independent dependent and control variables

... contrast, PF-4 strongly inhibited the Raf1, MEK1/2 and ERK1/2 activation stimulated by both VEGF165 and VEGF121 Thus, PF-4 inhibited the MAP kinase pathway independently of KDR activation, showing that ... obtained ` through local maternity units (Lariboisiere Hospital and Saint Isabelle Clinic) under approval, and with appropriate understanding and consent of the subjects DNA synthesis HUVEC were seeded ... obtained with VEGF165 (––) and VEGF121 (- - -) (B) Values are means ± SD of four independent experiments performed in triplicate effect of PF-4 on KDR activation VEGF165 and VEGF121 (10 ngÆmL)1)...

Ngày tải lên: 19/02/2014, 16:20

... We chose to study the regulation of chemokine (C-XC motif) ligand 10 (Cxcl10), Egr1 (partially GCN2 independent) and Dusp16 (GCN2 independent) because the structures of these genes were known In ... GCN2 independent and 21% were partially GCN2 dependent (Table S1) As the GCN2 pathway regulates gene expression via transcription factor ATF4, we determined the ATF4 dependence of a few GCN2 -dependent ... acid starvation (Fig and Table S1) Focusing on the effect of GCN2, we considered that a gene was GCN2 dependent when it was not regulated in GCN2) ⁄ ) cells, and GCN2 independent when more than...

Ngày tải lên: 07/03/2014, 03:20

... caspase -dependent and caspase -independent [22,25] In the case of CHO-K1 cells, OA appears to induce DNA fragmentation by at least three different pathways: caspase-3 and other caspase activationdependent ... involving DEVDase activity; caspase-3 -dependent and other caspase activation -independent pathways not involving DEVDase activity; and other caspase activation -dependent pathways involving DEVDase ... apoptosis proteins and caspase -independent cell death [28,29] In this study, TPCK and TLCK could not inhibit caspase-3 cleavage, and thus subsequently induce PARP degradation and DNA fragmentation...

Ngày tải lên: 22/03/2014, 21:20

... and WXH designed and directed studies, and were involved in the interpretation of the data and writing of manuscript BG, GFZ and FZ carried out the cells culture and HHV-6 infection BG, JFW and ... molecules including cytochrome c, Smac/Diablo, and AIF to induce apoptosis via the caspase -dependent and independent pathways [24-26] We separated the cytosolic and mitochondrial fractions to examine ... caspasedependent and -independent apoptosis pathways, as evidenced by (1) activation of caspase-3, -8 and -9; (2) increasing the ratio of Bax/Bcl-2; (3) increasing the presence of Smac/Diablo, AIF and...

Ngày tải lên: 18/06/2014, 18:20

... death We also report that CCL25 promotes proliferation and CCR9 -dependent anti-apoptotic signalling via the PI3K/Akt/GSK/FKHR pathway and independent of FAK These studies suggest expression of ... PI3K/Akt pathway and its downstream mediators, FKHR and GSK-3β Moreover, PI3K inhibition completely abrogated CCL25-mediated and CCR9 -dependent cisplatin resistance, Akt, GSK-3β, and FKHR phosphorylation ... the manuscript RS and CJH assisted with experiments and manuscript preparation WEG, EEP, JWL and SS conceptualized, edited, and/ or revised the manuscript All authors have read and approved the...

Ngày tải lên: 20/06/2014, 07:20

... contributions All authors conceived of the study, and participated in its design and coordination and helped to draft the manuscript All authors read and approved the final manuscript Competing interests ... surgical planning, and followup of patients with GIST [5,6] Most tumors are seen as well delineated soft tissue masses with heterogenous contrast enhancement Necrosis, calcification, and ulceration ... adenocarcinoma Dystrophic calcification occurs in ischemic and necrotic tissue Denatured proteins bind specifically to phosphate Page of ions and thereafter react with calcium ions to form calcium...

Ngày tải lên: 09/08/2014, 01:24

... factor-1- and CD106 (VCAM-1 )dependent mechanism J Clin Invest 2001, 107:305-315 Toyama-Sorimachi N, Miyake K, Miyasaka M: Activation of CD44 induces ICAM-1/LFA-1 -independent, Ca2+, Mg2+ -independent ... alternative ligand(s) for VLA-4 Other investigators have also reported the involvement of a VLA-4 -dependent/ VCAM-1 -independent adhesion pathway in the interaction between bone marrow stromal cells and leukocytes ... coculture Cellular adhesion and transmigration were evaluated independently, as described in Fig Values are means ± standard deviation of three different experiments (b) and (c) Phase-contrast micrographs...

Ngày tải lên: 09/08/2014, 06:22

... hypoxia and DFX on proliferation in p21, p27 and p53 gene silenced NHLF Effect of hypoxia and DFX on proliferation in p21, p27 and p53 gene silenced NHLF NHLF transfected with control (Control) , ... Each assay was replicated in four independent experiments Transfection of small interfering RNA (siRNA) into NHLF p21, p27, p53 and control siRNAs were designed and synthesized by B-Bridge International ... of Control (open bars), p21 KD (solid bars), p27 KD (shaded bars), and p53 KD (diagonal bars) protein bands relative to β-actin bands Data are expressed as mean ± SE (n = 4) *P < 0.05 versus control...

Ngày tải lên: 12/08/2014, 14:20

... protease -dependent and protease -independent Protease -dependent activation results in morphological changes, cell-desquamation and production of proinflammatory cytokines Protease -independent ... (pg/ml) 100 Der p 1- and Der p 5-induced cytokine release are protease -dependent and protease -independent, respectively Next, we determined the effects of heat treatment and protease inhibitors ... (Groningen, The Netherlands) The retrograde analogues of PAR-1 and PAR-2 were used to show specificity of the PAR-1 and PAR-2 agonists Table 1: Effects on cell shrinking and desquamation of house...

Ngày tải lên: 13/08/2014, 13:22

... Internal variables Input variables JHC/2001-04-03 p 15 Output variables OPEN DISTRIBUTED AUTOMATION AND CONTROL WITH IEC 61499 Software Encapsulation and Reuse: Software Encapsulation and Reuse: ... AUTOMATION AND CONTROL WITH IEC 61499 IEC 61131-3: Modern (1993) Software IEC 61131-3: Modern (1993) Software Engineering for Automation and Control Engineering for Automation and Control • Encapsulation/Reuse ... OPEN DISTRIBUTED AUTOMATION AND CONTROL WITH IEC 61499 Open Distributed Automation and Control Open Distributed Automation and Control with IEC 61499 with IEC 61499 • • • •...

Ngày tải lên: 20/08/2012, 11:15

... inventories (Chapter 4); designing and operating warehouses and crossdocks (Chapter 5); planning and controlling long-haul and short-haul freight transportation (Chapters and 7) Finally, Chapter provides ... process characteristics, as well as demand volume and variability MTO systems are more suitable whenever lead times are short, products are costly, and demand is low and highly variable In some cases, ... demand from local warehouses (replenished at low frequency) Coping with randomness in customer demand and lead times Inventories of finished goods (safety stocks) help satisfy customer demand...

Ngày tải lên: 16/08/2013, 08:50

... are demanded to find out highly efficacious and inexpensive drugs and vaccines REFERENCES Aguado-Martinez, A., G Alvarez-Garcia, A Fernandez-Garcia, V Risco-Castillo, V MaruganHernandez, and L ... is sensible and plausible to restrict contact between dogs (and other definitive hosts) and cattle to reduce the transmission and prevalence of the infection as well Aborted fetuses and placenta, ... PREVENTION AND CONTROL OF N CANINUM INFECTION IN CATTLE Prevention and control of neosporosis base on the reduction of number of positive animals in the herds by decreasing the risk of both vertical and...

Ngày tải lên: 29/08/2013, 08:14

... schedules Quality control records and audit trails Material test certificates Equipment test and performance certificates Equipment, material and system guarantees All contracts (and subcontracts) ... Stages and sequence Summary of project stages and sequence The following pages show the stages and sequences in diagrammatic and tabular format Figure 32.1 shows the normal sequence of controls ... project can be handed over, a large number of documents have to be checked and updated to reflect the latest version and as-built condition In addition, certain documents obtained and collated during...

Ngày tải lên: 17/10/2013, 21:15

... q variables and the string and rod vectors tαβγ and rβij From Figures 18.5 and 18.6, the position vectors from the origin of the reference frame, E, to the nodal points, p1ij, p2ij, p3ij, and ... axially loaded compression members and tendon members that easily allow the unification of structure and control functions Sensing and actuating functions can sense or control the tension or the length ... the integration of structure and control design appears in Skelton1,2 and Grigoriadis et al.3 Bendsoe and others4-7 optimize structures by beginning with a solid brick and deleting finite elements...

Ngày tải lên: 18/10/2013, 09:15

... Complete Flow and Level Measurement Handbook and Encyclopedia®, OMEGA Press, 1995 OMEGA Volume 29 Handbook & Encyclopedia, Purchasing Agents Edition, OMEGA Press, 1995 “Advanced Process Control for ... standard flow For liquids, this standard flow is the water equivalent in gpm; for gases, the standard flow is the air flow equivalent in standard cubic feet per minute (scfm) Tables listing standard ... polypropylene, PVDF, TFE and PFA, brass, aluminum, and stainless steel T References & Further Reading • OMEGA • • • • • • • • Complete Flow and Level Measurement Handbook and Encyclopedia®, OMEGA...

Ngày tải lên: 20/10/2013, 01:15

... Identity code given to a work element for cost control purposes Cost control The ability to monitor, compare and adjust expenditures and costs at regular and sufficiently frequent intervals to keep ... defined time, cost and quality/performance parameters Project life cycle All the processes and phases between the conception and termination of a project 367 Project Planning and Control Project ... aspects of quality criteria, control, documentation and assurance Quality plan A plan that sets out the quality standards and criteria of the various tasks of a project Random numbering The numbering...

Ngày tải lên: 20/10/2013, 13:15

... to control the project ensures that the focus is kept on achieving the outcomes within the budget and timescale agreed The word control sounds very authoritarian and inflexible However, control ... Monitoring and control 119 the project will not meet its targets because progress is too slow, or if a delay in one activity will impact on others, causing waste and further delay Control may ... of effective management and is a key responsibility of a project manager MONITORING To control a project you need a plan that details how things should be happening, and you need accurate information...

Ngày tải lên: 24/10/2013, 08:20

... problems, increased reliability and improved thermal capacity are achieved On the other hand, brushless motors require more complex and expensive control systems Sensors and switching circuitry are ... cheap, robust, and reliable, and at the same time offer good torque characteristics However, control of such motors is rather complicated Advanced vector controllers are expensive and not guarantee ... Sections 21.3.1 and 21.3.2 The problem of control is strongly influenced by the choice of actuators For instance, DC motors, stepper motors, and hydraulic actuators require different hardware and software...

Ngày tải lên: 25/10/2013, 13:15

... is shown in Tables 24.1, 24.2, and 24.3 24.4 SOUND POWER AND SOUND PRESSURE Sound power is measured in watts It is independent of distance from the source, and independent of the environment Sound ... also on the mass load on the spring, the mass and stiffness of the foundation, and the type of excitation If the foundation is very massive and rigid, and if the mounted machine vibrates at constant ... damping, produces a constant damping force, independent of displacement and velocity The damping force is produced by dry surfaces rubbing together, and it is opposite in direction to that of...

Ngày tải lên: 25/10/2013, 13:15