induction of an antitumor immune response is not the major problem
Báo cáo hóa học: "MAXIMUM NORM ANALYSIS OF AN OVERLAPPING NONMATCHING GRIDS METHOD FOR THE OBSTACLE PROBLEM" pot
Ngày tải lên :
22/06/2014, 22:20
... subdomains, it is impossible to formulate a global approximate problem which would be the direct discrete counterpart of problem (2.28) L∞ -error analysis This section is devoted to the proof of the main ... πh is an interpolation operator on ∂Ω, and rh is the usual finite element restriction operator on Ω The lemma below establishes a monotonicity property of the solution of (2.6) with respect to the ... problem, and define their respective finite element counterparts in the context of nonmatching overlapping grids Section is devoted to the L∞ -error analysis of the method The Schwarz method for the...
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Báo cáo y học: "Apoptosis is not the major death mechanism induced by celecoxib on rheumatoid arthritis synovial fibroblasts" pps
Ngày tải lên :
09/08/2014, 10:22
... work and the analysis of the data and participated in the writing of the manuscript VD performed several experiments MH participated in the analysis of the study and in the writing of the manuscript ... manuscript BC and JM participated in the design of the study and in the writing of the manuscript All authors read and approved the manuscript 16 17 Williams C, Mann M, DuBois R: The role of cyclooxygenases ... analysis using Annexin V binding and TO-PRO-3 uptake Values are expressed as the percentage of total cell death (upper panel) or apoptosis (lower panel) and are the mean ± standard error of the...
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báo cáo hóa học: " Boosting with intranasal dendrimeric Aβ1–15 but not Aβ1–15 peptide leads to an effective immune response following a single injection of Aβ1–40/42 in APP-tg mice" ppt
Ngày tải lên :
19/06/2014, 22:20
... immunohistochemistry and ELISAs, and guided or performed image analysis, analyzed data and drafted the manuscript LJ performed tissue preparation, immunohistochemistry, image analysisand ELISAs ... mediated immune response is hypothesized to be the basis of the meningoencephalitis reported in the AN1 792 trial [10], this may be an important consideration in the Page of 10 (page number not for ... humoral immune response The main advantage of the prime/boost strategy is the increased immune response due to the priming with the full-length peptide and then focusing the immune response to a...
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Báo cáo khoa học: Cyclosporin A-induced oxidative stress is not the consequence of an increase in mitochondrial membrane potential doc
Ngày tải lên :
30/03/2014, 08:20
... NIM811 and PSC833 induce an increase in cytosolic [Ca2+] and production of ROS The discrepancy in the effects of PSC833 between GLC4 cells and isolated mitochondria versus the consistency in the ... according to the Newman–Keuls multiple comparison test A B Fig Effects of different concentrations of CsA and its analogs on the Ca2+-dependent induction of opening of the MPTP The data are representative ... extract and 20 lgÆmL)1 gentamicin (Centafarm Services, EttenLeur, the Netherlands) The human small cell lung cancer (GLC4) cell line and GLC4 cell line transfected the human multidrug resistance...
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Báo cáo y học: "How possible is the development of an operational psychometric method to assess the presence of the 5-HTTLPR s allele? Equivocal preliminary findings" pdf
Ngày tải lên :
08/08/2014, 23:21
... equal and omission of any of them did not alter the a value significantly The calculation of sensitivity (Sn) and specificity (Sp) at various cut-off levels for the two scales is shown in Table The ... The discriminant function analysis results are shown in Table Both Sn and Sp as well as the discriminant function analysis results are poor and can not lead to the identification of cases The ... conceived the study, gathered and managed the data, performed the genetic analysis, participated in the statistical analysis and wrote the paper KNF conceived the study, carried out the literature...
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Báo cáo y học: "Deficiency of functional mannose-binding lectin is not associated with infections in patients with systemic lupus erythematosu" pptx
Ngày tải lên :
09/08/2014, 08:23
... and reviewed the draft of the manuscript MRD participated in the design of the study, supervised the performance of the MBL pathway activity ELISA, and reviewed the draft of the manuscript AEV ... in the design of the study, contributed to the coordination of the study, supervised the statistical analyses, and reviewed the draft of the manuscript All authors have read and approved the ... the Japanese study [10] Another explanation for the discrepancy between the genotypic and the phenotypic data could be that unidentified linkages between mutations or polymorphisms in the MBL...
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Báo cáo y học: "Identification of an altered peptide ligand based on the endogenously presented, rheumatoid arthritis-associated, human cartilage glycoprotein-39(263–275) epitope: an MHC anchor variant peptide for immune modulation" pot
Ngày tải lên :
09/08/2014, 10:20
... mice (data not shown) In conclusion, the analysis of both the hybridoma panel and the polyclonal T cell response to the 263–275 epitope has led to the identification of MHC binding and TCR contact ... potential of the F265(Dip) APL in the context of HLA-DR4 The results show that this APL does not give rise to increased immune responses to APL or native peptide/protein Rather, the partial agonistic ... context of experimental arthritis How to explain the immune modulating potential of this APL at the level of TCR recognition, triggering and beyond? The current paradigm is that the recognition of...
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Báo cáo y học: "volution of an adenocarcinoma in response to selection by targeted kinase inhibitors" potx
Ngày tải lên :
09/08/2014, 20:22
... methodology for the study of rare cancer types and can aid in the determination of relevant therapeutic approaches in the absence of established interventions Furthermore, the establishment of repositories ... changes have occurred within the tumor that likely contribute to the pathogenesis of the disease and our understanding of cancer biology is far from complete It is possible, therefore, that these ... gefitinib resistance [36] Therapeutic intervention The integration of copy number, expression and mutational data allowed for a compelling hypothesis of the mechanism driving the tumor and allowed...
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Báo cáo y học: "Role of TRPV3 in immune response to development of dermatitis" doc
Ngày tải lên :
11/08/2014, 08:22
... and could not be segregated from each other However, these phenotypes are segregated in C57BL/6-Nh mice and only the hairless phenotype is found [13] This means that the penetrance of the TRPV3Gly573Ser ... mice These results show clearly that adherence of S aureus does not lead to activation of the immune system in NC/Nga-Nh mice This discrepancy about the incidence of spontaneous dermatitis between ... out the experimental work, analyzed the data and drafted the manuscript TY carried out the experimental work, analyzed the data, and conceived the study and its design TH participated in animal...
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Báo cáo y học: " Off hour admission to an intensivist-led ICU is not associated with increased mortality" pps
Ngày tải lên :
13/08/2014, 16:21
... final manuscript JIvdS and RJB analyzed data of the OLVG and contributed in the preparation of the final manuscript JHR and PES analyzed data of the GH and contributed in the preparation of the ... together at a reunion party IAM analyzed the data from the RDGG and the aggregate data, wrote the first version of the manuscript and together with PES and MvS-V supervised the preparation of the ... quality of care round the clock In the present study, the definition of off hour was based on the presence or absence of the intensivist in the ICU Future studies should investigate whether the organisational...
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Báo cáo y học: " Implementation of an evidence-based sepsis program in the intensive care unit: evident or not" pptx
Ngày tải lên :
13/08/2014, 19:20
... was promoted by means of specially organized meetings, hospital intranet, and poster displays A ‘sepsis team’ (mentioned above) consisting of an ICU physician and an infectiologist, who were available ... Thijs LG: The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive ... admitted to the ICU and who met a comprehensive list of inclusion criteria were enrolled [1] Key issues of the present investigation were the development and other surrounding aspects of their educational...
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Báo cáo y học: " Derivation and preliminary validation of an administrative claims-based algorithm for the effectiveness of medications for rheumatoid arthritis"
Ngày tải lên :
25/10/2012, 10:45
... Ethnicity Caucasian, not Hispanic Non-Caucasian Hispanic Black, not Hispanic American Indian or Pacific Islander RA Drug Initiated Abatacept (5%) (3%) Adalimumab 74 (38%) 74 (24%) Etanercept 60 (31%) ... characteristics of the study populations of biologic and non-biologic DMARD users and the performance characteristics of the effectiveness algorithm between biologic and DMARD treatment episodes, the ... rate ranged from – 21% The results of the second sensitivity analysis that had no baseline VARA visit (and thus could not include change in disease activity as part of the effectiveness gold standard)...
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Tài liệu Novel Design of an Integrated Pulp Mill Biorefinery for the Production of Biofuels for Transportation pot
Ngày tải lên :
26/02/2014, 14:20
... system, consists of a physical mixture of a methanol synthesis catalyst and a methanol dehydration catalyst The methanol synthesis catalyst is generally a copper and/or zinc and/or aluminum and/or ... which type of catalyst system is used and regardless of whether the process is conducted in the gas or liquid phase, maintenance of the catalyst activity is a major challenge This is especially ... conventional methanol synthesis loop With respect to technology verification at industrial scale, the only major difference between the oxygenate synthesis and the methanol synthesis is the second...
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Báo cáo hóa học: " Optimization of an Electron Transport Layer to Enhance the Power Conversion Efficiency of Flexible Inverted " ppt
Ngày tải lên :
21/06/2014, 08:20
... thickness On the other hand, resistance of the seed layer increased with increasing thickness As a result, the Jsc of the device increased up to the optimum film thickness, after which it began to decrease ... resistance, as shown in Fig Consequently, the PV performance of the device varied in the same way Thus, an optimization process was necessary with respect to the thickness of the electron transport ... contributes to the bulk conductivity of each of the functional layers and the contact resistance between them, and because high charge carrier mobility is beneficial to obtaining a low Rs [19], the lower...
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Báo cáo khoa học: "Retrieval of an embolization coil accidentally dislodged in the descending aorta of a dog with a patent ductus arteriosus" doc
Ngày tải lên :
07/08/2014, 20:23
... derapmoC tcart lanitsetniortsag ro yawria eht ni seidob ngierof eveirter ot dengised yllanigiro ,specrof ydob ngierof gnisu ,ecnadiug cipocsodne rednu atroa lanimodba eht morf lioc noisulcco degdolsid ... ypocsoroulf lanimodba eht fo noitcejorp laretaL giF pit lian eriw-eerht a htiw specrof ydob ngierof gnisu ,atroa lanimodba eht morf lioc noisulcco degdolsid eht fo laveirter eht gniwohs ypocsoroulf lanimodba ... noisulcco degdolsid gnipsarg specrof ydob ngieroF )B( ,troper esac siht ni desu pit lian eriw-eerht htiw specrof ydob ngieroF )A( lioc giF lioc noisulcco degdolsid eht yb desuac atroa lanimodba...
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Báo cáo y học: "Association of the T allele of an intronic single nucleotide polymorphism in the colony stimulating factor 1 receptor with Crohn''''s disease: a case-control study" ppt
Ngày tải lên :
11/08/2014, 10:23
... staining of the terminal web and lateral junctions of the epithelial cells (green arrow) B Staining of the superficial epithelium of the colon C Staining of the superficial epithelium of the ileum ... In this analysis, patients with Crohn's disease still had significantly higher rates of the T allele than controls The CSF1R protein is expressed in the superficial epithelium of the ileum and ... that the differential expression of the SNP was more pronounced in some ethnic groups (Acadian) than in others (African American) In the case of Crohn's patients of Acadian descent, the rate of the...
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Báo cáo y học: " Protocol for a randomised controlled trial investigating the effectiveness of an online e health application for the prevention of Generalised Anxiety Disorder" pptx
Ngày tải lên :
11/08/2014, 16:22
... editing of the manuscript and writing of a second draft Author Information HC Particular expertise in mental health and the use of the Internet in the prevention of mental disorders and has published ... Research Assistant to Professor Christensen PJB Expertise in statistical analysis and data management of large-scale behavioural research studies, and experience in the design and implementation of longitudinal ... nature of attrition Page of A description of the methods, design, and current status of the trial is also included as is a discussion of the possible implications that may arise from the findings...
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Báo cáo y học: " Development and evaluation of an immunochromatographic strip test based on the recombinant UL51 protein for detecting antibody against duck enteritis virus" ppsx
Ngày tải lên :
12/08/2014, 01:22
... number of ELISA is 82.61% b The consistency ratio of the positive number of ICS to the positive number of NT is 19.51% and that of the negative number of ICS to the negative number of NT is 75.36% ... investigating the epidemiology of DEV in unvaccinated duck flocks The consistency ratio of the positive number of ICS to the positive number of ELISA is 85.37% and that of the negative number of ICS to the ... reagent of the ICS Page of Figure SDS-PAGE and western blotting analysis of recombinant UL51 protein (a) SDS-PAGE analysis of recombinant UL51 protein Lane M, molecular mass markers (in kDa); lane...
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Báo cáo y học: "Establishment of an early liver fibrosis model by the hydrodynamics-based transfer of TGF-β1 gene" docx
Ngày tải lên :
13/08/2014, 13:20
... performed the EMSA and edited the manuscript EL coordinated the study and finally edited the manuscript All authors have read and approved the content of the manuscript described in the User Bulletin ... to the liver and may have its usefulness for the clinical study of the prevention of early stage of liver fibrosis Methods Animals Mice of Balb/c strain were used All procedures of animal handling ... TGF-β1, further augmenting the autocrine regulating cycle Another involved pathway is the activation of Smad cascade The Col 1A2 gene expression is induced via the phosphorylation of Smad2 and Smad3,...
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Báo cáo y học: "Increased sinusoidal flow is not the primary stimulus to liver regeneration" pps
Ngày tải lên :
13/08/2014, 13:20
... conducted and supervised the biostatistical analysis of the microarray data EM was responsible for the preparation, analysis and interpretation of histological sections CB supervised the microarray analysis ... rats and for the outcome of acute liver failure in swine [45,46] Furthermore, analysis of the flux of liver enzymes, GT, ALP and bilirubin flux across the liver bed and cytokine analysis of blood ... drafted and revised the manuscript LNC was responsible for all aspects of the microarray analysis including parts of the biostatical analysis IN made substantial contributions to data acquisition...
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