in vitro methods for the prediction of ocular and dermal toxicity

... experiments and participated in writing the manuscript SW established the initial form of the in vitro destruction model and described it in his diploma thesis RWK contributed to the design of the study ... potent inductors of aggrecanase activity in both cases, underlining the key role of these cytokines in proteoglycan depletion On the other hand, the clearly increased aggrecan activity in co-cultures ... capable of inducing IL-6 and IL-8 mRNA in cartilage As in the case of MMP-1 and MMP-3, these results are in good agreement with previous reports [50,51] and underline the potential importance of these...

Ngày tải lên: 09/08/2014, 01:22

... Chapter Introduction The modern information technology consists of three parts: information acquiring, information processing, information transferring and information storage In fact, information ... of In- Situ Diagnosis Methods for the Evaluation of Mechanical and Magnetic Performance of Hard Disk Drives ZHU JIN （B.Eng (hons) HUST, P.R.China） A THESIS SUBMITTED FOR THE DEGREE OF MASTER OF ... those days, and worked down through the form factors of 5.25-inch, 3.5-inch, 2.5-inch, 1.8-inch and 1.3-inch The smallest disk drives are of size inch and 0.85 inch which were designed for personal...

Ngày tải lên: 05/10/2015, 22:15

... t D and hence the number of spins By linearity of the Fourier transform the direct relation between the peak integral and the number of spins of the corresponding chemical group holds for the ... organized the continuation of the research unit after the DFG funding as well as Prof Kasper, Prof Kind, Prof Nirschl, and Prof Elsner Prof Nirschl, Prof Kind, Prof Wilhelm, and Prof Elsner contributed ... real, the oscillating imaginary part of the sum in general leads to a small imaginary part of Qn The maximum of the real part of the sum is N times higher than the amplitude of the oscillating...

Ngày tải lên: 29/05/2014, 18:32

... defines the detector end of the capillary as the anode Sample is introduced at the cathodic end of the capillary and anions are separated on the basis of their differences in mobility in the ... error in the low boron range This interference springs from the insolubility of the hardness salts in 95% ethanol and consequent turbidity in the final solution Filter the final solution or pass the ... Standard Methods for the Examination of Water and Wastewater Precision and bias of the titrimetric method are on the order of ±10% of the known CO2 concentration 4500-CO2 D Carbon Dioxide and Forms...

Ngày tải lên: 29/07/2014, 18:58

... Water Environment Federation Standard Methods for the Examination of Water and Wastewater Algae General TAYLOR, W.R 1957 Marine Algae of the Northeastern Coast of North America, 2nd ed Univ Michigan ... Federation Standard Methods for the Examination of Water and Wastewater Agency, National Environmental Research Center, Cincinnati, Ohio PATRICK, R & C.W REIMER 1975 The Diatoms of the United States ... F.V 1953 The aquatic Hyphomycetes of California Farlowia 4:353 CRANE, J.L 1968 Freshwater Hyphomycetes of the northern Appalachian highlands including New England and three coastal plain states...

Ngày tải lên: 29/07/2014, 18:58

... of Water and Wastewater Pandorina © Copyright 1999 by American Public Health Association, American Water Works Association, Water Environment Federation Standard Methods for the Examination of ... Association, Water Environment Federation Standard Methods for the Examination of Water and Wastewater Plate 29 Filter- and screen-clogging algae Dinobryon © Copyright 1999 by American Public ... Examination of Water and Wastewater Dinobryon © Copyright 1999 by American Public Health Association, American Water Works Association, Water Environment Federation Standard Methods for the Examination...

Ngày tải lên: 29/07/2014, 18:58

... 12] The atomic weights of many elements are not invariant but depend on the origin and treatment of the material The standard values of Ar(E) and the uncertainties (in parentheses, following the ... Through educational and technical information programs, AWWA promotes the improvement of the quality and quantity of the drinking water supply Contact information: AWWA 6666 West Quincy Avenue Denver, ... the Examination of Water and Wastewater Remove sodium carbonate precipitate by keeping solution at the boiling point for a few hours in a hot water bath or by letting particles settle for at least...

Ngày tải lên: 29/07/2014, 18:58

... (9), and the additivity of the expectation is the implication of the expected accuracy of a joint structure, which is the sum of the expected accuracy of the intra-molecular structures and the ... http://www.almob.org/content/5/1/22 On the other hand, we have to find a combined score p s1 p s2 for the partial structures and , and the interaction σint to evaluate the quality of an predicted interaction The score must ... single-stranded in Step of the algorithm because we are interested in pseudoknots of the concatenated sequence and the interactions in these induced loop regions The drawback of this ansatz is that intra-molecular...

Ngày tải lên: 12/08/2014, 17:20

... is, therefore, well suited for studying the biology and immunology of HCV infections It is also an excellent system for testing the efficacy of candidate drugs and advancing ideas for vaccines Methods ... which explains both the low titer of infectious virus in patients and in cell culture and the long incubation period before the development of an acute disease The high titer of viral RNA in plasma/ ... probable that there is only one type of infectious and replicating HCV The variety of HCV RNA in patients could result from changes induced in the plasma/sera, including the production of noninfectious...

Ngày tải lên: 20/06/2014, 02:20

... assistance in providing information regarding the cocoa industry in Vietnam and in the establishment of solar driers and fermenting boxes at their demonstration farm sites in Ben Tre Province HARVESTING ... on the basis of the count of defective beans in the ‘cut test’ The cut test reveals the presence of certain defects which may cause off-flavours and indicates the degree of fermentation of the ... during rain and at night Also, with the basket drying shown in illustration 20, the baskets 14 need to be moved around during the day to position them in the sun During periods of heavy rain, the...

Ngày tải lên: 21/06/2014, 06:20

... Comparison of Diagnostic Methods for the Detection of Parasites in Fish and disadvantages, depending on the purpose and target of study For parasitological investigation, the classical methods (the ... placed in separate vials with PBS The content of selected separate organs (oesophagus, stomach, pyloric caeca and intestine) was scraped from the lumen and epithelial lining and inspected under the ... microscope Stretching of these metacercariae was done by hot formalin for two minutes Then, they were kept in Eppendorf tubes with neutral formalin (4%) Diagnosis of parasitic infections * Diagnosis...

Ngày tải lên: 06/08/2014, 19:20

... Furthermore, the value of analysing a single blood sample for prediction of litter size at farrowing has been debated (Hattersley et al 1980, Atkinson et al 1986), whereas specifying the interval ... into groups with the mean value and the mean value ± and standard deviations, respectively, as midpoints for each of the groups Estimated probability curves and proportions of small litters in ... preliminary trial some of the animals had decreasing E1S concentration before day 28 while others still had increasing concentrations This indicated that the peak of the E1S curve may occur before...

Ngày tải lên: 12/08/2014, 15:20

... displays the fits of these different minimal models for training and test data Most of the training and test data points were inside two root-meansquared errors of the training data In the case of ... ligands by developing a minimal residuals model using the same approach The overall minimal model is the combination of the minimal PP-model and the minimal residuals model The procedure for the ... macrophages modulate the inflammatory response [3] Thus, understanding the regulation of the expression and release of these mediators is crucial for understanding the course of the inflammation process...

Ngày tải lên: 14/08/2014, 16:21

... evaluated the influence of the geometry of window-shading device system on the final performance of the system itself using the mean shading factor, which is defined as the ratio of the global ... for outdoor and indoor Therefore, the integration of BS and CFD simulation is becoming an active research area in recent years The research work for integration of BS and CFD can be divided into ... energy-efficient sustainable building designs by providing rapid predictions of facade thermal behaviors, indoor air flow of the building and better understanding of the consequences of various design...

Ngày tải lên: 14/09/2015, 13:58

... demonstrated the same mobility in both stains, suggesting that these bands were complexes of protein and saccharide These included the band corresponding to a molecular weight of 103,000 in the steaming-extracted ... (1), the band corresponding to 38,000 in the NaOH-extracted polymer (2), the band corresponding to 24,700 in the SDS-extracted polymer (3), and the bands corresponding to 10,700, 29,200, and 39,000 ... shaking, absorbance at 660 nm (A660) was measured for min, and the relative A660 against the control test was calculated every minute using the following formula: The relative A660 = A660 of flocculating...

Ngày tải lên: 05/09/2013, 09:08

... useful in determining a) the efficacy of BCG vaccine in HCWs or b) the effects on efficacy of the vaccine strain administered Vol 45 / No RR-4 MMWR and the vaccinee’s age at the time of vaccination ... RR-4 MMWR The Role of BCG Vaccine in the Prevention and Control of Tuberculosis in the United States A Joint Statement by the Advisory Council for the Elimination of Tuberculosis and the Advisory ... re-evaluation of the role of BCG vaccination in the prevention and control of TB in the United States CDC, the Advisory Council for the Elimination of Tuberculosis (ACET), and the Advisory Committee...

Ngày tải lên: 15/02/2014, 13:20

... developed and the gold reserves in the mines are running out The collapse of the mining industry raises further problems, for example, most of the migrant labourers left the community when they lost their ... Springfontein ja, I think it’s Springfontein number one And the reason for that is that in Springfontein you have, it’s on the N1, the Springfontein, you have trucks coming in and out the area ... within these communities and feel they have a better understanding of the most needy people within their areas They work together with DSD and the community to determine the criteria for receiving...

Ngày tải lên: 19/02/2014, 00:20

... So, in 2000, in collaboration with the Population Health Division of the Commonwealth Department of Health and Ageing, the NHMRC initiated the development of the guidelines In working on the ... Behavioural therapy can increase the effectiveness of other weight-loss treatments, and the duration of the therapy influences the ability to maintain the weight loss No single behavioural therapy ... information to assist decision-making and are based on the best information available at the date of compilation It is planned to review this Guideline in 2006 For further information regarding...

Ngày tải lên: 08/03/2014, 14:20

... explain differences in droplet formation between indium and gold, we will consider in the following the effects of different diffusion coefficients of gold and indium on silicon, the solubility of ... nanowires after flooding the chamber with diluted silane and explained the absence of nanowires by considering the surface tension of indium and the low solubility of silicon in indium Iacopi et ... [9,10] They are of the same order of magnitude and thus cannot account for our very different experimental results We believe that a thin oxide layer forms during insertion of the sample into the...

Ngày tải lên: 16/03/2014, 15:17

... signal was observed in all peptides containing tyrosine 23 or 53 but not in peptides containing tyrosine 20 alone According to these results, tyrosines 23 and 53 could be involved in the dimerizations ... shown) For the first time in this kind of study, we tried to determine the nature of the final products in HEWL and TEWL We were expecting mostly dimers, since it is known that the fate of tyrosyl ... are found and their quantity increases with the dose The G-values of dimerization measured by HPLC or by SDS/PAGE not depend much on the origin of the protein [31] The presence of bityrosine could...

Ngày tải lên: 17/03/2014, 10:20