incidence prevalence and characteristics of nausea and vomiting in advanced cancer

... activity, and showed that CDO alone did not increase the extent of staining However, in cells that had been cocultured with CDO and a cytotoxic drug, staining was significantly increased, indicating ... reduction in cyclin D and E expression Disappointingly, the specific interactions between CDKs and cyclins were not assessed, and the effects of CDO on p21waf1 were not investigated, making direct ... Apoptosis, growth arrest and suppression of invasiveness by CRE-decoy oligonucleotide in ovarian cancer cells: protein kinase A downregulation and cytoplasmic export of CREbinding proteins Mol Cell Biochem...

Ngày tải lên: 07/03/2014, 15:20

... (OHEA) within the Office of Research and Development, with major contract funding provided by the Indoor Air Division within the Office of Air and Radiation's Office of Atmospheric and Indoor Air ... Average cotinine/creatinine levels for subgroups of nonsmoking women defined by sampling categories of exposure or by self-reporting exposure to ETS from different sources during the days preceding ... accuracy and conclusions The assessment was prepared at the request of the Indoor Air Division, Office of Atmospheric and Indoor Air Programs, Office of Air and Radiation, which defined the assessment's...

Ngày tải lên: 15/03/2014, 01:20

... study, including a description of patients' characteristics in terms of baseline socio-demographic and clinical variables, pattern of care and main outcomes, and a discussion of the feasibility of ... the prevalence of pain in advanced cancer is about 70% with ample variations according to the cancer type and disease stage [2] Despite the existence of published and well-known guidelines for cancer ... interested and/ or involved in issues related to cancer pain [13]; b) drug utilization and appropriateness: an evaluation of the volume and quality of prescriptions of analgesic drugs in a large administrative...

Ngày tải lên: 20/06/2014, 15:20

... Editor and Editor -in- Chief of Biological Signals and Biological Signals and Receptors, Adjunct Professor of University of Toronto and is Honorary or Visiting Professor of over ten universities Int ... apoptosis by inhibiting androgen receptor expression [1] Besides, soybeans contain various anti-carcinogenic compounds including lunasin and lectins that were shown to induce apoptosis in malignant ... inhibition of proliferation of gastric cancer cells However, further clinical trials in humans are needed to examine the pharmacokinetics and the therapeutic action of CKBM on cancer patients Competing...

Ngày tải lên: 08/08/2014, 18:20

... illustrating the need for physicians to maintain a high index of suspicion for paraneoplastic syndromes in women presenting with unusual neurological symptoms with no obvious cause In breast cancer ... antibodies in patients' serum that react with both the nervous system and the underlying cancer Each of these antibodies is associated with a narrow spectrum of clinical syndromes and a restricted ... antibody (SMA) remained elevated; creatinine kinase (CK) was checked and was elevated at 360 IgG remained greater than 20 A CT scan was therefore performed demonstrating cervical and axillary lymphadenopathy...

Ngày tải lên: 09/08/2014, 07:22

... effects of OPN inhibition are in agreement with previous findings that the knockdown of OPN reduces the clonogenic survival, migration and invasion rate, and proliferation in different breast cancer ... Tuck and coworkers [33,34] found an induction of uPA expression in response to OPN treatment and an association of uPA expression with OPN-induced invasion and migration in human breast cancer ... Parker C: Intrinsic markers of tumour hypoxia and angiogenesis in localised prostate cancer and outcome of radical treatment: a retrospective analysis of two randomised radiotherapy trials and one...

Ngày tải lên: 09/08/2014, 09:20

... NY) containing 10% (v/v) heat-inactivated fetal bovine serum (Gibco, Grand Island, NY), penicillin (100 U/mL) and streptomycin (100 mg/mL), and they were maintained in a 37°C humidified incubator ... lines, BGC-823 and SGC-7901, were established in the People’s Hospital of Peking University and China and No.6 Hospital of Shanghai, China, respectively These two human gastric cancer cell lines ... Analysis of the data and plotting of the figures were performed with the aid of software (Origin Version 7.5 and SPSS Version 13.0) Results Expression of b1- and b2-adrenergic receptors in SGC7901 and...

Ngày tải lên: 09/08/2014, 09:20

... inactivated in a variety of solid human tumors, including prostate cancer Increased levels of PIP3 trigger the recruitment of phosphatidylinositide-dependent serine/threonine kinase (PDK1) and Akt ... to induce apoptosis in tumor cells and their ability to increase cytotoxic efficacy of chemotherapy and radiotherapy in preclinical investigations [10-12] Induction of apoptosis by ErPC3 and ... to inhibition of proliferation, cell death induction, or both Therefore, in a next step, we examined whether the anti-neoplastic effects of ErPC3 and ionizing radiation include induction of cell...

Ngày tải lên: 09/08/2014, 09:20

... variety of proteins and activates other MSPs and MMPs [8,9] TATI is a trypsin inhibitor that balances concentrations of trypsin and also functions as a weak inhibitor of other serine proteinases ... concentrations and s-creatinine, this could in part be explained by an impaired renal function in elderly patients, which is in line with previous findings demonstrating an association between increased ... tumour-associated trypsin inhibitor (TATI), also called pancreatic secretory trypsin inhibitor (PSTI) and serine protease inhibitor Kazal type (SPINK1), is a biomarker of poor prognosis in colorectal cancer...

Ngày tải lên: 09/08/2014, 09:21

... relapse-free survival with increased external radiation doses in patients with localized prostate cancer: The combined experience of nine institutions in patients treated in 1994 and 1995 Int J Radiat Oncol ... Rectal bleeding after hypofractionated radiotherapy for prostate cancer: correlation between clinical and dosimetric parameters and the incidence of grade or worse rectal bleeding Int J Radiat ... on manual delineation of the outer contour of the rectal wall and automatic calculation the inner contour using a mm margin [11]3) entire rectal volume including the rectal wall and the rectal...

Ngày tải lên: 09/08/2014, 10:21

... moderately stringent in PITA and miRanda To further increase the prediction accuracy, PITA takes into account the local accessibility of the potential binding sites, whereas miRanda and PicTar apply ... miRanda, PicTar, and the intersection of PITA and miRanda can be found in Additional data file Use of alternative methods to compare miRNA inhibitory effects To further substantiate our findings, ... expression, an miRNA's inhibitory activity accordingly increases, which leads to low expression levels of genes involved in ER+ cell types and the predominant expression of genes involved in the oncogenic...

Ngày tải lên: 09/08/2014, 20:20

... regulating the activities of phosphotyrosine phosphatases [23] In the current study, we examined XAF1 mRNA and protein expression in four cell lines, and determined regulatory effects of somatostatin ... somatostatin and Octreotide in prostate cancer cell lines To examine the regulatory effects of somatostatin and Octreotide on XAF1 mRNA and protein expression, prostate cancer cell lines (LNCaP, ... cell lines: lower invasive ability of LNCaP, medium invasive ability for DU145 and a higher ability for PC3 The varying expression of XAF1 suggests a causal changing of androgen dependency and invasiveness...

Ngày tải lên: 10/08/2014, 10:20

... S: CD44 stimulation induces integrin-mediated adhesion of colon cancer cell lines to endothelial cells by up-regulation of integrins and c-Met and activation of integrins J Cancer Res 1999, 59:4427-4434 ... decreased, resulting in a decrease of cell invasion This finding confirms our deduction The interaction of CD44 and HA activates RhoA signals and Rho kinase, enhances serine/threonine phosphorylation ... binder-1), induces PI3K activation, triggers the PI3K/Akt pathway, and is involved in the progression of breast cancer[ 28] It is also confirmed that the binding of CD44 to HA induces c-Src kinase...

Ngày tải lên: 10/08/2014, 10:21

... Journal of Experimental & Clinical Cancer Research 2011, 30:29 http://www.jeccr.com/content/30/1/29 Ovarian cancer is the fifth leading cause of death in women and remains the leading cause of death ... (at final concentration of 20 mg/kg b.w.) was administered i.p twice/week for six weeks and Cisplatin (at final concentration of mg/kg b.w.) was administered i.p during weeks, once/week In general ... described as “naphthofuranone” by the National Cancer Institute (NCI) in their in vivo“ anti-tumor screening data, testing the drug against P388 Leukemia in CD2F1 mice, however, no final conclusive...

Ngày tải lên: 10/08/2014, 10:21

... proliferation and tumor growth of breast cancer cell was inhibited Combined treatment of ulinastatin plus docetaxel is more effective in anti-tumor invasion Therefore, the role of ulinastatin in the ... Plasminogen binding and activation at the breast cancer cell surface: the integral role of urokinase activity Breast Cancer Res 2007, 9(1):R14 Nguyen DH, Hussaini IM, Gonias SL: Binding of urokinase-type ... 0.05) Figure Inhibition of ulinastatin and docetaxel on MDA-MB231 and MCF-7 cell invasion Shown are the absorptions at 570 nm of cells treated with ulinastatin, docetaxe and ulinastatin plus docetaxe...

Ngày tải lên: 10/08/2014, 10:21

... MACC1 might implicate in growth and metastasis of ovarian carcinoma In ovarian carcinoma cells, the antitumor effects of MACC1 RNAi might involve in the inhibition of HGF/ Met and MEK/ERK pathways ... moderate brown staining scored as 2, with intense brown staining scored as The final positive scores = positive rate score × staining intensity score, score was negative staining (-), 1~4 scores ... poor prognosis and high risk of metastasis in colon cancer, gastric carcinoma, lung cancer, and hepatocellular carcinoma [5-8] However, the mechanism of MACC1 implicates in ovarian cancer is still...

Ngày tải lên: 10/08/2014, 10:21

... synthesised and transfected into human breast cancer cell line MDA-MB-231 The levels on JMJD2A mRNA and its protein expression, and biological characteristics of MDA-MB-231 cells including proliferation, ... were removed by wiping with a cotton swab The cells that migrated to the bottom surface of the insert were fixed in 100% methanol for min, stained in Giemsa for min, rinsed in PBS and then subjected ... JMJD2A may be, at least in part, involved in human breast cancer by constituting a key component of the estrogen signaling pathway or binding pRb and HDACs to suppress E2F-induced ARHI expression...

Ngày tải lên: 10/08/2014, 10:21

... demethylation and re-expression of CXCL12 in MCF-7 breast cancer as well as AsPC1 in pancreatic carcinoma cell lines, and suggested that they acted synergistically in inhibiting CpG island hypermethylation ... methylation of tumor suppressor genes and tumorigenesis in its early status Currently, functions and mechanisms of DNMTs in cervical cancer cells remained unclear, and whether DNMT1 and DNMT3b ... knockdown of DNMT1 resulted in significant reduction of promoter methylation and re-expression of RASSF1A, p16, and HPP1 in HCC1954 breast cancer cells [7] In ovarian cancer cell line CP70, DNMT1 siRNA...

Ngày tải lên: 10/08/2014, 10:21

... GCFC initiated the concept, wrote and revised the manuscript and creating the illustrations WKC involved in writing, coordination and revising the manuscript DMS involved in the preparation and ... effectively to our cancer patients in the future Competing interests The authors declare that there is no conflict of interests, including conflicts of financial nature involving any pharmaceutical ... release of cytokines including interleukin (IL)-12, IL-6, tumor necrosis factor (TNF)-α, and IL-10 Some of these cytokines may play important role in the cancer therapy On the other hand, the...

Ngày tải lên: 10/08/2014, 22:20