in abdominal organ transplantation

... declining allograft function after year post -transplantation and finally often result in allograft loss These processes remain Roedder et al Genome Medicine 2011, 3:37 http://genomemedicine.com/content/3/6/37 ... studies in transplantation is to find non-invasive biomarkers of transplant patho­ logies using patient urine or blood that indicate changes at the molecular level, before the development of a clinical ... prospective validation in large patient cohorts Multi-center studies have been introduced: the US ‘Clinical Trials in Organ Transplantation (CTOT and CTOTC), the Canadian ‘Biomarkers in Transplantation ...

Ngày tải lên: 11/08/2014, 12:21

... Background of Organ Transplant Medicine in Singapore This chapter will present some relevant background knowledge regarding organ transplantation in Singapore, primarily the laws regulating organ donation/reception ... in Singapore, and foreign medical organizations The centres and VWOs that supplied such information are those that are concerned with organ diseases and treatments The main institutions in Singapore ... brain stem In many countries, for the purpose of organ transplantation, death has been defined as that of the brain stem rather than that of the heart This means that the law covering organ transplantations...

Ngày tải lên: 07/10/2015, 10:02

... α and β chains in class II molecules are polymorphic In these chains, the α1 and β1 domains are of the PBG and therefore the diversity is found mainly in these do‐ mains These domains are encoded ... sibling hematopoietic stem cell transplantation On applying KIR genotyping, some studies investigated the effect of KIR in sibling HSCT A study of 220 donor-recipient pairs in HLA-matched sibling ... ideas contained in the book Publishing Process Manager Ana Pantar Technical Editor InTech DTP team Cover InTech Design team First published February, 2013 Printed in Croatia A free online edition...

Ngày tải lên: 18/02/2014, 04:20

... RNA binding protein and stem cell marker Inhibitor of microRNA processing in embryonic stem (ES) and carcinoma (EC) cells Table Combinations of the genes that have been used to obtain the induced ... medicine or reparative medicine During this last decade, the number of published articles or books investigating the role of stem cells in cell transplantation or regenerative medicine increased ... KIR family includes activating and inhibitory molecules Inhibitory KIRs (2DL and 3DL) have a long cytoplasmic tail containing tyrosine-based inhibitory motifs (ITIMs) that trigger inhibitory...

Ngày tải lên: 20/02/2014, 08:20

... IL interleukin IL-2 interleukin-2 IL-2R interleukin-2 receptor IMP inosine monophosphate IMV inferior mesenteric vein iNO inhaled nitric oxide INR international normalized ratio INTERMACS International ... established, scientific interest in organ transplantation waned until effective immunosuppressive regimens were found Abdominal organ transplantation Transplantation of abdominal organs has been a ... Following organ transplantation, donor-derived “passenger” APCs residing in the donor organ and expressing large amounts of donor HLA antigens migrate out of the transplant into the draining lymphoid...

Ngày tải lên: 28/03/2014, 10:20

... I, with light staining (in constructs red) in the area of fibrous ingrowth (circled) (b) Collagen type II, showing medium intensity staining (in red) in the entire matrix of the interfacial area ... crossing Collagen immunostaining Cryosections were fixed in acetone for procollagen type I, and collagen types I and III staining For collagen type II staining paraffin sections were deparaffinized ... between increased adhesive strength and an increased hydroxyproline incorporation in the interface area Furthermore, inhibition of collagen cross-link formation by β-aminopropionitrile resulted in...

Ngày tải lên: 09/08/2014, 01:24

... disease-modulating activity of fractalkine in RA, administration of anti-fractalkine antibodies ameliorated experimental RA [9] With regard to diseases involving the kidneys, a viral fractalkine antagonist ... to certain of its actions The study by Wildenberg and colleagues provides, however, a rationale for conducting such functional studies in the future In parallel, it would be interesting to address ... potential to modulate fractalkine related inflammatory processes Conclusion The recent study by Wildenberg and colleagues provides insight into the role of fractalkine in an experimental model of...

Ngày tải lên: 09/08/2014, 10:23

... 0.5 μg/mL epinephrine, 6.5 ng/mL triiodothyronine, μg/mL insulin, ng/mL retinoic acid, 10 μg/mL transferrin, and 0.001% gentamycin (v/v) 16HBE14o- cells were maintained in Dubelco's Minimum Essential ... bovine serum albumin (BSA), hydrocortisone, recombinant human epidermal growth factor (EGF), epinephrine hydrochloride, triiodothyronine, retinoic acid, trypsin and gentamycin were obtained from Sigma ... working Reagents Foetal Calf Serum (FCS), RPMI-1640 media, penicillin G, streptomycin sulphate, amphotericin B and L-glutamine were purchased from Invitrogen (Melbourne, Australia) Insulin, bovine...

Ngày tải lên: 12/08/2014, 14:20

... not show an increased risk of nosocomial pneumonia in medical intensive care patients receiving proton-pump inhibitors [8] Given these findings, the prescription of acid-suppressing medications ... teaching and hours of practical teaching, and provided a range of pre-recorded examinations for the intensivists to study in their own time The study group comprised 44 patients in whom the intensivists ... patients with abdominal septic shock [12] Polymyxin B is an antibiotic with a high affinity for endotoxin Haemoperfusion was performed using haemoperfusion polystyrene fibres with bound polymyxin B The...

Ngày tải lên: 13/08/2014, 18:22

... histopathology and clinical chemistry), referred to as 'phenotypic anchoring', allowed investigators to gain new insight into the processes involved in the adverse effects on target tissues [12-15] In addition ... establishing whether blood transcript data could provide insights into the presence and severity of injury within a target organ upon toxicant exposure In previously published work using these same in- life ... low dose In fact, in most instances this exposure dose did not elicit any injury at any of the time points However, the galactosamine and thioacetamide samples grouped together Interestingly, these...

Ngày tải lên: 14/08/2014, 20:22

... Cytomegalovirus infections in solid organ transplant recipients 1.3 Clinical findings associated with human cytomegalovirus infections 1.3.1 Infections in immunocompetent hosts CMV infection in normal ... perinatal infections 1.2.3 Immunosuppressed hosts 1.3 12 14 Clinical findings associated with human cytomegalovirus infections 16 1.3.1 Infections in immunocompetent hosts 16 1.3.2 Infections in ... useful in monitoring CMV infection in immunocompromised patients for several years However, problems arose in interpretation when rising levels of 24 Cytomegalovirus infections in solid organ...

Ngày tải lên: 13/09/2015, 19:41

... are used include intensity, colour and texture An example using intensity as the differentiating feature is shown below in Figure 2.2 [Brejl and Sonka, 1998] incorporated machine learning into an ... minima is located within the range spanned by the training samples However, it is very difficult to determine if the training set includes all possible variations of the objects of interest Increasing ... statistical information derived from training samples to guide the algorithm towards the global minima This statistical information is derived from various features of the training data, including shape,...

Ngày tải lên: 30/09/2015, 14:24

... studied mainly in intestinal [32-34] but not in lung cells A recent in vitro study demonstrated that in intestinal cells, the role of extracellular signal-regulated kinase pathway in Glnmediated ... cytokines are crucial for down regulating the incremented inflammatory process and maintaining homeostasis for the correct function of vital organs Therefore, a balance between pro- and anti-inflammatory ... and peripheral organs may also be attributed to the association of reduced pro-inflammatory cytokines (CINC-1 and IL-6) with an increase in anti-inflammatory cytokine (IL-10) in BALF and PLF...

Ngày tải lên: 13/08/2014, 16:20

... population [17,18] In our study, the obese and MetS group both demonstrated increased fasting insulin than control group rather than fasting blood glucose Meanwhile, fasting insulin and HOMA-IR levels ... analysis, suggesting a link between IMT, insulin resistance and dyslipidemia Insulin resistance is a common phenomenon and plays an important role in the cardio-cerebrovascular disease in obese population ... FBG = fasting blood glucose; FINS = fasting insulin; HOMA-IR = homoeostasis model assessment- insulin resistance; TG = triglyceride; TC = total cholesterol; HDL-C = high-density lipoprotein- cholesterol;...

Ngày tải lên: 25/10/2012, 11:40

... including erythema infectiosum in children, polyarthropathy syndrome in adults, transient aplastic crisis inpatients with chronic anemia, persistent infections manifesting as chronic anemia in ... remains obscure in 3-10% of cases in Europe [5] and the United States [6] and up to 30% of cases in Asia [7, 8] Particularly, the cause of fulminant hepatitis in children is unexplained in up ... not take place in the absence of reverse transcriptase, indicating minimal DNA contamination In addition to the above-described examinations, to characterize the B19 genomes, we obtained 14 isolates...

Ngày tải lên: 26/10/2012, 10:03

... for a minimum of months post-OLT After one year, reinfection occurred in 20% of patients in each group, but the finding of circulating HBV DNA by PCR in of 11 receiving HBIG and of 10 receiving ... survival In a prospective study of indefinite LAM pre-OLT therapy, 32 of 154 patients (21%) died and 25 of the 32 deaths occurred within months of initiating therapy [52] Bilirubin, creatinine and ... determined in future controlled trials Monotherapy to Prevent HBV Reinfection After Transplantation Hepatitis B Immune Globulin Monotherapy Long-term use of HBIG in the late 1980s in Europe and in...

Ngày tải lên: 02/11/2012, 11:17

... rash and itching may occur; the skin may become scaly; the skin may heal by scarring; hair loss may accompany the skin injury Look for dry eyes: no tears, constant rubbing and blinking; sensitivity ... produce additional proinflammatory cytokines, including tumor necrosis fac­ tor (TNF)-α, interferon (IFN)-γ, and interleukin (IL)-2, which in turn attract more T-cells to continue the cycle of tissue ... for difficulty swallowing or a sensation that food becomes caught in the throat; nausea/vomiting; diarrhea; poor appetite; abdominal pain; unexplained weight loss Look for joint and muscle aches;...

Ngày tải lên: 12/02/2014, 19:20

... (mainly causes by calcineurin inhibitors - CNI), and rejection In general, imaging tools in evaluating MC following renal transplantation are non-specific [24-26] The major role of imaging in ... waiting time if cure at the time of transplantation Incidental renal cell carcinoma In situ carcinoma of bladder In situ carcinoma of cervix Basal cell carcinoma Squamous cell carcinoma (skin) ... preceded by increased abdominal pain, reduction in urine volumes and sometimes, urine leakage from the wound US is essential in the evaluation of perirenal collections, including urinomes It is...

Ngày tải lên: 07/03/2014, 19:20