implications for the philosophy of the higher level sciences

... priority The output of this exercise was the basis for the formulation of a multi -level conservation action plan for forest wetlands in the MD, using the guidelines in the Ramsar Convention [3] and the ... provide information on the type and the location of wetland, the economic and ecological value of the wetland, and the type and incidence of human threat [2] They are used as basis for the formulation ... livelihood of the people;, and management strategies for the exploitation, development and conservation of the wetland The multi -level action plan for the conservation of forest wetlands in the MD...

Ngày tải lên: 09/12/2013, 22:15

... understand the “rules of the game” the way the United States does That is one interpretation of both the crude Chinese nuclear threats over the Taiwan crisis and Chinese views of the U.S bombing of the ... Russia and the United States and the rest of NATO suggest the danger of further friction in the future 26 Future Roles of U.S Nuclear Forces: Implications for U.S Strategy So far, there has been ... range of actions by threat of nuclear use • A means of offsetting an imbalance of conventional forces (e.g., the U.S rationale for its nuclear posture in Europe; the original motivation for the...

Ngày tải lên: 17/02/2014, 11:20

... (4.9%) 19 The report is prepared jointly by the Department of the Treasury, the Federal Reserve Bank of New York, and the Board of Governors of the Federal Reserve System 20 Department of the Treasury, ... depreciate If the value of the dollar depreciated, the trade deficit would decline, as the price of U.S exports fell abroad and the price of imports rose in the United States.52 The magnitude of these ... have been the main components of China’s rapid accumulation of FX reserves.9 For a discussion of the implications of a possible global sell-off of U.S securities, see CRS Report RL34319, Foreign...

Ngày tải lên: 20/02/2014, 20:20

... our understanding of the components of the long war, provided the basis for a set of seven strategy options for the United States in the long war xvi Unfolding the Future of the Long War Divide ... on by agencies other than the Army, but it has often been fulfilled by the Army Broad Observations From the consideration of the implications of the proposed trajectories for the United States, ... Agency for International Development, the State Department, the Peace Corps, the Department of Agriculture, and the Department of Justice would become the focus of the new U.S strategy Implications...

Ngày tải lên: 06/03/2014, 20:20

... preliminary analysis of secreted proteins indicated in the genomic sequence data of S aureus The criteria for selection of the substrate were a good prediction of the presence and location of the signal ... in the Fig SPase recognition sequence and cleavage sites of the SpsB substrates used in the present study: Showing part of the sequence of the IsaA precursor (upper row) and the sequence of the ... amount of preprotein processed at varying pH did not yield sufcient quantitative data, and therefore the FRET assay was used to study the effect of pH on the enzyme The stability of the synthetic...

Ngày tải lên: 07/03/2014, 01:20

... characteristic of the structure of the native epitope in Me2SO is the presence of a large number of electrostatic interactions, especially in the central region of the peptide The side chain of Arg78 ... studies of the epitope of MBP therefore we may conclude that the conformation of epitopes of the integral protein must be affected by posttranslational modifications Docking calculations of the MBP(74–85) ... between the side chains of Arg78 and Glu82/Asp81 independently of the nature of the solvent (protic or nonprotic) This might come from the peptide conformation, which drives the orientation of these...

Ngày tải lên: 07/03/2014, 16:20

... results in reduction of the enzyme-bound FAD, forming the EH4 or EH4ÆNAD(P)+ species In the case of a true oxidase, it makes sense for the enzyme to stabilize the EH4 form, since the reduced flavin ... During the anaerobic reduction of the S aureus enzyme there is loss of roughly 50% of the absorbance at 452 nm In that case, the loss of absorbance is attributed to an asymmetric reduction of the ... difficult to determine directly from the spectrum the fate of the reduced pyridine nucleotide During the addition of the first equivalent of NADPH, there is a blue shift in the 380 nm peak and subsequent...

Ngày tải lên: 07/03/2014, 17:20

... namely the presence of a linker domain between the two halves of the transporter The mouse ABCB1a structure is missing the 56 amino acids between the end of the first NBD and the start of the second ... number of concerns arise from close inspection of the structure Of most relevance to the current discussion are the resolution, the completeness of the structure, the spatial separation of the NBDs ... in the transition from the nucleotide-free to the ADP ⁄ Vi-trapped states of MsbA With all five pairs of residues (located along the axis of the protein perpendicular to the membrane) the sign of...

Ngày tải lên: 22/03/2014, 21:20

... phases from the final model of the halfreduced form, is contoured at the 1.5r level, where r represents the ˚ rms electron density for the unit cell Contours more than 1.5 A from any of the displayed ... blue) Also shown are the heme ligands (histidine and methionine in each case), the cysteines that form thioether bonds to the heme, and the methyl group of the alanine of the C fasciculata AXXCH ... vinyl), as is observed for the C-terminal cysteine of the typical CXXCH c-type cytochrome heme-binding motif [1,13] The heme iron is coordinated by the Ne of the histidine of the ‘AXXCH’ (actually...

Ngày tải lên: 23/03/2014, 04:21

... relative to the other For comparison, the corresponding angle found for (nonactivated) KlPDC is  36° The main difference between KlPDC and the activated form of ScPDC is the flexibility of the loop ... of the two dimers within the tetramer: the D2 symmetry of the nonactivated ScPDC is broken, and an open and a closed side of the tetrameric molecule is formed Two different binding sites of the ... The cofactors are depicted in space-filling mode The positions of the N-terminal and C-terminal amino acid residues of the model, the position of the flexible loop region, which is omitted in the...

Ngày tải lên: 30/03/2014, 10:20

... 105 pfu per eye of HSV-1 strain KOS-GFP or GFP relationship of the genotype and phenotype of these mice is defined in Table c The mean ± standard error of the mean of the logarithm of infectious ... compromised the integrity of the tissue Thus, consistent with other results, the Stat signaling pathway was essential to restrict the spread of wild-type HSV-1 from the site of inoculation to the TG ... mice, the number of latent GFP genomes per TG was ~115% of the wild-type level In stat1-/- mice (inoculated with a ten-fold lower dose of GFP), the number of Page of 23 (page number not for citation...

Ngày tải lên: 20/06/2014, 01:20

... physical performance test batteries, which averaged measures of performance over several domains of functioning [14,15,18-20] One explanation for the weak correlations in these studies may be the problem ... physical functioning, before they had the physical examination and performance testing Analytic framework To maximize the specificity of the association between physical performance tests and self-reported ... meters and then dividing by the time in seconds needed to complete the test We categorized performance on both tests into quartiles, with the bestperforming quartile as the reference group The lock...

Ngày tải lên: 20/06/2014, 16:20

... for the different tested variables in each of the [site x year] combinations of the study, for each stage and each provenance The coefficients of variation (CV), ie the ratio of the mean to the ... multivariate approach (Moser et al, 1990) The non-violation of the assumptions of the analysis of variance, particularly the adequacy of the model and the homogeneity of residual variances, were checked ... using the sine curve reconstitution of daily temperatures were slightly higher than those obtained with the simpler formula Tm (Tmin + Tmax)/2 The latter formula was therefore used for the threshold...

Ngày tải lên: 08/08/2014, 19:21

... illness, whereas of 12 not waiting had a psychotic illness Duration of stay was composed of the days preceding the chosen day and the number of days of further treatment in the acute ward Twenty-three ... Dorothy Rice found that the direct costs of schizophrenia and affective disorders were twice the indirect costs The share of the costs of these two illnesses was higher than the prevalence would ... in training at the time of the study, was aware of the registration of time from the senior psychiatrists decision to the actual day of referral to the next step in the treatment chain, called...

Ngày tải lên: 08/08/2014, 21:20

... spreading to other epitopes in the Sm particle This view of the battle between the virus and the immune system is further amplified by the results of the analysis of MHC II T cell epitopes using the ProPred ... sequences in the B/B' polypeptide followed by spreading to the rest of the Sm particle To further explore the relevance of disorder to the idea of spreading we carried out a PONDR® analysis of the EBNA1 ... in the frequency of prospective epitopes in Fig 4c While the effect here is far less dramatic than in the case of the three other autoantigens pictured, the degree of disorder seen in Fig for...

Ngày tải lên: 09/08/2014, 07:20

... stimulatory or inhibitory effect of the recombinant cytokines added to the cultures rather than any difference in the initial levels For type I collagen, there was a higher basal level in degenerate cells ... in the basal levels for expression of each of the genes studied between normal and degenerate untreated cells, with the exception of type I collagen; thus, any changes identified were due to the ... studied These studies investigated the protein expression of these receptors rather than gene expression and separated the groups according to age rather than Page of 10 (page number not for citation...

Ngày tải lên: 09/08/2014, 14:20

... being deleted RK: If there is a good chance that the data are going to be used by others, then yes, there is a good case for storing them Just storing the raw data for the sake of it, however, is ... where the US is paying to generate all these data - probably the majority of genomics data is coming from the US at Page of present - but where it’s not prepared to meet the cost of archiving the ... archiving project, one needs to con­ sider the cost of storage relative to the potential future reuse In the course of the 1000 Genomes project, for example, the raw sequencing reads have been realigned...

Ngày tải lên: 09/08/2014, 22:23

... Regardless of technique, however, the fundamental principle of neuroma surgery involves excising the injured nerve segment proximally to the level of grossly normal fascicles Yet the zone of injury of ... increase the number of neuromas created per animal (and thereby decrease the total number of animals sacrificed), and the amputation was performed in the proximal forelimb in order to mimic the clinical ... University for their assistance with animal care from the inception of the amputation model and throughout the course of this study The authors would also like to thank Linda Juarez at the University of...

Ngày tải lên: 10/08/2014, 10:20

... concomitantly with the layering of the exine [54] and the formation of the pollen aperture is related to endoplasmic reticulum blocking the deposition of primexine [3] The callose remnant at the pollen ... cherimola, the confined space that permits the delay in the dissolution of the PMC wall and the tapetal chamber and pollen rotation that allows the adhesion of the sticky proximal faces by the formation ... afternoon of the following day when the flower enters the male stage Anther dehiscence occurs concomitantly in all stamens of a flower and, as the anthers dehisce, they detach from the flower...

Ngày tải lên: 12/08/2014, 03:21

... reactivated in 60% of the patients tested (25 out of 42 patients) [302] These results constitute a proof -of- concept for the co-administration of (at least) two different categories of therapeutically ... Nucleotide (nt1) is the start of U3 in the 5'LTR The transcription start site corresponds to the junction of U3 and R (C) Schematic representation of the nucleosomal organization of the HIV-1 genome ... elongation (B) Following the synthesis of the first molecules of Tat, this viral protein migrates to the nucleus Tat then binds to the RNA hairpin TAR, located in the 5' region of all nascent HIV-1...

Ngày tải lên: 12/08/2014, 23:22