inflammation and cancer the role of the immune response and angiogenesis
Mechanisms and functions of lymphangiogenesis in regulating the immune response and inflammation resolution 2
... unlikely that they were the only cells driving the process Depletion of monocytes and macrophages by the use of AFS98 MAb inhibited lymphangiogenesis in the µMT LNs, indicating that these cells ... of the LN The heparin-binding carboxyl-domain of the predominant VEGF-A isoform, VEGF164 may bound the molecule to the extracellular matrix and limit its access deeper into the LN via the reticular ... 107 Altogether, these data indicate that as the inflammation evolved, spatial differences in the distribution of VEGF-A within DLNs may mediate the remodeling of cortical and medullary sinuses...
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Mechanisms and functions of lymphangiogenesis in regulating the immune response and inflammation resolution 1
... on the immune response Consequently, how cortical and medullary sinuses, which serve as exits for lymphocytes, are remodeled during inflammation and how this impacts the immune response and inflammation ... reabsorbed at the venous side of the capillary bed, where the colloid osmotic pressure of the blood exceeds the blood pressure The main function of the lymphatic vasculature is to return the remaining ... access of APCs to corneal antigens and the traffic of immune cells and inflammatory mediators to the regional LNs where an immune response may be primed (Patel and Dana, 2009) During inflammation, ...
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Báo cáo y học: "Circulating adenosine increases during human experimental endotoxemia but blockade of its receptor does not influence the immune response and subsequent organ injury" pdf
... supervised the genetic analyses and the writing of the manuscript WHMP performed the GSTA1-1 and GSTP1-1 analyses PP, NPR, and PS supervised the conduct of the study and the writing of the paper ... aggravated In the presence of the 34C > T variant of the AMPD1 gene, the inflammation- induced increase in adenosine concentration is augmented, and therefore the inflammatory response and organ injury ... Nijmegen, The Netherlands Authors’ contributions BPR carried out the study, gathered all data, performed the statistical analysis and wrote the manuscript PvdB performed the adenosine and caffeine...
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study on the immune response of orange spotted grouper (epinephelus coioides hamilton, 1822) cultured in khanh hoa province to bacteria vibrio parahaemolyticus
... causing the ulcerative disease in grouper Study on the effect of oral administration β-glucan on the native immune response of orange-spotted grouper Study on the specific immune response of orange-spotted ... haemorrhagic septicemia and ulceration of the skin, fins and tail are common symptoms of this disease The disease causes severe infection and often result in high mortality The common agents of this disease ... killed cells of V parahaemolyticus Significance and new conclusions from this dissertation The results of the dissertation contribute with scientific information about the immune response of orange-spotted...
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Báo cáo y học: "Application of in vivo microscopy: evaluating the immune response in living animals" pps
... occurred even in the presence of antigen These encounters of rapidly migrating T cells with DCs occurred preferentially in the vicinity of HEVs [25] The role of these early and short-lived interactions ... technique Moreover, the development of fluorescent fusion proteins and other indicators of signaling and differentiation events would allow the characterization of the functional capacity of DCs at distinct ... deepening understanding of the complex cellular choreography that is required for the initiation of a coordinate and appropriate immune response Competing interests The author(s) declare that they have...
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Báo cáo y học: " Characterisation of the immune response to type I collagen in scleroderma" pps
... progression, and immune responses to CI However, the importance of immunity to CI is emphasised by the finding that oral administration of CI to patients with SSc modulates T-cell responses and may ... characterization of the autoimmune T cell response in the HLA-DR1 mouse model of collagen-induced arthritis reveals long-term activation of type II collagen-specific cells and their presence in ... = 0.359) None of the SSc-related disease manifestations was predictive of an immune response to CI in vitro, except for a trend toward more lung fibrosis in the CI responders Of the CI responders,...
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Báo cáo y học: "Science review: Extracellular acidosis and the immune response: clinical and physiologic implications" potx
... clinical and laboratory settings; and to explore the capacity of pHo to improve the effectiveness of existing treatments Finally, an understanding of how pHo is involved in the regulation of inflammation ... understanding of the relationship between pHo and the synthesis and release of inflammatory molecules Investigators continue to seek means to modulate the inflammatory response as primary therapy ... although the patterns of response (Table 2) suggest that this is likely Effects of extracellular acidosis on other aspects of immune cell function While this review focuses on the effects of extracellular...
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Báo cáo y học: "Using an agent-based model to analyze the dynamic communication network of the immune response" docx
... ticks The plots show the frequency distribution of the contacts as log10 of the number of nodes vs the log10 of the number of links per node for the first 400 ticks of the simulation for the given ... “engaged” in the immune response, and the extent of engagement of each agent type for the response duration was determined Zero percent of the agents were engaged at the start of a simulation run The ... distributions of contacts for each immune agent type at 1000 ticks The plots show the frequency distribution of the contacts as log10 of the number of nodes vs the log10 of the number of links per...
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Báo cáo y học: "A poxvirus Bcl-2-like gene family involved in regulation of host immune response: sequence similarity and evolutionary history" pptx
... B15, K7 and N1, and may support a possible role in immune response evasion of the members of these families with still unknown function The above findings have implications in the use of poxviruses ... structure The same interaction is also conserved in K7 (Arg37 and Asp61) and A52 (Arg67 and Asp87) proteins On the other hand there are a number of charged residues which are exposed on the surface of ... classified in the Orthopox_N1 family Because of the importance of host immune response modulation for poxviruses we hypothesized the existence of additional genes involved in this role among those of still...
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Báo cáo y học: " Candida soluble cell wall β-glucan facilitates ovalbumin-induced allergic airway inflammation in mice: Possible role of antigen-presenting cells" ppt
... obtained from the vehicle group The infiltration of neutrophils was moderate in the lungs from the CSBG and modest in those from the OVA group On the other hand, the infiltration of eosinophils ... administration of CSBG can induce mucus hyperplasia, one of the consequences of the Th2 (IL-13)-dominant response and the enhanced phosphorylation of STAT6, one of the pivotal transcriptional factors in the ... increased the number of mucus cells as compared with the vehicle On the other hand, the number was significantly greater in the CSBG + OVA group than in the vehicle, CSBG, or OVA group (P < 0.01), and...
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Báo cáo y học: "Conservation and divergence of gene families encoding components of innate immune response systems in zebrafish" pdf
... representing the S100A and S100B domains, the red rectangle the intracellular domain of the ligand binding chains, and the gray rectangle the intracellular domain of the non-ligand-binding chains and ... trees of the innate immune signaling adaptors and diagrams of their protein structures Phylogenetic trees of the innate immune signaling adaptors and diagrams of their protein structures The fish ... tree of the kinases Phylogenetic tree of the kinases Details of the tree are as in Figure Figure Phylogenetic tree of the interferon response factors Phylogenetic tree of the interferon response...
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Heregulin enhanced tyrosine phosphorylation in breast cancer cells role of PP2A in HER 2 eu oncogenic signalling
... phosphorylation and the role of protein kinases Protein phosphorylation and the role of phosphatases 29 29 30 31 1.4 Protein phosphatase type 2A (PP2A) 1.4.1 PP2A structure and function 1.4.2 PP2A and cancer ... 2005; Xu et al., 2007) of the transforming functions of HER-2/neu and making them critical enhancers of HER-2/neu-driven tumorigenesis The polarized glandular organization of epithelial cells is frequently ... deleted in various cancers (Di Cristofano and Pandolfi, 2000); the dual specificities of the protein phosphatases, CDC25A and CDC25B, are important regulators of cell cycle progression and both exhibit...
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Báo cáo y học: "Modulation of humoral immune response to oral BCG vaccination by Mycobacterium bovis BCG Moreau Rio de Janeiro (RDJ) in healthy adults" ppsx
... demonstrate that proliferation and trafficking of primed T-cells shows stimulation of the mucosal immune response at the same time as the systemic immune response; peak responses in this study (d7-12) ... in the study design and participated in the drafting of the manuscript LRCB conceived the study, data analysis, coordination, the draft and finalisation of the manuscript All authors read and ... humoral immune response with antibodies of isotype IgA Arrows indicate time of immunisation and booster Page of (page number not for citation purposes) Journal of Immune Based Therapies and Vaccines...
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Mammographic density and breast cancer risk: the role of the fat surrounding the fibroglandular tissue pdf
... in their models [19] To obtain more insight into the role of the fat breast tissue, we investigated the independent effects of the size of dense tissue and the size of non-dense tissue in the ... is, mother or sister (no/yes), height and BMI To investigate the independent effects of the dense and the non-dense areas, the analyses of the dense area were additionally adjusted for the non-dense ... Netherlands (CBS) and Netherlands Cancer Registry (NKR) for data on cancer and death, and screening organization ‘Bevolkingsonderzoek Midden-West’ for making the mammograms available We thank the...
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Báo cáo y học: "The role of leptin in innate and adaptive immune responses" doc
... immune responses: adaptive immune- mediated responses are attenuated, whereas in models involving the innate immune response, leptin deficiency causes inadequate control of inflammation Role of ... a major role in the regulation of the inflammatory process in experimental models of hepatitis and colitis in mice, emphasizing the critical role of adipose tissue-derived leptin in immune modulation ... possess protective effects in some models of innate immune response- mediated inflammation [81] Direct and indirect effects of leptin during immune response and inflammation As mentioned above, leptin...
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Báo cáo khoa học: "The evolution of rectal and urinary toxicity and immune response in prostate cancer patients treated with two three-dimensional conformal radiotherapy techniques" ppt
... pointed to the significant association of acute GU toxicity and the percentage of the urinary bladder receiving 50 Gy, and the association of late GU toxicity with the percentage of the urinary ... excellent cooperation and valuable comments The work was supported by the Grant agency of the Charles University, GAUK 109908/ 2008 and the Grant agency of the Academy of Sciences of the Czech Republic, ... 14 of RT, and 15-20 days post-radiotherapy Negative correlation throughout the RT was detected between the NKT cell and T lymphocyte proportion and the volume of the rectum receiving lower and...
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Báo cáo y học: "The role of toll-like receptors in acute and chronic lung inflammation" pdf
... regulate the innate immune response during ALI, the failure of innate immunity to sterilize the lower respiratory tract in CF, and the role of innate immunity in tissue remodelling in asthma and COPD ... modulation of intracellular TLR signaling In addition to TLRs, a variety of other PRRs including the cytoplasmic NLRs and RLRs play important roles in the induction of lung inflammation For example, the ... infection, the viral G protein mediates attachment to lung epithelial cells and the F Page of 14 protein leads to the fusion of the viral envelope with the host cell plasma membrane [212] In response...
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Báo cáo y học: " Young adult obese subjects with and without insulin resistance: what is the role of chronic inflammation and how to weigh it non-invasively" docx
... above the umbilicus The SAAT was defined as the thickness between the skin-fat interface and the linea alba, and the VAT was defined as the distance between the anterior wall of the aorta and the ... obesity (BMI and WC, [21]) A second point of the problem to stress is whether the weight control can slow down the progression of IR and the worsening of fat deposition in organs in these obese ... http://www.journal -inflammation. com/content/6/1/6 entity of VAT and SAAT deposition and the severity of HS, all of them studied by US in basal condition, jjj) to find among the inflammation markers,...
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Báo cáo y học: " The role of vitamin D in pulmonary disease: COPD, asthma, infection, and cancer" ppsx
... deposition 1922 The effect of additions of fluorine to the diet of the rat on the quality of the teeth 1925 J Biol Chem 2002, 277:E8 Holick MF: Evolution and function of vitamin D Recent Results Cancer ... hours As the innate immune responses are mobilized more rapidly than acquired immune responses, the authors interpreted the 24- and 96-hour results as indicators of innate and acquired responses, ... RW: The effect of additions of fluorine to the diet of the rat on the quality of the teeth 1925 Studies on experimental rickets XXI An experimental demonstration of the existence of a vitamin which...
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Báo cáo y học: " The role of the humoral immune response in the molecular evolution of the envelope C2, V3 and C3 regions in chronically HIV-2 infected patients" pdf
... isolated the viruses and quantified the antibody responses HB and CR participated in virus isolation and in the sequencing analysis of some patients MD, FA and FM recruited the patients and were ... responsible for collecting the blood samples and the clinical data PG quantified the plasma viremia CN and PG helped with the interpretation of data and revision of the manuscript PB and NT preformed statistical ... at 405 and 492 nm against a reference wavelength of 620 nm The clinical cut-off value of the assay, calculated as the mean OD value of HIV-seronegative samples plus three times the standard deviation...
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