in clinical features of alzheimer s disease

... alertness, parkinsonism, and visual hallucinations DLB may be difficult to distinguish from Parkinson s disease, but the parkinsonism in DLB differs from Parkinson s disease by being more often symmetric, ... toward scan interpretation that integrates the visual and quantifying information present in clinical PET scans Visual Assessment Systematic visual examination of a clinical brain PET scan involves ... cognitive functioning Cognitive screening includes using validated screening instruments, such as the MMSE, and brief bedside assessments Cognitive screenings are usually sensitive to significant cognitive...

Ngày tải lên: 05/03/2014, 23:20

... subentities, making a clear definition very difficult The majority of AD researchers assume Risk Factors for Disease Progression in Alzheimer' s Disease a linear slope, but some investigators also suggest ... re-sampled repeatedly, allowing for longitudinal assessment of gene dysregulation at different disease stages This could assist in making diagnoses, tracking the disease course and evaluation of ... a disease modifier exerting its effect on disease risk by influencing age of onset rather than disease risk per se (Serretti et al., 2007) In this hypothesis, APOEe4 genotype modulates disease...

Ngày tải lên: 28/06/2014, 05:20

... helps in comparing results across studies and obtaining a global overview of the disease pathogenesis In this paper, we perform a transcriptomebased study by combining the analysis of co-expressed ... meaning co-expressionlinks expressed co-expression at since profiles number We are This of over-represented 6.4% shows biological ID of in disease- asso- Acknowledgements pcc − mpcc Zscore = spcc ... categories Check for genes associated with Alzheimer s disease and other human diseases WordSpy Identify significant cis-regulatory elements in disease associated genes Figure Steps taken to analyze Alzheimer' s...

Ngày tải lên: 14/08/2014, 21:20

... neurological, psychiatric and neuropsychological assessments were reviewed in a consensus conference comprised of neurologists, psychiatrists, and neuropsychologists Based on this review all participants ... role of apolipoprotein E in Alzheimer s disease, acute brain injury and cerebrovascular disease: evidence of common mechanisms and utility of animal models [In Process Citation] Neurobiol Aging ... repetition of phrases from the Boston Diagnostic Aphasia Evaluation [19] Abstract reasoning was evaluated using WAIS-R Similarities subtest [66], and the non-verbal Identities and Oddities subtest of...

Ngày tải lên: 05/03/2014, 21:20

... complements data from rat tissues showing that calcineurin is also expressed in neurons [14,15] RCAN1 gene expression is significant in several tissues, particularly human brain, spinal cord, kidney, liver, ... control tissues (a representative western blot is shown in Fig 3A) As human brain tissue is difficult to obtain, we focused on the most interesting regions for further studies These regions included ... shown to bind to and inhibit the serine–threonine protein phosphatase calcineurin [5] The brain is an especially interesting organ in which to examine RCAN1 expression, because calcineurin is...

Ngày tải lên: 16/03/2014, 11:20

... Cross-talk between calpains and caspases The striking similarity between the substrates for caspases and calpains raises the possibility that both protease families contribute to structural dysregulation ... Ca2+-mediated apoptosis in astrocytes In this model of astrocyte apoptosis, translocation of the NF-kB p65 subunit to the nucleus is observed These findings indicate that, in this case, NF-jB acts as a death-promoting ... mechanism associated with the proteolysis of several MAPs and leading to neuronal apoptosis in AD Conclusion In summary, the ubiquitous expression of calpains in distinct subcellular compartments at...

Ngày tải lên: 23/03/2014, 10:21

... of increased levels of cytokines in the brains of Alzheimer' s disease patients, and in transgenic mouse models of Alzheimer' s disease [10-12] However, all these reports have focused on a small ... brain slices was assessed using the Bioplex cytokine multi-array system Cytokine levels were not significantly elevated in PS1 brain slices compared to control slices, indicating that the PS1 Page ... brain slice cultures from transgenic mouse models of Alzheimer' s disease, and to further relate this increase to the level of Aβ present in the brain Another purpose of our study was to determine...

Ngày tải lên: 19/06/2014, 22:20

... memory loss in a mouse transgenic model of Alzheimer' s disease J Neurosci 2002, 22:6331-6335 Selkoe DJ, Schenk D: Alzheimer' s disease: molecular understanding predicts amyloid-based therapeutics Annu ... performed on sections processed at the same time Single ANOVA statistical analysis was used to assess the significance of the differences in plaque area, glial and C3 activation products reactivity ... numbers of Aβ-positive objects (or the sum of the areas of the Aβ positive objects) for the entire section and dividing by the sum of the areas of all ROIs This analysis was performed blinded...

Ngày tải lên: 19/06/2014, 22:20

... di-tyrosine-mediated cross-linking of Ab peptides [16–18] This is consistent with the high di-tyrosine content observed in AD brain tissue [17] Oxidative stress within the AD brain is also closely ... is increased in cerebrospinal fluid in Alzheimer s disease but not Parkinson s disease Alzheimer Dis Assoc Disord 8, 190–197 Hye A, Lynham S, Thambisetty M, Causevic M, Campbell J, Byers HL, Hooper ... Increased regional brain concentrations of ceruloplasmin in neurodegenerative disorders Brain Res 738, 265–274 24 Snaedal J, Kristinsson J, Gunnarsdottir S, Olafsdottir Baldvinsson M & Johannesson...

Ngày tải lên: 07/03/2014, 10:20

... treating Alzheimer s disease In 1984, the first clinical criteria for the diagnosis of Alzheimer s disease was published, and the first five Alzheimer s Disease Research Centers were established ... disease Frontotemporal and Parkinsonian dementias Huntington s disease Neuronal ceroid lipofuscinosis Multiple infarct dementia “Binswanger s disease “Small vessel ischemic disease CADASIL Schizophrenia ... important scientific advances in a single volume Those working in the areas of Alzheimer s disease and dementia will find this book of interest, including physicians, medical students, psychologists, scientists,...

Ngày tải lên: 14/03/2014, 21:20

... disorders, is representative of a number of inherited diseases The initiation of the disease process depends on the size of polyglutamine tails [32] The cognitive and psychiatric decline is caused ... glucose metabolism in the cytosol of mouse brain The model included the kinetic parameters of the glycolytic enzymes in normal brain tissues as established by ourselves (Table 2) and others (Doc S4 ) ... vulnerable striatal neurones in HD Our studies were performed with brain tissues containing different types of neuronal cells as well as a large excess of glial cells Astrocytes, a sub-type of the...

Ngày tải lên: 23/03/2014, 10:20

... ~8 weeks, ~10 weeks, ~12 weeks, and ~13 weeks Discussion Gait disturbances are characteristic of Parkinson 's disease, Huntington 's disease, and amyotrophic lateral sclerosis Gait reflects several ... cycle timing in Parkinson 's disease and Huntington 's disease Mov Disord 1998, 13:428-437 Blin O, Ferrandez AM, Serratrice G: Quantitative analysis of gait in Parkinson patients: increased variability ... and processing 20 21 22 References Salarian A, Russmann H, Vingerhoets FJ, Dehollain C, Blanc Y, Burkhard PR, Aminian K: Gait assessment in Parkinson 's disease: toward an ambulatory system for...

Ngày tải lên: 19/06/2014, 10:20

... neuritic SP (classic/burnt out)) Analyses also investigated SP density in a semi-quantitative manner, dividing SP counts into ‘no SP’, ‘sparse SP’, ‘moderate SP’ and ‘frequent SP’, comprising a scoring ... Affairs of Finland Senile plaques and neurofibrillary tangles SP and NFT assessments were made as previously described [28] A large number (70%) of cases had ‘no SP’ and using this skewed data as ... already have played its part Based on our studies and others’ results, the brains of most middle-aged to elderly persons possess some degree of persistent inflammation as well as SP and NFT It could...

Ngày tải lên: 19/06/2014, 22:20

... diagnosis that would be diagnostic aid to probable Alzheimer' s disease cases such as MRI brain, PET scan and computed tomography single photon SPECT Alzheimer' s disease was diagnosed clinically based ... This situation was similar to the clinical literature review in Alzheimer' s disease and in other countries 4.1.1.3 Quality of life of people with Alzheimer' s disease Assessing the quality of ... level of stress and psychological distress were significantly higher satisfaction and physical health were significantly lower in Alzheimer s disease caregivers than caregivers in other diseases In...

Ngày tải lên: 25/07/2014, 11:36

... Suzuki N, Nara K, Suzuki T: Skewed Th1 responses caused by excessive expression of Txk, a member of the Tec family of tyrosine kinases, in patients with Behcet s disease Clin Med Res 2006, 4:147-151 ... arthritis (PsA) resembles BD clinically; a further similarity is the presence of neutrophils in SF from PsA patients Increased levels of intra-articular CD15+ neutrophils, CD3+ T cells, and perforin ... inflammatory cells On the other hand, those micro-organisms are also capable of stimulating an immune response in BD Most tissue studies of the pathophysiology of BD are conducted in skin One of the unique...

Ngày tải lên: 09/08/2014, 14:20

... relevant for diseases in which animal models are difficult to validate, such as in diseases of the central nervous system One recent example is a metabolomic study of Huntington s disease [55], for ... expression of genes involved in cytoskeletal maintenance, DNA repair and redox homeostasis Profiling of small molecules (metabolites) is also a promising way to search for new AD biomarkers Concentration ... to its writing Page of Author information MO is a Research Professor of systems biology and bioinformatics His main research areas are metabolomic applications in biomedical research and integrative...

Ngày tải lên: 11/08/2014, 12:21

... frequencies of HLA-A alleles between patients and controls or between patients with and without certain clinical features Statistical calculation was done using SPSS version 17.0 (SPSS Inc., Chicago, ... retrospective studies of disease J Natl Cancer Inst 1959, 22:719-748 Higgins JP, Thompson SG, Deeks JJ, Altman DG: Measuring inconsistency in meta-analyses BMJ 2003, 327:557-560 Itoh Y, Inoko ... Katsuyama Y, Pivetti-Pezzi P, Ohno S, Inoko H: Significant associations of HLA-B*5101 and B*5108, and lack of association of class II alleles with Behçet s disease in Italian patients Tissue...

Ngày tải lên: 12/08/2014, 15:22

... cross-breeding experiments is strengthened if expression and deletion of the gene (s) results in the opposite outcome, or if the results are substantiated by in vitro studies or analyses of clinical samples ... pathogenesis Therapeutic studies in AD models Access to good animal models is crucial to success in developing disease- modifying therapeutics However, AD neuropathology is incomplete in the Ab-expressing ... by crossing PDGF–a-synuclein and APP-SweInd, which led to a 1.6-fold increase in a-synuclein inclusions in comparison with transgenic mice that expressed only wild-type human a-synuclein Similar...

Ngày tải lên: 16/02/2014, 09:20

... either polyglutamine or polyalanine expansions in Huntington disease, Huntington related diseases, and various forms of a-synuclein associated with Parkinson disease and synucleinopathies [27] Taken ... phosphorylate eEF2 in its N-terminus (Thr56) that subsequently blocks eEF2 binding to ribosomes, resulting in decreased rates of protein synthesis Dephosphorylation of eEF2 relieves its translational ... Foundation, SADF (Insamlingsstiftelsen for ¨ Alzheimer- och Demensforskning), Socialstyrelsens Stiftelser, Stiftelsen for Alderssjukdomar, and Svenska ¨ ˚ Lakaresallskapet ¨ ¨ FEBS Journal 272...

Ngày tải lên: 16/03/2014, 22:20

... present study was set slightly higher than the previously reported community-based mean values In the present study the cognitive assessment also included the Alzheimer s Disease Assessment Scale ... PASW software (former SPSS software, version 17.0.1 for Windows, SPSS Inc., Chicago, IL, USA) Non-parametric tests were used because normal distribution could not be assumed in the groups Spearman ... levels of different MMPs in plasma of AD patients [30] The increased levels of several MMPs in the CSF of individuals with increased risk for AD, as observed in the current study, could be explained...

Ngày tải lên: 22/03/2014, 14:20