increased cell death in the lungs of caspase 1 knock out mice

... Biochemistry of caspase- 1 14 1. 8.2 Substrates of caspase- 1 14 1. 8.3 Synthetic caspase inhibitors 15 1. 9 Animal models in influenza pneumonia 16 1. 10 Caspase- 1 and ... A/PR/8/34 (H1N1) infection of RAW264.7 macrophages 13 0 4.3 Insights into the role of caspase- 1 using a murine model of influenza pneumonitis 13 1 4.3 .1 Increased mortality of influenza ... (H1N1) infected, aged caspase- 1 knock- out mice 13 1 4.3.2 Weight loss as a crude read -out for influenza virus infection 13 2 4.3.3 Up-regulation of caspase- 1 in the lungs of infected...

Ngày tải lên: 13/10/2015, 16:41

... http://www.jmedicalcasereports.com/content/5 /1/ 111 Page of 10 11 12 Figure CT scan showing the absence of both lung metastases, which regressed after radiation therapy 13 14 mediastinal resulted in tumor mass regression in an untreated ... and approved the final manuscript Competing interests The authors declare that they have no competing interests Received: 19 May 2 010 Accepted: 19 March 2 011 Published: 19 March 2 011 References ... but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody Clin Cancer Res 2009, 15 (17 ):5379-5388 doi :10 .11 86 /17 52 -19 47-5 -11 1 Cite this...

Ngày tải lên: 11/08/2014, 00:23

... these works among us Who is going to take the lead? The Contents Introduction The Fountain of Energy The Mother of Tomorrow The Nations of the Occident The Nations of the Orient The Alaskan The ... Lama The Genius of Creation The Rising Sun Descending Night Winter The Portals of El Dorado Panel of the Fountain of El Dorado Youth The American Pioneer Cortez The End of the Trail Panel from the ... Falconer, the Indian Prince and Spirit of the East, the Lama, the Mohammedan Warrior, the Negro Servitor, the Mongolian Warrior On they come to join the Nations of the West in the great Court of the...

Ngày tải lên: 15/03/2014, 14:20

... per 10 ug/m3 15 LAG C2: NO2 + O3 15 25 C1 C2 C3 S C1 C2 C3 -5 -10 S C1 C2 C3 S C1 C2 C3 -10 S C1 C2 C3 S C1 C2 C3 S C1 C2 C3 S C1 C2 C3 Discussion Preliminary results suggest that increased concentrations ... per 10 ug/m3 C3 SO2 NO2 50 S 30 30 20 20 10 10 S: NO2 C2: NO2 + O3 -10 C3: NO2 + SO2 C1: NO2 + PM10 -10 -20 -20 S C1 C2 C3 S C1 C2 C3 S C1 C2 C3 S C1 C2 C3 Co-pollutant models: % increase in pneumonia ... ug/m3 C1 10 -5 -10 S 15 10 -5 -10 Percent change per 10 ug/m3 LAG 20 10 25 Percent change per 10 ug/m3 10 LAG 0-5 Percent change per 10 ug/m3 Percent change per 10 ug/m3 Percent change per 10 ug/m3...

Ngày tải lên: 13/09/2015, 17:48

... (9,4) Cell death 9.46E -10 - 2.60E-03 14 (3 ,11 ) Cellular movement 11 (2,9) 1. 52E-07 - 2.51E-03 15 (3 ,12 ) Cell cycle A/J 11 (2,9) 5.74E-08 - 2.51E-03 Cellular growth and proliferation Strain 4.44E-08 ... abnormalities 14 (3 ,11 ) 1. 13E-08 - 1. 25E-03 (2,7) 3.71E-08 - 2.51E-03 (1, 7) Immunological disease 3.71E-08 - 2.51E-03 (1, 8) Inflammatory disease 3.71E-08 - 1. 32E-03 (1, 7) p-valueb # of genes (up,down) Cellular ... roles in cellular stress responses and/or cell death and included DnaJ homolog subfamily B member 1( DNAJB1), heat shock protein 10 5 kDa (HSPH1) and zinc finger and BTB domain containing 16 (ZBTB16)...

Ngày tải lên: 12/08/2014, 11:22

... use that may be made of the information it contains Page 12 of 13 (page number not for citation purposes) Respiratory Research 2009, 10 :6 References 10 11 12 13 14 15 16 17 18 19 20 Dorfmuller P, ... immunostaining was less pronounced in lungs from IL-6/- mice than from IL-6+/+ mice (Figure 4b) Lung mRNA levels of the inflammatory biomarkers VCAM -1, ICAM -1, and MCP -1, as well as of endothelin -1 ... injection of endotoxin and cytokines II Interleukin-6 and transforming growth factor beta inhibit acute inflammation Am J Pathol 19 91, 13 8(5) :10 97 -11 01 Aderka D, Le JM, Vilcek J: IL-6 inhibits...

Ngày tải lên: 12/08/2014, 14:20

... biodefence: Therapeutic developments and diagnostics Nat Rev Drug Disc 2005, 4:2 81- 297 Page 12 of 13 (page number not for citation purposes) Virology Journal 2007, 4 :10 8 10 11 12 13 14 15 16 17 18 19 ... detectable viremia within days of infection (Figure 2B) The viremia in all the mice increased logarithmically over the course of the infection and peaked around 10 6 pfu/ml in the serum at days 6–8 ... Scid mice were infected with 10 00 pfu of the indicated 'scid-adapted' MARV (Ci67 P15, Musoke P10 or Ravn P10) (A) The weight of groups of 10 mice was assessed daily after infection with the 'scid-adapted'...

Ngày tải lên: 18/06/2014, 18:20

... 662.9 ± 15 6 640.6 ± 95 504.3* ± 11 6 CPF 0 .1 814 .7 ± 15 8 613 .8 ± 12 5 CPF 0 .1( s) 748.5* ± 18 5 564.5 ± 10 0 5 01* ± 11 9 CPF 0.2 768.7* ± 2 01 578.7* ± 10 3 483.3* ± 16 7 CPF 0.2(s) 746.6* ± 16 3 525.7* ... depth of 30 cm The water was heated to a temperature of 38°C The animals were then placed in the water for a swim session lasting minutes [19 ] After the session of forced-swimming, the mice were ... rats on the effects of gestational exposure to cholinotoxicants nicotine and CPF, alone and in combination, showed increased GFAP expression in offspring in the CA1 sub-field of the hippocampus,...

Ngày tải lên: 20/06/2014, 00:20

... biodefence: Therapeutic developments and diagnostics Nat Rev Drug Disc 2005, 4:2 81- 297 Page 12 of 13 (page number not for citation purposes) Virology Journal 2007, 4 :10 8 10 11 12 13 14 15 16 17 18 19 ... detectable viremia within days of infection (Figure 2B) The viremia in all the mice increased logarithmically over the course of the infection and peaked around 10 6 pfu/ml in the serum at days 6–8 ... Scid mice were infected with 10 00 pfu of the indicated 'scid-adapted' MARV (Ci67 P15, Musoke P10 or Ravn P10) (A) The weight of groups of 10 mice was assessed daily after infection with the 'scid-adapted'...

Ngày tải lên: 20/06/2014, 01:20

... purity of 76 .14 45%, the CLA (c9, t 11 isomer) was composed of c9, t 11, 27%; c12, t10, 26%; c18, t0, 5%; c18, t1, 27%; c18, t2, 0%; c16, t0, 13 % CLA at dose of 0.5% and 1. 5% was given at 13 3.5 mg/kg/day ... carefully obtained from the tubes The cells were washed again, the density was calculated as 1. 5x106 cells/ml, and then cells were cultured in 96 well plates containing 10 % fetal bovine serum Twelve ... Effects of Combination Dietary Conjugated Linoleic Acid with Vitamin A (Retinol) and Selenium on the Response of the Immunoglobulin Production in Mice 10 5 CONT CLA1 CLA2 CVA1 CVA2 CS1 CS2 CONT CLA1...

Ngày tải lên: 07/08/2014, 17:22

... Sons; 2007 pp 11 .4 .1- 11. 11. 5 14 Gulbis JM, Kelman Z, Hurwitz J, O'Donnell M, Kuriyan 15 16 17 18 19 20 21 22 23 24 25 26 27 28 J Structure of the C-terminal region of p 21( WAF1/CIP1) complexed ... 4E-PB1 and p-4E-BP1 protein in the lungs of mice fed a low Pi diet (0 .1% Pi) or a normal (0.5% Pi) diet for weeks (A) The expressions of mTOR, 4E-PB1 and p-4E-BP1 protein in the lungs (B) The ... repression in adult transgenic mice Mol Cell Biol 20 01, 21, 18 33 -18 40 10 El-Deiry WS p 21/ p53, cellular growth control and genomic integrity Curr Top Microbiol Immunol 19 98, 227, 12 1 -13 7 11 Fang MZ,...

Ngày tải lên: 07/08/2014, 23:22

... cAnNCrj mice were obtained from Charles River 1- 2 weeks before testing Mice were maintained according to the institutional animal care use committee guidelines The mice were anesthetized by i.p injection ... haematoxylin and eosin (H&E) or Azan For H&E staining, we evaluated an edema of the interstitial space, infiltration of inflammatory cells, thickening of the alveolar septa, and vessel thrombosis The ... protein synthesis in human hepatoma cells: differential regulation of serum amyloid A (SAA) and haptoglobin by interleukin -1 and interleukin-6 Clin Exp Immunol 19 91, 83:488-4 91 26 Trikha M, Corringham...

Ngày tải lên: 09/08/2014, 08:23

... Med 19 95, 1( 11) :11 55 -11 61 Caro JF, Sinha MK, Kolaczynski JW, Zhang PL, Considine RV: Leptin: the tale of an obesity gene Diabetes 19 96, 45 (11 ) :14 55 -14 62 Riddle TM, Fichtenbaum CJ, Hui DY: Leptin ... background or the age of the mice This difference was observed both in circulating levels of leptin in the serum as well as at the level of leptin expression in abdominal white adipose tissue In the present ... expression in the mouse Obes Res 2004, 12 (9) :14 81- 14 91 Ahren B: Diurnal variation in circulating leptin is dependent on gender, food intake and circulating insulin in mice Acta Physiol Scand 2000, 16 9(4):325-331...

Ngày tải lên: 10/08/2014, 05:20

... function2, n (%) 96.2 (12 .5) 16 (17 ) 88.2 (16 .7) (32) 91. 4 (13 .7) (18 %) 94.6 (11 .7) (17 %) 97 .1 (14 .4) 12 (23%) 94.5 (13 .8)** 24 (20) Asthma history, n (%) (7) (29) (7) (13 ) (14 ) 13 (11 )** Asthmatic by ... Journal of General Internal Medicine 2005, 20 :11 42 -11 45 11 Moscato G, Maserati R, Marraccini P, Caccamo F, Dellabianca A: Bronchial reactivity to methacholine in HIV-infected individuals without ... (%) 49 (52) 12 (48) 16 (36) (35) 37 ( 71) 61 ( 51) ## Sputum, n (%) 41 (44) 10 (40) 11 (25) (35) 32 (63) 51 (43)## (6) (8) (4) (14 ) (7)# Any respiratory symptom4, n (%) 51 (54) 12 (48) 16 (36) (39)...

Ngày tải lên: 10/08/2014, 05:21

... wheel-running In the timing of the siesta (a feature common to the locomotor activity profile of certain strains of inbred mice) B6 and AhR differed About 8–9 hours after their activity begins the ... cycling of expression Apparently, zinc finger proteins can modulate the circadian clock The promoter region of mPer1 contains targets for zinc finger protein binding and is essential in NG108 15 ... Zfp277 (zinc finger protein 277) Expression analysis The expression analysis of whole brain had 29 probe-sets representing 14 of 15 known genes in the QTL, and 12 probe-sets representing of the 12 ...

Ngày tải lên: 10/08/2014, 09:20

... Journal of Inflammation 2005, 2 :16 References 10 11 12 13 14 15 16 17 18 19 20 21 22 Bals R, Hiemstra PS: Innate immunity in the lung: how epithelial cells fight against respiratory pathogens Eur ... strong induction of the IFN-inducible chemokines IP -10 (CXCL10) and ITAC (CXCL 11) Page of 15 (page number not for citation purposes) Journal of Inflammation 2005, 2 :16 5.0 25 2500 15 500 3.0 15 00 1. 0 ... markedly increased secretion of the type-I collagenases MMP -1, MMP-8, MMP -13 as well as the release of the type-IV collagenase MMP-9 and the stromelysin MMP -10 Likewise, flagellin increased the release...

Ngày tải lên: 11/08/2014, 08:21

... globulin for prophylaxis of infectious hepatitis Am J Epidemiol 19 68, 87:539-550 Page of (page number not for citation purposes) Virology Journal 2008, 5 :15 5 10 11 12 13 14 15 16 17 18 19 20 21 22 ... http://www.virologyj.com/content/5 /1/ 155 Figure Schematic representation of the genome of the HAV-Bsd Schematic representation of the genome of the HAV-Bsd The infectious cDNA of wild type HM -17 5 strain of HAV (wt HAV) containing ... based on the antibiotic resistance of HAV-infected cells conferred by the blasticidin deaminase gene inserted into the virus genome In the presence of blasticidin, HAV-Bsd-infected cells continue...

Ngày tải lên: 12/08/2014, 04:21

... FEV1 (L), median 1. 63 ± 0.49 1. 63 1. 72 ± 0.53 1. 61 1.44 ± 0.60 1. 14 1. 35 ± 0.62 1. 14 1. 55 ± 0.56 1. 47 1. 48 ± 0.63 1. 38 0.553 FEV1% predicted, median 47.3 ± 11 .4 48.6 51. 2 ± 14 .5 49.0 46.3 ± 19 .6 ... (n = 59) p value 11 4 ± 14 .7 59.7 ± 16 .0 57.0 11 7 ± 16 .4 60 .1 ± 16 .3 65.0 94 ± 21. 8 50.7 ± 19 .5 47.6 98 ± 23.2 52.2 ± 15 .2 50 .1 103 .1 ± 21. 8 56.3 ± 17 .3 56 .1 104.7 ± 23.9 55.7 ± 15 .9 56.0 0.789 ... TLC-adjusted PD15† (g•L -1) 59.9 ± 11 .03 62.98 ± 13 .49 54.6 ± 17 .4 53.9 ± 16 .0 57 .1 ± 15 .2 58.2 ± 15 .7 0.6 91 Lung volume (L) 5. 71 ± 1. 27 5.52 ± 1. 34 7.46 ± 1. 60 7.27 ± 1. 78 6. 61 ± 1. 67 6.35 ± 1. 69 0.300...

Ngày tải lên: 12/08/2014, 11:22

... apoptosis in a single model of lung injury To evaluate the role of VEGF in the apoptosis of endothelial cells and their barrier function in the injured lung, we evaluated the effects of exogenous ... albumin (0 .1 mCi/ mouse) 15 before intratracheal administration of either PBS or LPS Two minutes before the end of the study, 13 1I-albuimn (0 .1 mCi/mouse) was injected to esti- Page of 13 (page ... using a murine model of http://respiratory-research.com/content/8 /1/ 60 LPS-induced lung injury Using the lung specimens, TUNEL staining and immunostaining of caspase- 3, Bax, apoptosis inducing...

Ngày tải lên: 12/08/2014, 15:21

... FR139 317 or PD 14 5065 Br J Pharmacol 19 94, 11 1(4) :10 09 -10 16 Henry PJ, Carr MJ, Goldie RG, Jeng AY: The role of endothelin in mediating virus-induced changes in endothelinB receptor density in ... effects of ET -1 on the lungs; in particular, the effects of the exogenous administration of ET1 on the lung function have been successfully inhibited by the administration of these agents [11 ,14 ] ... in the other groups of mice Discussion The involvement of ET -1 in the hyperoxia-induced lung function deterioration was characterized in detail in the present study by assessing the changes in...

Ngày tải lên: 12/08/2014, 16:20