inflammation organ function and clinical scores

... for inflammation and bacterial infection in clinical routine, CRP and PCT reached AUC statistics of 0.524/0.531 and 0.545/0.550 In comparison with these biomarkers of organ dysfunction and inflammation, ... suPAR with inflammation and organ function were also identified by a multivariate linear regression analysis revealing that organ function (kidney/urea, liver/pseudocholinesterase) and inflammation ... number of markers of inflammation, organ dysfunction and metabolism and to elucidate the prognostic impact of suPAR in critically ill patients Materials and methods Study design and patient characteristics...

Ngày tải lên: 14/08/2014, 07:21

... (i.e volume repletion and/ or increased cardiac output) being successful in improving and/ or correcting renal function Intra-renal etiology of sARF was defined when renal function failed to improve ... definitions and diagnoses Study protocol The study used a population-based surveillance cohort design The ICU Tracer database, a clinical research and departmental support database that prospectively and ... survived, 38% (46/120) and 68% (66/97) had recovered renal function to become RRT independent at ICU and hospital discharge, respectively The rates of renal recovery in survivors at 28 and 90 days were...

Ngày tải lên: 12/08/2014, 23:20

... first dose and 2.3 mg/L at steady state After the first few doses, colistin concentrations were below the Clinical and Laboratory Standards Institute MIC breakpoint of mg/L for P aeruginosa and Enterobacteriaceae ... relative clinical studies In addition, there is lack of colistin’s PK/PD data in critically ill patients Reliable colistin PK/ PD data, a better understanding of these data, and recent randomized, ... hospitalized in the ICUs A better understanding of the CMS and colistin (base) PKs could be beneficial for colistin use in humans It is known that CMS and colistin (base) PKs differ, given that...

Ngày tải lên: 21/06/2014, 01:20

... discrepancies between clinical diagnoses before death and postmortem findings were present in a significant number of cases Figure Method The retrospective review of clinical records and postmortem ... hospital The hospital offers most major medical and surgical specialties, and is a regional centre for thoracic surgery Neurosurgery, cardiac surgery and organ transplantation, including bone marrow ... of death was agreed after discussion Both the clinically diagnosed cause of death and other significant clinical diagnoses were recorded R130 The clinical diagnoses were then compared with the...

Ngày tải lên: 12/08/2014, 19:22

... We analyzed the following clinical and laboratory parameters: age, sex, underlying diseases and associated manifestations of SLE, causes of admission, Acute Physiology and Chronic Health Evaluation ... meningitis, with tuberculous bacilli isolated from the cerebrospinal fluid Clinical course, treatment and outcome The clinical courses and outcomes in the 51 patients for their first admissions are summarized ... radiographs, sites of infection and organisms cultured, treatments administered during the patient's ICU stay, occurrence of complications, duration of ICU study and outcome The cause of ICU admission...

Ngày tải lên: 12/08/2014, 22:21

... regarding the reason and transfusion trigger was documented by examining the pertinent clinical data and physician/nursing documentation When no apparent indications or clinical status changes ... transfer to the study hospital and 10 patients for whom phlebotomy and transfusion data were unavailable were excluded Baseline characteristics at ICU admission and clinical outcomes for the remaining ... as reflected by higher admission APACHE II scores, mean daily SOFA scores, requirements for life support therapies, ICU LOS, and mortality (Tables and 2) In addition, non- Available online http://ccforum.com/content/10/5/R140...

Ngày tải lên: 13/08/2014, 03:20

... ED: Mitochondrial dysfunction in septic shock and multiple organ dysfunction syndrome Mitochondrion 2004, 4:729-741 Skulachev VP: Programmed death phenomena: from organelle to organism Ann NY Acad ... 30:276-284 Brealey D, Brand M, Hargreaves I, Heales S, Land J, Smolenski R, Davies NA, Cooper CE, Singer M: Association between mitochondrial dysfunction and severity and outcome of septic shock ... that cellular depletion of the mitochondria organelles may contribute to the apparent mitochondrial dysfunction noted in shock and multi -organ dysfunction syndrome [5] The recovery of cellular...

Ngày tải lên: 13/08/2014, 08:20

... fasting and for hours postprandially, and ii GE was inversely related to both fasting and postprandial plasma CCK and PYY concentrations, but the postprandial increases in plasma CCK and PYY ... between GE, plasma CCK, and PYY is complex Whilst GE is inversely related to fasting and postprandial plasma CCK and PYY concentra- tions, it may also be a determinant of CCK and PYY response to ... elevated plasma concentrations of CCK and PYY, and (b) GE is a determinant of postprandial concentrations of CCK and PYY in the critically ill Materials and methods Subjects Studies were performed...

Ngày tải lên: 13/08/2014, 08:21

... between standard references and serially diluted serum sample curves for Ang-1 and Ang-2 assays, respectively (Figure 3) Association of circulating Ang-1 and Ang-2 concentrations with clinical and ... detection limits and precision, the interference, and the preanalytic performance of the Ang-1 immunoradiometric sandwich assay (IRMA)/immunoluminometric sandwich assay (ILMA) and of the Ang-2 ... lipopolysaccharide triggers functional inhibition of the Ang-1/ Tie-2 receptor pathway by reducing Ang-1 and Tie-2 expression and inducing Ang-2 concentrations [29,30] Experimental and clinical studies...

Ngày tải lên: 13/08/2014, 11:22

... damage and apoptosis in neurons FASEB J 2005, 19:638-640 Chonkar A, Hopkin R, Adeghate E, Singh J: Contraction and cation contents of skeletal soleus and EDL muscles in agematched control and diabetic ... mitochondrial function in skeletal muscle of normal and diabetic rats Metabolism 1996, 45:810-816 Schrauwen-Hinderling VB, Roden M, Kooi ME, Hesselink MK, Schrauwen P: Muscular mitochondrial dysfunction and ... Callahan and Supinski force generation and muscle mass are different In this context, only a few studies have examined the effects of more prolonged hyperglycemia on skeletal muscle contractile function, ...

Ngày tải lên: 13/08/2014, 15:21

... figures and wrote the manuscript AL, RL, and KB performed the measurements, and contributed to the manuscript CH, RF, and DF designed, conducted, and supervised the original HANDOUT trial, and reviewed ... designed, conducted, and supervised the original HANDOUT trial, and contributed to the manuscript PK and CH contributed equally to the work and are both considered first authors JTK and RF contributed ... Materials and methods Patients and study design The present investigation is a sub-study from the Hannover Dialysis Outcome Trial (HANDOUT), a single-center randomized controlled trial comparing standard...

Ngày tải lên: 13/08/2014, 20:21

... accuracy and reproducibility It used robust and clinically relevant outcomes It is the first to study the independent relationship between relative hyperlactatemia and outcome and identified clinically ... ANZICS-APD: Australian and New Zealand Intensive Care Society - Adult Patient Database; ANZICS-CORE: Australian and New Zealand Intensive Care Society - Centre for Outcome and Resources Evaluation; ... death and investigated the relationship between ICU admission, maximal and timeweighted blood lactate concentrations and hospital mortality in a large cohort of critically ill patients Materials and...

Ngày tải lên: 13/08/2014, 20:21

... contributions AP, VG and LB organized the Clinical Psychological Service AP, MB, MLM, DI and AB designed the study AP, MB and GZ reviewed the literature MLM, AB, MD, DI, EV, MS, IB, EB and IB collected ... at high risk for PTSD (IES-R scores ≥33) did not differ from patients with IESR scores

Ngày tải lên: 14/08/2014, 07:21

Ngày tải lên: 14/08/2014, 08:21

... contributions TS and PT conceived and designed the study and drafted the manuscript RRJ and JOP collected data All authors contributed to the review and revisions of the manuscript All authors read and approved ... indicating Risk of renal dysfunction, Injury to the kidney, Failure of kidney function, Loss of kidney function and End-stage kidney disease criteria; SOFA: Sequential Organ Failure Assessment 14 ... the need for vasoactive drugs; diminish the need for extra fluid; and improve renal function Materials and methods Patients and study intervention In the original study we included patients who...

Ngày tải lên: 14/08/2014, 08:21

... patients and its correlation to renal and liver function, and metabolism Future studies are required to establish if resistin might serve as a novel prognostic biomarker predicting ICU and overall ... in a medical ICU to understand the regulation of resistin with respect to inflammation, infection, hyperglycemia, and insulin resistance in critically ill patients and its potential use as a ... mellitus, and severity of disease using the APACHE II score [18] at admittance ICU treatment such as volume therapy, vasopressor infusions, demand of ventilation and ventilation hours, antibiotic and...

Ngày tải lên: 13/08/2014, 16:21

... renal function and significant improvement of ICU monitoring (in particular of the patient’s hydration status) and treatment (more rapid and adequate resuscitation of severe sepsis and shock and ... between 0% and 53.5% [2-27], but comparison between studies is hazardous and complicated by a lack of control for risk factors and a case mix of patients with and without renal dysfunction at ... dysfunction, shock, and respiratory failure Dose, duration, and efficacy of colistimethate sodium treatment CMS was mostly administered for 10 to 14 days Dose regimens varied considerably and...

Ngày tải lên: 21/06/2014, 03:20

... patients according to H2RA and antacids; gastric group and to group infiltrate and computer sucralfate and patients crossed assignment three of: purulent generated random either H2RA or over from ... table stratified for nurses, positive sputum standard enteral age, center and technicians, culture and feeding burn size’ (>10% BSA) NR NR clinical and systemic (Osmolite vs research antibotics ... OR purulent secretions, fever and leukocytosis Montecalvo et al [27] Gastric vs jejunal Medical and `Randomly 25 Patients received Patients crossed Cultures New and tube feeding surgical ICU...

Ngày tải lên: 12/08/2014, 18:20

... used to diagnose DVT and PE, and to understand national interest in a VTE research program in the ICU Instrument administration Analysis We report means and standard deviations, and proportions as ... conditions, admitting diagnoses such as sepsis and trauma, and events and exposures in the ICU such as central venous catheterization, invasive tests and procedures, and drugs that potentiate immobility ... DVT and PE in critically ill patients, its potential morbidity and mortality, and the need for accurate diagnosis To select individuals with managerial responsibility and representative clinical...

Ngày tải lên: 12/08/2014, 18:21