increased risk of second primary tumors

... comparison of the incidence of second primary tumors among study patients (observed) with the incidence of the same tumors in the general population of California males (expected) Calculation of the ... observed number of second primary malignancies was 221 compared to 190.42 expected, thereby producing an SIR of 1.16 (95% CI = 1.01–1.32), which shows an excess risk of 16% The excess risk of subsequent ... to non-Hispanic whites The increased risk of second primary breast cancer among the 'other' racial/ethnic category is largely due to the risk among blacks The risk of melanoma among non-Hispanic...

Ngày tải lên: 22/03/2014, 17:20

... Consorti et al.: Nulliparity enhances the risk of second primary malignancy of the breast in a cohort of women treated for thyroid cancer World Journal of Surgical Oncology 2011 9:88 Submit your ... effect of multiparity for SPM of the breast Obesity has been associated with increased incidence of thyroid cancer [15] In our study, the majority of patients were overweight with a mean BMI of 26.83 ... incidence only of in situ SPM breast cancer, we observed an increased risk of invasive breast cancer Chen et al (2001) [3] and Brown et al (2008) [11] observed a higher incidence of SPM of the breast...

Ngày tải lên: 09/08/2014, 02:20

... an expected number of 16.8, RR = 1.61, 95%CI 1.04-2.34) trimester with an upper confidence limit of 10.5 The authors calculate that in order to rule out a doubling of the risk, they would need ... Conflict of interest The authors have declared that no conflict of interest exists References Pedersen L, Vinther Skriver M, Nørgaard M, Sørensen HT Maternal use of Loratadine during pregnancy and risk ... noticed effect of loratadine during the first period could be the result of a synergism with an unknown factor – a search for such a factor has yielded no likely candidate The second possibility,...

Ngày tải lên: 31/10/2012, 17:03

... the bone strength leading to risk of fracture Osteoporosis is characterized as either primary or secondary Primary osteoporosis occurs in both sexes at all ages but often follows menopause in women ... Reference [25] B RISK FACTORS FOR OSTEOPOROSIS IN AIDS The risk factors for osteoporosis are fairly straight forward (fig 1) Fig.1 Schema of the object of environmental and genetic risk factors on ... manufacture Source of Fig - Reference [29] In AIDS, the mainly suggested risk factors for the development of osteopoenia and osteoporosis are the use of protease inhibitors, longer duration of HIV infection,...

Ngày tải lên: 03/11/2012, 09:54

... or risk factors for future development of AD, a finding that is supported by a previous study that investigated the levels of different MMPs in plasma of AD patients [30] The increased levels of ... levels implying an increased risk of future development of AD In addition, increased CSF MMP-3 and MMP-9 levels in healthy elderly individuals correlated with the CSF levels of T-tau and P-tau ... CSF levels of MMPs are influenced by the production of MMPs by neurons and glial cells, the release of MMPs by inflammatory cells and extravasation of MMPs from peripheral blood All of these mechanisms...

Ngày tải lên: 22/03/2014, 14:20

... cohort study suggest that individuals with PMR have an increased risk of PAD This increased risk may be due to premature atherosclerosis Page of (page number not for citation purposes) Arthritis ... not associated with a higher risk of PAD Moreover, timing of glucocorticoid exposure and cumulative glucocorticoid dose was also not associated with a greater risk of PAD in these patients [31] ... influence of PMR disease characteristics on the development of PAD within the PMR cohort A time-dependent covariate was used to examine the effect of GCA in order to account for development of GCA...

Ngày tải lên: 09/08/2014, 14:20

... score Score > 0.01 50% of samples, 97% accuracy Score > 0.05 69% of samples, 89% accuracy Figure A graph of the accuracy of the method as a function of the similarity score of the best hit The graph ... capable of identifying the tissue of origin of CUP samples with 89% accuracy when excluding the most uncertain 30% of the samples If we, like some of the previously published Page 10 of 12 studies ... program to that of the cancer of origin This is reflected in the ability to identify the origin of metastases with reference data on primary tumors, but it is also visible at the level of individual...

Ngày tải lên: 11/08/2014, 12:21

... other types of death were analysed after exclusion of heroin overdoses The risk of undetermined suicide is presented in Figure There is a significant trend towards increased risk of undetermined ... number of substances 80 Heroin overdoses The risk of death by fatal heroin overdoses increased by an average of 3.5 times for every additional substance used 70 60 50 40 30 20 10 Number of substances ... relationship between number of substances used risk for The relationship between number of substances used risk for unnatural death Percent of all unnatural deaths Page of (page number not for citation...

Ngày tải lên: 11/08/2014, 17:20

... Promotion, Office on Smoking and Health 2006 Department of Health Department of Health and Social Services Northern Ireland, The Scottish Office Department of Health and Welsh Office: Report of the ... and Health (SCOTH): Secondhand smoke: Review of evidence since 1998 Update of evidence on health effects of secondhand smoke London: Department of Health; 2004 Royal College of Physicians: Passive ... relationships An assessment of the relation between amount of exposure and disease risk was included in 26 of the 60 papers studied, quantifying exposure in terms of the numbers of cigarettes per day...

Ngày tải lên: 12/08/2014, 13:22

... volume in one second ments of daily tobacco consumption and years of smoking, female smokers had a higher risk of hospitalization for COPD compared with male smokers (relative risk, RR, 1.5, ... additional data and/ or clarification of data, where necessary Study selection and data abstraction The primary objective of this study was to compare the annual decline of lung function, measured as ... currently the 4th-leading cause of mortality and the 12th-leading cause of disability, by the year 2020 it will be the 3rd-leading cause of death and the 5thleading cause of disability worldwide [3,4]...

Ngày tải lên: 12/08/2014, 16:20

... correlated with increased risk of postoperative delirium Other independent risk factors included increasing age, history of diabetes mellitus, longer duration of surgery, and occurrence of complications ... predictors of postoperative delirium (Table 4) Of particular note was that high serum cortisol level was associated with significantly increased risk of postoperative delirium in this risk- adjusted ... identified risk factor of delirium [2,12,36], suggesting that the naturally aged brain might be the basis of the occurrence of delirium A history of diabetes mellitus is associated with increased...

Ngày tải lên: 14/08/2014, 07:21

... conclusion of CPB is associated with a significant risk of the development of postoperative infections Further research is necessary to assess whether a targeted strategy of rapid measurement of endotoxin ... cardiac surgery The finding of a substantially increased risk of post-operative infections in patients who have endotoxemia after CPB is novel Given the elective nature of the surgical patients ... sub-population of patients who develop endotoxemia Our study has a number of important limitations First, we studied a relatively low risk patient population Page of and thus had a small number of patients...

Ngày tải lên: 14/08/2014, 07:21

... population risk of developing breast cancer (that is, a 10-year risk of less than 3% for women aged 40–49 years and a lifetime risk of less than 17%) are cared for in primary care • Women at raised risk ... at high risk of developing breast cancer (that is, a 10-year risk of greater than 8% for women aged 40–49 years or a lifetime risk of 30% or greater) are cared for in tertiary care High risk also ... The scope of this guideline is available from www.nice.org.uk/CG041 The scope of this guideline was care and classification of women at risk of breast cancer because of a family history of breast...

Ngày tải lên: 15/03/2014, 00:20

... multitude of methods for introducing glial-type neoplasms into the rodent CNS, which histologically mimic human primary tumors, these methods can be described as belonging to one of two groups: 1) Tumors ... via suppression of the PI3-kinase signaling pathway [53] Loss of function mutations of PTEN have been observed in approximately 50% of de novo GBM patients [54] One significance of this observation ... (EGF-R) EGF-R is a member of the ErbB tyrosine kinase receptor family that is mutated or overexpressed in a variety of human tumors, including approximately 30-50% of primary glioblastoma multiforme...

Ngày tải lên: 18/06/2014, 15:20

... biomarker of poor outcome in primary melanoma Higher levels of HU177 were associated with an increased rate of recurrence and increasing mortality Clinical decision making in the care of melanoma ... biomarkers of advanced disease A notable advantage of our study is that 65% of patients included had stage I melanoma, and the level of HU177 shedding in the serum was predictive of decreased ... Author details Department of Dermatology, New York University School of Medicine, New York, NY, USA 2Division of Biostatistics and Epidemiology, Weill Medical Page of College of Cornell University,...

Ngày tải lên: 18/06/2014, 16:20

... unit of increased BMI Table Demographics of Total Evaluated and Included Patients Characteristics Number of subjects evaluated Number of subjects included Number of subjects excluded Reasons of ... (RRs), and attributable risks (ARs) (AR risk ratio 1 /risk ratio) were estimated for AHR in the presence of obesity Correlates of BMI and AHR were studied with analysis of variance (ANOVA) or Wilcoxon ... relationship of AHR, a marker of asthma, to obesity in adult subjects We hypothesized that in a large sample of patients with respiratory symptoms suggestive of asthma referred for confirmation of asthma...

Ngày tải lên: 08/08/2014, 21:20

... with an increased risk of primary knee replacement, only waist circumference but not WHR was significantly associated with the risk of primary hip replacement Moreover, for all measures of obesity, ... with an increased risk of both primary knee and hip replacement – except that WHR was not significantly associated with the risk of primary hip replacement (Table 4) Moreover, all of the adiposity ... measures of adipose mass (FM and percentage fat) were associated with an increased risk of primary knee and hip joint replacement 10 to 15 years after their measurement Whilst both measures of central...

Ngày tải lên: 09/08/2014, 13:22

... with level of C-reactive protein, a classical marker of systemic inflammation Increased levels of platelet activation biomarkers (sCD40L and sCD62P) in AIDs As we found increased levels of platelet-derived ... sPLA2, despite the absence of increased levels of other classical biological markers of systemic inflammation (C-reactive protein and fibrinogen; Table 1) Thus, the exact role of sPLA2 in AIDs, in ... functional role of MPs remains to be elucidated, as does the role of platelet activation, despite the absence of increased thrombosis in this disease Conclusions We demonstrate that the level of circulating...

Ngày tải lên: 09/08/2014, 14:22

... measurement of healthrelated quality of life Health Policy 1990, 16:199-208 39 Spitzer RL, Kroenke K, Williams JB: Validation and utility of a self-report version of PRIME-MD: the PHQ primary care ... the specific characteristics of primary care in Germany Chronic care in Germany is mainly delivered by small primary care practices: The practice team usually consists of one or two physicians (general ... deal with deterioration of symptoms) Decision support Provider training (GP) on guidelines for the treatment of index conditions/adjustment of treatment regimens in case of co-occuring conditions...

Ngày tải lên: 10/08/2014, 10:23

... range of risk preferences across participants is represented from risk seeking (left) to risk averse (right) The indifference point of each choice function is shown with a red inverted-triangle Risk ... range of risk preferences is represented from risk averse (left) to risk seeking (right) Frontiers in Human Neuroscience | www.frontiersin.org (C) Relationship between premium metric and risk ... shows the mean of each distribution FIGURE | Choice strategy – utilization of trial information Relationship of independent r2 -values of relative expected value (rEV) and probability of winning...

Ngày tải lên: 22/09/2015, 15:18