetrameric duck d2-crystallin pdf

Ngày tải lên : 08/03/2014, 08:20
... d2-crystallin was used in calculation of dissociation constant [5] The fit quality of the models was examined by the residuals and by minimization of the fit variance Results Dissociation of tetrameric ... Diagram of the surface of duck d-crystallin (1AUWÆpdb) (A) Each subunit of the tetrameric d-crystallin shows a surface with several convex and concave areas as indicated by ÔaÕ, ÔbÕ and ÔcÕ, ... different estimate of stability depending on the contributions of electrostatic interactions Protein Sci 3, 1984–1991 28 Jaenicke, R & Lilie, H (2000) Folding and association of oligomeric and multimeric...
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Báo cáo khoa học: Using directed evolution to improve the solubility of the C-terminal domain of Escherichia coli aminopeptidase P Implications for metal binding and protein stability pptx

Báo cáo khoa học: Using directed evolution to improve the solubility of the C-terminal domain of Escherichia coli aminopeptidase P Implications for metal binding and protein stability pptx

Ngày tải lên : 23/03/2014, 07:20
... genes of mutants that confer increased TMP resistance are isolated and shuffled, and the new mutant library is monitored for increasingly higher levels of TMP resistance After several rounds of evolution, ... mutant proteins This mutation is close to the N-terminus of the fragment ) it lies between the start of the fragment and the predicted start of the domain (Fig 1) From the round mutants, three were ... domain of AMPP Different-length domains were tested, and mutations were made to the sequences of these domains It is known that the location of domain boundaries is critical to the formation of stable,...
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Báo cáo Y học: Extra terminal residues have a profound effect on the folding and solubility of a Plasmodium falciparum sexual stage-specific protein over-expressed in Escherichia coli pptx

Báo cáo Y học: Extra terminal residues have a profound effect on the folding and solubility of a Plasmodium falciparum sexual stage-specific protein over-expressed in Escherichia coli pptx

Ngày tải lên : 23/03/2014, 21:20
... (a) the role of the N-terminal extension; (b) the role of the D to N mutation; and (c) the role of the sequence and length of the C-terminal extension To address whether presence of extra residues ... only once the protein of interest has been cleaved off and shown to retain both its folded state and its biological activity It is possible that the exact sequence and length of the 17 residue extension ... subsequently crystallized The final yield of Pfg27 from Pfg27A was 24 mgÆL)1 of starting culture while it was for Pfg27B–F Effect of temperature on the expression profiles We examined the role of temperature...
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báo cáo hóa học:" Research Article Strong Convergence for Mixed Equilibrium Problems of Infinitely Nonexpansive Mappings Jintana Joomwong" pot

báo cáo hóa học:" Research Article Strong Convergence for Mixed Equilibrium Problems of Infinitely Nonexpansive Mappings Jintana Joomwong" pot

Ngày tải lên : 21/06/2014, 10:20
... element of EP Θ and the set of fixed points of nonexpansive mappings Furthermore,Yao et al 8, 10 introduced an iterative scheme for finding a common element of EP Θ and the set of fixed points of finitely ... element of the set of solutions of an equilibrium problem and the set of common fixed point of infinitely many nonexpansive mappings in H Let {Tn }∞ be a sequence of n nonexpansive mappings of C into ... suggest and analyze an iterative scheme for finding a common element of the set of fixed point of infinitely nonexpansive mappings, the set of solutions of an equilibrium problem and the set of solutions...
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Báo cáo hóa học: "Research Article Stability of Equilibrium Points of Fractional Difference Equations with Stochastic Perturbations" pdf

Báo cáo hóa học: "Research Article Stability of Equilibrium Points of Fractional Difference Equations with Stochastic Perturbations" pdf

Ngày tải lên : 22/06/2014, 11:20
... 4: Stability regions, σ region one can see the regions of stability of the point of equilibrium x1 that were obtained by condition 3.3 grey and green regions and by conditions 3.4 , 3.5 cyan and ... are 47–49 conditions for stability in the probability of the trivial solution of nonlinear equation 2.2 and therefore for stability in probability of the equilibrium point of 2.1 Advances in Difference ... asymptotically mean square stable Consider also the necessary and sufficient condition for asymptotic mean square stability of the trivial solution of 2.3 Let U and Γ be two square matrices of dimension k...
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Báo cáo y học: "Association of PTPN22 1858 single-nucleotide polymorphism with rheumatoid arthritis in a German cohort: higher frequency of the risk allele in male compared to female patients" potx

Báo cáo y học: "Association of PTPN22 1858 single-nucleotide polymorphism with rheumatoid arthritis in a German cohort: higher frequency of the risk allele in male compared to female patients" potx

Ngày tải lên : 09/08/2014, 08:22
... aspects of the laboratory work, analyzed the data and prepared the manuscript SK, SA, MW and CB participated in the collection of clinical data and the recruitment of patients into the study UW and ... the patient and the control cohort and all analyzed subgroups The distribution of genotypes and the resulting allele frequencies of the variant PTPN22 1858T allele in RA patients and healthy ... in RA patients The CT and TT genotype was present in 37.9% of patients and 19.2% of healthy controls, resulting in an OR of 2.57 (95% CI 1.85–3.58, p < 0.001) Carriage of a homozygous TT genotype...
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Báo cáo y học: "Explicit equilibrium modeling of transcription-factor binding and gene regulation" pdf

Báo cáo y học: "Explicit equilibrium modeling of transcription-factor binding and gene regulation" pdf

Ngày tải lên : 14/08/2014, 14:22
... Materials and methods) and have used this model to study the interaction of yeast transcription factors Ndt80p and Sum1p Ndt80p is an activator of genes expressed during the middle stage of sporulation ... set of sequences and the thermodynamics and specificity of binding (see Materials and methods for a fuller discussion) [9] A variation on this idea treats the PWM as a predictor of affinity and ... that assigns a weight of for adjacent sites and a weight of to all other sites The concentration of the dimer, [XY], is the product of [X], [Y], and the dimerization constant, Ka,dimer ([XY]...
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Thermochemical equilibrium modeling of biomass downdraft gasifier: Stoichiometric models

Thermochemical equilibrium modeling of biomass downdraft gasifier: Stoichiometric models

Ngày tải lên : 01/08/2016, 09:31
... (2014) 189e201 presented here: 52.28% of C, 6.61% of H, 41.05% of O, 0.1% of N, 0.01% of S, 1.54% of Ash In work by Leoneti et al [60] it is stated that one of the possible applications for the ... yj A @ nj nTot P0 j¼1 p (16) r where the standard-state Gibbs function change and the exponent in the right hand side of Eq (16) are given by Eqs (17) and (18), respectively Methane formation ... independent The concept of independence of reactions states that if for any particular group of reactions one of them could be written as a combination of at least two of the others, then this...
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Study on the Photolytic Mechanisms of Red 141 Dye Wastewaters with an 185nm Vacuum-UV lamp

Study on the Photolytic Mechanisms of Red 141 Dye Wastewaters with an 185nm Vacuum-UV lamp

Ngày tải lên : 05/09/2013, 09:08
... requirements of the VUV photolysis of water according to Eq (1) are related to the formation of high local concentration of hydroxyl radicals (OH.) and a series of other species (Gonzalez and Braun, ... volume Each run of the experiments in this work was replicated twice The standard deviations of the concentration of Red 141 was analyzed to be ±0.1 mg/l, respectively The concentration of H2O2 in ... decomposition of Red 141 by direct photolysis, and free hydroxyl - 25 - Journal of Water and Environment Technology, Vol.3, No.1, 2005 radicals destruction generated from the excitement of O2, H2O, and...
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Tài liệu THE PRINCIPLES OF CHEMICAL EQUILIBRIUM doc

Tài liệu THE PRINCIPLES OF CHEMICAL EQUILIBRIUM doc

Ngày tải lên : 12/02/2014, 16:20
... differential of a function of state and its integral is Us- UA• which depends only on the initial and final states A and B; dq and dw, on the other hand, are not the differentials of a function of state, ... ampere (A) and candela (cd) The mole is the unit of 'amount of substance' and is defined as that amount of substance which contains as many elementary entities as there are atoms in 0.012 kg of ca.rbon-12 ... functions of I and I 1• Thus I =/(I1,I1 ) might stand for I =Ifi:, I =IJ.q, etc A simple relation of this kind is T=constant pfp for the temperature of a gas as a function of its pres· sure and density...
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Tài liệu Correspondence & Conversations of Alexis de Tocqueville with Nassau William Senior from 1834 to 1859, Vol. 2 docx

Tài liệu Correspondence & Conversations of Alexis de Tocqueville with Nassau William Senior from 1834 to 1859, Vol. 2 docx

Ngày tải lên : 18/02/2014, 08:20
... the caprice of one man, a foreigner by race and by education, and of a set of military ruffians and of infamous civilians, fit only to have formed the staff and the privy council of Catiline ... conversation; every individual stands defenceless and insulated, in the face of this unscrupulous executive, with its thousands of armed hands and its thousands of watching eyes The only opposition ... of France, her statesmen and her generals, stand aloof from him Those who are not in exile have retired from public life, and offer neither assistance nor advice Advice, indeed, he refuses, and, ...
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Tài liệu Báo cáo khoa học: Mechanism of dihydroneopterin aldolase NMR, equilibrium and transient kinetic studies of the Staphylococcus aureus and Escherichia coli enzymes docx

Tài liệu Báo cáo khoa học: Mechanism of dihydroneopterin aldolase NMR, equilibrium and transient kinetic studies of the Staphylococcus aureus and Escherichia coli enzymes docx

Ngày tải lên : 19/02/2014, 00:20
... the measurements of both equilibrium and kinetic constants of the physical steps by equilibrium and stopped-flow fluorimetric analysis and the determination of the rate constants of the chemical ... 35, and 70 after the addition of the enzyme The top spectrum is that of DHMP for comparison Only the NMR signals of the 2¢ and 3¢ protons of DHNP and DHMP are shown The chemical structures of ... inhibitors NP and MP To assess the differences in the rate constants of the reduced and oxidized pterins, we also measured the association and dissociation rate constants of HPO and compared them...
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On the Segregation of Genetically Modified, Conventional, and Organic Products in European Agriculture: A Multi-market Equilibrium Analysis doc

On the Segregation of Genetically Modified, Conventional, and Organic Products in European Agriculture: A Multi-market Equilibrium Analysis doc

Ngày tải lên : 05/03/2014, 20:20
... n stands for normal, the subscript b stands for biological, and the subscript g stands for genetically modified product We assume that u ( q) is such that the consumer will buy some amount of ... maize and 1.4% and 3.2% for potatoes (to meet a 1% threshold level) Desquilbet and Bullock (2001) considered the segregation costs at the farm and handling stages to be 4% of the farm price and ... of an agricultural and food sector before and after GM innovation are specified as follows 3.1 Demand Because it is widely accepted that such features of food demand arise from a collection of...
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24,185 OUTLETS - The number of JApAN pOST BANk outlets in Japan docx

24,185 OUTLETS - The number of JApAN pOST BANk outlets in Japan docx

Ngày tải lên : 06/03/2014, 10:20
... needs of the customers in each area For example, deposits and domestic remittance services are offered at nearly all outlets, including post offices However, some post offices not handle sales of ... significance of Japan post Bank’s operations   COnVenIenCe COnfIdenCe  SAfeTY • A network of outlets that is within  • The largest number of accounts  walking distance of nearly every  and the largest customer base  ... conduct  of the  Bank’s  operations.  JApAN  pOST  BANk  and JApAN  pOST  NETWORk have been one operation for more than 130 years, ever since the  post Offi   ce started postal savings and domestic remittance operations in ...
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AN ECONOMIC HISTORY OF THE ENGLISH POOR LAW 1750-1850 pptx

AN ECONOMIC HISTORY OF THE ENGLISH POOR LAW 1750-1850 pptx

Ngày tải lên : 07/03/2014, 03:20
... adoption of outdoor relief policies in the 1770s and 1780s and for the significant differences in the administration of relief between the southeast of England and the west and north, and it analyzes ... increase in labor demand for hedging and ditching, and a long-run increase in labor demand by the cultivation of commons and waste, and the adoption of new cropping systems that often followed However, ... owe my understanding of implicit contracts theory to two of my colleagues at Cornell, Kenneth Burdett and Randall Wright Ken taught me contracts theory at the University of Wisconsin, and has continued...
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Báo cáo Y học: The folding of dimeric cytoplasmic malate dehydrogenase Equilibrium and kinetic studies doc

Báo cáo Y học: The folding of dimeric cytoplasmic malate dehydrogenase Equilibrium and kinetic studies doc

Ngày tải lên : 08/03/2014, 23:20
... the unfolded state the relative stabilities of the ÔNÕ, ÔMCÕ, ÔMEÕ state are 24, 21.8 and 11.5 kJÆmol)1, respectively Our equilibrium and the kinetic studies indicate that folding of this dimeric ... the standard procedure of s-MDH assay, monitoring the rate of the fall of absorbance of 0.2 mM NADH at 340 nm at 25 °C in 150 mM sodium phosphate buffer (pH 7.6) containing 0.5 mM oxaloacetate and ... Ôexpanded monomer (ME)Õ state, which shows most of the properties of a Ômolten globule stateÕ This intermediate retains secondary structure similar to the compact monomer but has lost most of...
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