implications in irritable bowel syndrome

... important measure in the management of Irritable Bowel Syndrome (IBS) Controversy exists in the findings of studies evaluating QOL in IBS subtypes, and little is known about this issue in Iranian patients ... biochemical profiles including thyroid function tests, anti tissue transglutaminase antibodies, stool exam, and urinalysis) findings, 6) abnormal findings in barium contrast radiographies, or in upper and ... bowel syndrome, IBS-C: Irritable bowel syndrome constipation predominant type, IBS-D: Irritable bowel syndrome diarrhea predominant type, IBSM: Irritable bowel syndrome mixed type, IBS-QOL: Disease...

Ngày tải lên: 20/06/2014, 16:20

... Chapter Spectrum of Irritable Bowel Syndrome and Brain-Gut Axis 1.1 Introduction The irritable bowel syndrome (IBS) is a common disorder producing abdominal pain, bloating and altered bowel habits, ... DNIC relies on spinobulbo-spinal loops involving ascending pathways in the anterolateral spinal columns, integration in the lower brain stem, and descending influences reaching the dorsal horn ... travel in humans (Kirby et al, 1999) 3.3.4 Gastrointestinal regulation function of melatonin 3.3.4.1 Gastrointestinal melatonin The finding that the concentration of melatonin in the gastrointestinal...

Ngày tải lên: 16/09/2015, 08:30

... centres in the city of Linköping located in the south-east region of Sweden [20] In this study, a postal questionnaire, including SF-36, demographics, lifestyle indicators, gastrointestinal and ... differences found in this study is that coping with IBS in everyday life might be more problematic in the Cretan environment than in Sweden and this represents the main finding The outdoor living tradition ... 2006, 4:21 trol group The link between IBS and psychosocial factors such as stress in everyday life has been reported in many earlier studies [33,34] An interesting finding in this study was that...

Ngày tải lên: 20/06/2014, 15:20

... [10], induced visceral hyperalgesia in rats [9] It would be of interest in future study to examine whether serotonin acting on 5-HT1A receptor and tryptase acting on PAR-2 are involved in visceral ... enteric neuropathy in irritable bowel syndrome Gastroenterology 2002, 123, 1972-1979 28 Weston AP, Biddle WL, Bhatia PS, Miner PB Jr Terminal ileal mucosal mast cells in irritable bowel syndrome Dig ... pseudaffective reflexes in the rat Brain Res 1988, 450, 153-169 21 O'Sullivan M, Clayton N, Breslin NP, Harman I, Bountra C, McLaren A, O'Morain CA Increased mast cells in the irritable bowel syndrome Neurogastroenterol...

Ngày tải lên: 07/08/2014, 18:20

... regulating GI smooth muscle contraction, resulting in abnormal intestinal motility 2) There may be dysregulation of the sensory nerves linking intestinal receptors and nerve endings to CNS, resulting ... are trying to find the role of GIT transit using bran scan in IBS patients with bloating (See later chapter) 1.3 The role of Serotonin in IBS Serotonin (5-hydroxytryptamine, 5-HT) has gained recognition ... thus hypothesized that 1) bloating predominant IBS patients in Asia have delayed intestinal transit; and 2) tegaserod could improve bloating and intestine transit in these patients Therefore, the...

Ngày tải lên: 26/09/2015, 10:05

...  Antimuscarinics (Dicyclomine, Hyoscyfamine)  Smooth muscle relaxants (Mebeverine, Pinaverine)  Calcium channel blocker(Nifedipine, Pepermint oil)  Antidepressants-Amiltriptyline  Probiotics ... distension, increased belching or flatulence (Increased gas)-Quantitative measurement reveal: no more than a normal amount of intestinal gas -Impaired transit and tolerance of intestinal gas loads ... the distal to the more proximal intestine belching IBS- Dr Trần Ngọc Ánh CLINICAL FEATURES 4,Upper Gastrointestinla symptoms  -Dyspepsia, heartburn, nausea, vomiting: 31.7% Dyspepsia have IBS...

Ngày tải lên: 08/07/2014, 10:08

... “căn bệnh” khó chịu Vì IBS không gây hư hỏng thể xác hệ thống tiêu hóa, người ta tin số bệnh nhân “yếu đuối” mặt tinh thần dễ mắc bệnh Người ta nhận thấy người bị hành hạ thể xác nạn nhân xách nhiễu ... đề tâm lý tinh thần, triệu chứng kể thường xuyên bệnh nhân hoàn cảnh điều kiện khó khăn trở nên buồn phiền, chán nản u sầu Ngay số phụ nữ, triệu chứng IBS trở nên rõ rệt theo chu kỳ kinh nguyệt ... uống: Tuy số thức ăn nước uống tăng thêm thuyên giảm triệu chứng IBS số bệnh nhân, điều khó chứng minh cách cụ thể Tiếc thay, số bệnh nhân, sợ hãi, nên nhịn ăn cách đáng, không cần thiết Tôi thường...

Ngày tải lên: 13/07/2014, 16:20

... giao cảm ức chế nhu động ruột - Một số hormon làm tăng nhu động ruột non : gastrin, cholecystokinin, insulin.serotonin - Sự vận động ruột già tương tự ruột non, có loại co bóp khối đặc biệt, ép ... nhiên điều chưa chứng minh - Mất cân hệ thống hormon - Stress, lo âu Causes and symptoms of irritable bowel syndrome 3.TRIỆU CHỨNG -Hội chứng ruột kích thích tác động đến người theo cách khác Tiêu ... liên quan đến thay đổi liên kết thần kinh não ống tiêu hóa -Sau giai đoạn viêm dày - ruột -Sự dị ứng với thức ăn tính nhạy cảm thức ăn, nhiên điều chưa chứng minh - Mất cân hệ thống hormon - Stress,...

Ngày tải lên: 28/07/2014, 23:21

... considering our patient’s age and symptoms included several diseases that would manifest with alternating constipation and diarrhea These diseases include inflammatory bowel disease, irritable bowel ... undergoing a colonoscopy every 10 years, beginning at the age of 50, as the preferred colorectal cancer screening strategy [17] Taking into consideration our patient’s age and the ongoing worsening ... foreign body ingestion highlights the need for high index of suspicion from primary care physicians when diagnosing and treating abdominal complaints Consent Written informed consent was obtained from...

Ngày tải lên: 11/08/2014, 03:21

... alternating bowel habit subtype in patients with irritable bowel syndrome Am J Gastroenterol 2005;100:896–904 13 Mearin F, Balboa A, Badia X, et al Irritable bowel syndrome subtypes according to bowel ... described as pain Downloaded from gut.bmj.com on 11 August 2008 Guidelines on the irritable bowel syndrome 1773 Table Prevalence of irritable bowel syndrome in the United Kingdom and in other Western ... with change in stool frequency or consistency (suggesting a link to changes in intestinal transit, Box Rome III diagnostic criteria* for irritable bowel syndrome Recurrent abdominal pain or discomfortÀ...

Ngày tải lên: 13/08/2014, 09:44

...  Antimuscarinics (Dicyclomine, Hyoscyfamine)  Smooth muscle relaxants (Mebeverine, Pinaverine)  Calcium channel blocker(Nifedipine, Pepermint oil)  Antidepressants-Amiltriptyline  Probiotics ... distension, increased belching or flatulence (Increased gas)-Quantitative measurement reveal: no more than a normal amount of intestinal gas -Impaired transit and tolerance of intestinal gas loads ... the distal to the more proximal intestine belching IBS- Dr Trần Ngọc Ánh CLINICAL FEATURES 4,Upper Gastrointestinla symptoms  -Dyspepsia, heartburn, nausea, vomiting: 31.7% Dyspepsia have IBS...

Ngày tải lên: 05/08/2015, 09:24

... synthesis, and inosine that will be degraded into hypoxanthine and xanthine and finally into uric acid Hypoxanthine and guanine may enter in a salvage pathway, using hypoxanthine-guanine phosphoribosyltranferase ... The PEGylation consists in binding with a covalent link a protein (adenosine-deaminase, asparaginase, interferons, granulocyte colonystimulating factor, liposomal doxyrubicin) to poly(ethylene) ... conversion of hypoxanyhine into xanthine and this latter into uric acid During this reaction an active metabolite, deriving by enzymatic action on allopurinol, oxypurinol, inhibits xanthine oxidase and...

Ngày tải lên: 31/10/2012, 14:59

... Analysis of Proverbs Denoting Humans with Dispraising Implications in English and Vietnamese An Investigation into Idioms Denoting Humans with Praising Implications in English and Vietnamese ... Sorry, I’m going to a party tonight, and I’m thinking of what to wear Hence, dialogue writing and role-play are useful and interesting activities for learners learners’ in meaningful describing and ... TEACHING classified into noun phrases (31 in IDHDIE; 34 in IDHDIV), verb It is true that Vietnamese learners often find learning and phrases (104 in IDHDIE; 110 in IDHDIV), adjective phrases (29 in...

Ngày tải lên: 26/11/2013, 13:31

... spectroscopy in D2O Spectrograms of solutions containing the same peptides included in Fig were analyzed in D2O (known to prevent intra- and intermolecular hydrogen bonds) Note the absence of in exion ... complete protein in vivo, our findings are in perfect agreement with the phenotype–genotype associations observed in clinical reports and identify some important factors determining the appearance ... the same way, removing the CONH2-terminus of the peptides resulted in increased amyloid fibril formation This increase may be due to a direct inhibitory effect of this nine-amino-acid sequence,...

Ngày tải lên: 21/02/2014, 01:21

... overexpressing SMO cells further confirmed the increased SMO activity, with decreases in intracellular spermine pools and increased spermidine levels in SMO1 and SMO5 cells These changes in spermine ... oxidation of spermine to spermidine diminishes nuclear spermine pools Because spermine has essential roles in the the protection of DNA, including free radical scavenging and DNA shielding, this reduction ... Correlations between polyamine analogue-induced increases in spermidine ⁄ spermine N1-acetyltransferase activity, polyamine pool depletion, and growth inhibition in human melanoma cell lines Cancer Res...

Ngày tải lên: 07/03/2014, 05:20

... rhodanese-like proteins have roles in ‘managing’ stress tolerance and in maintaining redox homeostasis [15–18] It is also noteworthy that a study, using microarray to examine the gene expression in colonic ... compounds in the cell, inducing the onset of degenerative states and apoptosis The in vitro study of their interaction with enzymes probably involved in the metabolism of sulfur may explain their in ... cleavage at the interdomain tether that connects the two domains into which the single polypeptide chain protein is folded [42,43,45] Thus, the inactivation of the rhodanese by 2-PTS induces local...

Ngày tải lên: 07/03/2014, 06:20

... analysis of rinderpest viruses has been vital in determining the lineages circulating in the world and instrumental in aiding the Global Rinderpest Eradication Programme Enzyme-linked immunosorbent ... constraints for using gene-based technologies in animal agriculture in developing countries and possible role of international donor agencies in promoting R&D in this field In FAO/IAEA international ... benefit in the short term In determining future policy, policy-makers and funding bodies must not lose sight of the substantial benefits that can be gained in the longer term by investing in strategic...

Ngày tải lên: 13/03/2014, 22:00

... as a 15-kDa band, containing both the N- and C-terminal chains that are identical in size (band A) Activation of double-chain trypsinogen to double-chain trypsin results in the appearance of band ... chance for premature trypsinogen activation inside the pancreas, while maintaining acceptable trypsin function in the duodenum In other words, increased anionic trypsinogen levels not cause or ... anionic trypsinogen resulted in lower trypsin generation in pathological mixtures of the two human trypsinogens Finally, at pH 5.0 cationic trypsinogen was completely activated to trypsin in the physiological...

Ngày tải lên: 17/03/2014, 03:20

... compartment in isolated mitochondria and in COS-7 cells transiently or stably expressing the human protein Mutation of the putative mitochondrial targeting signal eliminates this targeting mechanism in ... total protein bound and imported into mitochondria is present; T, trypsin-treated mitochondria in which only the protein imported into mitochondria is present In the lanes marked In , 20% of ... could convert certain substrates into reactive species within the mitochondria, thereby inducing toxicity The exact reason for the high level of inter-individual variability in the level of the...

Ngày tải lên: 29/03/2014, 23:20

... via adaptor molecules, such as integrin linked kinase, to the actin cytoskeleton and to various signaling molecules including mitogen-activated protein (MAP) kinases and small GTPases [67,68] ... lining endothelium against fibrotic and atherosclerotic diseases which are predominantly initiated in areas of turbulent flow However, other studies reported conflicting data In particular, Eskin ... migrate generating strong contractile forces that permit wound tissue edge closing Interestingly, increased levels of CTGF and Cyr61 were found in fibroblasts in closing wounds [29,30] In addition,...

Ngày tải lên: 30/03/2014, 10:20