in silico methods for modeling endocrine disruption

... protein LOC58493; 79069 bp at 5' end: ACN9 homolog; 472310 bp at 3' end: tachykinin isoform beta precursor; huntingtin interacting protein 1; integrin, alpha precursor; 225678 bp at 3' end: embigin ... phosphatidylinositol transfer protein, beta; 3859 bp at 5' side: beta-galactoside-binding lectin precursor; 2761 bp at 3' side: nucleolar protein 12; cajalin isoform a; cytokine induced protein 29 kDa; integrin, ... Culex Culex quinquefasciatus quinquefasciatus quinquefasciatus quinquefasciatus quinquefasciatus quinquefasciatus quinquefasciatus quinquefasciatus quinquefasciatus quinquefasciatus quinquefasciatus...

Ngày tải lên: 13/08/2014, 16:20

... used in the manufacturing industry for quality engineering purposes In DoE, a design matrix is constructed in a combinatorial fashion that specifies the levels for several different factors for ... screening is to filter, score and rank structures of compounds using in silico methods Virtual screening may be used to select and prioritize compounds for screening in assays, 19 selecting which ... ‘thinking’ approach to conducting innovative research Dr Nilar achieved that by providing abundant ‘space’ for me to tinker with alternative methods to solve problems instead of merely shoving...

Ngày tải lên: 08/09/2015, 22:12

... nonlinear body [27], variational methods can be used for modeling of nonlinear biological soft tissue deformation in the finite deformation regime By defining the modeling problem as an energy minimization ... approach in dealing with nonlinear problem Variational based modeling methods have many applications in soft tissue deformation modeling Realistic and efficient modeling and animation of skin for ... related works in soft tissue modeling 2.1 Non-physical based computational methods The non-physical computational methods for tool-tissue interaction modeling include free-form deformation methods...

Ngày tải lên: 09/09/2015, 11:30

... additional ring (b) one additional ring with smaller Gaussian integration points in each triangle Here (+) are Gauss points for domain integration; (◦) are Gauss points for line integration ... (XFEM) for heterogeneous materials, including porous structures Instead of using the Heaviside enrichment function for the strong discontinuity of the holes’ interfaces, the penalty method is introduced ... cell containing 29 circular inclusions: VCFEM (thickline) and FEM (thin line) 85 4-14 Von Mises stress distribution of the composite unit cell containing 29 circular inclusions:...

Ngày tải lên: 10/09/2015, 15:51

... nite element model (LEVCFEM) for simulating evolving fracture in ductile microstructures containing inclusions, International Journal for Numerical Methods in Engineering, vol 76, pp 19551992, 2009 ... and T Belytschko, Blending in the extended nite element method by discontinuous Garlerkin and assumed strain methods, International Journal for Numerical Methods in Engineering, vol 74, pp 16451669, ... method for modeling phase transformations, International Journal for Numerical Methods in Engineering, vol 54, pp 12091233, 2002 [67] M Stolarska, D Chopp, N Moăs, and T Belytschko, Modelling crack...

Ngày tải lên: 10/09/2015, 15:51

... required for maintaining cell growth rates 166 7.4 Succinate production limits for wild type and the mutants The bold line indicates the limits for wild type strain and the points indicate ... techniques and in silico modeling approaches for characterizing cell culture fermentation and exploring the internal cell metabolism The most relevant statistical methods for examining the experimental ... current research work It involves developing a frame work for modeling and analyzing microbial and mammalian systems using a combined statistical and in silico approach to gain insights about the effect...

Ngày tải lên: 11/09/2015, 21:27

... useful information from data for the purposes of process modeling, control, and monitoring is one of the challenges in chemical industries In this thesis, a new just -in- time learning (JITL) modeling ... competition getting more intense than before, growing demands for improving performance of process still stimulate researchers to develop more efficient and reliable methods for process modeling, control ... approaches for nonlinear process modeling 2.1.1 Standard-learning methods The standard-learning approach includes NARMAX (nonlinear autoregressive moving average models with exogenous inputs),...

Ngày tải lên: 30/09/2015, 05:58

... approach in comparison with existing work Instead of working on analysing a general event-driven system or proposing any new formal language of ECA, we focus on modeling and verifying specific domain ... axm1 : RAINING = BOOL axm2 : SHARP = BOOL END MACHINE ACC M1 REFINES ACC M0 SEES Weather Road VARIABLES isRain speed target det isSharp INVARIANTS inv1 : isRain RAINING cxt ct : isRain = TRUE ... refined machine disc and one of abstract machine dis have a gluing variant (inv 3) Chapter Verifying imprecise system requirements 6.1 Introduction Formal methods are used not only for specifying...

Ngày tải lên: 12/05/2016, 22:37

... environment for modeling and proving in Event-B It is built on top the Eclipse platform and it contains a set of plug-ins used to support modeling and proving Event-B models The Rodin tool provides ... in comparison with the existing work Instead of working on analysing a general eventdriven system or proposing any new formal language of ECA, we focus on modeling and verifying specific domain ... specification for discrete transitions modeling A part of Event-B specification for continuous transitions modeling A part of Event-B specification for eventuality property modeling Container Crane...

Ngày tải lên: 05/07/2016, 10:51

... reviewing available methods for detecting endocrine disrupting effects of chemicals in wildlife, including fish An implementation of Vtg as a core endpoint in a piscine shortterm endocrine disrupter ... sex steroid-binding protein in plasma from Svalbard Charr (Sal v elinus alpinus L) Gen Comp Endocrinol 2001, 122:31-39 Tollefsen K-E Interaction of estrogen mimics singly and in combination with ... Vtg/Zrp as biomarkers in chemical product testing The increased awareness that chemicals in the environment can cause endocrine disruption in wildlife and, possibly, humans, has lead international organizations...

Ngày tải lên: 13/08/2014, 13:20

... Christopher Manning 2005 Incorporating Non-local Information into Information Extraction Systems by Gibbs Sampling In Proceedings of the Annual Meeting of the Association for Computational Linguistics ... FICTION contains more out-ofdomain language Therefore, RB (which exclusively uses domain-independent knowledge) outperforms both learning-based methods including the ones incorporating generalization ... is, indeed, an improvement by adding information from RB resulting in a large boost in recall Already the application of our induction approach Induc results in an increase of more than 8% points...

Ngày tải lên: 22/02/2014, 02:20

... reproducible research in this area Topics for future work include the incorporation of other kinds of semantic constraint for improved class-instance acquisition, further investigation into per-node ... end up acquiring all the labels injected into the graph This is undesirable for two reasons: (1) for experiments involving a large numbers of classes (as in the previous section and in the general ... class-instance acquisition performance can be significantly improved by incorporating additional semantic constraints in the class-instance acquisition process, which for the experiments in this...

Ngày tải lên: 07/03/2014, 22:20

... combinations of form-function values of gender, number and rationality for nominals in our corpus In terms of gender, the M value seems to be twice as common as F both in form and function In ... features to the in ected forms Default form-based gender and number are provided As for rationality, adjectives receive a default N and everything else gets I The guidelines explained the form-function ... pluMS rals: ktAb ( M P )4 and ktb¯ ( MS ) In adh FP dition to broken plurals, Arabic has a class of broken feminines in which the feminine singular form is derived templatically: e.g., the adjective...

Ngày tải lên: 07/03/2014, 22:20

... entailment information when identifying answers to questions Results from this baseline are presented in Table Creating New Sources of Training Data In order to obtain more training data for our ... System Processing textual entailment, or recognizing whether the information expressed in a text can be inferred from the information expressed in another text, can be performed in four ways We ... to the original question Integrating Textual Entailment in Question Answering In this section, we describe three different methods for integrating a textual entailment (TE) system into the architecture...

Ngày tải lên: 08/03/2014, 02:21

Ngày tải lên: 08/03/2014, 05:21

... the infrastructure of the chemical industries to reduce and control pollution in chemical industries especially in India A through study of pollution caused by these chemical industries in India ... products Costs for properly dealing with wastes are escalating and much attention is not given uniformly, only when serious problems they think about it; for instance the dying units in the year ... stage and bribery, form the major art of the industrialists to continue with the running of the faulty industries Further these flourishing industries are not going to make India a developed country,...

Ngày tải lên: 15/03/2014, 16:20

... data for each domain We created the training samples for discriminative learning as follows For each phonetic string A in adaptation training data, we produced a lattice of candidate word strings ... training procedure The resulting algorithms run in around 15 and 30 minutes respectively for Boosting and BLasso to converge on an XEON™ MP 1.90GHz machine when training on an 8K-sentnece training ... Exploiting headword dependency and predictive clustering for language modeling In EMNLP 2002 Gao J., Yu, H., Yuan, W., and Xu, P 2005 Minimum sample risk methods for language modeling In HLT/EMNLP...

Ngày tải lên: 17/03/2014, 04:20

... extensively investigated by other researchers including foreign ones Additional information in such problems is provided in the integral form and admits a physical interpretation as a result of measuring ... noting that the characteristics of the boundary being an equilibria in thermodynamics lead to supplementary problems for investigating inverse problems with the final overdetermination, since in ... reader an understanding of relevant special cases as well as providing one with insight into what is going on in general In mastering the challenges involved, the monographincorporates the well-known...

Ngày tải lên: 17/03/2014, 14:30

... work for information collection and methods for estimating and forecasting health expenditures linked to a growing elderly population in developing countries II Linking Health Spending to Ageing: ... useful in assessing the importance of these links and other possible “indirect” influences of ageing, defined in the sense of a changing age-distribution, on health spending One key source of information ... people living with disability is increasing in age in a population at any given point in time Cutler and Sheiner (1998), for example, show this for United States for different age-groups in the...

Ngày tải lên: 22/03/2014, 13:20

... problems in numerical linear algebra, and are finding increasing applications in control and digital signal processing The potential of SVD technique is first exploited in the domain of linear algebra, ... μTS(15) = μL (1)=0 min{[0,μVL(Z)]} min{[0,μM(Z)]} min{[0,μH(Z)]} μM(1)=1 min{[0,μL(Z)]} min{[0,μM(Z)]} min{[0,μH(Z)]} μH(1)=0 min{[0,μM(Z)]} min{[0,μH(Z)]} min{[0,μH(Z)]} X To find the aggregate ... μL(400) =0 min{[1,μVL(Z)]} min{[0,μM(Z)]} μM(400)=1 min{[0, μL(Z)]} min{[1,μM(Z)]} μH(400)=0 min{[0, μM(Z)]} min{[0,μH(Z)]} 32 μTS(13020) = min{[0,μH(Z)]} min{[0,μH(Z)]} min{[0,μvH(Z)]} To find the...

Ngày tải lên: 22/03/2014, 22:20